IL112712D0 - Piperazino- and morpholino-amidines - Google Patents

Piperazino- and morpholino-amidines

Info

Publication number
IL112712D0
IL112712D0 IL11271295A IL11271295A IL112712D0 IL 112712 D0 IL112712 D0 IL 112712D0 IL 11271295 A IL11271295 A IL 11271295A IL 11271295 A IL11271295 A IL 11271295A IL 112712 D0 IL112712 D0 IL 112712D0
Authority
IL
Israel
Prior art keywords
amidines
piperazino
morpholino
Prior art date
Application number
IL11271295A
Inventor
Jean Dr Ackermann
David Dr Banner
Klaus Dr Gubernator
Paul Dr Hadvary
Kurt Dr Hilpert
Klaus Prof Dr Mueller
Ludvik Dr Labler
Gerard Dr Schmid
Thomas Dr Tschopp
Hans Peter Dr Wessel
Beat Dr Wirz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH225090 priority Critical
Priority to CH131591 priority
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to IL9869095 priority
Publication of IL112712D0 publication Critical patent/IL112712D0/en

Links

IL11271295A 1990-07-05 1995-02-21 Piperazino- and morpholino-amidines IL112712D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH225090 1990-07-05
CH131591 1991-05-02
IL9869095 1995-02-21

Publications (1)

Publication Number Publication Date
IL112712D0 true IL112712D0 (en) 1995-05-26

Family

ID=25687300

Family Applications (3)

Application Number Title Priority Date Filing Date
IL9869091A IL98690A (en) 1990-07-05 1991-07-01 Amidinopiperidinyl methylsulphonamido alkane-carboxylates and carboxamides their manufacture intermediates therefor and pharmaceutical compositions containing them
IL11271291A IL112712A (en) 1990-07-05 1991-07-01 Piperazino- and morpholino-amidines
IL11271295A IL112712D0 (en) 1990-07-05 1995-02-21 Piperazino- and morpholino-amidines

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL9869091A IL98690A (en) 1990-07-05 1991-07-01 Amidinopiperidinyl methylsulphonamido alkane-carboxylates and carboxamides their manufacture intermediates therefor and pharmaceutical compositions containing them
IL11271291A IL112712A (en) 1990-07-05 1991-07-01 Piperazino- and morpholino-amidines

Country Status (18)

Country Link
US (6) US5260307A (en)
EP (1) EP0468231B1 (en)
JP (1) JPH0730022B2 (en)
AT (1) AT111890T (en)
AU (1) AU650458B2 (en)
CA (1) CA2044636A1 (en)
DE (1) DE59103021D1 (en)
DK (1) DK0468231T3 (en)
ES (1) ES2061125T3 (en)
FI (1) FI102966B (en)
HU (1) HU217815B (en)
IE (1) IE66047B1 (en)
IL (3) IL98690A (en)
MC (1) MC2261A1 (en)
NO (1) NO177704C (en)
NZ (1) NZ238773A (en)
PT (1) PT98221B (en)
TW (1) TW201303B (en)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201303B (en) * 1990-07-05 1993-03-01 Hoffmann La Roche
SE9103612D0 (en) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
GB9200420D0 (en) * 1992-01-09 1992-02-26 James Black Foundation The Lim Amino acid derivatives
TW223629B (en) * 1992-03-06 1994-05-11 Hoffmann La Roche
DE4242655A1 (en) * 1992-12-17 1994-06-23 Behringwerke Ag Use of thrombin inhibitors for the inhibition of ocular fibrin
JPH06329627A (en) * 1993-05-03 1994-11-29 Bristol Myers Squibb Co Guanidinyl-or amidinyl-substituted heterocyclic thrombin inhibitor
JPH06340619A (en) * 1993-05-03 1994-12-13 Bristol Myers Squibb Co Guanidinyl-or amidinyl-substituted methylaminoheterocycle as thrombin inhibitor
SE9301916D0 (en) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
US5536867A (en) * 1994-04-27 1996-07-16 Hoffmann-La Roche Inc. Process for the manufacture of dicarboxamides
EP0684238A3 (en) * 1994-04-27 1997-01-15 Hoffmann La Roche Process for the manufacture of dicarboxamides.
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
SE9404196D0 (en) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
US5731439A (en) * 1995-03-24 1998-03-24 The Dupont Merck Pharmaceutical Company Piperidine containing aminobornic acids
SA96170106A (en) 1995-07-06 2005-12-03 أسترا أكتيبولاج New amino acid derivatives
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
WO1997011693A1 (en) * 1995-09-29 1997-04-03 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
TR199800849T2 (en) * 1995-11-13 1998-07-21 Hoechst Aktiengesellschaft Cyclic and heterocyclic N-substituted alpha-iminohidroksa with carboxylic acids
AR005245A1 (en) * 1995-12-21 1999-04-28 Astrazeneca Ab Prodrugs of thrombin inhibitors, a pharmaceutical formulation which comprises the use of said prodrugs for the manufacture of a medicament and a process for its preparation
HU9902256A3 (en) * 1995-12-29 2000-01-28 Dimensional Pharm Inc Amidino protease inhibitors and pharmaceutical compositions containing them
ZA9700056B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
US6919375B1 (en) 1996-01-23 2005-07-19 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
CA2242416C (en) * 1996-01-23 2006-03-21 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
NZ325939A (en) * 1996-01-23 2000-06-23 Shionogi & Co Sulphonated amino acid derivatives and matrix metalloproteinase inhibitors (MMP) containing these derivatives
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
SE9602263D0 (en) * 1996-06-07 1996-06-07 Astra Ab New Amino Acid Derivatives
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors
SE9602646D0 (en) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-Useful Compounds
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US5872138A (en) * 1996-09-13 1999-02-16 Merck & Co., Inc. Thrombin inhibitors
US5869487A (en) * 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
SG88737A1 (en) * 1996-10-30 2002-05-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6017934A (en) * 1997-01-22 2000-01-25 Merck & Co., Inc. Thrombin inhibitors
US5792779A (en) * 1997-02-19 1998-08-11 Merck & Co., Inc. Pyridinone thrombin inhibitors
US5932606A (en) * 1997-03-24 1999-08-03 Merck & Co., Inc. Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors
EP0877019B1 (en) 1997-05-09 2001-12-12 Hoechst Aktiengesellschaft Substituted diaminocarboxylic acid
DE19719621A1 (en) 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
DE19719817A1 (en) * 1997-05-13 1998-11-19 Hoechst Ag Substituted 6- and 7-Aminotetrahydroisochinolincarbonsäuren
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
AR013084A1 (en) 1997-06-19 2000-12-13 Astrazeneca Ab Amidino derivatives useful as inhibitors of thrombin, pharmaceutical composition, use of said compounds for the preparation demedicamentos and process for preparing said compounds
US6011038A (en) * 1997-09-05 2000-01-04 Merck & Co., Inc. Pyrazinone thrombin inhibitors
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
US6133297A (en) * 1997-09-30 2000-10-17 Merck & Co., Inc. Thrombin inhibitors
SE9704543D0 (en) 1997-12-05 1997-12-05 Astra Ab New compounds
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
US6001855A (en) * 1998-01-02 1999-12-14 Hoffman-La Roche Inc. Thiazole derivatives
AU750561B2 (en) 1998-04-24 2002-07-25 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
US6147078A (en) * 1998-05-19 2000-11-14 Merck & Co., Inc. Pyrazinone thrombin inhibitors
CA2333040A1 (en) * 1998-05-26 1999-12-02 Merck & Co., Inc. Imidazopyridine thrombin inhibitors
DE19824470A1 (en) * 1998-05-30 1999-12-02 Boehringer Ingelheim Pharma Neurokininantagonisten new, processes for their preparation and to pharmaceutical compositions
WO2000004030A1 (en) 1998-07-16 2000-01-27 Aventis Pharma Deutschland Gmbh Phosphinous and phosphonic acid derivatives used as medicaments
EP1117660A4 (en) * 1998-09-28 2002-01-09 Merck & Co Inc Thrombin inhibitors
JP2002528542A (en) 1998-10-30 2002-09-03 メルク エンド カムパニー インコーポレーテッド Thrombin inhibitors
US6610692B1 (en) 1998-10-30 2003-08-26 Merck & Co., Inc. Thrombin inhibitors
DE19851184A1 (en) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-arylsulfonyl amino acid, omega-amides
SE9804313D0 (en) 1998-12-14 1998-12-14 Astra Ab New compounds
JP2002535250A (en) 1999-01-13 2002-10-22 アストラゼネカ アクチボラグ Their use as a novel amidino benzylamine derivative and thrombin inhibitors
JP2000302757A (en) * 1999-04-16 2000-10-31 Shiseido Co Ltd N-substituted piperidine derivative
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
CN1353705A (en) 1999-06-04 2002-06-12 麦克公司 Pyrazinone thrombin inhibitors
CA2374654A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Thrombin inhibitors
EP1259506A1 (en) 1999-11-23 2002-11-27 Merck & Co., Inc. Pyrazinone thrombin inhibitors
ES2189572B1 (en) * 1999-12-31 2004-06-01 Jose Manuel Valero Salinas Used for application reinforcing glass fiber in disposable formwork for columns.
JP2003527426A (en) 2000-03-23 2003-09-16 メルク エンド カムパニー インコーポレーテッド Thrombin inhibitors
SE0001803D0 (en) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds in
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (en) 2000-12-01 2004-05-05 Astrazeneca Ab Mandelic acid derivatives, pharmaceutically acceptable derivatives, use of these derivatives for the manufacture of medicaments, methods of treatment, processes for preparing these derivatives, and intermediate compounds
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
SK6862003A3 (en) * 2000-12-06 2004-02-03 Aventis Pharma Gmbh Guanidine and amidine derivatives as factor XA inhibitors, process for the preparation thereof, pharmaceutical composition and use thereof
AR034517A1 (en) * 2001-06-21 2004-02-25 Astrazeneca Ab pharmaceutical formulation
US7534897B2 (en) 2002-05-16 2009-05-19 Shionogi & Co., Ltd. Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
SE0201659D0 (en) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (en) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
DE10344936A1 (en) 2003-09-27 2005-04-21 Aventis Pharma Gmbh Bicyclic Iminosäurederivate as inhibitors of matrix metalloproteinases
WO2005062851A2 (en) * 2003-12-22 2005-07-14 Pappolla Miguel A Indole-3-propionamide and derivatives thereof
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20160068486A1 (en) 2013-04-22 2016-03-10 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE420919B (en) * 1973-08-13 1981-11-09 Mitsubishi Chem Ind Process for the tell accession n? 722-dansyl-L-arginine derivatives and pharmaceutically acceptable acid addition salts derav
US4258192A (en) * 1977-12-16 1981-03-24 Mitsubishi Chemical Industries Limited N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
JPS6212218B2 (en) * 1978-11-10 1987-03-17 Banyu Pharma Co Ltd
US4433152A (en) * 1981-05-25 1984-02-21 Nippon Chemiphar Co., Ltd. Amidinopiperidine derivatives
JPH021831B2 (en) * 1982-05-10 1990-01-12 Nippon Chemiphar Co
IT1231238B (en) * 1987-09-21 1991-11-26 Angeli Inst Spa ammidinici Derivatives
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US5053393A (en) * 1988-07-20 1991-10-01 Monsanto Company Novel platelet-aggregation inhibitor
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
TW201303B (en) * 1990-07-05 1993-03-01 Hoffmann La Roche
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
TW223629B (en) * 1992-03-06 1994-05-11 Hoffmann La Roche
JPH0864561A (en) * 1994-08-23 1996-03-08 Nippon Steel Corp Detection of end point in chemical and mechanical polishing method and chemical and mechanical polishing device

Also Published As

Publication number Publication date
US5595999A (en) 1997-01-21
EP0468231B1 (en) 1994-09-21
NO177704C (en) 1995-11-08
FI102966B (en) 1999-03-31
US5763436A (en) 1998-06-09
PT98221B (en) 1999-01-29
FI913282A0 (en) 1991-07-05
FI913282D0 (en)
FI913282A (en) 1992-01-06
EP0468231A3 (en) 1992-04-01
HU912206D0 (en) 1991-12-30
JPH0730022B2 (en) 1995-04-05
ES2061125T3 (en) 1994-12-01
NO912626D0 (en) 1991-07-04
US5583133A (en) 1996-12-10
FI102966B1 (en) 1999-03-31
DK0468231T3 (en) 1995-01-23
NZ238773A (en) 1994-02-25
TW201303B (en) 1993-03-01
US5393760A (en) 1995-02-28
IL98690A (en) 1996-05-14
HUT58288A (en) 1992-02-28
CA2044636A1 (en) 1992-01-06
IL98690D0 (en) 1992-07-15
AT111890T (en) 1994-10-15
IE912344A1 (en) 1992-01-15
JPH04230363A (en) 1992-08-19
US5532232A (en) 1996-07-02
MC2261A1 (en) 1993-04-26
NO177704B (en) 1995-07-31
US5260307A (en) 1993-11-09
DE59103021D1 (en) 1994-10-27
AU650458B2 (en) 1994-06-23
HU217815B (en) 2000-04-28
PT98221A (en) 1992-05-29
NO912626L (en) 1992-01-06
AU7949091A (en) 1992-01-09
IE66047B1 (en) 1995-12-13
IL112712A (en) 1996-09-12
EP0468231A2 (en) 1992-01-29

Similar Documents

Publication Publication Date Title
DE69118889D1 (en) R(+)-terazosin
DE69130944D1 (en) Endocurietherapie
DE69125712D1 (en) Hüftprothese
GB2246776B (en) Oxorapamycin
DE69129497D1 (en) Restecholöschung
DE69127457D1 (en) 6-0-methylerythromycin a-derivat
DE4190756D2 (en) Mikrotom
DE59109027D1 (en) Arylpyridazinone
DE69125252D1 (en) Röntgentherapie-simulatormachine
GB2248494B (en) Multi-airconditioner
DE69125374D1 (en) Endonukleasen
AP9100313A0 (en) Compounds
GR3021371T3 (en) Novel neurothrophic factor
DE69126781D1 (en) Fabry-perot-modulator
EP0468231A3 (en) Guanidins
LU90935I2 (en) Azopt-brinzolamide
EP0440282A3 (en) Sensormatrix
HUT60120A (en) Spine-fixture
GB2248257B (en) Corebarrel
GB9015910D0 (en) Novel use
HUT64194A (en) Tooth-brushe
DE69132291D1 (en) Xanthinderivate
GB9001993D0 (en) Photobooth
GB2248044B (en) Improved doll-carriages
ZA9109035B (en) Tnf-muteins