IL116325D0 - Substituted 1h-imidazoles their preparation and use - Google Patents

Substituted 1h-imidazoles their preparation and use

Info

Publication number
IL116325D0
IL116325D0 IL11632595A IL11632595A IL116325D0 IL 116325 D0 IL116325 D0 IL 116325D0 IL 11632595 A IL11632595 A IL 11632595A IL 11632595 A IL11632595 A IL 11632595A IL 116325 D0 IL116325 D0 IL 116325D0
Authority
IL
Israel
Prior art keywords
imidazoles
substituted
Prior art date
Application number
IL11632595A
Other versions
IL116325A (en
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB9425211.1A priority Critical patent/GB9425211D0/en
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of IL116325D0 publication Critical patent/IL116325D0/en
Publication of IL116325A publication Critical patent/IL116325A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
IL11632595A 1994-12-14 1995-12-11 Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them IL116325A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (2)

Publication Number Publication Date
IL116325D0 true IL116325D0 (en) 1996-03-31
IL116325A IL116325A (en) 1999-10-28

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11632595A IL116325A (en) 1994-12-14 1995-12-11 Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US5658938A (en)
EP (1) EP0717037A1 (en)
JP (1) JPH08208622A (en)
KR (1) KR960022474A (en)
CN (1) CN1054376C (en)
AR (1) AR002257A1 (en)
AU (1) AU693614B2 (en)
BG (1) BG63043B1 (en)
BR (1) BR9505815A (en)
CA (1) CA2165133A1 (en)
CZ (1) CZ327195A3 (en)
EE (1) EE9500064A (en)
FI (1) FI955927A (en)
GB (1) GB9425211D0 (en)
HU (1) HUT73980A (en)
IL (1) IL116325A (en)
IS (1) IS4311A (en)
MX (1) MX9505063A (en)
NO (1) NO305316B1 (en)
NZ (1) NZ280646A (en)
PL (1) PL311736A1 (en)
RO (1) RO113346B1 (en)
RU (1) RU2156239C2 (en)
SK (1) SK155095A3 (en)
TW (1) TW303362B (en)
ZA (1) ZA9510554B (en)

Families Citing this family (48)

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GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
ZA9801080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
WO2001085698A1 (en) 2000-05-08 2001-11-15 Orion Corporation New polycyclic indanylimidazoles with alpha2 adrenergic activity
TW200306783A (en) * 2002-04-29 2003-12-01 Fmc Corp Pesticidal heterocycles
FI20022007A0 (en) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromucosal preparation and method of preparation thereof
FI20022159A0 (en) * 2002-12-05 2002-12-05 Orion Corp New pharmaceutical compounds
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
CN101374517A (en) * 2006-01-27 2009-02-25 弗·哈夫曼-拉罗切有限公司 Use of 2-imidazoles for the treatment of CNS disorders
KR101172940B1 (en) * 2006-10-19 2012-08-10 에프. 호프만-라 로슈 아게 Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
CN101528710B (en) * 2006-10-19 2012-11-07 弗·哈夫曼-拉罗切有限公司 Aminomethyl-4-imidazoles
CN101535292A (en) * 2006-11-02 2009-09-16 弗·哈夫曼-拉罗切有限公司 Substituted 2-imidazoles as modulators of the trace amine associated receptors
CA2669112A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
AU2007332641A1 (en) * 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
AU2008209860A1 (en) 2007-02-02 2008-08-07 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as TAAR1 ligands for CNS disorders
CA2678072A1 (en) * 2007-02-13 2008-08-21 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
JP2010518161A (en) * 2007-02-13 2010-05-27 シェーリング コーポレイションSchering Corporation Chroman derivatives and analogs as function selective α2C adrenergic receptor agonists
RU2009134059A (en) * 2007-02-13 2011-03-20 Шеринг Корпорейшн (US) Functionally selective alpha2c adrenoreceptor agonists
KR101335845B1 (en) * 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 2-aminooxazolines as taar1 ligands
BRPI0812840A2 (en) 2007-07-02 2014-12-09 Hoffmann La Roche 2-immedazolins
KR101150628B1 (en) * 2007-07-03 2012-05-31 에프. 호프만-라 로슈 아게 4-imidazolines and their use as antidepressants
AU2008281918A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
AU2008281877A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of CNS disorders
CN101784515A (en) * 2007-08-03 2010-07-21 弗·哈夫曼-拉罗切有限公司 Pyridinecarboxamide and benzamide derivatives as taar1 ligands
CL2008003553A1 (en) * 2007-12-05 2009-11-27 Grindeks Jsc Process to prepare atipamezole or 5- (2-ethyl-2,3-dihydro-1h-inden-2-yl) -1h-imidazole hydrochloride: and the intermediate compounds considered in the process
US8383818B2 (en) 2008-02-21 2013-02-26 Merck Sharp & Dohme Corp. Functionally selective alpha2C adrenoreceptor agonists
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
EP2321287B1 (en) * 2008-07-24 2015-11-11 F. Hoffmann-La Roche AG 4,5-dihydro-oxazol-2-yl derivatives
US20110190247A1 (en) * 2008-08-04 2011-08-04 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
AR073628A1 (en) 2008-10-07 2010-11-17 Schering Corp Analogs of biaryl spiroaminooxazoline and spiroaminodiazoline modulators of alpha2c adrenergic receptors, pharmaceutical compositions comprising them and their use in allergic rhinitis, cardiac disorders and other diseases
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
ES2554843T3 (en) 2012-01-12 2015-12-23 F. Hoffmann-La Roche Ag Heterocyclic derivatives as associated amine trace receptors (TAARs)
AU2013314388B2 (en) 2012-09-14 2016-07-14 F. Hoffmann-La Roche Ag Pyrazole carboxamide derivatives as TAAR modulators for use in the treatment of several disorders, such as depression, diabetes and Parkinson's disease
RU2637938C2 (en) 2012-09-17 2017-12-08 Ф. Хоффманн-Ля Рош Аг Triazolcarboxamide derivatives
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
MX2016016488A (en) 2014-08-27 2017-03-30 F Hoffmann-La Roche Ag Substituted azetidine derivatives as taar ligands.
EP3186250B1 (en) 2014-08-27 2018-04-18 F.Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
SI3430010T1 (en) 2016-03-17 2020-10-30 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0374216B2 (en) * 1983-08-25 1991-11-26
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5151526A (en) * 1990-10-11 1992-09-29 The United States Of America As Represented By The Secretary Of The Army 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic
JPH04210680A (en) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd Imidazole derivative and plant growth regulator
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles

Also Published As

Publication number Publication date
EE9500064A (en) 1996-06-17
KR960022474A (en) 1996-07-18
IL116325A (en) 1999-10-28
CN1133837A (en) 1996-10-23
AU693614B2 (en) 1998-07-02
IS4311A (en) 1996-06-15
CN1054376C (en) 2000-07-12
CZ327195A3 (en) 1996-07-17
NO305316B1 (en) 1999-05-10
SK155095A3 (en) 1997-02-05
AU4036895A (en) 1996-06-20
MX9505063A (en) 1997-01-31
CA2165133A1 (en) 1996-06-15
JPH08208622A (en) 1996-08-13
NO955034L (en) 1996-06-17
FI955927D0 (en)
BG63043B1 (en) 2001-02-28
ZA9510554B (en) 1996-06-13
PL311736A1 (en) 1996-06-24
RU2156239C2 (en) 2000-09-20
GB9425211D0 (en) 1995-02-15
NO955034D0 (en) 1995-12-12
NZ280646A (en) 1996-08-27
HUT73980A (en) 1996-10-28
HU9503549D0 (en) 1996-02-28
EP0717037A1 (en) 1996-06-19
FI955927A (en) 1996-06-15
BG100208A (en) 1996-07-31
FI955927A0 (en) 1995-12-11
TW303362B (en) 1997-04-21
RO113346B1 (en) 1998-06-30
AR002257A1 (en) 1998-03-11
US5658938A (en) 1997-08-19
BR9505815A (en) 1998-01-06

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Legal Events

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees