IL130635D0 - Evolution of whole cells and organisms by recursive sequence recombination - Google Patents

Evolution of whole cells and organisms by recursive sequence recombination

Info

Publication number
IL130635D0
IL130635D0 IL13063598A IL13063598A IL130635D0 IL 130635 D0 IL130635 D0 IL 130635D0 IL 13063598 A IL13063598 A IL 13063598A IL 13063598 A IL13063598 A IL 13063598A IL 130635 D0 IL130635 D0 IL 130635D0
Authority
IL
Israel
Prior art keywords
organisms
evolution
whole cells
recursive sequence
sequence recombination
Prior art date
Application number
IL13063598A
Original Assignee
Maxygen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US3505497P priority Critical
Application filed by Maxygen Inc filed Critical Maxygen Inc
Priority to PCT/US1998/000852 priority patent/WO1998031837A1/en
Publication of IL130635D0 publication Critical patent/IL130635D0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00Processes for modifying genotypes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • C12N15/1027Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8273Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
IL13063598A 1997-01-17 1998-01-16 Evolution of whole cells and organisms by recursive sequence recombination IL130635D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US3505497P true 1997-01-17 1997-01-17
PCT/US1998/000852 WO1998031837A1 (en) 1997-01-17 1998-01-16 Evolution of whole cells and organisms by recursive sequence recombination

Publications (1)

Publication Number Publication Date
IL130635D0 true IL130635D0 (en) 2000-06-01

Family

ID=21880347

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13063598A IL130635D0 (en) 1997-01-17 1998-01-16 Evolution of whole cells and organisms by recursive sequence recombination

Country Status (12)

