IL117962A0 - Sulfonamide derivatives and pharmaceutical compositions containing the same - Google Patents

Sulfonamide derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL117962A0
IL117962A0 IL11796296A IL11796296A IL117962A0 IL 117962 A0 IL117962 A0 IL 117962A0 IL 11796296 A IL11796296 A IL 11796296A IL 11796296 A IL11796296 A IL 11796296A IL 117962 A0 IL117962 A0 IL 117962A0
Authority
IL
Israel
Prior art keywords
same
pharmaceutical compositions
compositions containing
sulfonamide derivatives
sulfonamide
Prior art date
Application number
IL11796296A
Other languages
English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IL117962A0 publication Critical patent/IL117962A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
IL11796296A 1995-04-19 1996-04-18 Sulfonamide derivatives and pharmaceutical compositions containing the same IL117962A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/424,810 US5691372A (en) 1995-04-19 1995-04-19 Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (1)

Publication Number Publication Date
IL117962A0 true IL117962A0 (en) 1996-08-04

Family

ID=23683966

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11796296A IL117962A0 (en) 1995-04-19 1996-04-18 Sulfonamide derivatives and pharmaceutical compositions containing the same

Country Status (35)

Country Link
US (2) US5691372A (fr)
EP (3) EP0833826B1 (fr)
JP (1) JP4240532B2 (fr)
KR (1) KR100485237B1 (fr)
CN (1) CN1110491C (fr)
AP (2) AP9600827A0 (fr)
AR (1) AR004663A1 (fr)
AT (3) ATE314360T1 (fr)
AU (1) AU712913B2 (fr)
BG (1) BG102041A (fr)
BR (1) BR9608033A (fr)
CA (1) CA2217745C (fr)
CO (1) CO4700433A1 (fr)
CZ (1) CZ329497A3 (fr)
DE (3) DE69638252D1 (fr)
DK (1) DK0833826T3 (fr)
EA (1) EA000906B1 (fr)
EE (1) EE9700254A (fr)
ES (3) ES2256117T3 (fr)
GE (1) GEP20001915B (fr)
HK (2) HK1009811A1 (fr)
HU (1) HUP9801948A3 (fr)
IL (1) IL117962A0 (fr)
IS (1) IS4575A (fr)
MY (1) MY115797A (fr)
NO (1) NO974744D0 (fr)
NZ (1) NZ307342A (fr)
PE (1) PE43697A1 (fr)
PL (1) PL322904A1 (fr)
PT (1) PT833826E (fr)
SK (1) SK143097A3 (fr)
TR (1) TR199701194T1 (fr)
TW (1) TW404945B (fr)
WO (1) WO1996033187A1 (fr)
ZA (1) ZA962891B (fr)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
ATE218541T1 (de) 1992-08-25 2002-06-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US7141609B2 (en) 1992-08-25 2006-11-28 G.D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
JP2002515051A (ja) 1996-12-31 2002-05-21 ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド ヘテロ環式チオエステルのｎ−結合スルホンアミド
US5874449A (en) * 1996-12-31 1999-02-23 Gpi Nil Holdings, Inc. N-linked sulfonamides of heterocyclic thioesters
AU8017298A (en) * 1997-05-17 1998-12-11 Glaxo Group Limited Antiviral combinations containing the carbocyclic nucleoside 1592u89
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6576231B2 (en) * 1997-09-12 2003-06-10 Schering Ag Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor
JP2001527062A (ja) * 1997-12-24 2001-12-25 バーテックス ファーマシューティカルズ インコーポレイテッド アスパルチルプロテアーゼインヒビターのプロドラッグ
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
OA11573A (en) 1998-06-19 2004-07-01 Vertex Pharma Sulfonamide inhibitors of aspartyl protease.
PT1088098E (pt) * 1998-06-23 2011-05-25 Univ Illinois Medicamento para tratar mam?feros infectados com hiv
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
WO2000047551A2 (fr) * 1999-02-12 2000-08-17 Vertex Pharmaceuticals Incorporated Inhibiteurs d'aspartyle protease
TWI260322B (en) 1999-02-12 2006-08-21 Vertex Pharma Inhibitors of aspartyl protease
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
BR0014602A (pt) * 1999-10-06 2002-06-11 Tibotec Pharm Ltd Hexaidrofluoro'2,3-bifuran-3-il-n-{3'(1,3-benzodioxol- 5ilsulfonil)(isobutil)amino-1 -benzil-2-hidroxipropil}carbamato como inibidor da protease retroviral
CN1187052C (zh) 2000-03-30 2005-02-02 布里斯托尔-迈尔斯斯奎布公司 含有司他夫定(stavudine)的持续释放微球
CA2442870C (fr) * 2001-04-09 2011-08-02 Tibotec Pharmaceuticals Ltd. 2-(amino substitue)-benzoxazole sulfonamides utilises comme inhibiteurs de la protease dans le traitement de l'infection par le vih
CA2473231A1 (fr) * 2002-01-07 2003-08-07 Sequoia Pharmaceuticals Inhibiteurs de protease retrovirale anti-resistance
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
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AU2003293155A1 (en) * 2002-11-27 2004-06-23 Elan Pharmaceutical, Inc. Substituted ureas and carbamates
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
US7763609B2 (en) * 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
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Also Published As

Publication number Publication date
BG102041A (en) 1998-09-30
JP4240532B2 (ja) 2009-03-18
DE69635679T2 (de) 2006-08-31
EP1637528B1 (fr) 2010-09-01
HK1092791A1 (en) 2007-02-16
GEP20001915B (en) 2000-01-05
BR9608033A (pt) 1999-01-12
CA2217745C (fr) 2011-07-05
AR004663A1 (es) 1999-03-10
KR100485237B1 (ko) 2005-09-30
SK143097A3 (en) 1998-03-04
US5990155A (en) 1999-11-23
ATE314360T1 (de) 2006-01-15
KR19990007823A (ko) 1999-01-25
PT833826E (pt) 2002-06-28
CZ329497A3 (cs) 1998-03-18
ES2171670T3 (es) 2002-09-16
ATE479674T1 (de) 2010-09-15
AU712913B2 (en) 1999-11-18
US5691372A (en) 1997-11-25
CA2217745A1 (fr) 1996-10-24
DE69618779D1 (de) 2002-03-14
MY115797A (en) 2003-09-30
HUP9801948A2 (hu) 1999-09-28
EP1637528A1 (fr) 2006-03-22
EA199700330A1 (ru) 1998-04-30
DK0833826T3 (da) 2002-05-06
AU5665596A (en) 1996-11-07
HK1009811A1 (en) 1999-06-11
NO974744L (no) 1997-10-14
EE9700254A (et) 1998-04-15
EP0833826B1 (fr) 2002-01-23
EP1136479B1 (fr) 2005-12-28
JPH11504628A (ja) 1999-04-27
CN1184474A (zh) 1998-06-10
CO4700433A1 (es) 1998-12-29
EP1136479A1 (fr) 2001-09-26
ES2256117T3 (es) 2006-07-16
TR199701194T1 (xx) 1998-03-21
AP862A (en) 2000-08-04
ZA962891B (en) 1996-10-15
DE69638252D1 (de) 2010-10-14
NO974744D0 (no) 1997-10-14
IS4575A (is) 1997-10-02
AP9600827A0 (en) 1997-10-17
CN1110491C (zh) 2003-06-04
EA000906B1 (ru) 2000-06-26
PE43697A1 (es) 1997-10-11
DE69635679D1 (de) 2006-02-02
EP0833826A1 (fr) 1998-04-08
AP9701104A0 (en) 1997-10-31
PL322904A1 (en) 1998-03-02
ATE212344T1 (de) 2002-02-15
ES2351970T3 (es) 2011-02-14
WO1996033187A1 (fr) 1996-10-24
HUP9801948A3 (en) 2002-04-29
NZ307342A (en) 1999-04-29
DE69618779T2 (de) 2002-08-29
TW404945B (en) 2000-09-11

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