IL133265A0 - Heparanase specific molecular probes and their use in research and medical applications - Google Patents
Heparanase specific molecular probes and their use in research and medical applicationsInfo
- Publication number
- IL133265A0 IL133265A0 IL13326599A IL13326599A IL133265A0 IL 133265 A0 IL133265 A0 IL 133265A0 IL 13326599 A IL13326599 A IL 13326599A IL 13326599 A IL13326599 A IL 13326599A IL 133265 A0 IL133265 A0 IL 133265A0
- Authority
- IL
- Israel
- Prior art keywords
- heparanase
- specific molecular
- research
- molecular probe
- medical applications
- Prior art date
Links
- 102100024025 Heparanase Human genes 0.000 title abstract 10
- 108010037536 heparanase Proteins 0.000 title abstract 10
- 239000003068 molecular probe Substances 0.000 title abstract 7
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/071,739 US6177545B1 (en) | 1997-09-02 | 1998-05-01 | Heparanase specific molecular probes and their use in research and medical applications |
PCT/US1999/009255 WO1999057153A1 (en) | 1998-05-01 | 1999-04-29 | Heparanase specific molecular probes and their use in research and medical applications |
Publications (1)
Publication Number | Publication Date |
---|---|
IL133265A0 true IL133265A0 (en) | 2001-04-30 |
Family
ID=22103268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13326599A IL133265A0 (en) | 1998-05-01 | 1999-04-29 | Heparanase specific molecular probes and their use in research and medical applications |
Country Status (11)
Country | Link |
---|---|
US (6) | US6177545B1 (ja) |
EP (2) | EP1734133A2 (ja) |
JP (1) | JP2002512533A (ja) |
AT (1) | ATE328008T1 (ja) |
AU (1) | AU754228B2 (ja) |
CA (1) | CA2295323A1 (ja) |
DE (1) | DE69931624T2 (ja) |
ES (1) | ES2267266T3 (ja) |
IL (1) | IL133265A0 (ja) |
NO (1) | NO996229L (ja) |
WO (1) | WO1999057153A1 (ja) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040213789A1 (en) * | 1997-09-02 | 2004-10-28 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies |
US5968822A (en) * | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
US6699672B1 (en) * | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
US6562950B2 (en) * | 1997-09-02 | 2003-05-13 | Insight Strategy & Marketing Ltd. | Heparanase activity neutralizing anti-heparanase monoclonal antibody |
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US20030161823A1 (en) * | 1998-08-31 | 2003-08-28 | Neta Ilan | Therapeutic and cosmetic uses of heparanases |
US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
EP1157118A4 (en) * | 1999-03-01 | 2002-07-17 | Insight Strategy & Marketing | POLYNUCLEOTID ENCODING A POLYPEPTIDE WITH HEPARANASE ACTIVITY AND ITS EXPRESSION IN GENETICALLY MODIFIED CELLS |
KR20020028906A (ko) * | 1999-06-25 | 2002-04-17 | 추후보정 | 폴리누클레오티드 및 그에 의해 코딩된 헤파라나제와간접적으로 유사한 폴리펩티드 |
US20040161745A1 (en) * | 1999-12-23 | 2004-08-19 | Gerhard Siemeister | Human heparanase-related polypeptide and nucleic acid |
US6656699B2 (en) | 2000-09-15 | 2003-12-02 | Reddy Us Therapeutics, Inc. | Methods and compositions for glycosidase assays |
US20040033218A1 (en) * | 2000-12-19 | 2004-02-19 | Oron Yacoby-Zeevi | Use of ecm degrading enzymes for the improvement of cell transplantation |
EP1385990A4 (en) * | 2001-05-09 | 2004-09-22 | Insight Biopharmaceuticals Ltd | METHODS AND MATERIALS USING HEPARANASE AS A DIAGNOSTIC MARKER FOR HEMOSTATIC DISORDERS |
EP1417304A4 (en) * | 2001-07-13 | 2005-11-23 | Imclone Systems Inc | METHOD AND COMPOSITION FOR INHIBITING HEPARANASE ACTIVITY |
WO2003011119A2 (en) * | 2001-07-31 | 2003-02-13 | Reddy Us Therapeutics, Inc. | Methods and compositions for diagnosis and treatment of vascular conditions |
US6671189B2 (en) * | 2001-11-09 | 2003-12-30 | Minebea Co., Ltd. | Power converter having primary and secondary side switches |
EP1382574A3 (en) * | 2002-06-21 | 2004-05-26 | Sanden Corporation | Mineral water making apparatus |
WO2004043989A2 (en) * | 2002-11-07 | 2004-05-27 | Medarex, Inc. | Human monoclonal antibodies to heparanase |
US20060166315A1 (en) * | 2002-12-26 | 2006-07-27 | Masatoshi Murai | Process for producing pnpase |
US20060269552A1 (en) * | 2003-06-09 | 2006-11-30 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies |
ITMI20031714A1 (it) | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
ES2388435T3 (es) * | 2003-12-10 | 2012-10-15 | Medarex, Inc. | Anticuerpos de IP-10 y sus usos |
IL162276A0 (en) * | 2004-06-01 | 2005-11-20 | Hadasit Med Res Service | Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof |
US7510842B2 (en) * | 2005-03-11 | 2009-03-31 | Vermilllion, Inc. | Biomarker for ovarian and endometrial cancer: hepcidin |
EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
US20100248260A1 (en) * | 2007-12-05 | 2010-09-30 | Massachusetts Institute Of Technology | Glycosaminoglycan-coated particles and uses thereof |
KR20160003188A (ko) * | 2008-03-31 | 2016-01-08 | 가부시키가이샤 시세이도 | 주름을 방지 또는 개선하기 위한 경구, 주사, 피부 외용제 및 미용 방법 |
WO2010033601A1 (en) * | 2008-09-16 | 2010-03-25 | Dow Global Technologies Inc. | Polymeric compositions and foams, methods of making the same, and articles prepared from the same |
WO2011067711A2 (en) * | 2009-12-01 | 2011-06-09 | Compugen Ltd | Novel heparanase splice variant |
DK2637672T3 (en) | 2010-11-12 | 2018-10-22 | Gentium S R L | DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD) |
ES2660969T5 (es) | 2012-06-22 | 2021-09-03 | Gentium S R L | Método basado en euglobulina para determinar la actividad biológica de defibrotida |
US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
US11161912B2 (en) | 2015-10-13 | 2021-11-02 | Technion Research & Development Foundation Limited | Heparanase-neutralizing monoclonal antibodies |
US10349968B2 (en) * | 2016-05-02 | 2019-07-16 | Covidien Lp | Devices, systems, and methods for establishing electrical and fluid connections to surgical instruments |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US931129A (en) * | 1904-03-30 | 1909-08-17 | Henry La Casse | Shaft-hanger. |
US2295323A (en) * | 1940-08-02 | 1942-09-08 | Edwin H Armstrong | Current limiting device |
US4117841A (en) * | 1977-02-07 | 1978-10-03 | Anthony Perrotta | Medicated bandage pocket |
US4659581A (en) * | 1981-09-16 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Method of producing granular chemical seasoning of high specific volume and product |
US4455296A (en) * | 1982-02-02 | 1984-06-19 | Board Of Regents, The University Of Texas System | Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4859581A (en) * | 1986-03-10 | 1989-08-22 | Board Of Regents, The University Of Texas System | Endoglycosidase assay |
US5206223A (en) * | 1986-06-26 | 1993-04-27 | Yeda Research And Development Co. Ltd. | Method for inhibiting heparanase activity |
IL79255A0 (en) * | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
DK173067B1 (da) * | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
WO1988001280A1 (en) * | 1986-08-21 | 1988-02-25 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5061689A (en) | 1986-12-24 | 1991-10-29 | Bioderm, Inc. | Zinc bacitracin containing wound dressing |
US4937747A (en) * | 1988-02-16 | 1990-06-26 | Amoco Corporation | Iterative disjoint cluster and discriminant function processing of formation log responses and other data |
US5129877A (en) * | 1988-04-29 | 1992-07-14 | University Of Georgia Research Foundation, Inc. | Receptor-mediated delivery system |
CA2045126A1 (en) * | 1989-01-10 | 1990-07-11 | Nicholas M. Gough | Leukaemia inhibitory factor from livestock species and use thereof to enhance implantation and development of embryonic cells |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US5571506A (en) | 1989-08-14 | 1996-11-05 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aromatic oligomeric compounds useful as mimics of bioactive macromolecules |
AU654804B2 (en) * | 1989-08-23 | 1994-11-24 | Zvi Fuks | Wound healing preparations containing heparanase |
US5145679A (en) * | 1989-10-05 | 1992-09-08 | Hinson Joan B | Topical emollient for prevention and treatment of circulatory induced lesions |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
CA2083052A1 (en) | 1990-05-31 | 1991-12-01 | Garth L. Nicolson | Immunochemical localization of heparanase in mouse and human melanomas |
US5246698A (en) * | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
JPH04187408A (ja) | 1990-11-21 | 1992-07-06 | Toyo Ink Mfg Co Ltd | 熱可塑性樹脂ペレットの製造方法およびその装置 |
FR2669932B1 (fr) * | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
US5714345A (en) * | 1990-12-24 | 1998-02-03 | Pharmaceutical Proteins Limited | Increased expression of a gene by a second transferred mammary gland specific sequence transgenic |
JPH06507307A (ja) * | 1991-01-11 | 1994-08-25 | アメリカン・レツド・クロス | トランスジェニック動物の乳腺組織における活性ヒトプロテインcの発現 |
US5300059A (en) | 1991-11-19 | 1994-04-05 | Hydro Slip Technologies Inc. | Bloodbag and method of making same |
US5360735A (en) * | 1992-01-08 | 1994-11-01 | Synaptic Pharmaceutical Corporation | DNA encoding a human 5-HT1F receptor, vectors, and host cells |
WO1993018745A1 (en) | 1992-03-23 | 1993-09-30 | Geda International S.A. | Use of antiviral coating for latex items such as condoms |
FR2690162B1 (fr) * | 1992-04-21 | 1995-08-04 | Rhone Poulenc Rorer Sa | Peptides ayant une activite de facteur d'echange du gdp, sequences d'acides nucleiques codant pour ces peptides, preparation et utilisation. |
US5616483A (en) * | 1992-06-11 | 1997-04-01 | Aktiebolaget Astra | Genomic DNA sequences encoding human BSSL/CEL |
DE69333951D1 (de) * | 1992-06-18 | 2006-02-02 | Us Gov Health & Human Serv | Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität |
WO1994006442A1 (en) * | 1992-09-11 | 1994-03-31 | The Regents Of The University Of California | Sulfated ligands for l-selectins and use of chlorates and or sulfatases for the treatment of inflammation |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
GB9225581D0 (en) * | 1992-12-08 | 1993-01-27 | Courtaulds Plc | Wound dressings |
US5474983A (en) * | 1993-03-15 | 1995-12-12 | The Research Foundation Of State University Of New York | Method of inhibiting pro-inflammatory mediator release from basophils and mast cells |
US5565193A (en) | 1993-08-05 | 1996-10-15 | Procter & Gamble | Hair styling compositions containing a silicone grafted polymer and low level of a volatile hydrocarbon solvent |
US5739115A (en) * | 1993-10-07 | 1998-04-14 | Glycomed Incorporated | Sulfated maltooligosaccharides with heparin-like properties |
US5618709A (en) * | 1994-01-14 | 1997-04-08 | University Of Pennsylvania | Antisense oligonucleotides specific for STK-1 and method for inhibiting expression of the STK-1 protein |
EP0750671A1 (en) * | 1994-03-09 | 1997-01-02 | Abbott Laboratories | Transgenic animals producing oligosaccharides and glycoconjugates |
US5997863A (en) * | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
US5830759A (en) * | 1994-08-18 | 1998-11-03 | The Trustees Of Columbia University In The City Of New York | Unique associated Kaposi's sarcoma virus sequences and uses thereof |
US5600366A (en) * | 1995-03-22 | 1997-02-04 | Npb Partners, Ltd. | Methods and apparatus for digital advertisement insertion in video programming |
US5799276A (en) * | 1995-11-07 | 1998-08-25 | Accent Incorporated | Knowledge-based speech recognition system and methods having frame length computed based upon estimated pitch period of vocalic intervals |
US5859929A (en) * | 1995-12-01 | 1999-01-12 | United Parcel Service Of America, Inc. | System for character preserving guidelines removal in optically scanned text |
WO1997023345A1 (en) | 1995-12-21 | 1997-07-03 | Contra-Shear Holdings Limited | Screw press head |
US5859660A (en) * | 1996-02-29 | 1999-01-12 | Perkins; Michael G. | Non-seamless splicing of audio-video transport streams |
US6314420B1 (en) * | 1996-04-04 | 2001-11-06 | Lycos, Inc. | Collaborative/adaptive search engine |
US6020931A (en) * | 1996-04-25 | 2000-02-01 | George S. Sheng | Video composition and position system and media signal communication system |
US5799311A (en) * | 1996-05-08 | 1998-08-25 | International Business Machines Corporation | Method and system for generating a decision-tree classifier independent of system memory size |
US5917830A (en) * | 1996-10-18 | 1999-06-29 | General Instrument Corporation | Splicing compressed packetized digital video streams |
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
US5968822A (en) | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US6348344B1 (en) * | 1997-09-02 | 2002-02-19 | Insight Strategy & Marketing Ltd. | Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same |
US6699672B1 (en) * | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
US6190875B1 (en) * | 1997-09-02 | 2001-02-20 | Insight Strategy & Marketing Ltd. | Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe |
US20030161823A1 (en) * | 1998-08-31 | 2003-08-28 | Neta Ilan | Therapeutic and cosmetic uses of heparanases |
US6153187A (en) * | 1997-09-02 | 2000-11-28 | Insight Strategy & Marketing Ltd. | Use of glycosaminoglycans degrading enzymes for management of airway associated diseases |
US6562950B2 (en) * | 1997-09-02 | 2003-05-13 | Insight Strategy & Marketing Ltd. | Heparanase activity neutralizing anti-heparanase monoclonal antibody |
US6242238B1 (en) * | 1997-10-28 | 2001-06-05 | The Australian National University | Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor |
JP2002504376A (ja) * | 1998-02-24 | 2002-02-12 | ファルマシア・アンド・アップジョン・カンパニー | ヒト血小板ヘパラナーゼポリペプチド、それをコードするポリヌクレオチド分子、およびヘパラナーゼ活性を改変する化合物の同定方法 |
US6230151B1 (en) * | 1998-04-16 | 2001-05-08 | International Business Machines Corporation | Parallel classification for data mining in a shared-memory multiprocessor system |
US6307965B1 (en) * | 1998-04-30 | 2001-10-23 | International Business Machines Corporation | System and method for detecting clusters of information |
US20030236215A1 (en) * | 1998-08-31 | 2003-12-25 | Insight Strategy & Marketing Ltd. | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells |
US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
US6226792B1 (en) * | 1998-10-14 | 2001-05-01 | Unisys Corporation | Object management system supporting the use of application domain knowledge mapped to technology domain knowledge |
EP1157118A4 (en) * | 1999-03-01 | 2002-07-17 | Insight Strategy & Marketing | POLYNUCLEOTID ENCODING A POLYPEPTIDE WITH HEPARANASE ACTIVITY AND ITS EXPRESSION IN GENETICALLY MODIFIED CELLS |
JP3717420B2 (ja) * | 2001-04-27 | 2005-11-16 | シャープ株式会社 | モバイルコンセント、電力供給ゲート装置、サーバ装置および電力利用管理システム |
US20020194625A1 (en) * | 2001-05-25 | 2002-12-19 | Insight Strategy & Marketing Ltd. | Transgenic animals expressing heparanase and its uses |
AU2002351002A1 (en) * | 2001-12-21 | 2003-07-09 | Pfizer Products Inc. | Transgenic expression of glycogen synthase kinase 3 in muscle |
US20060269552A1 (en) * | 2003-06-09 | 2006-11-30 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies |
-
1998
- 1998-05-01 US US09/071,739 patent/US6177545B1/en not_active Expired - Lifetime
-
1999
- 1999-04-29 EP EP06009462A patent/EP1734133A2/en not_active Withdrawn
- 1999-04-29 JP JP55552899A patent/JP2002512533A/ja active Pending
- 1999-04-29 DE DE69931624T patent/DE69931624T2/de not_active Expired - Lifetime
- 1999-04-29 IL IL13326599A patent/IL133265A0/xx unknown
- 1999-04-29 ES ES99921513T patent/ES2267266T3/es not_active Expired - Lifetime
- 1999-04-29 CA CA002295323A patent/CA2295323A1/en not_active Abandoned
- 1999-04-29 WO PCT/US1999/009255 patent/WO1999057153A1/en active IP Right Grant
- 1999-04-29 AU AU38706/99A patent/AU754228B2/en not_active Ceased
- 1999-04-29 AT AT99921513T patent/ATE328008T1/de not_active IP Right Cessation
- 1999-04-29 EP EP99921513A patent/EP1073682B1/en not_active Expired - Lifetime
- 1999-06-01 US US09/322,977 patent/US6531129B2/en not_active Expired - Lifetime
- 1999-12-15 NO NO996229A patent/NO996229L/no not_active Application Discontinuation
-
2001
- 2001-01-16 US US09/759,207 patent/US7049407B2/en not_active Expired - Fee Related
- 2001-09-04 US US09/944,602 patent/US6800441B2/en not_active Expired - Fee Related
-
2004
- 2004-02-26 US US10/786,149 patent/US6986996B2/en not_active Expired - Fee Related
- 2004-05-24 US US10/851,135 patent/US7790376B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20020102619A1 (en) | 2002-08-01 |
WO1999057153A1 (en) | 1999-11-11 |
EP1734133A2 (en) | 2006-12-20 |
US20020004585A1 (en) | 2002-01-10 |
DE69931624T2 (de) | 2007-05-03 |
US20040146925A1 (en) | 2004-07-29 |
ATE328008T1 (de) | 2006-06-15 |
EP1073682A4 (en) | 2001-02-07 |
EP1073682B1 (en) | 2006-05-31 |
US6800441B2 (en) | 2004-10-05 |
US6986996B2 (en) | 2006-01-17 |
JP2002512533A (ja) | 2002-04-23 |
NO996229D0 (no) | 1999-12-15 |
NO996229L (no) | 2000-02-24 |
US7049407B2 (en) | 2006-05-23 |
US20020114801A1 (en) | 2002-08-22 |
US20040229834A1 (en) | 2004-11-18 |
DE69931624D1 (de) | 2006-07-06 |
CA2295323A1 (en) | 1999-11-11 |
AU3870699A (en) | 1999-11-23 |
US6177545B1 (en) | 2001-01-23 |
US6531129B2 (en) | 2003-03-11 |
ES2267266T3 (es) | 2007-03-01 |
EP1073682A1 (en) | 2001-02-07 |
AU754228B2 (en) | 2002-11-07 |
US7790376B2 (en) | 2010-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL133265A0 (en) | Heparanase specific molecular probes and their use in research and medical applications | |
NZ507185A (en) | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues | |
WO2004021882A3 (en) | Measuring properties of an anatomical body | |
WO2003079887A3 (en) | Measuring blood flow rate or cardiac output | |
WO2005028015A3 (en) | Methods and apparatus for localized and semi-localized drug delivery | |
WO2004016309A3 (en) | Catheter securement device | |
ATE493946T1 (de) | Darmmanagementsystem mit physiologischen sensoren | |
AU2003285876A1 (en) | Treatment of spinal metastases | |
WO1999055285A3 (en) | Dilating and support apparatus with disease inhibitors and methods for use | |
DE60131156D1 (de) | Gerät zum einbringen eines medikamentes in das respiratorische system | |
ATE343969T1 (de) | Beschichtete medizinische geräte | |
WO2001002050A3 (en) | Method and system for use in treating a patient with any drug to optimize therapy and prevent an adverse drug response | |
ATE518011T1 (de) | Erhöhte expression von t- zellenrezeptorvermittelter tumornekrosefaktorsuperfamilie und chemokin-mrna in peripheren blut leukozyten bei patienten mit morbus& xa;crohn | |
DE60228605D1 (de) | Katheteranordnung zur arzneimittelabgabe mit aufblasbarem ballon | |
BR0309256A (pt) | Sistemas de liberação responsivos à temperatura | |
DE60037657D1 (de) | Infektionsmittel enthaltendes medizinisches gerät und verfahren zu ihrer darstellung | |
WO2003011215A3 (en) | Method and system to determine revised dosage | |
BRPI0414912A (pt) | sistema infusor e método de administração de medicamentos a paciente | |
WO2002082972A3 (en) | Method and apparatus to optimize drug therapy | |
BR0110512A (pt) | Preparação para medir a taxa de esvaziamento gástrico | |
CA2480956C (en) | Single use catheter | |
NO20003055D0 (no) | Medisinsk anordning for innvendig varmebehandling og medisinlevering | |
ATE411342T1 (de) | Scfv antikörper gegen krankheiten-assoziierte moleküle | |
ATE444705T1 (de) | Sensorsystem mit permanent implantiertem zugang | |
FR2791357B1 (fr) | Diagnostic de la maladie de whipple |