IL134480A0 - Kay - an immune system protein and dna sequences encoding the same - Google Patents
Kay - an immune system protein and dna sequences encoding the sameInfo
- Publication number
- IL134480A0 IL134480A0 IL13448098A IL13448098A IL134480A0 IL 134480 A0 IL134480 A0 IL 134480A0 IL 13448098 A IL13448098 A IL 13448098A IL 13448098 A IL13448098 A IL 13448098A IL 134480 A0 IL134480 A0 IL 134480A0
- Authority
- IL
- Israel
- Prior art keywords
- kay
- same
- immune system
- dna sequences
- sequences encoding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5878697P | 1997-09-12 | 1997-09-12 | |
PCT/US1998/019037 WO1999012964A2 (en) | 1997-09-12 | 1998-09-11 | Kay - a novel immune system protein |
Publications (1)
Publication Number | Publication Date |
---|---|
IL134480A0 true IL134480A0 (en) | 2001-04-30 |
Family
ID=22018915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13448098A IL134480A0 (en) | 1997-09-12 | 1998-09-11 | Kay - an immune system protein and dna sequences encoding the same |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1012270A2 (is) |
JP (1) | JP2001515711A (is) |
KR (1) | KR20010023892A (is) |
CN (1) | CN1269832A (is) |
AU (1) | AU9315298A (is) |
BR (1) | BR9812433A (is) |
CA (1) | CA2303424A1 (is) |
EA (1) | EA200000311A1 (is) |
EE (1) | EE200000148A (is) |
HU (1) | HUP0004034A3 (is) |
IL (1) | IL134480A0 (is) |
IS (1) | IS5375A (is) |
NO (1) | NO20001240L (is) |
PL (1) | PL339740A1 (is) |
SK (1) | SK3532000A3 (is) |
TR (1) | TR200000654T2 (is) |
WO (1) | WO1999012964A2 (is) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
JP2002503444A (ja) * | 1997-11-26 | 2002-02-05 | イーライ・リリー・アンド・カンパニー | リガンドファミリー遺伝子 |
US6297367B1 (en) | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
WO1999033980A2 (en) * | 1997-12-30 | 1999-07-08 | Chiron Corporation | Members of tnf and tnfr families |
US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
GB9828628D0 (en) | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
PT1146892E (pt) | 1999-01-25 | 2003-12-31 | Biogen Inc | Fabf seus inibidores e o seu uso na modulacao da resposta as celulas b |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
US6475986B1 (en) | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
AU777536B2 (en) * | 1999-02-23 | 2004-10-21 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
AU4986700A (en) * | 1999-05-06 | 2000-11-21 | National Jewish Medical And Research Center | Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof |
HU230583B1 (hu) * | 1999-08-17 | 2017-02-28 | Biogen Idec Ma Inc. | BAFF-receptor (BCMA) alkalmazásai immunszabályozó szerként |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
AU3495301A (en) | 2000-02-11 | 2001-08-20 | Biogen Inc | Heterologous polypeptide of the tnf family |
EP1666052B1 (en) | 2000-02-16 | 2011-06-08 | Genentech, Inc. | Anti-APRIL monoclonal antibody and its use for the treatment of an immune related disease or cancer |
ATE361318T1 (de) | 2000-05-12 | 2007-05-15 | Amgen Inc | Polypeptiden, die die april-vermittelte aktivierung von t-und b-zellen hemmen |
KR20060088905A (ko) | 2000-06-16 | 2006-08-07 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 면역특이적으로 BLyS에 결합하는 항체 |
US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
AU2001288260A1 (en) * | 2000-08-15 | 2002-03-13 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
AU2001288301A1 (en) | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
ES2295404T3 (es) | 2001-05-11 | 2008-04-16 | Amgen, Inc. | Peptidos y moleculas relacionadas que se unen a tall-1. |
AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
US7700317B2 (en) | 2003-03-28 | 2010-04-20 | Biogen Idec Ma Inc. | Truncated baff receptors |
DK1631313T3 (en) | 2003-06-05 | 2015-06-15 | Genentech Inc | Combination therapy for b cell disorders |
EP1675609A1 (en) | 2003-10-20 | 2006-07-05 | Biogen Idec MA Inc. | Therapeutic regimens for baff antagonists |
JP2008505607A (ja) * | 2004-01-29 | 2008-02-28 | ジェネンテック・インコーポレーテッド | Bcmaの細胞外ドメインの変異体とその使用法 |
CA2580271A1 (en) | 2004-10-05 | 2006-04-20 | Genentech, Inc. | Method for treating vasculitis |
CA2583900A1 (en) | 2004-10-13 | 2006-04-27 | The Washington University | Use of baff to treat sepsis |
AU2005318086B2 (en) | 2004-12-23 | 2011-07-07 | Merck Serono Sa | BCMA polypeptides and uses thereof |
WO2007019575A2 (en) | 2005-08-09 | 2007-02-15 | Zymogenetics, Inc. | Methods for treating b-cell malignancies using taci-ig fusion molecule |
WO2007019573A2 (en) | 2005-08-09 | 2007-02-15 | Zymogenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
WO2007123765A2 (en) | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
NZ572373A (en) | 2006-05-15 | 2012-02-24 | Ares Trading Sa | Methods for treating rheumatoid arthritis using a taci-ig fusion molecule |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
EP3211094A3 (en) | 2009-09-03 | 2017-11-01 | F. Hoffmann-La Roche AG | Methods for treating, diagnosing, and monitoring rheumatoid arthritis |
RU2013140975A (ru) | 2011-02-28 | 2015-04-10 | Дженентек, Инк. | Биологические маркеры и способы прогнозирования восприимчивости к антагонистам в-клеток |
EP2953972B1 (en) | 2013-02-05 | 2020-07-08 | EngMab Sàrl | Method for the selection of antibodies against bcma |
JOP20140087B1 (ar) | 2013-03-13 | 2021-08-17 | Amgen Inc | بروتينات مخصصة ل baff و b7rp1 وإستخداماتها |
US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
EP3129380B1 (en) | 2014-04-11 | 2018-11-28 | Boehringer Ingelheim International Gmbh | Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one derivatives and their use as mdm2-p53 inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6001094A (en) * | 1993-02-03 | 1994-08-29 | N.V. Innogenetics S.A. | Tnf-alpha muteins and a process for preparing them |
AU6166396A (en) * | 1995-06-07 | 1996-12-30 | Biogen, Inc. | Complexes of modified lymphotoxins as pharmaceutical prepara tions |
DK0939804T4 (da) * | 1996-10-25 | 2011-07-18 | Human Genome Sciences Inc | Neutrokin-alpha |
WO1998027114A2 (en) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Mammalian cell surface antigens; related reagents |
CA2232743A1 (en) * | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | A tnf homologue, tl5 |
-
1998
- 1998-09-11 PL PL98339740A patent/PL339740A1/xx not_active Application Discontinuation
- 1998-09-11 HU HU0004034A patent/HUP0004034A3/hu unknown
- 1998-09-11 TR TR2000/00654T patent/TR200000654T2/xx unknown
- 1998-09-11 CA CA002303424A patent/CA2303424A1/en not_active Abandoned
- 1998-09-11 AU AU93152/98A patent/AU9315298A/en not_active Abandoned
- 1998-09-11 KR KR1020007002576A patent/KR20010023892A/ko not_active Application Discontinuation
- 1998-09-11 IL IL13448098A patent/IL134480A0/xx unknown
- 1998-09-11 CN CN98809023A patent/CN1269832A/zh active Pending
- 1998-09-11 EE EEP200000148A patent/EE200000148A/xx unknown
- 1998-09-11 EA EA200000311A patent/EA200000311A1/ru unknown
- 1998-09-11 SK SK353-2000A patent/SK3532000A3/sk unknown
- 1998-09-11 BR BR9812433-1A patent/BR9812433A/pt not_active IP Right Cessation
- 1998-09-11 JP JP2000510769A patent/JP2001515711A/ja not_active Withdrawn
- 1998-09-11 EP EP98946052A patent/EP1012270A2/en not_active Withdrawn
- 1998-09-11 WO PCT/US1998/019037 patent/WO1999012964A2/en not_active Application Discontinuation
-
2000
- 2000-02-11 IS IS5375A patent/IS5375A/is unknown
- 2000-03-09 NO NO20001240A patent/NO20001240L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1269832A (zh) | 2000-10-11 |
CA2303424A1 (en) | 1999-03-18 |
WO1999012964A3 (en) | 1999-05-27 |
KR20010023892A (ko) | 2001-03-26 |
IS5375A (is) | 2000-02-11 |
NO20001240D0 (no) | 2000-03-09 |
PL339740A1 (en) | 2001-01-02 |
EA200000311A1 (ru) | 2000-10-30 |
BR9812433A (pt) | 2000-09-26 |
TR200000654T2 (tr) | 2000-07-21 |
HUP0004034A3 (en) | 2002-08-28 |
SK3532000A3 (en) | 2001-12-03 |
NO20001240L (no) | 2000-05-10 |
JP2001515711A (ja) | 2001-09-25 |
EE200000148A (et) | 2001-02-15 |
EP1012270A2 (en) | 2000-06-28 |
WO1999012964A2 (en) | 1999-03-18 |
HUP0004034A2 (en) | 2001-03-28 |
AU9315298A (en) | 1999-03-29 |
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