IL159580A0 - Cells of the cardiomyocyte lineage produced from human pluripotent stem cells - Google Patents

Cells of the cardiomyocyte lineage produced from human pluripotent stem cells

Info

Publication number
IL159580A0
IL159580A0 IL15958002A IL15958002A IL159580A0 IL 159580 A0 IL159580 A0 IL 159580A0 IL 15958002 A IL15958002 A IL 15958002A IL 15958002 A IL15958002 A IL 15958002A IL 159580 A0 IL159580 A0 IL 159580A0
Authority
IL
Israel
Prior art keywords
cells
pluripotent stem
human pluripotent
cardiomyocyte lineage
stem cells
Prior art date
Application number
IL15958002A
Other languages
English (en)
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of IL159580A0 publication Critical patent/IL159580A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C12N2500/62—DMSO
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
IL15958002A 2001-07-12 2002-07-12 Cells of the cardiomyocyte lineage produced from human pluripotent stem cells IL159580A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30508701P 2001-07-12 2001-07-12
US32269501P 2001-09-10 2001-09-10
PCT/US2002/022245 WO2003006950A2 (en) 2001-07-12 2002-07-12 Cells of the cardiomyocyte lineage produced from human pluripotent stem cells

Publications (1)

Publication Number Publication Date
IL159580A0 true IL159580A0 (en) 2004-06-01

Family

ID=26974401

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15958002A IL159580A0 (en) 2001-07-12 2002-07-12 Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
IL159580A IL159580A (en) 2001-07-12 2003-12-25 Cells of cardiomyocytic origin extracted from pluripotent human stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159580A IL159580A (en) 2001-07-12 2003-12-25 Cells of cardiomyocytic origin extracted from pluripotent human stem cells

Country Status (11)

