IL114586A - Droloxifene for use in the treatment of cardiovascular diseases and pharmaceutical compositions comprising same - Google Patents

Droloxifene for use in the treatment of cardiovascular diseases and pharmaceutical compositions comprising same

Info

Publication number
IL114586A
IL114586A IL11458695A IL11458695A IL114586A IL 114586 A IL114586 A IL 114586A IL 11458695 A IL11458695 A IL 11458695A IL 11458695 A IL11458695 A IL 11458695A IL 114586 A IL114586 A IL 114586A
Authority
IL
Israel
Prior art keywords
droloxifene
treatment
same
pharmaceutical compositions
cardiovascular diseases
Prior art date
Application number
IL11458695A
Other languages
English (en)
Other versions
IL114586A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL114586A0 publication Critical patent/IL114586A0/xx
Publication of IL114586A publication Critical patent/IL114586A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
IL11458695A 1994-07-19 1995-07-13 Droloxifene for use in the treatment of cardiovascular diseases and pharmaceutical compositions comprising same IL114586A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/276,969 US5441986A (en) 1994-07-19 1994-07-19 Estrogen agonists as remedies for prostate and cardiovascular diseases

Publications (2)

Publication Number Publication Date
IL114586A0 IL114586A0 (en) 1995-11-27
IL114586A true IL114586A (en) 2000-06-29

Family

ID=23058874

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11458595A IL114585A (en) 1994-07-19 1995-07-13 Droloxifene for use as a medicament against prostate diseases endometriosis and obesity and medicament comprising same
IL11458695A IL114586A (en) 1994-07-19 1995-07-13 Droloxifene for use in the treatment of cardiovascular diseases and pharmaceutical compositions comprising same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL11458595A IL114585A (en) 1994-07-19 1995-07-13 Droloxifene for use as a medicament against prostate diseases endometriosis and obesity and medicament comprising same

Country Status (17)

Country Link
US (4) US5441986A (ja)
EP (3) EP0771194A1 (ja)
JP (2) JPH09507859A (ja)
KR (2) KR100221854B1 (ja)
CN (2) CN1076967C (ja)
AU (2) AU689257B2 (ja)
CA (2) CA2195093C (ja)
FI (2) FI970215A0 (ja)
HK (1) HK1000697A1 (ja)
HU (2) HUT77392A (ja)
IL (2) IL114585A (ja)
MX (2) MX9700538A (ja)
MY (1) MY113079A (ja)
NZ (2) NZ285158A (ja)
TW (1) TW403649B (ja)
WO (2) WO1996002242A1 (ja)
ZA (2) ZA955964B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5595722A (en) 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5441986A (en) * 1994-07-19 1995-08-15 Pfizer Inc. Estrogen agonists as remedies for prostate and cardiovascular diseases
CA2223595C (en) 1995-06-07 2008-08-05 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
IL120266A (en) * 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US5985932A (en) * 1996-02-28 1999-11-16 Pfizer Inc Inhibition of autoimmune diseases
US5726207A (en) * 1996-02-28 1998-03-10 Pfizer Inc. Protection of ischemic myocardium against reperfusion damage
TW442286B (en) * 1996-02-28 2001-06-23 Pfizer New therapeutic uses of estrogen agonists
IL120262A (en) * 1996-02-28 2001-01-28 Pfizer Droloxifene and derivatives thereof for use in increasing serum testosterone levels
IL120269A0 (en) * 1996-02-28 1997-06-10 Pfizer 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease
US5733937A (en) * 1996-02-28 1998-03-31 Pfizer Inc. Methods for alleviating symptoms of premenstrual syndrome and late luteal phase dysphoric disorder
IL120270A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis
US5719190A (en) * 1996-02-28 1998-02-17 Pfizer Inc. Inhibition of myeloperoxidase activity
IL120268A0 (en) * 1996-02-28 1997-06-10 Pfizer Use of (E)-1-[4'-(2-alkylaminoethioxy)phenyl]1-(3'-hydroxyphenyl)-2-phenylbut-1-enes in inhibiting pathological conditions
IL120263A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to prevent bone loss-progesterone and estrogen agonists
US6034102A (en) * 1996-11-15 2000-03-07 Pfizer Inc Atherosclerosis treatment
US6069175A (en) * 1996-11-15 2000-05-30 Pfizer Inc. Estrogen agonist/antagonists treatment of atherosclerosis
US6114395A (en) * 1996-11-15 2000-09-05 Pfizer Inc. Method of treating atherosclerosis
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US20040092602A1 (en) * 1998-05-07 2004-05-13 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US6413533B1 (en) * 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US20040186185A1 (en) * 1998-05-07 2004-09-23 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
FI982733A (fi) * 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
JP5005127B2 (ja) 1999-05-04 2012-08-22 ストラカン・インターナショナル・リミテッド アンドロゲングリコシド及びそのアンドロゲン作用活性
KR101141763B1 (ko) * 1999-07-06 2012-05-08 앙도르쉐르슈 인코포레이티드 체중 증가의 치료 및/또는 억제에 사용하는 약학 조성물
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
CO5271709A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
ES2551690T3 (es) * 2006-05-22 2015-11-23 Hormos Medical Ltd. Método de tratamiento de la prostatitis crónica no bacteriana con moduladores selectivos del receptor de estrógeno o inhibidores de aromatasa
WO2008099059A1 (en) * 2007-02-14 2008-08-21 Hormos Medical Ltd Method for the preparation of therapeutically valuable triphenylbutene derivatives
WO2008099060A2 (en) * 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
DE3323321A1 (de) * 1983-06-24 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels
US5262319A (en) * 1985-04-19 1993-11-16 Oncogene Science, Inc. Method for obtaining bone marrow free of tumor cells using transforming growth factor β3
FR2619383B1 (fr) * 1987-08-12 1989-12-08 Inst Vaisseaux Sang Proteine a activite vasculaire, derivee des monocytes et ses analogues, procede pour son extraction et leurs utilisations en therapeutique et pour la preparation d'anticorps
JPH04312526A (ja) * 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd 骨疾患治療剤
DE4401554A1 (de) * 1993-02-16 1994-08-18 Freund Andreas Präparat zur Therapie und Prophylaxe von Erkrankungen, die bei Imbalancen von Plasmalipiden auftreten
US5426123A (en) * 1994-05-11 1995-06-20 Eli Lilly And Company Method for lowering serum cholesterol with 1,1,2-triphenylbut-1-ene derivatives
US5384332A (en) * 1994-05-11 1995-01-24 Eli Lilly And Company Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives
US5455275A (en) * 1994-05-11 1995-10-03 Eli Lilly And Company Methods for inhibiting endometriosis and uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives
US5441986A (en) * 1994-07-19 1995-08-15 Pfizer Inc. Estrogen agonists as remedies for prostate and cardiovascular diseases

Also Published As

Publication number Publication date
NZ285158A (en) 2000-07-28
TW403649B (en) 2000-09-01
CA2195213A1 (en) 1996-02-01
FI970215A (fi) 1997-01-17
WO1996002242A1 (en) 1996-02-01
AU2417095A (en) 1996-02-16
KR970704429A (ko) 1997-09-06
NZ285159A (en) 2000-10-27
MX9700534A (es) 1997-04-30
EP0771194A1 (en) 1997-05-07
US5852059A (en) 1998-12-22
IL114585A (en) 2000-01-31
EP0769941A1 (en) 1997-05-02
CN1152868A (zh) 1997-06-25
AU694220B2 (en) 1998-07-16
US5827892A (en) 1998-10-27
KR100212352B1 (ko) 1999-08-02
JPH09507859A (ja) 1997-08-12
FI970214A (fi) 1997-01-17
MY113079A (en) 2001-11-30
JP2930424B2 (ja) 1999-08-03
FI970214A0 (fi) 1997-01-17
HU9700163D0 (en) 1997-03-28
CN1076967C (zh) 2002-01-02
WO1996002243A1 (en) 1996-02-01
CN1153473A (zh) 1997-07-02
HU9700162D0 (en) 1997-03-28
HUT77392A (hu) 1998-04-28
US5441986A (en) 1995-08-15
CA2195093A1 (en) 1996-02-01
ZA955964B (en) 1997-01-20
EP1029540A2 (en) 2000-08-23
US5902830A (en) 1999-05-11
IL114586A0 (en) 1995-11-27
MX9700538A (es) 1997-04-30
KR970704430A (ko) 1997-09-06
CA2195213C (en) 2000-03-14
ZA955963B (en) 1997-01-20
JPH09507860A (ja) 1997-08-12
KR100221854B1 (ko) 1999-09-15
AU689257B2 (en) 1998-03-26
CA2195093C (en) 2000-03-07
IL114585A0 (en) 1995-11-27
FI970215A0 (fi) 1997-01-17
EP1029540A3 (en) 2001-05-16
HK1000697A1 (en) 2002-05-10
HUT77391A (hu) 1998-04-28
AU2416995A (en) 1996-02-16

Similar Documents

Publication Publication Date Title
IL114586A (en) Droloxifene for use in the treatment of cardiovascular diseases and pharmaceutical compositions comprising same
IL122733A0 (en) Pharmaceutical compositions for use in the treatment of allergic asthma
IL113844A (en) N-(alpha-ETHYLBENZYL)-3-HYDROXY-2-PHENYLQUINOLINE-4-CARBOXAMIDE AND ITS USE IN THE PREPARATION OF MEDICAMENTS
HK1105580A1 (en) Use of isoflavone compounds in the manufacture of medicament and composition comprising the same
GR980300033T1 (en) Compositions for the treatment of dermatological disorders and methods for their use
IL125446A0 (en) Pharmaceutical composition for the treatment of asthma allergy and inflammation
HUP9802795A3 (en) Pharmaceutical compositions containing beta-adrenergic agent and anorectic agent for the treatment of corpulence
HU9503624D0 (en) Use of p antagonist in pharmaceutical compositions
HUP9904027A3 (en) Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
CZ63895A3 (en) 5-vinyl-quinolone-carboxylic, 5-vinyl-naphthyridon-carboxylic, +5-ethinyl-quinolone-carboxylic and 5-ethinyl-naphthyridon-carboxylic acids, process of their preparation, medicaments in which said compounds are comprised and their use
HUP9901434A3 (en) Substituted benzylamines and their use for the preparation of medicaments for treating depression
GB9321341D0 (en) Therapeutic compositions for use in the treatment of skin lesions and method of making same
HUP0003244A2 (en) Novel triptolide derivatives useful in the treatment of autoimmune diseases and pharmaceutical compositions thereof
IL119225A (en) Pharmaceutical compositions for the treatment of asthma in mammals
IL164513A0 (en) Pyrazolopyrimidines, pharmaceutical compositions containing them, and their use in the preparation of medicaments
GB2294637B (en) Therapeutic compositions and methods of use
GB9413090D0 (en) Benzazepine derivatives compositions containing them and their use in therapy
IL91451A0 (en) Pharmaceutical compositions comprising azapiron compounds and their use in the treatment of addiction
IL117395A0 (en) Bicyclic compounds preparation thereof and use in pharmaceutical compositions
AU5963396A (en) Cis-resorcylide, pharmaceutical composition containing it, use thereof in the treatment of thrombosis and related disorders
IL115505A (en) Use of inhibitors of cyclooxygenase in the preparation of medicaments for the treatment of neurodegenerative diseases
IL121407A0 (en) Substituted indanylidineacetylguanidines process for their preparation their use as medicaments or in diagnosis and medicaments containing them
IL113415A0 (en) Dihydrodibenzoquinolinediones their preparation and use and pharmaceutical compositions containing them
IL114161A0 (en) Amido- quinoxalinediones pharmaceutical compositions containing them and their use
HUP9701606A3 (en) Use of sulbutiamine to obtain pharmaceutical compositions useful in the treatment of certain psychomotor and psychointellectual disorders

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees