IL149401A0 - 1-amino-alkylcyclohexane nmda receptor antagonists - Google Patents

1-amino-alkylcyclohexane nmda receptor antagonists

Info

Publication number
IL149401A0
IL149401A0 IL14940199A IL14940199A IL149401A0 IL 149401 A0 IL149401 A0 IL 149401A0 IL 14940199 A IL14940199 A IL 14940199A IL 14940199 A IL14940199 A IL 14940199A IL 149401 A0 IL149401 A0 IL 149401A0
Authority
IL
Israel
Prior art keywords
amino
receptor antagonists
nmda receptor
compounds
alleviation
Prior art date
Application number
IL14940199A
Other languages
English (en)
Original Assignee
Merz Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharmaceuticals Gmbh filed Critical Merz Pharmaceuticals Gmbh
Publication of IL149401A0 publication Critical patent/IL149401A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL14940199A 1999-11-01 1999-11-01 1-amino-alkylcyclohexane nmda receptor antagonists IL149401A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/008317 WO2001032640A1 (en) 1999-11-01 1999-11-01 1-cyclic amino-alkylcyclohexane compounds, pharmaceutical compositions thereof, and their use as anticonvulsants

Publications (1)

Publication Number Publication Date
IL149401A0 true IL149401A0 (en) 2002-11-10

Family

ID=8167482

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14940199A IL149401A0 (en) 1999-11-01 1999-11-01 1-amino-alkylcyclohexane nmda receptor antagonists
IL149401A IL149401A (en) 1999-11-01 2002-04-29 1-amino-alkylcyclohexane NMDA receptor antagonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149401A IL149401A (en) 1999-11-01 2002-04-29 1-amino-alkylcyclohexane NMDA receptor antagonists

Country Status (24)

Country Link
EP (1) EP1228052B1 (ja)
JP (1) JP4043236B2 (ja)
KR (1) KR100548600B1 (ja)
CN (1) CN1264827C (ja)
AT (1) ATE361284T1 (ja)
AU (1) AU782760B2 (ja)
CA (1) CA2389325C (ja)
CY (1) CY1106672T1 (ja)
CZ (1) CZ20021533A3 (ja)
DE (1) DE69936004T2 (ja)
DK (1) DK1228052T3 (ja)
EA (1) EA005684B1 (ja)
ES (1) ES2285870T3 (ja)
HK (1) HK1049160B (ja)
HU (1) HUP0203275A3 (ja)
IL (2) IL149401A0 (ja)
MX (1) MXPA02004368A (ja)
NO (1) NO322359B1 (ja)
PL (1) PL199587B1 (ja)
PT (1) PT1228052E (ja)
SI (1) SI1228052T1 (ja)
TW (1) TWI242547B (ja)
UA (1) UA72558C2 (ja)
WO (1) WO2001032640A1 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
CN104211663B (zh) * 2014-08-11 2017-01-11 杭州偶联医药科技有限公司 一种(s)-n-甲氧基-甲基-2-(四氢吡咯基)丙酰胺及其制备方法和应用
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
RU2714135C1 (ru) * 2019-11-22 2020-02-12 Федеральное государственное бюджетное учреждение науки "Институт токсикологии Федерального медико-биологического агентства" Гидрохлорид (1-метилпиперидин-4-ил)-2-пропилпентаноата, обладающий холинолитической и противосудорожной активностью

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097207A (en) * 1958-03-06 1963-07-09 Parke Davis & Co 1-halophenyl and 1-alkoxyphenyl cyclohexylamines
EP1009732B1 (en) * 1997-06-30 2003-05-21 MERZ + CO. GmbH & Co. 1-amino-alkylcyclohexane nmda receptor antagonists

Also Published As

Publication number Publication date
PL199587B1 (pl) 2008-10-31
EA005684B1 (ru) 2005-04-28
HK1049160B (zh) 2006-11-17
SI1228052T1 (sl) 2007-10-31
DK1228052T3 (da) 2007-06-18
JP4043236B2 (ja) 2008-02-06
AU782760B2 (en) 2005-08-25
IL149401A (en) 2008-03-20
AU1158500A (en) 2001-05-14
PL354519A1 (en) 2004-01-26
NO20022044L (no) 2002-04-30
CY1106672T1 (el) 2012-05-23
CA2389325C (en) 2007-01-09
MXPA02004368A (es) 2002-11-14
CA2389325A1 (en) 2001-05-10
CZ20021533A3 (cs) 2002-08-14
NO322359B1 (no) 2006-09-18
HUP0203275A2 (hu) 2003-01-28
KR100548600B1 (ko) 2006-02-01
DE69936004T2 (de) 2008-01-10
ATE361284T1 (de) 2007-05-15
EP1228052B1 (en) 2007-05-02
JP2003513083A (ja) 2003-04-08
WO2001032640A1 (en) 2001-05-10
PT1228052E (pt) 2007-05-31
EP1228052A1 (en) 2002-08-07
ES2285870T3 (es) 2007-11-16
TWI242547B (en) 2005-11-01
DE69936004D1 (de) 2007-06-14
KR20020063172A (ko) 2002-08-01
EA200200522A1 (ru) 2002-10-31
CN1374956A (zh) 2002-10-16
CN1264827C (zh) 2006-07-19
HUP0203275A3 (en) 2003-11-28
UA72558C2 (uk) 2005-03-15
HK1049160A1 (en) 2003-05-02
NO20022044D0 (no) 2002-04-30

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