Country Link
US (3) US7425448B2 (xx)
EP (1) EP1412479A4 (xx)
JP (4) JP2004535199A (xx)
KR (2) KR101073411B1 (xx)
CN (1) CN1543500B (xx)
AU (1) AU2002313670C1 (xx)
CA (1) CA2453438C (xx)
GB (1) GB2393734B (xx)
HK (1) HK1067661A1 (xx)
IL (2) IL159580A0 (xx)
WO (1) WO2003006950A2 (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US7288521B2 (en) 2000-04-06 2007-10-30 Franco Wayne P Growth factor therapy mobilization of stem cells into the peripheral blood
US7291597B2 (en) * 2000-04-06 2007-11-06 Franco Wayne P Growth factor therapy mobilization of stem cells into the peripheral blood
US20040087016A1 (en) * 2000-05-12 2004-05-06 University Of Utah Research Foundation Compositions and methods for cell dedifferentiation and tissue regeneration
CA2408701A1 (en) * 2000-05-12 2001-11-22 University Of Utah Research Foundation Compositions and methods for tissue dedifferentiation and regeneration
FR2819265B1 (fr) * 2001-01-10 2004-01-02 Centre Nat Rech Scient Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques
AU2002313670C1 (en) 2001-07-12 2009-08-06 Asterias Biotherapeutics, Inc. Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
WO2003008535A2 (en) * 2001-07-20 2003-01-30 Technion Research And Development Foundation Ltd. Methods of generating human cardiac cells and tissues and uses thereof
GB2394958B (en) * 2001-07-24 2006-03-01 Es Cell Int Pte Ltd Methods of inducing differentiation of stem cells
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US7192752B2 (en) 2002-12-20 2007-03-20 Acea Biosciences Real time electronic cell sensing systems and applications for cell-based assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US20050031598A1 (en) * 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
ES2571355T3 (es) 2002-12-16 2016-05-24 Technion Res & Dev Foundation Sistema de cultivo sin células alimentadoras ni xenocontaminantes para células madre embrionarias humanas
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
WO2004091476A2 (ja) * 2003-04-16 2004-10-28 Ono Pharmaceutical Co 心臓疾患治療物質のスクリーニング方法および心臓疾患治療医薬組成物
CA2526490C (en) * 2003-05-19 2014-03-04 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US20070204351A1 (en) * 2004-01-14 2007-08-30 Davidson Bruce P Direct differentiation of cardiomyocytes from human embryonic stem cells
CN1968608B (zh) 2004-01-23 2011-06-29 先进细胞技术公司 用于治疗视网膜变性病的改良模式
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
JP4971131B2 (ja) * 2004-03-19 2012-07-11 ジェロン・コーポレーション 再生医学に適した高純度心筋細胞調製物を作製するための方法
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
EP1740945B1 (en) 2004-04-07 2018-09-19 Ncardia AG Non-invasive, in vitro functional tissue assay systems
EP1745144B1 (en) 2004-05-11 2010-12-01 Axiogenesis Ag Assay for drug discovery based on in vitro differentiated cells
US20050277124A1 (en) 2004-06-10 2005-12-15 White Steven M Cardiac conduction system cells and uses thereof
GB2431165B (en) 2004-07-13 2009-04-01 Geron Corp Medium for growing human embryonic stem cells
US8173118B2 (en) * 2004-07-30 2012-05-08 Mayo Foundation For Medical Education And Research Compositions consisting essentially of TGF-β, BMP-2 FGF-4, leukemia inhibitory factor, IGF-1, IL-6 and H-α-thrombin
US20060040389A1 (en) * 2004-08-17 2006-02-23 Murry Charles E Purified compositions of stem cell derived differentiating cells
US20080254002A1 (en) * 2004-09-03 2008-10-16 Edelberg Jay M Bone Marrow Derived Oct3/4+ Stem Cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US8073210B2 (en) * 2005-02-14 2011-12-06 University Of Lowa Research Foundation Methods of smoothing segmented regions and related devices
WO2006122005A2 (en) * 2005-05-09 2006-11-16 Mytogen, Inc. Cellular cardiomyoplasty as supportive therapy in patients with heart disease
WO2007002136A2 (en) * 2005-06-22 2007-01-04 Geron Corporation Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
US9074181B2 (en) 2005-06-22 2015-07-07 Asterias Biotherapeutics, Inc. Suspension culture of human embryonic stem cells
WO2007002358A1 (en) * 2005-06-23 2007-01-04 Mount Sinai School Of Medicine Of New York University Cardiomyocyte cell populations
US8476070B2 (en) 2005-08-29 2013-07-02 Technion Research & Development Foundation Limited Media for culturing stem cells
WO2007038492A2 (en) * 2005-09-26 2007-04-05 The Trustees Of Columbia University In The City Of New York Side population cells in cardiac repair
JP5312804B2 (ja) * 2006-01-31 2013-10-09 第一三共株式会社 幹細胞及び胎児由来の心筋細胞及び予定心筋細胞の精製方法
CN101384706B (zh) 2006-02-16 2013-11-06 圣拉法埃莱医院有限公司 骨骼肌周成血管细胞和心脏中成血管细胞、其分离方法和用途
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
CA2650685C (en) 2006-04-28 2014-02-04 Asubio Pharma Co., Ltd. Method for inducing differentiation of pluripotent stem cells into cardiomyocytes
EP2044196A2 (en) * 2006-07-13 2009-04-08 Cellartis AB A novel population of multipotent cardiac precursor cells derived from human blastocysts derived stem cells
US9765298B2 (en) 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
ES2874223T3 (es) 2006-08-02 2021-11-04 Technion Res & Dev Foundation Métodos de expansión de células madre embrionarias en un cultivo en suspensión
WO2008150030A1 (ja) 2007-06-07 2008-12-11 Keiichi Fukuda G-csfを用いた心筋細胞への分化誘導方法
WO2008156708A2 (en) * 2007-06-15 2008-12-24 Massachusetts Institute Of Technology Methods and compositions for enhanced differentiation from embryonic stem cells
WO2009012357A2 (en) 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
AU2008300897B2 (en) * 2007-07-18 2014-12-04 Cellartis Ab Cardiomyocyte-like cell clusters derived from hBS cells
ES2325715B1 (es) * 2007-08-03 2010-06-17 Genetrix, S.L. Poblacion de celulas madre adultas derivadas de tejido adiposo cardiaco y su uso en regeneracion cardiaca.
EP2028268A1 (en) * 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
CN104946591A (zh) 2007-10-12 2015-09-30 奥卡塔治疗公司 制备rpe 细胞和rpe 细胞的组合物的改良方法
US8512696B2 (en) * 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
CA2712891A1 (en) * 2008-01-30 2009-08-06 Corning Incorporated Synthetic surfaces for culturing stem cell derived cardiomyocytes
EP2100954A1 (en) * 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
WO2009120891A2 (en) 2008-03-27 2009-10-01 Geron Corporation Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
US10077428B2 (en) * 2008-03-27 2018-09-18 Icahn School Of Medicine At Mount Sinai Human cardiovascular progenitor cells
WO2009137440A1 (en) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
WO2009145761A1 (en) * 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
NZ595919A (en) 2009-05-20 2014-01-31 Cardio3 Biosciences Sa Method for determining the cardio-generative potential of mammalian cells
AU2010266016B2 (en) 2009-06-25 2016-05-26 Asterias Biotherapeutics, Inc. Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes
WO2011005326A1 (en) 2009-07-09 2011-01-13 Massachusetts Institute Of Technology Methods and compositions for increased safety of stem cell-derived populations
WO2011056416A2 (en) 2009-10-19 2011-05-12 Cellular Dynamics International, Inc. Cardiomyocyte production
WO2011060342A2 (en) * 2009-11-13 2011-05-19 Wisconsin Alumni Research Foundation Cardiac differentiation of human pluripotent stem cells under defined conditions using matrix overlay methods
KR102073730B1 (ko) 2009-11-17 2020-02-05 아스텔라스 인스티튜트 포 리제너러티브 메디슨 인간 ｒｐｅ 세포의 생산 방법 및 인간 ｒｐｅ 세포의 제약 제제
US20110212480A1 (en) * 2010-02-26 2011-09-01 Kyle Louis Kolaja Use of primary human cardiomyocytes
US20110212461A1 (en) * 2010-02-26 2011-09-01 Hans Marcus Ludwig Bitter Prediction of cardiotoxicity
KR20130008560A (ko) 2010-03-12 2013-01-22 다이이찌 산쿄 가부시키가이샤 마이크로 ｒｎａ를 이용한 심근 세포의 증식 방법
EP2558571A4 (en) 2010-04-16 2014-09-24 Immune Disease Inst Inc DELAYED POLYPEPTIDE EXPRESSION FROM MODIFIED SYNTHETIC RNAS AND USES THEREOF
WO2011139688A2 (en) 2010-04-28 2011-11-10 The J. David Gladstone Institutes Methods for generating cardiomyocytes
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
EP2582793B1 (en) 2010-06-15 2017-09-06 Cellular Dynamics International, Inc. A compendium of ready-built stem cell models for interrogation of biological response
CA2802525C (en) 2010-06-18 2021-06-22 Cellular Dynamics International, Inc. Cardiomyocyte medium with dialyzed serum
PT2596119T (pt) * 2010-07-23 2021-06-18 Astellas Inst For Regenerative Medicine Métodos para a deteção de subpopulações raras de células e composições de células altamente purificadas
US8765470B2 (en) 2010-08-04 2014-07-01 Cellular Dynamics International, Inc. Reprogramming immortalized B-cells to induced pluripotent stem cells
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
CN103209968B (zh) * 2010-08-26 2015-08-05 国立大学法人京都大学 多能干细胞心肌细胞分化促进剂
SG10202109393RA (en) 2010-09-07 2021-10-28 Technion Res & Dev Foundation Novel Methods And Culture Media For Culturing Pluripotent Stem Cells
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
AU2012236707B2 (en) 2011-03-29 2017-07-20 Asterias Biotherapeutics, Inc. Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
JP6185907B2 (ja) 2011-03-30 2017-08-23 セルラー ダイナミクス インターナショナル， インコーポレイテッド 神経分化のための多能性幹細胞の予備刺激
EP3460064B8 (en) 2011-04-03 2024-03-20 The General Hospital Corporation d/b/a Massachusetts General Hospital Efficient protein expression in vivo using modified rna (mod-rna)
