IL152904D0 - Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations - Google Patents

Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations

Info

Publication number
IL152904D0
IL152904D0 IL15290402A IL15290402A IL152904D0 IL 152904 D0 IL152904 D0 IL 152904D0 IL 15290402 A IL15290402 A IL 15290402A IL 15290402 A IL15290402 A IL 15290402A IL 152904 D0 IL152904 D0 IL 152904D0
Authority
IL
Israel
Prior art keywords
retinoid
vitamin
utilization
expansion
stem cell
Prior art date
Application number
IL15290402A
Original Assignee
Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US35036002P priority Critical
Priority to US37618302P priority
Priority to US40413702P priority
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Priority to IL15290402A priority patent/IL152904D0/en
Publication of IL152904D0 publication Critical patent/IL152904D0/en
Priority claimed from PCT/IL2003/000681 external-priority patent/WO2004016731A2/en
Priority claimed from US10/767,064 external-priority patent/US20050054097A1/en
Priority claimed from US14/970,155 external-priority patent/US20160097037A1/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073Stem cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/125Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/145Thrombopoietin [TPO]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/26Flt-3 ligand (CD135L, flk-2 ligand)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • CCHEMISTRY; METALLURGY
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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    • C12N2503/00Use of cells in diagnostics
    • C12N2503/02Drug screening
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    • C12N2510/00Genetically modified cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
IL15290402A 2002-01-24 2002-11-17 Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations IL152904D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US35036002P true 2002-01-24 2002-01-24
US37618302P true 2002-04-30 2002-04-30
US40413702P true 2002-08-19 2002-08-19
IL15290402A IL152904D0 (en) 2002-01-24 2002-11-17 Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
IL15290402A IL152904D0 (en) 2002-01-24 2002-11-17 Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
DE60332157A DE60332157D1 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
ES10003540T ES2391318T3 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
EP03706871A EP1576089B1 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
ES03706871T ES2344258T3 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations.
PCT/IL2003/000064 WO2003062369A2 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
EP10003540A EP2206773B1 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
CA2474344A CA2474344C (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
EP10010858A EP2305794A1 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
AU2003208577A AU2003208577B9 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
AT03706871T AT464372T (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
JP2003562237A JP4738738B2 (en) 2002-01-24 2003-01-26 The expansion of renewable stem cell population
PCT/IL2003/000681 WO2004016731A2 (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
MXPA05001992A MXPA05001992A (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures.
AU2003250519A AU2003250519A1 (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
JP2005502022A JP2006508692A (en) 2002-08-19 2003-08-17 Ex vivo expansion of hematopoietic stem cell populations in the mononuclear cell cultures
EP03787995A EP1534820A4 (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
CA002495824A CA2495824A1 (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
BR0314402-0A BR0314402A (en) 2002-08-19 2003-08-17 ex-vivo expansion of populations of cells in roots mononuclear cell cultures
US10/767,064 US20050054097A1 (en) 2002-11-17 2004-01-29 EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
US10/774,843 US7955852B2 (en) 2002-01-24 2004-02-09 Expansion of renewable stem cell populations
IL163180A IL163180A (en) 2002-01-24 2004-07-22 Expansion of renewable hematopoietic stem cell populations and use thereof
AU2008229689A AU2008229689B9 (en) 2002-01-24 2008-09-29 Expansion of Renewable Stem Cell Populations
US12/908,296 US20110033427A1 (en) 2002-01-24 2010-10-20 Expansion Of Renewable Stem Cell Populations
AU2010241200A AU2010241200B2 (en) 2002-01-24 2010-11-03 Expansion of Renewable Stem Cell Populations
HK11100299.5A HK1146091A1 (en) 2002-01-24 2011-01-13 Expansion of renewable stem cell populations
JP2011045102A JP2011155976A (en) 2002-01-24 2011-03-02 The expansion of renewable stem cell population
IL229355A IL229355D0 (en) 2002-01-24 2013-11-10 Expansion of renewable stem cell populations
US14/970,155 US20160097037A1 (en) 2002-01-24 2015-12-15 Expansion of renewable stem cell populations
US16/036,638 US20180320139A1 (en) 2002-01-24 2018-07-16 Expansion of renewable stem cell populations

Publications (1)

Publication Number Publication Date
IL152904D0 true IL152904D0 (en) 2003-06-24

Family

ID=27617675

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15290402A IL152904D0 (en) 2002-01-24 2002-11-17 Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
IL163180A IL163180A (en) 2002-01-24 2004-07-22 Expansion of renewable hematopoietic stem cell populations and use thereof
IL229355A IL229355D0 (en) 2002-01-24 2013-11-10 Expansion of renewable stem cell populations

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL163180A IL163180A (en) 2002-01-24 2004-07-22 Expansion of renewable hematopoietic stem cell populations and use thereof
IL229355A IL229355D0 (en) 2002-01-24 2013-11-10 Expansion of renewable stem cell populations

Country Status (11)

Country Link
US (2) US7955852B2 (en)
EP (3) EP1576089B1 (en)
JP (2) JP4738738B2 (en)
AT (1) AT464372T (en)
AU (3) AU2003208577B9 (en)
CA (1) CA2474344C (en)
DE (1) DE60332157D1 (en)
ES (2) ES2391318T3 (en)
HK (1) HK1146091A1 (en)
IL (3) IL152904D0 (en)
WO (1) WO2003062369A2 (en)

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IL152904D0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
AU2005200679B2 (en) * 2002-08-19 2008-11-20 Gamida-Cell Ltd. Ex-Vivo Expansion of Hematopoietic Stem Cell Populations in Mononuclear Cell Cultures
WO2005007799A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
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AU2003208577B9 (en) 2008-07-31
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US20050008624A1 (en) 2005-01-13
AU2008229689B9 (en) 2011-07-28
AT464372T (en) 2010-04-15
CA2474344C (en) 2013-10-22
WO2003062369A2 (en) 2003-07-31
AU2003208577B2 (en) 2008-07-10
IL229355D0 (en) 2013-12-31
EP1576089A4 (en) 2007-02-14
ES2391318T3 (en) 2012-11-23
EP1576089A2 (en) 2005-09-21
AU2008229689A1 (en) 2008-10-30
US7955852B2 (en) 2011-06-07
IL163180A (en) 2014-08-31
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AU2008229689B2 (en) 2011-04-07
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EP2206773A1 (en) 2010-07-14
JP4738738B2 (en) 2011-08-03
EP1576089B1 (en) 2010-04-14
JP2005528088A (en) 2005-09-22
DE60332157D1 (en) 2010-05-27
AU2010241200B2 (en) 2012-02-16
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EP2305794A1 (en) 2011-04-06
AU2010241200A1 (en) 2010-11-25

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