IL132273D0 - Process for preparation of pyrazolo ¬4,3 - d¾ pyrimidin-7-ones and intermediates thereof - Google Patents

Process for preparation of pyrazolo ¬4,3 - d¾ pyrimidin-7-ones and intermediates thereof

Info

Publication number
IL132273D0
IL132273D0 IL13227399A IL13227399A IL132273D0 IL 132273 D0 IL132273 D0 IL 132273D0 IL 13227399 A IL13227399 A IL 13227399A IL 13227399 A IL13227399 A IL 13227399A IL 132273 D0 IL132273 D0 IL 132273D0
Authority
IL
Israel
Prior art keywords
d3⁄4
pyrazolo
pyrimidin
intermediates
ones
Prior art date
Application number
IL13227399A
Other versions
IL132273A (en
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to GB9822238A priority Critical patent/GB9822238D0/en
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of IL132273D0 publication Critical patent/IL132273D0/en
Publication of IL132273A publication Critical patent/IL132273A/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL132273(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
IL13227399A 1998-10-12 1999-10-07 5-[(4-methyl-1-piperazinylsulfonyl)-2-substituted benzamido] -1-methyl-3-propyl-1h-pyrazole-5- carboxamides, their preparation and a process for the preparation of sildenafil therefrom IL132273A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9822238A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 5-(4-methyl-1-piperazinylsulfonyl)-2-substituted benzoic acids
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 5-(4-ethyl-1-piperazinylsulphonyl)2-substituted benzoic acids
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1-[3-(6, 7-DIHYDRO-1-METHYL-7-OXO-3-PROPYL-1H- PYRAZOLO [4, 3-d] - PYRIMIDIN-5-YL) -4- SUBSTITUTED PHENYLSULFONYL] -4- METHYL PIPERAZINES
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 PROCESS FOR PREPARATION OF 1-ETHYL-4-{3-[3-ETHYL-6, 7-DIHYDRO-7-OXO-2-(PYRIDYLMETHYL)-2H-PYRAZOLO [4,3-d] PYRIMIDIN-5-YL]-4-PROPOXYSULFONYL}-PIPERAZINE AND THE 4-[2-SUBSTITUTED-5-(4-ETHYL-1-PIPERAZINYLSUPHONYL)-BENZAMIDO]-5-ETHYL-1-(2-PYRIDYLMETHYL)1H-PYRAZOLE-3-CARBOXAMIDE INTERMEDIATES THEREFOR
IL15292702A IL152927D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292302A IL152923D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292802A IL152928D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
IL132273D0 true IL132273D0 (en) 2001-03-19
IL132273A IL132273A (en) 2004-06-20

Family

ID=10840421

Family Applications (11)

Application Number Title Priority Date Filing Date
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1-[3-(6, 7-DIHYDRO-1-METHYL-7-OXO-3-PROPYL-1H- PYRAZOLO [4, 3-d] - PYRIMIDIN-5-YL) -4- SUBSTITUTED PHENYLSULFONYL] -4- METHYL PIPERAZINES
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 5-(4-methyl-1-piperazinylsulfonyl)-2-substituted benzoic acids
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 PROCESS FOR PREPARATION OF 1-ETHYL-4-{3-[3-ETHYL-6, 7-DIHYDRO-7-OXO-2-(PYRIDYLMETHYL)-2H-PYRAZOLO [4,3-d] PYRIMIDIN-5-YL]-4-PROPOXYSULFONYL}-PIPERAZINE AND THE 4-[2-SUBSTITUTED-5-(4-ETHYL-1-PIPERAZINYLSUPHONYL)-BENZAMIDO]-5-ETHYL-1-(2-PYRIDYLMETHYL)1H-PYRAZOLE-3-CARBOXAMIDE INTERMEDIATES THEREFOR
IL13227399A IL132273A (en) 1998-10-12 1999-10-07 5-[(4-methyl-1-piperazinylsulfonyl)-2-substituted benzamido] -1-methyl-3-propyl-1h-pyrazole-5- carboxamides, their preparation and a process for the preparation of sildenafil therefrom
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 5-(4-ethyl-1-piperazinylsulphonyl)2-substituted benzoic acids
IL15292899A IL152928A (en) 1998-10-12 1999-10-07 1 - ethyl - 4 - [3 - [3 - ethyl - 6, 7 - dihydro - 7 - oxo - 2 - ( 2 - pyridylmethyl) - 2h - pyrazolo [4, 3 - d] pyrimidin - 5 - yl] - (4 - substituted phenyl) sulphonyl] piperazines
IL15292302A IL152923D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292802A IL152928D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof

Family Applications Before (3)

Application Number Title Priority Date Filing Date
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1-[3-(6, 7-DIHYDRO-1-METHYL-7-OXO-3-PROPYL-1H- PYRAZOLO [4, 3-d] - PYRIMIDIN-5-YL) -4- SUBSTITUTED PHENYLSULFONYL] -4- METHYL PIPERAZINES
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 5-(4-methyl-1-piperazinylsulfonyl)-2-substituted benzoic acids
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 PROCESS FOR PREPARATION OF 1-ETHYL-4-{3-[3-ETHYL-6, 7-DIHYDRO-7-OXO-2-(PYRIDYLMETHYL)-2H-PYRAZOLO [4,3-d] PYRIMIDIN-5-YL]-4-PROPOXYSULFONYL}-PIPERAZINE AND THE 4-[2-SUBSTITUTED-5-(4-ETHYL-1-PIPERAZINYLSUPHONYL)-BENZAMIDO]-5-ETHYL-1-(2-PYRIDYLMETHYL)1H-PYRAZOLE-3-CARBOXAMIDE INTERMEDIATES THEREFOR

Family Applications After (7)

Application Number Title Priority Date Filing Date
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 5-(4-ethyl-1-piperazinylsulphonyl)2-substituted benzoic acids
IL15292899A IL152928A (en) 1998-10-12 1999-10-07 1 - ethyl - 4 - [3 - [3 - ethyl - 6, 7 - dihydro - 7 - oxo - 2 - ( 2 - pyridylmethyl) - 2h - pyrazolo [4, 3 - d] pyrimidin - 5 - yl] - (4 - substituted phenyl) sulphonyl] piperazines
IL15292302A IL152923D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292802A IL152928D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927D0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof

Country Status (49)

Country Link
US (3) US6207829B1 (en)
EP (1) EP0994115B1 (en)
JP (1) JP3721021B2 (en)
KR (1) KR100380954B1 (en)
CN (2) CN1207295C (en)
AP (1) AP1233A (en)
AR (1) AR019244A1 (en)
AT (1) AT290003T (en)
AU (1) AU756463B2 (en)
BG (1) BG63205B1 (en)
BR (1) BR9905092A (en)
CA (1) CA2285733C (en)
CO (1) CO5150214A1 (en)
CR (1) CR6118A (en)
CU (1) CU22928A3 (en)
CZ (1) CZ296816B6 (en)
DE (1) DE69923906T2 (en)
DK (1) DK0994115T3 (en)
DZ (1) DZ2912A1 (en)
EA (1) EA003774B1 (en)
EE (1) EE04192B1 (en)
EG (1) EG22630A (en)
ES (1) ES2237049T3 (en)
GB (1) GB9822238D0 (en)
GE (1) GEP20022700B (en)
GT (1) GT199900172A (en)
HK (1) HK1027559A1 (en)
HR (1) HRP990318B1 (en)
HU (1) HU226162B1 (en)
ID (1) ID23351A (en)
IL (11) IL152927A (en)
IS (1) IS1951B (en)
MA (1) MA25007A1 (en)
MY (1) MY124620A (en)
NO (1) NO313700B1 (en)
OA (1) OA11165A (en)
PE (1) PE10862000A1 (en)
PL (1) PL198150B1 (en)
PT (1) PT994115E (en)
RS (1) RS49762B (en)
SG (1) SG118060A1 (en)
SI (1) SI0994115T1 (en)
SK (1) SK285215B6 (en)
TN (1) TNSN99189A1 (en)
TR (1) TR199902541A2 (en)
TW (1) TW589314B (en)
UA (1) UA66787C2 (en)
UY (1) UY25750A1 (en)
ZA (1) ZA9906412B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078760A1 (en) * 1999-06-21 2000-12-28 The Biochemical Pharmaceutical Factory Of Zhuhai Sez Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
JP2004501142A (en) * 2000-06-22 2004-01-15 ファイザー・インク The method of manufacturing pyrazolopyrimidinone
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE03942002A1 (en) 2000-08-18 2002-06-21 Agouron Pharma Pyrazole compounds and pharmaceutical compositions containing them, which modulate and / or inhibit the activity of erab / HADH2
EP1458679B1 (en) 2001-12-20 2010-01-20 Merck Serono SA Pyrrolidine derivatives as prostaglandin modulators
WO2003059258A2 (en) * 2001-12-21 2003-07-24 Cytokinetics, Inc. Compositions and methods for treating heart failure
EP1719772A1 (en) 2002-05-31 2006-11-08 Schering Corporation Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (en) 2003-03-27 2012-04-16 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (en) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 Pyrazolopyrimidine compounds for prevention and cure of impotence and frigidity
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (en) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1- (1- (2-ethoxyethyl) -3-ethyl-7- (4-methylpyridin-2-ylamino) -1H-pyrazolo (4,3-d) pyrimidin-5-yl) piperidine-4-carboxylic acid and salts thereof.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd Novel process for the preparation of sildenafil citrate
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
AU730670B2 (en) * 1997-04-25 2001-03-08 Pfizer Limited Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction

Also Published As

Publication number Publication date
CA2285733C (en) 2004-08-24
RS49762B (en) 2008-04-04
JP3721021B2 (en) 2005-11-30
UY25750A1 (en) 2001-08-27
YU48999A (en) 2002-06-19
TR199902541A2 (en) 2000-07-21
CN1207295C (en) 2005-06-22
GB9822238D0 (en) 1998-12-09
IL152926A (en) 2004-02-19
EA003774B1 (en) 2003-08-28
JP2000119273A (en) 2000-04-25
EP0994115A3 (en) 2000-05-24
PE10862000A1 (en) 2000-10-18
BG63205B1 (en) 2001-06-29
IL152927D0 (en) 2003-06-24
ID23351A (en) 2000-04-13
SG118060A1 (en) 2006-01-27
PT994115E (en) 2005-06-30
ZA9906412B (en) 2001-04-11
SK285215B6 (en) 2006-09-07
MY124620A (en) 2006-06-30
DE69923906D1 (en) 2005-04-07
IL132273A (en) 2004-06-20
EP0994115B1 (en) 2005-03-02
IL152927A (en) 2004-06-01
EA199900822A2 (en) 2000-04-24
IL152923A (en) 2004-02-08
KR100380954B1 (en) 2003-04-21
HRP990318A2 (en) 2000-06-30
HU9903469A2 (en) 2000-08-28
EP0994115A2 (en) 2000-04-19
PL198150B1 (en) 2008-05-30
ES2237049T3 (en) 2005-07-16
IS1951B (en) 2004-10-13
AU756463B2 (en) 2003-01-16
CN1473831A (en) 2004-02-11
OA11165A (en) 2003-04-22
AP9901672A0 (en) 1999-12-31
US20010009962A1 (en) 2001-07-26
DK0994115T3 (en) 2005-06-20
EG22630A (en) 2003-05-31
SI0994115T1 (en) 2005-08-31
HRP990318B1 (en) 2004-06-30
GEP20022700B (en) 2002-01-10
EE04192B1 (en) 2003-12-15
HU226162B1 (en) 2008-05-28
AR019244A1 (en) 2001-12-26
HK1027559A1 (en) 2006-01-13
NO994943L (en) 2000-04-13
CU22928A3 (en) 2004-02-20
BG103794A (en) 2000-09-29
DZ2912A1 (en) 2004-03-01
NO313700B1 (en) 2002-11-18
EE9900507A (en) 2000-06-15
TW589314B (en) 2004-06-01
CR6118A (en) 2005-09-16
TNSN99189A1 (en) 2005-11-10
CO5150214A1 (en) 2002-04-29
PL335959A1 (en) 2000-04-25
US6207829B1 (en) 2001-03-27
CZ296816B6 (en) 2006-06-14
NO994943D0 (en) 1999-10-11
IL152926D0 (en) 2003-06-24
HU9903469A3 (en) 2000-10-30
IL152928D0 (en) 2003-06-24
IL152923D0 (en) 2003-06-24
UA66787C2 (en) 2004-06-15
MA25007A1 (en) 2000-07-01
AU5358199A (en) 2000-04-13
BR9905092A (en) 2000-08-08
DE69923906T2 (en) 2006-04-06
AP1233A (en) 2003-12-18
CN1255497A (en) 2000-06-07
CA2285733A1 (en) 2000-04-12
IL152924D0 (en) 2003-06-24
US20030069422A1 (en) 2003-04-10
IL152928A (en) 2007-07-04
AT290003T (en) 2005-03-15
SK138599A3 (en) 2000-05-16
CZ353299A3 (en) 2000-05-17
HU9903469D0 (en) 1999-12-28
IS5209A (en) 2000-04-13
EA199900822A3 (en) 2000-08-28
IL152924A (en) 2004-02-19
KR20000028987A (en) 2000-05-25
GT199900172A (en) 2001-03-28

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