WO2013006364A1 (en) 2011-07-05 2013-01-10 Baylor Research Institute Establishment of patient - or person - specific cardiac myocyte cell lines from human induced pluripotent stem cells (ipscs)
US9395354B2 (en) 2011-07-21 2016-07-19 The Board Of Trustees Of The Leland Stanford Junior University Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof
EP2737056B1 (en) 2011-07-29 2018-03-07 Cellular Dynamics International, Inc. Metabolic maturation in stem cell-derived tissue cells
EP2750509B1 (en) 2011-08-30 2016-12-28 The J. David Gladstone Institutes Methods for generating cardiomyocytes
WO2013106677A1 (en) 2012-01-13 2013-07-18 The General Hospital Corporation Isolated human lung progenitor cells and uses thereof
WO2013111875A1 (ja) 2012-01-27 2013-08-01 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
US9994812B2 (en) 2012-04-04 2018-06-12 University Of Washington Through Its Center For Commercialization Systems and method for engineering muscle tissue
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
US9884076B2 (en) 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
JP6373253B2 (ja) * 2012-07-17 2018-08-15 国立大学法人京都大学 新規心筋細胞マーカー
EP2882445B1 (en) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
US10149922B1 (en) 2012-10-24 2018-12-11 The Board Of Trustees Of The Leland Stanford Junior University Engineered collagen matrices for myocardial therapy
WO2014078414A1 (en) 2012-11-13 2014-05-22 Joseph Wu Chemically defined production of cardiomyocytes from pluripotent stem cells
US10202579B2 (en) 2012-11-29 2019-02-12 Takara Bio Europe Ab Methods for producing mammalian pluripotent stem cell-derived endodermal cells
EP2966166B1 (en) 2013-03-08 2019-04-03 Kyoto University Promoter of differentiation of pluripotent stem cell into myocardium, which comprises egf receptor inhibitor
GB201304831D0 (en) * 2013-03-15 2013-05-01 Coretherapix Slu Adult cardiac stem cell population
ES2831424T3 (es) 2013-04-23 2021-06-08 Yeda Res & Dev Células madre pluripotentes naif aisladas y métodos para generarlas
US10696947B2 (en) * 2013-06-11 2020-06-30 Ncardia B.V. Culture medium composition for maturating cardiomyocytes derived from pluripotent mammalian stem cells
US9624471B2 (en) 2013-06-12 2017-04-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
WO2014201431A1 (en) 2013-06-14 2014-12-18 Massachusetts Institute Of Technology Articles and methods for stem cell differentiation
EP3044310A4 (en) 2013-09-13 2017-06-21 University Health Network Methods and compositions for generating epicardium cells
AU2014331947B2 (en) * 2013-10-09 2020-02-13 The United States Government As Represented By The Department Of Veterans Affairs Muscle cell patches and uses therefor
AR097890A1 (es) 2013-10-17 2016-04-20 Lilly Co Eli Compuestos de urea
CA2945393C (en) 2014-04-24 2021-03-23 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
AU2015286462B2 (en) * 2014-07-11 2021-04-15 Metcela Inc. Cardiac cell culture material
JP2017525351A (ja) 2014-07-30 2017-09-07 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． 多能性幹細胞の培養用培地
CN106574248B (zh) 2014-08-19 2020-11-24 富士胶片细胞动力有限公司 由源自多能干细胞的细胞形成的神经网络
US9765299B2 (en) 2014-09-10 2017-09-19 Wisconsin Alumni Research Foundation Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
CN108463548B (zh) 2015-10-30 2023-04-18 加利福尼亚大学董事会 由干细胞产生t细胞的方法及使用所述t细胞的免疫治疗方法
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US11859232B2 (en) 2016-06-19 2024-01-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
CN117467608A (zh) 2016-08-16 2024-01-30 富士胶片细胞动力股份有限公司 分化多能细胞的方法
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
WO2018090084A1 (en) * 2016-11-16 2018-05-24 Cynata Therapeutics Limited Pluripotent stem cell assay
CN118460528A (zh) 2017-03-03 2024-08-09 安捷伦科技有限公司 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统
EP3612191A4 (en) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY
CN107828884A (zh) * 2017-12-08 2018-03-23 南京医科大学 一组评估心肌细胞受损的dna甲基化标志物及其应用
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
CN109589337B (zh) * 2018-12-29 2022-04-26 南京艾尔普再生医学科技有限公司 心肌细胞制剂及其制备方法和应用
JP7051242B2 (ja) 2019-02-06 2022-04-11 株式会社タチエス 車両用ヘッドレスト
KR20200102329A (ko) * 2019-02-21 2020-08-31 고려대학교 산학협력단 TGFβ1을 이용한 줄기세포를 성숙한 유형별 심근세포로 분화시키는 방법
JP2022533745A (ja) 2019-05-22 2022-07-25 ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド ヒト多能性細胞を培養する方法
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
WO2023087109A1 (en) * 2021-11-17 2023-05-25 The Governing Council Of The University Of Toronto Maturation medium for pluripotent stem cell-derived cardiomyocytes

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013066A1 (en) 1991-01-24 1992-08-06 Loyola University Of Chicago Mammalian cardiac myocyte cell line
US5543318A (en) * 1991-06-12 1996-08-06 Smith; David A. Method of isolation, culture and proliferation of human atrial myocytes
US5602301A (en) * 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US6015671A (en) * 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
DE4441327C1 (de) * 1994-11-22 1995-11-09 Inst Pflanzengenetik & Kultur Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
DE69735622T2 (de) * 1996-08-16 2007-04-12 MCW Research Foundation, Inc., Milwaukee Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese
US20020061837A1 (en) * 1996-09-05 2002-05-23 Lough John W. Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis
US6261836B1 (en) * 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6110459A (en) * 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
ES2251773T5 (es) * 1997-07-14 2009-05-12 Osiris Therapeutics, Inc. Regeneracion del musculo cardiaco usando celulas precursoras mesenquimatosas.
CA2307807C (en) 1997-10-23 2008-09-02 Andrea G. Bodnar Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
EP1064356A2 (en) 1998-03-23 2001-01-03 ZymoGenetics, Inc. Cardiac-derived stem cells
EP1068295A4 (en) * 1998-04-09 2002-08-21 Bresagen Ltd CELL DIFFERENTIATION / PROLIFERATION AND CONSERVATION FACTOR AND METHODS OF USE THEREOF
JP2002521493A (ja) 1998-07-31 2002-07-16 ジェンザイム コーポレーション 間葉幹細胞移植による心機能の改善
US7368420B1 (en) * 1998-10-02 2008-05-06 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Akt compositions for enhancing survival of cells
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
IL129966A (en) * 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
JP2003502065A (ja) 1999-06-18 2003-01-21 アドヴァンスト リサーチ アンド テクノロジー インスティチュート、インコーポレイティッド 高められた増殖能を持つ心筋細胞、およびその製造および使用法
EP1221956A2 (en) 1999-09-30 2002-07-17 McGILL UNIVERSITY Autologous marrow stem cell (msc) transplantation for myocardial regeneration
CA2395950A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Cells capable of differentiating into heart muscle cells
US20020142457A1 (en) * 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US7795026B2 (en) 2000-01-21 2010-09-14 The Johns Hopkins University School Of Medicine Methods for obtaining human embryoid body-derived cells
JP2004504807A (ja) 2000-03-10 2004-02-19 アドヴァンスト　リサーチ　アンド　テクノロジー　インスティチュート、インコーポレイティッド 多分化能細胞および心筋細胞集団、並びに該集団への経路およびその使用
US20020098167A1 (en) 2000-07-31 2002-07-25 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
EP1315510A4 (en) 2000-07-31 2005-08-03 New York Medical College METHODS AND COMPOSITIONS FOR THE REPAIR AND / OR REGENERATION OF DAMAGED MYOCARDE
IL154159A0 (en) * 2000-08-01 2003-07-31 Yissum Res Dev Co Directed differentiation of ebryonic cells
US6534052B1 (en) 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
US6607720B1 (en) 2000-09-05 2003-08-19 Yong-Fu Xiao Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction
EP1390473A4 (en) 2001-04-13 2005-04-06 Anterogen Co Ltd METHOD AND REAGENTS FOR CELL TRANSPLANTATION
US7732199B2 (en) * 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
AU2002313670C1 (en) * 2001-07-12 2009-08-06 Asterias Biotherapeutics, Inc. Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
WO2003008535A2 (en) * 2001-07-20 2003-01-30 Technion Research And Development Foundation Ltd. Methods of generating human cardiac cells and tissues and uses thereof
GB2394958B (en) * 2001-07-24 2006-03-01 Es Cell Int Pte Ltd Methods of inducing differentiation of stem cells
IL163948A0 (en) * 2002-03-15 2005-12-18 Wicell Res Inst Inc Method for generating primate trophoblasts
US6898272B2 (en) * 2002-08-01 2005-05-24 Spirent Communications System and method for testing telecommunication devices
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state

