IL115771A - Apolipoprotein-B synthesis inhibitors their preparation and pharmaceutical compositions containing them - Google Patents

Apolipoprotein-B synthesis inhibitors their preparation and pharmaceutical compositions containing them

Info

Publication number
IL115771A
IL115771A IL11577195A IL11577195A IL115771A IL 115771 A IL115771 A IL 115771A IL 11577195 A IL11577195 A IL 11577195A IL 11577195 A IL11577195 A IL 11577195A IL 115771 A IL115771 A IL 115771A
Authority
IL
Israel
Prior art keywords
apolipoprotein
preparation
pharmaceutical compositions
compositions containing
synthesis inhibitors
Prior art date
Application number
IL11577195A
Other languages
English (en)
Other versions
IL115771A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/455,304 external-priority patent/US5521186A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to IL13199295A priority Critical patent/IL131992A/xx
Publication of IL115771A0 publication Critical patent/IL115771A0/xx
Publication of IL115771A publication Critical patent/IL115771A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11577195A 1994-10-27 1995-10-26 Apolipoprotein-B synthesis inhibitors their preparation and pharmaceutical compositions containing them IL115771A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL13199295A IL131992A (en) 1994-10-27 1995-10-26 Derivatives of 1,3-dioxolane

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203120 1994-10-27
US08/455,304 US5521186A (en) 1994-10-27 1995-05-31 Apolipoprotein-β synthesis inhibitors

Publications (2)

Publication Number Publication Date
IL115771A0 IL115771A0 (en) 1996-01-19
IL115771A true IL115771A (en) 2000-02-29

Family

ID=26136684

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11577195A IL115771A (en) 1994-10-27 1995-10-26 Apolipoprotein-B synthesis inhibitors their preparation and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (1) US5929075A (sk)
EP (1) EP0788496B1 (sk)
JP (1) JP3025907B2 (sk)
KR (1) KR100227231B1 (sk)
CN (1) CN1068000C (sk)
AP (1) AP779A (sk)
AT (1) ATE198889T1 (sk)
AU (1) AU697744C (sk)
BG (1) BG63694B1 (sk)
BR (1) BR9509436A (sk)
CA (1) CA2203274C (sk)
CY (1) CY2256B1 (sk)
CZ (1) CZ286476B6 (sk)
DE (3) DE122007000005I1 (sk)
DK (1) DK0788496T3 (sk)
ES (1) ES2155535T3 (sk)
FI (1) FI119548B (sk)
GR (1) GR3035519T3 (sk)
HR (1) HRP950532B1 (sk)
HU (1) HU219862B (sk)
IL (1) IL115771A (sk)
LU (1) LU91306I2 (sk)
NO (1) NO311937B1 (sk)
NZ (1) NZ295353A (sk)
OA (1) OA10479A (sk)
PT (1) PT788496E (sk)
RO (1) RO118715B1 (sk)
SK (1) SK281908B6 (sk)
TR (1) TR199501295A2 (sk)
WO (1) WO1996013499A1 (sk)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010023661A (ko) 1997-11-03 2001-03-26 디르크 반테 지질 저하제 조성물
CN1308523A (zh) * 1998-04-27 2001-08-15 詹森药业有限公司 含有用降脂剂和聚合物包衣的丸芯的微丸
WO2000037463A1 (en) * 1998-12-22 2000-06-29 Janssen Pharmaceutica N.V. S-oxide lipid lowering compounds
DE19945982A1 (de) 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) * 2003-12-12 2005-06-16 International Business Machines Corporation Computer system with LAN-based I/O
EP1708680A2 (en) * 2004-01-21 2006-10-11 Janssen Pharmaceutica N.V. Mitratapide oral solution
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
WO2007015162A1 (en) * 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8138188B2 (en) * 2006-02-23 2012-03-20 Pfizer Inc. Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
KR20090064478A (ko) 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
BRPI0811902B1 (pt) 2007-05-25 2020-03-24 Janssen Pharmaceutica N.V. Síntese aprimorada do (2s-cis)-2-(bromometil)-2-(-4-clorofenil)-1,3-dioxolano-4-metanol metanosulfonato (éster)
DK2326638T5 (da) * 2008-08-06 2014-01-13 Pfizer Ltd Diazepin- og diazocan-forbindelser som mc4-agonister
CA2798002C (en) * 2010-05-19 2019-12-03 Sandoz Ag Process for the preparation of chiral triazolones
KR20200142508A (ko) 2018-03-08 2020-12-22 인사이트 코포레이션 PI3K-γ 저해제로서의 아미노피라진 다이올 화합물
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313953A (en) * 1978-06-23 1982-02-02 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
WO1994020063A2 (en) * 1993-03-04 1994-09-15 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) * 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors

Also Published As

Publication number Publication date
LU91306I2 (fr) 2007-03-19
IL115771A0 (en) 1996-01-19
WO1996013499A1 (en) 1996-05-09
KR100227231B1 (ko) 1999-11-01
DE122007000005I1 (de) 2007-04-26
BR9509436A (pt) 1998-01-06
CA2203274C (en) 2002-02-19
OA10479A (en) 2002-04-09
BG63694B1 (bg) 2002-09-30
HUT77360A (hu) 1998-03-30
HRP950532B1 (en) 2001-06-30
SK281908B6 (sk) 2001-09-11
CA2203274A1 (en) 1996-05-09
HRP950532A2 (en) 1997-08-31
DK0788496T3 (da) 2001-06-18
CZ119897A3 (cs) 1998-03-18
FI971784A0 (fi) 1997-04-25
DE69519995D1 (en) 2001-03-01
AU3868095A (en) 1996-05-23
NO311937B1 (no) 2002-02-18
AU697744B2 (en) 1998-10-15
HU219862B (hu) 2001-08-28
BG101402A (en) 1997-10-31
JPH09511759A (ja) 1997-11-25
SK50797A3 (en) 1998-04-08
ATE198889T1 (de) 2001-02-15
EP0788496A1 (en) 1997-08-13
EP0788496B1 (en) 2001-01-24
TR199501295A2 (tr) 1996-06-21
AU697744C (en) 2002-08-22
FI119548B (fi) 2008-12-31
RO118715B1 (ro) 2003-09-30
GR3035519T3 (en) 2001-06-29
DE69519995T2 (de) 2001-08-23
NO971895L (no) 1997-04-24
AP779A (en) 1999-11-03
JP3025907B2 (ja) 2000-03-27
MX9703074A (es) 1997-07-31
FI971784A (fi) 1997-04-25
DE122007000005I2 (de) 2008-04-24
NZ295353A (en) 1998-08-26
NO971895D0 (no) 1997-04-24
CN1161695A (zh) 1997-10-08
CN1068000C (zh) 2001-07-04
US5929075A (en) 1999-07-27
CY2256B1 (en) 2003-07-04
ES2155535T3 (es) 2001-05-16
CZ286476B6 (en) 2000-04-12
PT788496E (pt) 2001-07-31
AP9700968A0 (en) 1997-04-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees