IL144792A0 - Heterocyclic derivatives as inhibitors of factor xa - Google Patents
Heterocyclic derivatives as inhibitors of factor xaInfo
- Publication number
- IL144792A0 IL144792A0 IL14479200A IL14479200A IL144792A0 IL 144792 A0 IL144792 A0 IL 144792A0 IL 14479200 A IL14479200 A IL 14479200A IL 14479200 A IL14479200 A IL 14479200A IL 144792 A0 IL144792 A0 IL 144792A0
- Authority
- IL
- Israel
- Prior art keywords
- heterocyclic derivatives
- inhibitors
- factor
- antithrombotic
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9902989.4A GB9902989D0 (en) | 1999-02-11 | 1999-02-11 | Heterocyclic derivatives |
PCT/GB2000/000354 WO2000047573A1 (en) | 1999-02-11 | 2000-02-08 | Heterocyclic derivatives as inhibitors of factor xa |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144792A0 true IL144792A0 (en) | 2002-06-30 |
Family
ID=10847476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14479200A IL144792A0 (en) | 1999-02-11 | 2000-02-08 | Heterocyclic derivatives as inhibitors of factor xa |
Country Status (24)
Country | Link |
---|---|
US (1) | US6723723B1 (pt) |
EP (1) | EP1150974B1 (pt) |
JP (1) | JP2002536443A (pt) |
KR (1) | KR20010102072A (pt) |
AT (1) | ATE223402T1 (pt) |
AU (1) | AU757738B2 (pt) |
BR (1) | BR0008130A (pt) |
CA (1) | CA2362392A1 (pt) |
CZ (1) | CZ20012867A3 (pt) |
DE (1) | DE60000410T2 (pt) |
DK (1) | DK1150974T3 (pt) |
ES (1) | ES2181637T3 (pt) |
GB (1) | GB9902989D0 (pt) |
HU (1) | HUP0105102A3 (pt) |
IL (1) | IL144792A0 (pt) |
NO (1) | NO20013921L (pt) |
NZ (1) | NZ513350A (pt) |
PL (1) | PL349220A1 (pt) |
PT (1) | PT1150974E (pt) |
RU (1) | RU2226193C2 (pt) |
SK (1) | SK11462001A3 (pt) |
TR (1) | TR200102306T2 (pt) |
WO (1) | WO2000047573A1 (pt) |
ZA (1) | ZA200106337B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
EP1870401A4 (en) * | 2005-04-06 | 2011-06-15 | Msd Kk | SUBSTITUTE DERIVATIVE PIPERAZINE IN 1,4 |
JP5214096B2 (ja) * | 2005-06-17 | 2013-06-19 | 富士フイルムファインケミカルズ株式会社 | 新規なビピリジン誘導体 |
AU2020300002A1 (en) | 2019-07-01 | 2022-02-24 | Tonix Pharma Limited | Anti-CD154 antibodies and uses thereof |
CA3207098A1 (en) | 2021-01-06 | 2022-07-14 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (63)
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AT340933B (de) | 1973-08-20 | 1978-01-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze |
US4167567A (en) | 1978-05-05 | 1979-09-11 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
SE8203887D0 (sv) | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | Nya trombininhiberande foreningar |
DE3246932A1 (de) | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
FR2557570B1 (fr) | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US4840963A (en) | 1984-03-14 | 1989-06-20 | Merck & Co., Inc. | 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure |
GB8601160D0 (en) | 1986-01-17 | 1986-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
GB8603120D0 (en) | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
GB8609630D0 (en) | 1986-04-19 | 1986-05-21 | Pfizer Ltd | Anti-arrhythmia agents |
GB8710494D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Antiarrhythmic agents |
JPH0696575B2 (ja) | 1987-09-17 | 1994-11-30 | 三菱化成株式会社 | 4−アミノピリジン誘導体及びその酸付加塩 |
US4871721A (en) | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
GB8817315D0 (en) | 1988-07-20 | 1988-08-24 | Pfizer Ltd | Triazole antifungal agents |
GB8819307D0 (en) | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
DE3905364A1 (de) | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
GB8905526D0 (en) | 1989-03-10 | 1989-04-19 | Fujisawa Pharmaceutical Co | N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same |
IE64358B1 (en) | 1989-07-18 | 1995-07-26 | Ici Plc | Diaryl ether heterocycles |
US5032604A (en) | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
DE3943225A1 (de) | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
KR920703558A (ko) | 1990-11-15 | 1992-12-18 | 원본미기재 | 메타-치환 페닐알라닌 유도체 |
EP0495750A3 (en) | 1991-01-14 | 1992-09-16 | Ciba-Geigy Ag | Heterocyclic hydroxylamine |
IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
FR2676054B1 (fr) | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
JPH07502014A (ja) | 1991-06-21 | 1995-03-02 | ベーリンガー マンハイム イタリア エス.ピー.エイ. | 気道に対して抗喘息性、抗炎症性活性を有する2−アミノ−4−アリール−チアゾール |
CA2119467A1 (en) | 1991-09-19 | 1993-04-01 | Pamela Anne Chambers | Pyridine compounds for treating leukotriene-related diseases |
US5541330A (en) | 1991-12-10 | 1996-07-30 | Eastman Kodak Company | Ion-sensitive compounds |
PH31294A (en) | 1992-02-13 | 1998-07-06 | Thomae Gmbh Dr K | Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them. |
HU211995B (en) | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
US5371091A (en) | 1992-08-31 | 1994-12-06 | Bristol-Myers Squibb Company | Heteroaromatic amine thrombin inhibitors |
FR2697252B1 (fr) | 1992-10-28 | 1994-12-09 | Fournier Ind & Sante | Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique. |
DE4243858A1 (de) | 1992-12-23 | 1994-06-30 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5332822A (en) | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
US5364865A (en) | 1992-12-30 | 1994-11-15 | Sterling Winthrop Inc. | Phenoxy- and phenoxyalkyl-piperidines as antiviral agents |
DE4302485A1 (de) | 1993-01-29 | 1994-08-04 | Merck Patent Gmbh | Piperazinderivate |
JPH07509731A (ja) | 1993-02-10 | 1995-10-26 | ペンタファルム アクチェンゲゼルシャフト | トロンビン阻害剤としての置換されたフェニルアラニン誘導体のピペラジド |
DE4306506A1 (de) | 1993-03-03 | 1994-09-08 | Boehringer Mannheim Gmbh | Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
TW257757B (pt) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
DE4306873A1 (de) | 1993-03-05 | 1994-09-08 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridine-Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
ZW4294A1 (en) | 1993-03-29 | 1994-12-21 | Zeneca Ltd | Heterocyclic derivatives |
CA2155307A1 (en) | 1993-03-29 | 1994-10-13 | Michael Garth Wayne | Heterocyclic compounds as platelet aggregation inhibitors |
US5681954A (en) | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
WO1996005189A1 (de) | 1994-08-09 | 1996-02-22 | Pentapharm Ag | Neue inhibitoren vom benzamidintyp |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5795893A (en) | 1994-12-22 | 1998-08-18 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
US6037343A (en) | 1994-12-22 | 2000-03-14 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
US5856326A (en) | 1995-03-29 | 1999-01-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IT1282797B1 (it) | 1995-04-21 | 1998-03-31 | Colla Paolo | Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids |
GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
JP2000504336A (ja) | 1996-02-02 | 2000-04-11 | ゼネカ・リミテッド | 薬学製剤として有用なヘテロ環式化合物 |
GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
GB9602294D0 (en) | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
CA2244851A1 (en) | 1996-02-22 | 1997-08-28 | Petrus Fredericus Wilhelmus Stouten | M-amidino phenyl analogs as factor xa inhibitors |
KR20000029984A (ko) | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
PT966462E (pt) | 1997-02-13 | 2003-10-31 | Astrazeneca Ab | Compostos heterociclicos uteis como inibidores da ciclase do oxido-esqualeno |
US6440972B1 (en) | 1997-02-13 | 2002-08-27 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
GB9715894D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
GB9715892D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
GB9809349D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
EP1082321B1 (en) * | 1998-05-02 | 2004-11-17 | AstraZeneca AB | Heterocyclic derivatives which inhibit factor xa |
-
1999
- 1999-02-11 GB GBGB9902989.4A patent/GB9902989D0/en not_active Ceased
-
2000
- 2000-02-08 RU RU2001124855/04A patent/RU2226193C2/ru not_active IP Right Cessation
- 2000-02-08 AU AU24470/00A patent/AU757738B2/en not_active Ceased
- 2000-02-08 PL PL00349220A patent/PL349220A1/xx not_active Application Discontinuation
- 2000-02-08 TR TR2001/02306T patent/TR200102306T2/xx unknown
- 2000-02-08 CA CA002362392A patent/CA2362392A1/en not_active Abandoned
- 2000-02-08 WO PCT/GB2000/000354 patent/WO2000047573A1/en not_active Application Discontinuation
- 2000-02-08 NZ NZ513350A patent/NZ513350A/xx unknown
- 2000-02-08 PT PT00902725T patent/PT1150974E/pt unknown
- 2000-02-08 AT AT00902725T patent/ATE223402T1/de active
- 2000-02-08 HU HU0105102A patent/HUP0105102A3/hu unknown
- 2000-02-08 DE DE60000410T patent/DE60000410T2/de not_active Expired - Lifetime
- 2000-02-08 EP EP00902725A patent/EP1150974B1/en not_active Expired - Lifetime
- 2000-02-08 BR BR0008130-2A patent/BR0008130A/pt not_active IP Right Cessation
- 2000-02-08 ES ES00902725T patent/ES2181637T3/es not_active Expired - Lifetime
- 2000-02-08 DK DK00902725T patent/DK1150974T3/da active
- 2000-02-08 IL IL14479200A patent/IL144792A0/xx unknown
- 2000-02-08 JP JP2000598493A patent/JP2002536443A/ja active Pending
- 2000-02-08 CZ CZ20012867A patent/CZ20012867A3/cs unknown
- 2000-02-08 US US09/913,071 patent/US6723723B1/en not_active Expired - Fee Related
- 2000-02-08 KR KR1020017010184A patent/KR20010102072A/ko not_active Application Discontinuation
- 2000-02-08 SK SK1146-2001A patent/SK11462001A3/sk unknown
-
2001
- 2001-08-01 ZA ZA200106337A patent/ZA200106337B/en unknown
- 2001-08-10 NO NO20013921A patent/NO20013921L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE223402T1 (de) | 2002-09-15 |
GB9902989D0 (en) | 1999-03-31 |
AU757738B2 (en) | 2003-03-06 |
DE60000410T2 (de) | 2003-06-05 |
ZA200106337B (en) | 2002-11-01 |
PL349220A1 (en) | 2002-07-01 |
WO2000047573A1 (en) | 2000-08-17 |
EP1150974A1 (en) | 2001-11-07 |
RU2226193C2 (ru) | 2004-03-27 |
HUP0105102A3 (en) | 2003-01-28 |
NO20013921D0 (no) | 2001-08-10 |
JP2002536443A (ja) | 2002-10-29 |
HUP0105102A2 (hu) | 2002-05-29 |
TR200102306T2 (tr) | 2001-12-21 |
NO20013921L (no) | 2001-10-10 |
CA2362392A1 (en) | 2000-08-17 |
BR0008130A (pt) | 2002-02-05 |
EP1150974B1 (en) | 2002-09-04 |
KR20010102072A (ko) | 2001-11-15 |
NZ513350A (en) | 2003-01-31 |
AU2447000A (en) | 2000-08-29 |
US6723723B1 (en) | 2004-04-20 |
DE60000410D1 (de) | 2002-10-10 |
ES2181637T3 (es) | 2003-03-01 |
SK11462001A3 (sk) | 2001-12-03 |
DK1150974T3 (da) | 2002-12-02 |
CZ20012867A3 (cs) | 2001-10-17 |
PT1150974E (pt) | 2003-01-31 |
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