Also Published As

Publication number Publication date
US7425448B2 (en) 2008-09-16
KR101073411B1 (ko) 2011-10-17
KR20100010951A (ko) 2010-02-02
WO2003006950B1 (en) 2004-05-13
AU2002313670B2 (en) 2007-02-08
HK1067661A1 (en) 2005-04-15
JP2016146836A (ja) 2016-08-18
WO2003006950A3 (en) 2003-10-02
US20050164382A1 (en) 2005-07-28
KR20040022448A (ko) 2004-03-12
GB0400570D0 (en) 2004-02-11
CA2453438C (en) 2016-04-05
GB2393734A (en) 2004-04-07
US20030022367A1 (en) 2003-01-30
JP2004535199A (ja) 2004-11-25
JP6253689B2 (ja) 2017-12-27
IL159580A (en) 2008-08-07
JP2011050385A (ja) 2011-03-17
AU2002313670C1 (en) 2009-08-06
EP1412479A4 (en) 2004-07-28
JP5758604B2 (ja) 2015-08-05
CA2453438A1 (en) 2003-01-23
WO2003006950A2 (en) 2003-01-23
JP5917429B2 (ja) 2016-05-11
CN1543500A (zh) 2004-11-03
CN1543500B (zh) 2014-04-09
JP2013143950A (ja) 2013-07-25
US7851167B2 (en) 2010-12-14
US20090017465A1 (en) 2009-01-15
EP1412479A2 (en) 2004-04-28
GB2393734B (en) 2005-07-27
US7763464B2 (en) 2010-07-27

Similar Documents

Publication Publication Date Title
GB2393734B (en) Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
GB2412379B (en) Hematopoietic cells from human embryonic stem cells
GB2415432B (en) Islet cells from human embryonic stem cells
GB2392674B (en) Mesenchymal cells and osteoblasts from human embryonic stem cell
AU2002366380A8 (en) Pluripotent stem cells derived without the use of embryos or fetal tissue
IL165943A0 (en) Functional cardiomyocytes from human embryonic stem cells
GB2380490B (en) Hepatocyte lineage cells derived from pluripotent stem cells
GB2394958B (en) Methods of inducing differentiation of stem cells
IL162132A0 (en) Chondrocyte precursors derived from human embryonic stem cells
AU2002319780A1 (en) Alternative compositions and methods for the culture of stem cells
PL2336298T3 (pl) Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek
EP1546112A4 (en) IMIDAZOLOPYRIDINE AND METHOD FOR THE PRODUCTION AND USE THEREOF
IL163699A0 (en) Endothelial cells derived from human embryonic stem cells
EP1638513A4 (en) HIGHLY UNAVAILABLE CONNECTIONS AND METHOD OF USE THEREFOR
AU2003303926A8 (en) Ceramics and methods of making the same
AU2002364506A8 (en) Compositions for the derivation of germ cells from stem cells and methods of use thereof
CA96874S (en) Set of flatware
CA96875S (en) Set of flatware
CA96876S (en) Set of flatware
IL156841A0 (en) Pluripotent adult stem cells derived from regenerative tissue
IL143155A0 (en) Insulin producing cells derived from human embryonic stem cells

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed