IL157800A0 - Il-18 mutants, their production and use - Google Patents

Il-18 mutants, their production and use

Info

Publication number
IL157800A0
IL157800A0 IL15780002A IL15780002A IL157800A0 IL 157800 A0 IL157800 A0 IL 157800A0 IL 15780002 A IL15780002 A IL 15780002A IL 15780002 A IL15780002 A IL 15780002A IL 157800 A0 IL157800 A0 IL 157800A0
Authority
IL
Israel
Prior art keywords
mutants
production
molecule
wild type
lower affinity
Prior art date
Application number
IL15780002A
Other languages
English (en)
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of IL157800A0 publication Critical patent/IL157800A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL15780002A 2001-03-08 2002-03-08 Il-18 mutants, their production and use IL157800A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27432701P 2001-03-08 2001-03-08
PCT/IB2002/002344 WO2002101049A2 (en) 2001-03-08 2002-03-08 Interleukin-18 mutants, their production and use

Publications (1)

Publication Number Publication Date
IL157800A0 true IL157800A0 (en) 2004-03-28

Family

ID=23047735

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15780002A IL157800A0 (en) 2001-03-08 2002-03-08 Il-18 mutants, their production and use
IL157800A IL157800A (en) 2001-03-08 2003-09-08 IL-18 mutants, their preparation and use

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157800A IL157800A (en) 2001-03-08 2003-09-08 IL-18 mutants, their preparation and use

Country Status (19)

Country Link
US (2) US7524488B2 (zh)
EP (1) EP1392830B1 (zh)
JP (1) JP2004530432A (zh)
KR (1) KR100862136B1 (zh)
CN (1) CN100503829C (zh)
AT (1) ATE315647T1 (zh)
AU (1) AU2002324249B2 (zh)
BR (1) BRPI0207933B8 (zh)
CA (1) CA2438851C (zh)
DE (1) DE60208692T2 (zh)
DK (1) DK1392830T3 (zh)
EA (1) EA005769B1 (zh)
ES (1) ES2251610T3 (zh)
HK (1) HK1084151A1 (zh)
IL (2) IL157800A0 (zh)
MX (1) MXPA03008110A (zh)
SI (1) SI1392830T1 (zh)
UA (1) UA79235C2 (zh)
WO (1) WO2002101049A2 (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004263274B2 (en) * 2003-07-21 2009-11-05 Transgene S.A. Novel multifunctional cytokines
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
ES2285543T3 (es) * 2003-11-05 2007-11-16 Ares Trading S.A. Procedimiento para la purificacion de la proteina de union a il-18.
WO2005097998A2 (en) * 2004-03-31 2005-10-20 Regeneron Pharmaceuticals, Inc. Il-18 specific polypeptides and therapeutic uses thereof
ATE557038T1 (de) 2005-06-03 2012-05-15 Ares Trading Sa Herstellung von rekombinantem il-18 bindendem protein
ATE529433T1 (de) 2005-06-10 2011-11-15 Ares Trading Sa Verfahren zur reinigung eines il-18-bindenden proteins
CN101177454B (zh) * 2007-05-09 2010-09-22 郑骏年 Il-18突变体多肽及制备及用途
WO2012078936A2 (en) * 2010-12-10 2012-06-14 Glaxosmithkline Llc Methods to produce a purified peptide chain fraction
CN111315395A (zh) * 2017-09-06 2020-06-19 耶鲁大学 白细胞介素-18变体和使用方法
US12029778B2 (en) 2019-05-13 2024-07-09 Yale University Interleukin-18 mimics and methods of use
JP2021170968A (ja) * 2020-04-22 2021-11-01 国立大学法人 長崎大学 マウスｉｌ−１８の製造方法及びそのための組換えｄｎａ
KR20230052956A (ko) * 2020-08-19 2023-04-20 브라이트 피크 테라퓨틱스 아게 변형된 il-18 폴리펩티드 및 이의 용도
WO2022094473A1 (en) 2020-11-02 2022-05-05 Simcha IL-18, Inc. Interleukin-18 variants and methods of use
CN116848130A (zh) * 2021-02-10 2023-10-03 国立大学法人长崎大学 新型人白细胞介素-18突变体及其用途
WO2023010021A1 (en) 2021-07-27 2023-02-02 Xencor, Inc. Il-18-fc fusion proteins
JP2023024168A (ja) 2021-08-06 2023-02-16 国立大学法人 長崎大学 がんの治療剤
WO2023056193A2 (en) * 2021-09-29 2023-04-06 Chimera Bioengineering, Inc. Il-18 variants and uses thereof
WO2023118497A1 (en) * 2021-12-22 2023-06-29 Pieris Pharmaceuticals Gmbh Novel il-18 variants
WO2023161853A1 (en) 2022-02-23 2023-08-31 Bright Peak Therapeutics Ag Activatable il-18 polypeptides
AU2023224445A1 (en) * 2022-02-23 2024-08-29 Bright Peak Therapeutics Ag Modified il-18 polypeptides
US20230355795A1 (en) * 2022-02-23 2023-11-09 Bright Peak Therapeutics Ag Immune antigen specific il-18 immunocytokines and uses thereof
WO2024044780A1 (en) * 2022-08-26 2024-02-29 Sutro Biopharma, Inc. Interleukin-18 variants and uses thereof
WO2024102693A2 (en) 2022-11-07 2024-05-16 Xencor, Inc. Il-18-fc fusion proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4024366B2 (ja) * 1996-11-29 2007-12-19 株式会社林原生物化学研究所 ポリペプチド
TWI227136B (en) * 1998-05-21 2005-02-01 Smithkline Beecham Corp Novel pharmaceutical composition for the prevention and/or treatment of cancer
IL129427A0 (en) 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules

Also Published As

Publication number Publication date
CN1764723A (zh) 2006-04-26
US20020169291A1 (en) 2002-11-14
HK1084151A1 (en) 2006-07-21
KR100862136B1 (ko) 2008-10-09
BR0207933A (pt) 2004-03-02
MXPA03008110A (es) 2003-12-12
DE60208692T2 (de) 2006-07-13
DE60208692D1 (de) 2006-04-06
WO2002101049A2 (en) 2002-12-19
ATE315647T1 (de) 2006-02-15
DK1392830T3 (da) 2006-05-08
BRPI0207933B1 (pt) 2020-11-24
EA200300987A1 (ru) 2004-02-26
AU2002324249B2 (en) 2007-04-05
CN100503829C (zh) 2009-06-24
ES2251610T3 (es) 2006-05-01
CA2438851C (en) 2011-07-26
IL157800A (en) 2009-08-03
KR20030088448A (ko) 2003-11-19
US20090286855A1 (en) 2009-11-19
UA79235C2 (en) 2007-06-11
SI1392830T1 (sl) 2006-06-30
US7875709B2 (en) 2011-01-25
JP2004530432A (ja) 2004-10-07
BRPI0207933B8 (pt) 2021-05-25
WO2002101049A3 (en) 2003-12-18
EA005769B1 (ru) 2005-06-30
EP1392830A2 (en) 2004-03-03
CA2438851A1 (en) 2002-12-19
EP1392830B1 (en) 2006-01-11
US7524488B2 (en) 2009-04-28

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