IL112243A - Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them - Google Patents

Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL112243A
IL112243A IL11224395A IL11224395A IL112243A IL 112243 A IL112243 A IL 112243A IL 11224395 A IL11224395 A IL 11224395A IL 11224395 A IL11224395 A IL 11224395A IL 112243 A IL112243 A IL 112243A
Authority
IL
Israel
Prior art keywords
fribinogen
benzazepine
benzodiazepine
antagonists
preparation
Prior art date
Application number
IL11224395A
Other languages
English (en)
Other versions
IL112243A0 (en
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IL112243A0 publication Critical patent/IL112243A0/xx
Publication of IL112243A publication Critical patent/IL112243A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
IL11224395A 1994-01-07 1995-01-04 Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them IL112243A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17901194A 1994-01-07 1994-01-07

Publications (2)

Publication Number Publication Date
IL112243A0 IL112243A0 (en) 1995-03-30
IL112243A true IL112243A (en) 1999-12-31

Family

ID=22654859

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11224395A IL112243A (en) 1994-01-07 1995-01-04 Benzazepine and benzodiazepine fribinogen antagonists a process for their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US6117866A (no)
EP (1) EP0738150B1 (no)
JP (1) JPH09508620A (no)
KR (1) KR100388772B1 (no)
CN (1) CN1117569C (no)
AP (1) AP542A (no)
AT (1) ATE238993T1 (no)
AU (1) AU699186B2 (no)
BG (2) BG62844B1 (no)
BR (1) BR9506499A (no)
CZ (1) CZ292323B6 (no)
DE (1) DE69530571T2 (no)
DK (1) DK0738150T3 (no)
ES (1) ES2197914T3 (no)
HK (1) HK1014668A1 (no)
HU (1) HUT76282A (no)
IL (1) IL112243A (no)
MA (1) MA23420A1 (no)
NO (1) NO962859L (no)
NZ (1) NZ279394A (no)
OA (1) OA10368A (no)
PT (1) PT738150E (no)
SG (1) SG64884A1 (no)
SK (1) SK86996A3 (no)
TW (1) TW420682B (no)
WO (1) WO1995018619A1 (no)
ZA (1) ZA9545B (no)

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US6458784B1 (en) * 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
EP0777657A1 (en) * 1994-08-22 1997-06-11 Smithkline Beecham Corporation Bicyclic compounds
DE19516483A1 (de) 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
ZA9610853B (en) * 1995-12-29 1998-04-06 Smithkline Beecham Corp Processes and intermediates for preparing pharmaceuticals.
ATE245984T1 (de) 1996-09-03 2003-08-15 Smithkline Beecham Corp Kristallines pharmazeutisches produkt
WO1998029561A1 (en) * 1996-12-27 1998-07-09 Smithkline Beecham Plc Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase
KR20010015866A (ko) * 1997-12-09 2001-02-26 모치즈키 노부히코 톨루엔 유도체의 제조방법
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (en) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
GB9908662D0 (en) * 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel process for preparing benzodiazepines
CO5180550A1 (es) * 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
DE60017180T2 (de) 1999-10-08 2005-12-08 Affinium Pharmaceuticals, Inc., Toronto Fab i inhibitoren
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
US6964974B2 (en) * 2000-09-08 2005-11-15 Hoffmann-La Roche Inc. 2,3-oxidosqualene-lanosterol cyclase inhibitors
US7049310B2 (en) 2001-04-06 2006-05-23 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
EP1443963B1 (en) 2001-10-22 2014-05-21 The Scripps Research Institute Antibody targeting compounds
US7691847B2 (en) * 2002-10-17 2010-04-06 The Trustees Of The University Of Pennsylvania Method of treating neurological diseases and disorders
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040234699A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
WO2005035495A2 (en) 2003-10-08 2005-04-21 Nicholas Piramal India Limited Fibrinogen receptor antagonists and their use
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法
IN2014KN02915A (no) 2012-06-19 2015-05-08 Debiopharm Int Sa
ES2842443T3 (es) 2016-02-26 2021-07-14 Debiopharm Int Sa Medicamento para el tratamiento de infecciones del pie diabético

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Also Published As

Publication number Publication date
BR9506499A (pt) 1997-09-09
CN1143323A (zh) 1997-02-19
DE69530571T2 (de) 2004-03-04
CZ292323B6 (cs) 2003-09-17
BG62844B1 (bg) 2000-09-29
HU9601849D0 (en) 1996-09-30
CN1117569C (zh) 2003-08-13
US6117866A (en) 2000-09-12
BG102863A (en) 1999-05-31
CZ198196A3 (en) 1997-06-11
DE69530571D1 (de) 2003-06-05
AP542A (en) 1996-10-01
SK86996A3 (en) 1997-02-05
WO1995018619A1 (en) 1995-07-13
NZ279394A (en) 1998-05-27
ZA9545B (en) 1996-01-23
KR100388772B1 (ko) 2003-11-20
JPH09508620A (ja) 1997-09-02
WO1995018619A9 (en) 2004-10-21
HK1014668A1 (en) 1999-09-30
PT738150E (pt) 2003-08-29
TW420682B (en) 2001-02-01
DK0738150T3 (da) 2003-08-25
AU699186B2 (en) 1998-11-26
ES2197914T3 (es) 2004-01-16
EP0738150A1 (en) 1996-10-23
ATE238993T1 (de) 2003-05-15
AU1600195A (en) 1995-08-01
MA23420A1 (fr) 1995-10-01
SG64884A1 (en) 1999-05-25
AP9500710A0 (en) 1995-01-31
OA10368A (en) 2001-11-15
NO962859L (no) 1996-09-05
EP0738150A4 (en) 1997-03-19
EP0738150B1 (en) 2003-05-02
NO962859D0 (no) 1996-07-05
HUT76282A (en) 1997-07-28
BG100698A (bg) 1997-02-28
IL112243A0 (en) 1995-03-30

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