Country Link
US (3) US6379964B1 (en)
EP (3) EP1007732B1 (en)
JP (1) JP4062366B2 (en)
KR (2) KR100570935B1 (en)
AT (1) AT334225T (en)
AU (1) AU743305C (en)
CA (1) CA2276064C (en)
DE (1) DE69835360T2 (en)
DK (1) DK1717322T3 (en)
ES (1) ES2270505T3 (en)
IL (1) IL130635D0 (en)
WO (1) WO1998031837A1 (en)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7150982B2 (en) 1991-09-09 2006-12-19 Third Wave Technologies, Inc. RNA detection assays
US7045289B2 (en) 1991-09-09 2006-05-16 Third Wave Technologies, Inc. Detection of RNA Sequences
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US6326204B1 (en) * 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
IL130635D0 (en) 1997-01-17 2000-06-01 Maxygen Inc Evolution of whole cells and organisms by recursive sequence recombination
US6159687A (en) * 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
US7153655B2 (en) * 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
AU1124499A (en) 1997-10-28 1999-05-17 Maxygen, Inc. Human papillomavirus vectors
US6596539B1 (en) 1997-10-31 2003-07-22 Maxygen, Inc. Modification of virus tropism and host range by viral genome shuffling
AU746786B2 (en) * 1997-12-08 2002-05-02 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US6468745B1 (en) 1998-01-16 2002-10-22 Large Scale Biology Corporation Method for expressing a library of nucleic acid sequence variants and selecting desired traits
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
IL139093D0 (en) 1998-05-01 2001-11-25 Maxygen Inc Optimization of pest resistance genes using dna shuffling
US6902918B1 (en) 1998-05-21 2005-06-07 California Institute Of Technology Oxygenase enzymes and screening method
WO2003097834A2 (en) * 2002-05-17 2003-11-27 Alligator Bioscience Ab A method for in vitro molecular evolution of protein function
IL140125D0 (en) 1998-06-17 2002-02-10 Maxygen Inc Method for producing polynucleotides with desired properties
US6991922B2 (en) * 1998-08-12 2006-01-31 Proteus S.A. Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation
US6951719B1 (en) 1999-08-11 2005-10-04 Proteus S.A. Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained
US20030092023A1 (en) * 1998-08-12 2003-05-15 Daniel Dupret Method of shuffling polynucleotides using templates
CA2333914A1 (en) * 1998-08-12 2000-02-24 Maxygen, Inc. Dna shuffling to produce herbicide selective crops
US20030104417A1 (en) * 1998-08-12 2003-06-05 Proteus S.A. Template-mediated, ligation-oriented method of nonrandomly shuffling polynucleotides
JP2002522072A (en) 1998-08-12 2002-07-23 マキシジェン, インコーポレイテッド dna shuffling of the mono-oxygenase gene for the production of industrial chemicals.
EP1114168A2 (en) * 1998-09-15 2001-07-11 Syngenta Participations AG Uracil permease from arabidopsis as herbicidal target gene
US6500639B2 (en) 1998-10-07 2002-12-31 Maxygen, Inc. DNA shuffling to produce nucleic acids for mycotoxin detoxification
AU1619400A (en) 1998-11-10 2000-05-29 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plantphenotypes
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
IL137868D0 (en) 1999-01-19 2001-10-31 Maxygen Inc Oligonucleotide mediated nucleic acid recombination
EP1147229A2 (en) * 1999-02-02 2001-10-24 Bernhard O. Palsson Methods for identifying drug targets based on genomic sequence data
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
IL144657D0 (en) 1999-02-11 2002-06-30 Maxygen Inc High throughput mass spectrometry
CN1341146A (en) * 1999-02-24 2002-03-20 诺维信公司 Fungal cells with inactivated DNA mismatch repair system
US6518042B1 (en) 1999-02-24 2003-02-11 Novozymes A/S Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells
EP2199392A3 (en) * 1999-03-04 2010-12-15 Revivicor, Inc. Genetic modification of somatic cells and uses thereof
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
DE19920712A1 (en) * 1999-05-05 2000-11-09 Rhein Biotech Proz & Prod Gmbh A method for preparing a recombinant Proteines
US6365410B1 (en) * 1999-05-19 2002-04-02 Genencor International, Inc. Directed evolution of microorganisms
IL146743D0 (en) * 1999-05-31 2002-07-25 Novozymes As Screening method for peptides
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
WO2001096551A2 (en) * 2000-06-14 2001-12-20 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
PT1200606E (en) 1999-08-12 2006-12-29 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
WO2001038504A2 (en) * 1999-11-23 2001-05-31 Maxygen, Inc. Homologous recombination in plants
US6686515B1 (en) * 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
US6569681B1 (en) * 2000-03-14 2003-05-27 Transkaryotic Therapies, Inc. Methods of improving homologous recombination
US20020035739A1 (en) * 2000-05-05 2002-03-21 Michael Lassner Evolution of plant disease response plant pathways to enable the development of based biological sensors and to develop novel disease resistance strategies
US7115403B1 (en) 2000-05-16 2006-10-03 The California Institute Of Technology Directed evolution of galactose oxidase enzymes
US6759226B1 (en) 2000-05-24 2004-07-06 Third Wave Technologies, Inc. Enzymes for the detection of specific nucleic acid sequences
DE60140211D1 (en) * 2000-06-08 2009-11-26 Virco Bvba A method for resistance to a therapeutic agent predict using neural networks
US7074590B2 (en) 2000-06-23 2006-07-11 Maxygen, Inc. Chimeric promoters
WO2002000717A2 (en) 2000-06-23 2002-01-03 Maxygen, Inc. Novel co-stimulatory molecules
US20020072097A1 (en) * 2000-07-07 2002-06-13 Delcardayre Stephen Molecular breeding of transposable elements
US6858422B2 (en) 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
WO2002010183A1 (en) 2000-07-31 2002-02-07 Menzel, Rolf Compositions and methods for directed gene assembly
DE60143959D1 (en) 2000-08-25 2011-03-10 Basf Plant Science Gmbh encode s
US7083945B1 (en) * 2000-10-27 2006-08-01 The Board Of Regents Of The University Of Texas System Isolation of binding proteins with high affinity to ligands
JP2007500514A (en) 2003-04-29 2007-01-18 イー.アイ. デュ ポン デ ヌムール アンド カンパニー Novel glyphosate n- acetyltransferase (gat) gene
US6808894B1 (en) * 2000-11-07 2004-10-26 Morphotek, Inc. Methods for generating genetically altered antibody producing cell lines with improved antibody characteristics
US6958213B2 (en) * 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
US20020086292A1 (en) 2000-12-22 2002-07-04 Shigeaki Harayama Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
EP1364005B1 (en) * 2001-01-25 2008-09-17 Evolva Ltd. A method for evolving a cell having desired phenotype and evolved cells
AT501251T (en) 2001-01-25 2011-03-15 Evolva Ltd cell library
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
US6861248B2 (en) * 2001-01-26 2005-03-01 M. Clark Dale High speed, consecutive batch or continuous, low effluent process for the production of ethanol from molasses, starches, or sugars
US7127379B2 (en) * 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
EP1363935B1 (en) * 2001-02-07 2012-11-14 Life Technologies Corporation Ter sites and ter binding proteins
CN102618564B (en) 2003-03-06 2014-10-29 维莱尼姆公司 Amylases, nucleic acids encoding method of preparation and application
WO2002070730A2 (en) * 2001-03-01 2002-09-12 The Regents Of The University Of California Models and methods for determining systemic properties of regulated reaction networks
EP1470219A4 (en) 2001-04-16 2005-10-05 California Inst Of Techn Peroxide-driven cytochrome p450 oxygenase variants
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US7226768B2 (en) 2001-07-20 2007-06-05 The California Institute Of Technology Cytochrome P450 oxygenases
EP1409667B2 (en) 2001-07-23 2009-06-10 DSM IP Assets B.V. Process for preparing variant polynucleotides
US20030082591A1 (en) * 2001-07-24 2003-05-01 Donald Awrey Methods for gene disruption and uses thereof
US7751981B2 (en) * 2001-10-26 2010-07-06 The Regents Of The University Of California Articles of manufacture and methods for modeling Saccharomyces cerevisiae metabolism
WO2003075129A2 (en) 2002-03-01 2003-09-12 Maxygen, Inc. Methods, systems, and software for identifying functional bio-molecules
EP1488335A4 (en) 2002-03-09 2006-11-15 Maxygen Inc Optimization of crossover points for directed evolution
US20030224363A1 (en) * 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
US8949032B2 (en) * 2002-03-29 2015-02-03 Genomatica, Inc. Multicellular metabolic models and methods
AU2003222128A1 (en) * 2002-03-29 2003-10-13 Genomatica, Inc. Human metabolic models and methods
WO2003089620A2 (en) 2002-04-19 2003-10-30 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7208317B2 (en) * 2002-05-02 2007-04-24 The University Of North Carolina At Chapel Hill In Vitro mutagenesis, phenotyping, and gene mapping
US7856317B2 (en) * 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
EP1516053B1 (en) 2002-06-14 2012-10-17 Verenium Corporation Xylanases, nucleic adics encoding them and methods for making and using them
CN1681923B (en) 2002-07-18 2010-06-02 孟山都技术有限公司 Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing
JP4527531B2 (en) * 2002-07-19 2010-08-18 モーフオテク・インコーポレーテツド Method of generating improved growth antibody-producing cell lines enhanced with characteristic of
DK1529110T3 (en) 2002-08-01 2012-01-30 Evolva Ltd A method of mixing large number of heterologous genes
AU2003256731A1 (en) * 2002-08-02 2004-02-23 Aromagen Corporation Methods for making (-) -menthol and oxygenated menthane compounds
WO2004013290A2 (en) * 2002-08-05 2004-02-12 Invitrogen Corporation Compositions and methods for molecular biology
CA2494798A1 (en) 2002-08-06 2005-01-13 Verdia, Inc. Ap1 amine oxidase variants
AU2003222214B2 (en) * 2002-10-15 2010-08-12 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
US7869957B2 (en) * 2002-10-15 2011-01-11 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
EP1601332A4 (en) 2003-03-07 2012-05-02 Verenium Corp Hydrolases, nucleic acids encoding them and mehods for making and using them
US20050054597A1 (en) * 2003-03-28 2005-03-10 Neo-Morgan Laboratory Incorporated Method and system for rapidly conferring a desired trait to an organism
CA2521402C (en) 2003-04-04 2015-01-13 Diversa Corporation Pectate lyases, nucleic acids encoding them and methods for making and using them
CN1871352A (en) * 2003-06-06 2006-11-29 阿博根有限公司 Compositions and methods for regulating polysaccharides of a plant cell
US7524664B2 (en) 2003-06-17 2009-04-28 California Institute Of Technology Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
CN108486086A (en) 2003-07-02 2018-09-04 维莱尼姆公司 Glucanases, nucleic acids encoding them and methods for making and using them
WO2005017116A2 (en) 2003-08-11 2005-02-24 California Institute Of Technology Thermostable peroxide-driven cytochrome p450 oxygenase variants and methods of use
CA2891101A1 (en) 2003-08-11 2005-03-10 Basf Enzymes Llc Laccases, nucleic acids encoding them and methods for making and using them
WO2005019251A2 (en) 2003-08-25 2005-03-03 Funzyme Biotechnologies Sa Novel fungal proteins and nucleic acids encoding same
FR2868081A1 (en) * 2004-03-23 2005-09-30 Libragen Sa Method of metabolic pathway family identification by positive selection
BRPI0511921B1 (en) 2004-06-08 2016-08-30 Microbiogen Pty Ltd method for producing a Saccharomyces strain, use of a Saccharomyces strain to produce yeast biomass, use of a Saccharomyces strain for ethanol production, method of producing yeast biomass, method for producing a compound, method to produce ethanol and method to mark a strain of Saccharomyces
CA2569767C (en) 2004-06-09 2011-07-26 Pioneer Hi-Bred International, Inc. Plastid transit peptides
BRPI0510939A (en) 2004-06-16 2007-07-17 Diversa Corp Compositions and methods for enzymatic discoloration of chlorophyll
US7578790B2 (en) * 2004-07-20 2009-08-25 Boston Scientific Scimed, Inc. Systems and methods for detecting and presenting textural information from medical images
US7799906B1 (en) 2004-09-22 2010-09-21 Arborgen, Llc Compositions and methods for modulating lignin of a plant
JP2008519602A (en) 2004-11-11 2008-06-12 モジュラー ジェネティクス, インコーポレイテッド Ladder assembly and system for producing a diversity
WO2006055836A2 (en) * 2004-11-16 2006-05-26 President And Fellows Of Harvard College In vivo alteration of cellular dna
US20060204979A1 (en) * 2004-12-01 2006-09-14 Invitrogen Corporation Reverse two-hybrid system for identification of interaction domains
WO2006099207A2 (en) 2005-03-10 2006-09-21 Diversa Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
MX300732B (en) 2005-03-15 2012-06-28 Verenium Corp Cellulases, nucleic acids encoding them and methods for making and using them.
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
AT442438T (en) * 2005-07-26 2009-09-15 Council Scient Ind Res A method for identifying the stress tolerance in yeast erhíhenden genes and use of these genes for improving yeast strains
WO2007021944A2 (en) * 2005-08-11 2007-02-22 The J. Craig Venter Institute In vitro recombination method
CA2618665C (en) * 2005-08-11 2012-11-13 J. Craig Venter Institute Method for in vitro recombination
GB2432366B (en) * 2005-11-19 2007-11-21 Alligator Bioscience Ab A method for in vitro molecular evolution of protein function
EP1987142A4 (en) 2006-02-02 2009-07-15 Verenium Corp Esterases and related nucleic acids and methods
EP2444490B1 (en) 2006-02-10 2014-02-12 Verenium Corporation Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
USRE45660E1 (en) 2006-02-14 2015-09-01 Bp Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
BR122017003017B1 (en) 2006-03-07 2018-10-23 Basf Enzymes Llc nucleic acid, expression cassette, vector, cloning vehicle transgenic organism, polypeptide, signal peptide, composition, and methods for producing a recombinant polypeptide, to generate a variant of a nucleic acid to cleave a carbon-carbon bond in a composition to form a carbon-carbon bond, to a foodstuff, an animal feed or drink, and to convert a biomass or any lignocellulosic material in a fuel
CN101437954B (en) 2006-03-07 2015-09-09 嘉吉公司 Aldolase and nucleic acids encoding the aldolase and their preparation and use
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
MX2009000712A (en) 2006-07-21 2009-03-23 Xyleco Inc Conversion systems for biomass.
US8026085B2 (en) 2006-08-04 2011-09-27 California Institute Of Technology Methods and systems for selective fluorination of organic molecules
US8252559B2 (en) 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
CA2669453C (en) 2006-08-04 2018-11-13 Verenium Corporation Glucanases, nucleic acids encoding them and methods for making and using them
CN101558154B (en) 2006-09-21 2016-02-24 帝斯曼知识产权资产管理有限公司 Phospholipase, nucleic acids encoding method of preparation and application
CN101541822B (en) 2006-09-21 2014-10-22 维莱尼姆公司 Phytase, nucleic acids encoding them and methods for their preparation and use
CN101600804A (en) * 2006-11-13 2009-12-09 丹尼斯科美国公司 Method for improving yield of cellulose conversion processes
EP2069490B2 (en) 2006-12-21 2018-02-21 BASF Enzymes LLC Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them
MX2009008129A (en) 2007-01-30 2010-03-17 Verenium Corp Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them.
US20090023182A1 (en) * 2007-07-18 2009-01-22 Schilling Christophe H Complementary metabolizing organisms and methods of making same
CN101952437B (en) 2007-10-03 2014-04-09 维莱尼姆公司 Xylanases, nucleic acids encoding them and methods for making and using them
CA2710683A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
WO2009088753A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Isomerases, nucleic acids encoding them and methods for making and using them
JP5725540B2 (en) 2008-02-15 2015-05-27 シンセティック ジェノミクス インコーポレーテッド The method for connecting and combining assembly in vitro of a nucleic acid molecule
EP2297310A2 (en) 2008-05-23 2011-03-23 E. I. du Pont de Nemours and Company Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
EP2346995B1 (en) 2008-09-26 2018-11-07 Tocagen Inc. Gene therapy vectors and cytosine deaminases
EA021178B1 (en) 2009-05-21 2015-04-30 Верениум Корпорейшн Phytases, nucleic acids encoding them and methods for making and using them
CN102549009A (en) 2009-08-20 2012-07-04 先锋国际良种公司 Functional expression of shuffled yeast nitrate transporter (YNT1) in maize to improve nitrate uptake under low nitrate environment
US20110195505A1 (en) * 2009-10-08 2011-08-11 Butamax(Tm) Advanced Biofuels Llc Bacterial strains for butanol production
ES2590037T3 (en) 2009-10-16 2016-11-17 Dsm Ip Assets B.V. Phospholipases, nucleic acids encoding them and methods to obtain and use
CN102575243B (en) 2009-10-16 2016-02-03 邦奇油类公司 Oil degumming
BR112012016290A2 (en) 2009-12-31 2015-09-01 Pioneer Hi Bred Int Acid isolated or recombinant nucleic, expression cassette, non-human host cell, plant and transgenic seed variant polypeptide isolated or recombinant oxox of oxalate oxidase protein level modulation method (oxox) in a plant or plant cell, method for increasing the resistance of a plant to a pathogen, the pathogen-resistant plant, a method to identify variants with oxox oxox activity maintained or increased method for generating a plant having increased resistance to a pathogen
EP2576804B1 (en) 2010-05-28 2016-12-14 Codexis, Inc. Pentose fermentation by a recombinant microorganism
US8993837B2 (en) 2010-08-13 2015-03-31 Pioneer Hi-Bred International, Inc Chimeric promoters and methods of use
WO2012024662A2 (en) 2010-08-20 2012-02-23 Codexis, Inc. Expression constructs comprising fungal promoters
WO2012024698A1 (en) 2010-08-20 2012-02-23 Codexis, Inc. Use of glycoside hydrolase 61 family proteins in processing of cellulose
WO2013028701A1 (en) 2011-08-22 2013-02-28 Codexis, Inc. Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity
WO2012135110A1 (en) 2011-03-30 2012-10-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
BR112013033614A2 (en) 2011-06-30 2018-05-29 Codexis Inc pentose fermentation by recombinant microorganism
WO2013016207A2 (en) 2011-07-22 2013-01-31 California Institute Of Technology Stable fungal cel6 enzyme variants
US20130084608A1 (en) 2011-09-30 2013-04-04 Codexis, Inc. Fungal proteases
BR112014015030A2 (en) 2011-12-20 2017-06-13 Codexis Inc endoflucanase variants 1b (eg1b)
WO2013096082A1 (en) 2011-12-20 2013-06-27 Codexis, Inc. Fatty alcohol forming acyl reductase (far) variants and methods of use
CA2872096A1 (en) 2012-05-04 2013-11-07 E. I. Du Pont De Nemours And Company Compositions and methods comprising sequences having meganuclease activity
BR112014031024A2 (en) 2012-06-11 2017-06-27 Codexis Inc xylanase and fungal xylosidases.
US9206435B2 (en) 2012-08-31 2015-12-08 Synthetic Genomics, Inc. Crowding agent-induced nucleic acid transfer into a recipient host cell
US9611515B2 (en) 2012-11-20 2017-04-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
US20140170087A1 (en) * 2012-12-17 2014-06-19 Raul G. Cuero Uv-resistant microbes and uv-blocking microbial extract
CA2905595A1 (en) 2013-03-14 2014-09-25 Pioneer Hi-Bred International, Inc. Compositions having dicamba decarboxylase activity and methods of use
EP2970935A1 (en) 2013-03-14 2016-01-20 Pioneer Hi-Bred International, Inc. Compositions having dicamba decarboxylase activity and methods of use
CN105473605A (en) 2013-03-15 2016-04-06 先锋国际良种公司 Phi-4 polypeptides and methods for their use
EP3521423A1 (en) 2013-04-18 2019-08-07 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides
CN106232820A (en) 2013-08-16 2016-12-14 先锋国际良种公司 Insecticidal proteins and methods for their use
WO2015038734A2 (en) 2013-09-13 2015-03-19 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
DK3049973T3 (en) 2013-09-27 2018-10-22 Codexis Inc Automated screen up of enzyme variants
CN105849104A (en) * 2013-10-25 2016-08-10 阿西洛玛生物公司 Strigolactone formulations and uses thereof
CN106232619A (en) 2013-11-13 2016-12-14 科德克希思公司 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
BR112016018287A2 (en) 2014-02-07 2017-10-10 Du Pont insecticidal proteins and methods of use thereof
BR112016018103A2 (en) 2014-02-07 2018-02-20 Du Pont ? Polypeptide and its use, polynucleotide, composition, fusion protein, method for controlling a population, a method for inhibiting the growth method of controlling infestation plant or plant cell constructs?
US9605252B2 (en) 2014-04-16 2017-03-28 Codexis, Inc. Engineered tyrosine ammonia lyase
EP3167052A4 (en) 2014-07-09 2018-07-04 Codexis, Inc. Novel p450-bm3 variants with improved activity
US9708587B2 (en) 2014-07-09 2017-07-18 Codexis, Inc. P450-BM3 variants with improved activity
WO2016061206A1 (en) 2014-10-16 2016-04-21 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CA2968275A1 (en) 2014-11-25 2016-06-02 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
KR20180004169A (en) 2015-05-07 2018-01-10 코덱시스, 인코포레이티드 Penicillin -g Asilah Ajay
CA2985198A1 (en) 2015-05-19 2016-11-24 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
US9683220B2 (en) 2015-07-07 2017-06-20 Codexis, Inc. P450-BM3 variants with improved activity
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US20180325119A1 (en) 2015-12-18 2018-11-15 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CN109715817A (en) 2016-06-09 2019-05-03 科德克希思公司 Hydroxylated biocatalyst and method for compound
WO2018009863A1 (en) * 2016-07-07 2018-01-11 New York University Scramble of heterozygous diploid yeast
WO2018084936A1 (en) 2016-11-01 2018-05-11 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2018111551A1 (en) 2016-12-14 2018-06-21 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2018208882A1 (en) 2017-05-11 2018-11-15 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2018226893A2 (en) * 2017-06-06 2018-12-13 Zymergen Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa
WO2018226810A1 (en) * 2017-06-06 2018-12-13 Zymergen Inc. High throughput transposon mutagenesis
WO2018226880A1 (en) * 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving escherichia coli

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0348792B2 (en) * 1978-04-26 1991-07-25 Glaxo Group Ltd
US4407956A (en) 1981-03-13 1983-10-04 The Regents Of The University Of California Cloned cauliflower mosaic virus DNA as a plant vehicle
US4873196A (en) 1982-05-27 1989-10-10 University Patents, Inc. Protoplasts of temperature-sensitive strains of neurospora crassa OS-1
CA1220733A (en) 1982-12-27 1987-04-21 Shigeru Takahashi Method for promoting fusion of plant protoplast
HU194306B (en) * 1983-05-16 1988-01-28 Gyogyszerkutato Intezet Process for influencing biosynthesis of antibiotics with in vivo genetical recombination
US4608339A (en) 1983-10-25 1986-08-26 Yoakum George H Protoplast fusion method for high-frequency DNA transfection in human cells
EP0160692A1 (en) 1983-11-03 1985-11-13 DE WET, Johannes Martenis Jacob Method for the transfer of exogenous genes in plants using pollen as a vector
US4940834A (en) 1983-12-05 1990-07-10 Lofts, Inc. Plants having endophytio-fungus-enhanced performance and method of producing same
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
DE229046T1 (en) 1985-03-30 1987-12-17 Marc Genf/Geneve Ch Ballivet A process for obtaining DNA, RNA, peptides, polypeptides or proteins dns-recombinant procedures.
US5866363A (en) 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US5824469A (en) 1986-07-17 1998-10-20 University Of Washington Method for producing novel DNA sequences with biological activity
US5250433A (en) 1986-09-20 1993-10-05 Mitsubishi Kasei Corporation Gramineous hybrid plants and process for preparing them
US4889806A (en) 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US4970154A (en) 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
DE3889546D1 (en) 1987-12-21 1994-06-16 Univ Toledo Transformation of germinating plant seed using Agrobacterium.
US5360725A (en) 1988-02-02 1994-11-01 Mitsui Toatsu Chemicals, Inc. Method of producing rice cybrid cells
FR2641793B1 (en) 1988-12-26 1993-10-01 Setratech Process for in vivo recombination of sequences of DNA having base mismatches
DD282028A5 (en) 1989-02-16 1990-08-29 Akad Wissenschaften Ddr Process for preparing thermostabiles, hybriden bacillus beta-1,3-1,4-glucanase
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
US5426040A (en) 1989-08-17 1995-06-20 Northeastern University Methods for producing improved strains of seaweed by fusion of spore-protoplasts, and resultant seaweeds and phycocolloids
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
DE69027526T3 (en) 1989-11-06 2005-03-24 Cell Genesys, Inc., Foster City Production of proteins by means of homologous recombination
US5877402A (en) 1990-05-01 1999-03-02 Rutgers, The State University Of New Jersey DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein
CA2090473A1 (en) 1990-08-29 1992-03-01 Robert M. Kay Homologous recombinatin in mammalian cells
US5512463A (en) 1991-04-26 1996-04-30 Eli Lilly And Company Enzymatic inverse polymerase chain reaction library mutagenesis
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
AU2778992A (en) 1991-10-07 1993-05-03 Idaho Research Foundation Inc., The Genetic construct for selection of homologous recombinants on a single selective medium
US5843643A (en) 1992-02-21 1998-12-01 Ratner; Paul L. Site-specific transfection of eukaryotic cells using polypeptide-linked recombinant nucleic acid
DE69333669T2 (en) 1992-03-16 2006-03-09 Wohlstadter, Jacob N. Mutagenesis and selection-methods in the same host cells
WO1993020233A1 (en) 1992-03-27 1993-10-14 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
CA2118513A1 (en) 1992-04-24 1993-11-11 David A. Zarling In vivo homologous sequence targeting in eukaryotic cells
US5763240A (en) 1992-04-24 1998-06-09 Sri International In vivo homologous sequence targeting in eukaryotic cells
DE4319496A1 (en) 1992-06-17 1994-04-07 Sandoz Ag Fungi for reducing the pitch content and their recovery
WO1995003400A1 (en) 1993-07-23 1995-02-02 Johns Hopkins University School Of Medicine Recombinationally targeted cloning in yeast artificial chromosomes
US5643745A (en) 1994-02-03 1997-07-01 University Of Hawaii Heterologous dimeric proteins produced in heterokaryons
US5683899A (en) 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5521077A (en) * 1994-04-28 1996-05-28 The Leland Stanford Junior University Method of generating multiple protein variants and populations of protein variants prepared thereby
US5605820A (en) 1994-06-23 1997-02-25 Chemgenics Pharmaceuticals, Inc. Production of strains having biological activities by sexual crosses between vegetatively incompatible strains of Aspergillus nidulans
US5514588A (en) 1994-12-13 1996-05-07 Exxon Research And Engineering Company Surfactant-nutrients for bioremediation of hydrocarbon contaminated soils and water
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US5824485A (en) 1995-04-24 1998-10-20 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5783431A (en) 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6168919B1 (en) 1996-07-17 2001-01-02 Diversa Corporation Screening methods for enzymes and enzyme kits
US6030779A (en) 1995-07-18 2000-02-29 Diversa Corporation Screening for novel bioactivities
US6004788A (en) 1995-07-18 1999-12-21 Diversa Corporation Enzyme kits and libraries
US6057103A (en) 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
CN1128875C (en) 1995-08-11 2003-11-26 诺沃奇梅兹有限公司 Method for preparing polypeptide variants
US5962258A (en) 1995-08-23 1999-10-05 Diversa Corporation Carboxymethyl cellulase fromthermotoga maritima
US6051409A (en) 1995-09-25 2000-04-18 Novartis Finance Corporation Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
US5962283A (en) 1995-12-07 1999-10-05 Diversa Corporation Transminases and amnotransferases
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US5773221A (en) 1995-12-15 1998-06-30 Oceanix Biosciences Corporation Method of recovering a biological molecule from a recombinant microorganism
DK0873398T3 (en) 1996-01-10 2005-08-15 Novozymes As A process for in vivo production of a mutant library in cells
US5814473A (en) 1996-02-09 1998-09-29 Diversa Corporation Transaminases and aminotransferases
US5942430A (en) 1996-02-16 1999-08-24 Diversa Corporation Esterases
US5958751A (en) 1996-03-08 1999-09-28 Diversa Corporation α-galactosidase
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US5789228A (en) 1996-05-22 1998-08-04 Diversa Corporation Endoglucanases
US5877001A (en) 1996-06-17 1999-03-02 Diverso Corporation Amidase
US5763239A (en) 1996-06-18 1998-06-09 Diversa Corporation Production and use of normalized DNA libraries
WO1997048416A1 (en) 1996-06-19 1997-12-24 Recombinant Biocatalysis, Inc. Thermostable phosphatases
US5939300A (en) 1996-07-03 1999-08-17 Diversa Corporation Catalases
AU6487196A (en) 1996-07-09 1998-02-02 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Transformation-associated recombination cloning
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5869718A (en) 1996-07-15 1999-02-09 Julien; Jean-Pierre Homologous recombination for animal model exhibiting reduced levels or elimination of a neuronal intermediate filament protein
US6093873A (en) 1996-08-19 2000-07-25 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the gene encoding RXR
US6173410B1 (en) 1996-08-21 2001-01-09 Texas Instruments Incorporated Microprocessor circuits, systems and methods for conditioning information prefetching based on resource burden
WO1998013485A1 (en) 1996-09-27 1998-04-02 Maxygen, Inc. Methods for optimization of gene therapy by recursive sequence shuffling and selection
EP0964922A4 (en) 1996-09-27 2000-10-25 Maxygen Inc Methods for optimization of gene therapy by recursive sequence shuffling and selection
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
DE69733322T2 (en) 1996-12-06 2006-02-02 Diversa Corp., San Diego Glycosidase enzymes
WO1998028416A1 (en) 1996-12-20 1998-07-02 Novo Nordisk A/S In vivo recombination
IL130635D0 (en) 1997-01-17 2000-06-01 Maxygen Inc Evolution of whole cells and organisms by recursive sequence recombination
US5929250A (en) 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
IL131209D0 (en) 1997-02-13 2001-01-28 Dow Chemical Co Recombinant haloaliphatic dehalogenases
EP0996718B1 (en) 1997-03-18 2008-12-24 Novozymes A/S Method for constructing a library using dna shuffling
US6159687A (en) 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
US6159688A (en) 1997-03-18 2000-12-12 Novo Nordisk A/S Methods of producing polynucleotide variants
US5948653A (en) 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US20030215798A1 (en) 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
US5948666A (en) 1997-08-06 1999-09-07 Diversa Corporation Isolation and identification of polymerases
US5876997A (en) 1997-08-13 1999-03-02 Diversa Corporation Phytase
AU9374298A (en) 1997-09-12 1999-04-05 Oceanix Biosciences Corporation Preparation and use of biofilm-degrading, multiple-specificit y, hydrolytic enzyme mixtures
US6232112B1 (en) 1997-11-24 2001-05-15 Flinders Technologies Pty Ltd Of Flinders University Reagents and methods for diversification of DNA
US9093064B2 (en) 2013-03-11 2015-07-28 The Nielsen Company (Us), Llc Down-mixing compensation for audio watermarking
KR20170030863A (en) 2015-09-10 2017-03-20 에스케이하이닉스 주식회사 Memory system and operating method thereof

Also Published As

Publication number Publication date
US6379964B1 (en) 2002-04-30
CA2276064A1 (en) 1998-07-23
CA2276064C (en) 2013-12-17
DE69835360D1 (en) 2006-09-07
KR100570935B1 (en) 2006-04-13
ES2270505T3 (en) 2007-04-01
AU743305B2 (en) 2002-01-24
KR100568008B1 (en) 2006-04-07
AT334225T (en) 2006-08-15
EP1717322B1 (en) 2012-07-18
EP1007732B1 (en) 2006-07-26
US6352859B1 (en) 2002-03-05
EP1007732A1 (en) 2000-06-14
KR20050043983A (en) 2005-05-11
DE69835360T2 (en) 2007-08-16
JP4062366B2 (en) 2008-03-19
DK1717322T3 (en) 2012-10-22
EP2261373A2 (en) 2010-12-15
JP2001508662A (en) 2001-07-03
KR20000070258A (en) 2000-11-25
AU5920998A (en) 1998-08-07
AU743305C (en) 2006-03-30
EP1717322A2 (en) 2006-11-02
EP1717322A3 (en) 2007-01-24
EP1007732A4 (en) 2003-05-14
WO1998031837A1 (en) 1998-07-23
EP2261373A3 (en) 2011-12-14
US6251674B1 (en) 2001-06-26

Similar Documents

Publication Publication Date Title
EG22051A (en) Novel pyrimidin -4- one and pyrimidin -4- thione as fungicide
GB2251119B (en) Electrochemical cell
GB2276594B (en) Subframe and subframe assembly
GB2323700B (en) Electrochemical cells
GB2299202B (en) Battery
GB2244593B (en) Electrochemical cells
NZ278252A (en) Lyophilised stem cell factor formulations
LTIP1979A (en) New sulphonylaminopyrimidines with therapic activity
HUT72900A (en) Spinning cell
GB2269061B (en) Elastic interconnector
GB2270195B (en) Electrochemical cell
AU6564294A (en) Electrochemical cell
PT755511E (en) Electrochemical cells
IL135068D0 (en) Stimulation of hematopoietic cells in vitro
SG63814A1 (en) Thin type cell
EP0602984A3 (en) Electrochemical cell.
GB9413029D0 (en) Stem cell immobilisation
EP0670735A1 (en) Peripheralization of hematopoietic stem cells.
GB9417862D0 (en) Fuel cell voltage generator
GR3034249T3 (en) Telomerase activity assays
EP0712779A3 (en) Battery holding structure
EP0451611A3 (en) Human hematopoietic stem cell
IL108157D0 (en) An enzyme with endoglucanase activity
IL111143D0 (en) Rechargeable electrochemical cells
PL316845A1 (en) Method of implanting encapsulated cells into host organisms