IL141588A0 - Method for down-regulating osteoprotegerin ligand activity - Google Patents
Method for down-regulating osteoprotegerin ligand activityInfo
- Publication number
- IL141588A0 IL141588A0 IL14158899A IL14158899A IL141588A0 IL 141588 A0 IL141588 A0 IL 141588A0 IL 14158899 A IL14158899 A IL 14158899A IL 14158899 A IL14158899 A IL 14158899A IL 141588 A0 IL141588 A0 IL 141588A0
- Authority
- IL
- Israel
- Prior art keywords
- opgl
- osteoprotegerin ligand
- regulating
- nucleic acids
- ligand activity
- Prior art date
Links
- 102000014128 RANK Ligand Human genes 0.000 title abstract 7
- 108010025832 RANK Ligand Proteins 0.000 title abstract 7
- 230000002222 downregulating effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 2
- 230000003053 immunization Effects 0.000 abstract 2
- 238000002649 immunization Methods 0.000 abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003828 downregulation Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA199801164 | 1998-09-15 | ||
US10289698P | 1998-10-02 | 1998-10-02 | |
PCT/DK1999/000481 WO2000015807A1 (en) | 1998-09-15 | 1999-09-13 | Method for down-regulating osteoprotegerin ligand activity |
Publications (1)
Publication Number | Publication Date |
---|---|
IL141588A0 true IL141588A0 (en) | 2002-03-10 |
Family
ID=26065320
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14158899A IL141588A0 (en) | 1998-09-15 | 1999-09-13 | Method for down-regulating osteoprotegerin ligand activity |
IL141588A IL141588A (en) | 1998-09-15 | 2001-02-22 | Use of OPGL polypeptide for the preparation of pharmaceutical preparations and a method for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL141588A IL141588A (en) | 1998-09-15 | 2001-02-22 | Use of OPGL polypeptide for the preparation of pharmaceutical preparations and a method for their preparation |
Country Status (24)
Country | Link |
---|---|
US (2) | US6645500B1 (et) |
EP (1) | EP1114166B1 (et) |
JP (1) | JP2002525060A (et) |
KR (1) | KR100671036B1 (et) |
CN (1) | CN1318105A (et) |
AT (1) | ATE291628T1 (et) |
AU (1) | AU754971B2 (et) |
CA (1) | CA2343654A1 (et) |
CZ (1) | CZ2001789A3 (et) |
DE (1) | DE69924392T2 (et) |
EE (1) | EE200100149A (et) |
ES (1) | ES2239457T3 (et) |
HK (1) | HK1040261A1 (et) |
HR (1) | HRP20010188A2 (et) |
HU (1) | HUP0103578A3 (et) |
ID (1) | ID28386A (et) |
IL (2) | IL141588A0 (et) |
NO (1) | NO20011304L (et) |
NZ (1) | NZ510508A (et) |
PL (1) | PL196790B1 (et) |
PT (1) | PT1114166E (et) |
SK (1) | SK3062001A3 (et) |
TR (1) | TR200100737T2 (et) |
WO (1) | WO2000015807A1 (et) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
SK288559B6 (sk) * | 1997-04-16 | 2018-05-02 | Amgen, Inc. | Nukleová kyselina, polypeptid, expresný vektor a hostiteľská bunka; proteín viažuci osteoprotegerín a spôsob jeho prípravy, protilátka a liečivo na prevenciu alebo liečenie chorôb kostí |
ID28386A (id) * | 1998-09-15 | 2001-05-17 | M & E Biotech As | Metode penurunan aktivitas ligan osteoprotegerin |
GB9908263D0 (en) * | 1999-04-13 | 1999-06-02 | Binding Site The Limited | Eliciting improved immune responses |
WO2000067777A1 (en) * | 1999-05-07 | 2000-11-16 | Biofan Pty Ltd | A method of prophylaxis and treatment and agents useful therefor |
US6673771B1 (en) | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
AU778190B2 (en) * | 1999-07-28 | 2004-11-18 | Trustees Of The University Of Pennsylvania, The | Methods of inhibiting osteoclast activity |
WO2001023559A1 (en) * | 1999-09-27 | 2001-04-05 | Eli Lilly And Company | Osteoclast differentiation factor regulatory region |
AUPQ314799A0 (en) * | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
MXPA02007796A (es) * | 2000-02-21 | 2003-12-08 | Pharmexa As | Metodo novedoso para la disminucion de cuerpos amiloides. |
EP1259251B1 (en) * | 2000-02-21 | 2005-10-19 | Pharmexa A/S | Novel method for down-regulation of amyloid |
DK2105449T3 (da) * | 2000-02-23 | 2019-10-07 | Amgen Inc | Antagonistiske selektive bindemidler af osteoprotegerinbindende protein |
US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
US20030215450A1 (en) * | 2000-05-26 | 2003-11-20 | Blake Simon M | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
EP1458411A4 (en) * | 2000-08-21 | 2004-09-22 | Smithkline Beecham Corp | ANTI-RANK LIGAND MONOCLONAL ANTIBODIES SUITABLE FOR THE TREATMENT OF RANK LIGAND RELATED DISORDERS |
WO2002024228A1 (fr) * | 2000-09-21 | 2002-03-28 | Center For Advanced Science And Technology Incubation, Ltd. | Méthode de régulation de la formation d'ostéoclastes |
MXPA03002443A (es) | 2000-09-22 | 2004-12-06 | Immunex Corp | Ensayos de clasificacion para agonistas o antagonistas del activador receptor de nf-kb. |
US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
EP1385532A4 (en) * | 2001-03-22 | 2004-12-15 | Barnes Jewish Hospital | STIMULATION OF THE OSTEOGENESIS WITH RANG-LIGAND FUSION PROTEINS |
AU2002253133B2 (en) | 2001-04-03 | 2008-02-28 | Societe Des Produits Nestle S.A. | Osteoprotegerin in milk |
EP2087908B1 (en) | 2001-06-26 | 2018-05-30 | Amgen Inc. | Antibodies to opgl |
MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
US20030109444A1 (en) * | 2001-10-12 | 2003-06-12 | Jonathan Lam | Bone anti-resorptive compounds |
JP4336467B2 (ja) * | 2001-10-15 | 2009-09-30 | 株式会社林原生物化学研究所 | 破骨細胞形成抑制因子の産生を調節し得る物質のスクリーニング方法 |
JP2005530482A (ja) | 2002-01-04 | 2005-10-13 | ゼンコー・インコーポレイテッド | ドミナントネガティブタンパク質およびそれらの用法 |
AU2003217174A1 (en) * | 2002-01-04 | 2003-07-30 | Xencor | Novel variants of rankl protein |
US7381792B2 (en) | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
WO2003086289A2 (en) * | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
US6921538B2 (en) * | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
WO2004052233A2 (en) | 2002-12-10 | 2004-06-24 | Schering-Plough Ltd. | Canine rankl and methods for preparing and using the same |
CN1960752A (zh) * | 2004-06-02 | 2007-05-09 | 赛托斯生物技术公司 | 非人类tnf-肽的载体偶联物的医药用途 |
US20080107597A1 (en) * | 2006-01-12 | 2008-05-08 | Anaptys Biosciences, Inc. | Isolation of antibodies that cross-react and neutralize rankl originating from multiple species |
WO2008088594A2 (en) * | 2007-01-12 | 2008-07-24 | Anaptysbio, Inc. | Isolation of antibodies that cross-react and neutralize rankl orginating from multiple species |
CN101434656B (zh) * | 2007-11-16 | 2011-12-14 | 首都医科大学 | Opg-hsp70融合蛋白的制备方法及用途 |
EP3029061B1 (en) * | 2008-06-18 | 2017-09-13 | The Texas A&M University System | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
WO2011128892A2 (en) * | 2010-04-12 | 2011-10-20 | Protea Vaccine Technologies Ltd. | Modified forms of pneumococcal surface immunogenic protein b (psipb) |
CN107286245B (zh) * | 2016-04-11 | 2021-10-08 | 北京普纳生物科技有限公司 | Pd-l1和pd-l2重组蛋白及其用途 |
CN107286244B (zh) * | 2016-04-11 | 2021-10-08 | 北京普纳生物科技有限公司 | 抗免疫检查点pd-l1和pd-l2肿瘤疫苗 |
CN108498786A (zh) * | 2018-02-13 | 2018-09-07 | 南昌大学第二附属医院 | 载骨保护素的缓释纳米粒及其制备方法和应用 |
KR102154637B1 (ko) * | 2018-11-12 | 2020-09-10 | 조선대학교산학협력단 | Rankl의 돌연변이체, 및 이를 포함하는 골다공증 예방 또는 치료용 약학 조성물 |
WO2024054566A1 (en) * | 2022-09-07 | 2024-03-14 | The Regents Of The University Of California | Treatment of cancer by blockade of osteoprotegerin |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
DK96493D0 (da) * | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
WO1995005879A1 (en) | 1993-08-27 | 1995-03-02 | The Dow Chemical Company | Process for the separation of enantiomers |
EP0755444A4 (en) * | 1994-04-01 | 1998-01-14 | Univ Utah | MOLECULAR CLONING AND EXPRESSION OF AN INDUCTIBLE PROTEASOME ACTIVATOR BY INTERFERON GAMMA |
US6340459B1 (en) * | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
US6369027B1 (en) * | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
AU5697098A (en) * | 1996-12-13 | 1998-07-03 | Schering Corporation | Mammalian cell surface antigens; related reagents |
DE69740107D1 (de) * | 1996-12-23 | 2011-03-10 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
SK288559B6 (sk) * | 1997-04-16 | 2018-05-02 | Amgen, Inc. | Nukleová kyselina, polypeptid, expresný vektor a hostiteľská bunka; proteín viažuci osteoprotegerín a spôsob jeho prípravy, protilátka a liečivo na prevenciu alebo liečenie chorôb kostí |
ID28386A (id) * | 1998-09-15 | 2001-05-17 | M & E Biotech As | Metode penurunan aktivitas ligan osteoprotegerin |
-
1999
- 1999-09-13 ID IDW20010822A patent/ID28386A/id unknown
- 1999-09-13 CZ CZ2001789A patent/CZ2001789A3/cs unknown
- 1999-09-13 PL PL346698A patent/PL196790B1/pl not_active IP Right Cessation
- 1999-09-13 AU AU56173/99A patent/AU754971B2/en not_active Ceased
- 1999-09-13 IL IL14158899A patent/IL141588A0/xx unknown
- 1999-09-13 ES ES99942778T patent/ES2239457T3/es not_active Expired - Lifetime
- 1999-09-13 TR TR2001/00737T patent/TR200100737T2/xx unknown
- 1999-09-13 HU HU0103578A patent/HUP0103578A3/hu unknown
- 1999-09-13 DE DE69924392T patent/DE69924392T2/de not_active Expired - Fee Related
- 1999-09-13 WO PCT/DK1999/000481 patent/WO2000015807A1/en active IP Right Grant
- 1999-09-13 CA CA002343654A patent/CA2343654A1/en not_active Abandoned
- 1999-09-13 EE EEP200100149A patent/EE200100149A/et unknown
- 1999-09-13 KR KR1020017003379A patent/KR100671036B1/ko not_active IP Right Cessation
- 1999-09-13 EP EP99942778A patent/EP1114166B1/en not_active Expired - Lifetime
- 1999-09-13 JP JP2000570334A patent/JP2002525060A/ja active Pending
- 1999-09-13 NZ NZ510508A patent/NZ510508A/en unknown
- 1999-09-13 CN CN99810872A patent/CN1318105A/zh active Pending
- 1999-09-13 PT PT99942778T patent/PT1114166E/pt unknown
- 1999-09-13 SK SK306-2001A patent/SK3062001A3/sk not_active Application Discontinuation
- 1999-09-13 AT AT99942778T patent/ATE291628T1/de not_active IP Right Cessation
- 1999-09-15 US US09/396,937 patent/US6645500B1/en not_active Expired - Fee Related
-
2001
- 2001-02-22 IL IL141588A patent/IL141588A/en not_active IP Right Cessation
- 2001-03-14 HR HR20010188A patent/HRP20010188A2/hr not_active Application Discontinuation
- 2001-03-14 NO NO20011304A patent/NO20011304L/no not_active Application Discontinuation
-
2002
- 2002-01-08 HK HK02100128.3A patent/HK1040261A1/zh unknown
-
2003
- 2003-09-17 US US10/664,801 patent/US20040115199A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HUP0103578A3 (en) | 2005-11-28 |
KR20010085807A (ko) | 2001-09-07 |
PL196790B1 (pl) | 2008-01-31 |
DE69924392D1 (de) | 2005-04-28 |
HRP20010188A2 (en) | 2002-04-30 |
NO20011304D0 (no) | 2001-03-14 |
AU5617399A (en) | 2000-04-03 |
EE200100149A (et) | 2002-08-15 |
US20040115199A1 (en) | 2004-06-17 |
EP1114166A1 (en) | 2001-07-11 |
PT1114166E (pt) | 2005-08-31 |
ID28386A (id) | 2001-05-17 |
DE69924392T2 (de) | 2006-03-09 |
CZ2001789A3 (cs) | 2001-08-15 |
PL346698A1 (en) | 2002-02-25 |
HUP0103578A2 (hu) | 2002-01-28 |
US6645500B1 (en) | 2003-11-11 |
CN1318105A (zh) | 2001-10-17 |
NZ510508A (en) | 2005-05-27 |
HK1040261A1 (zh) | 2002-05-31 |
AU754971B2 (en) | 2002-11-28 |
TR200100737T2 (tr) | 2001-07-23 |
NO20011304L (no) | 2001-05-15 |
KR100671036B1 (ko) | 2007-01-18 |
WO2000015807A1 (en) | 2000-03-23 |
ATE291628T1 (de) | 2005-04-15 |
EP1114166B1 (en) | 2005-03-23 |
IL141588A (en) | 2008-07-08 |
CA2343654A1 (en) | 2000-03-23 |
SK3062001A3 (en) | 2002-02-05 |
ES2239457T3 (es) | 2005-09-16 |
JP2002525060A (ja) | 2002-08-13 |
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