IL110060A - 5-Amino-8- methyl-7-pyrrolidinylquinoline 3-carboxylic acid derivatives their preparation and pharmaceutical compositions containing them - Google Patents

5-Amino-8- methyl-7-pyrrolidinylquinoline 3-carboxylic acid derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL110060A
IL110060A IL11006094A IL11006094A IL110060A IL 110060 A IL110060 A IL 110060A IL 11006094 A IL11006094 A IL 11006094A IL 11006094 A IL11006094 A IL 11006094A IL 110060 A IL110060 A IL 110060A
Authority
IL
Israel
Prior art keywords
compounds
carboxylic acid
hydrogen atom
alkyl group
lower alkyl
Prior art date
Application number
IL11006094A
Other languages
English (en)
Other versions
IL110060A0 (en
Original Assignee
Hokuriku Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical filed Critical Hokuriku Pharmaceutical
Publication of IL110060A0 publication Critical patent/IL110060A0/xx
Publication of IL110060A publication Critical patent/IL110060A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
IL11006094A 1993-08-27 1994-06-20 5-Amino-8- methyl-7-pyrrolidinylquinoline 3-carboxylic acid derivatives their preparation and pharmaceutical compositions containing them IL110060A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP23431093 1993-08-27
JP28627293 1993-10-22
JP7631894 1994-03-24

Publications (2)

Publication Number Publication Date
IL110060A0 IL110060A0 (en) 1994-10-07
IL110060A true IL110060A (en) 1999-10-28

Family

ID=27302121

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11006094A IL110060A (en) 1993-08-27 1994-06-20 5-Amino-8- methyl-7-pyrrolidinylquinoline 3-carboxylic acid derivatives their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US5547962A (sv)
EP (1) EP0641793B1 (sv)
JP (1) JP2673937B2 (sv)
KR (1) KR100218807B1 (sv)
CN (1) CN1048242C (sv)
AT (1) ATE144508T1 (sv)
AU (1) AU676729B2 (sv)
CA (1) CA2126118C (sv)
CZ (1) CZ286524B6 (sv)
DE (1) DE69400791T2 (sv)
DK (1) DK0641793T3 (sv)
ES (1) ES2096413T3 (sv)
FI (1) FI113174B (sv)
GR (1) GR3021715T3 (sv)
HU (1) HU221952B1 (sv)
IL (1) IL110060A (sv)
MY (1) MY111702A (sv)
NO (1) NO305515B1 (sv)
NZ (1) NZ260851A (sv)
PL (1) PL175870B1 (sv)
SG (1) SG52147A1 (sv)
TW (1) TW252107B (sv)
UA (1) UA39859C2 (sv)

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Publication number Priority date Publication date Assignee Title
CA2210007A1 (en) * 1995-01-24 1996-08-01 Yasuo Ito Quinoline carboxylic acid
US6121285A (en) 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
NZ503740A (en) * 1997-09-15 2002-09-27 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
EP1132375B1 (en) 1998-11-18 2003-07-16 Asahi Glass Company Ltd. Aminoacrylic acid derivatives and process for producing the same
RU2270695C2 (ru) 1999-03-17 2006-02-27 Дайити Фармасьютикал Ко., Лтд. Фармацевтическая композиция
KR100817425B1 (ko) * 2000-02-09 2008-03-27 다이이찌 세이야꾸 가부시기가이샤 피리돈카복실산류를 유효성분으로 하는 항항산균제
KR20020075447A (ko) * 2000-02-25 2002-10-04 다이이찌 세이야꾸 가부시기가이샤 퀴놀론카복실산의 제조방법 및 이의 중간체
US6825353B2 (en) 2000-02-25 2004-11-30 Daiichi Pharmaceutical Co., Ltd. Process for producing quinolonecarboxylic acids and intermediates thereof
KR20010044286A (ko) * 2001-02-01 2001-06-05 남근수 알킬-3-(2,6-디할로겐-5-플루오로)-옥소-3-피리딘프로피오네이트의 제조방법
WO2006123767A1 (ja) * 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited 不斉四置換炭素原子含有化合物の製法
EP1930321A4 (en) * 2005-09-28 2011-04-27 Daiichi Sankyo Co Ltd PROCESS FOR THE SYNTHESIS OF 5-AZASPIRO [2.4] -HEPTANE TETRASUBSTITUTED DERIVATIVES AND OPTICALLY ACTIVE INTERMEDIATES THEREOF
KR20110082635A (ko) * 2006-03-28 2011-07-19 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
PL2001862T3 (pl) * 2006-03-28 2011-09-30 Warner Chilcott Co Llc Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego
JP4876165B2 (ja) * 2006-03-28 2012-02-15 ザ プロクター アンド ギャンブル カンパニー キノロン中間体を調製するための水素化物還元法
TWI362386B (en) 2007-03-30 2012-04-21 Daiichi Sankyo Co Ltd A production method for the qunolon-carboxylic acid derivative
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens

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US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
JPH0637489B2 (ja) * 1985-09-21 1994-05-18 杏林製薬株式会社 キノロンカルボン酸誘導体およびその製造方法
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
ATE58538T1 (de) * 1986-07-04 1990-12-15 Chemie Linz Gmbh 4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
JPS63152318A (ja) * 1986-08-07 1988-06-24 Dainippon Pharmaceut Co Ltd 抗マイコプラズマ剤
US5190955A (en) * 1987-01-28 1993-03-02 Bayer Aktiengesellschaft Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
JPS63275567A (ja) * 1987-05-07 1988-11-14 Dainippon Pharmaceut Co Ltd 新規キノリン誘導体、そのエステルおよびその塩
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
JPH0219377A (ja) * 1988-07-08 1990-01-23 Kyorin Pharmaceut Co Ltd ８‐メチルキノロンカルボン酸誘導体
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
US5286723A (en) * 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
IL91648A (en) * 1988-09-22 1997-03-18 Abbott Lab Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
PT93420A (pt) * 1989-03-15 1990-11-07 Kanebo Ltd Processo para a preparacao de derivados de acido quinolinocarboxilico e de composicoes antibacterianas que os contem
US5153203A (en) * 1989-03-30 1992-10-06 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and salts thereof, preparation processes thereof, and antibacterial agents containing the same
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
DE3910920A1 (de) * 1989-04-05 1990-10-11 Bayer Ag Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren
DE4032560A1 (de) * 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
WO1992010492A1 (en) * 1990-12-05 1992-06-25 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds useful as antibacterial agents
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
KR950014567B1 (ko) * 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체

Also Published As

Publication number Publication date
TW252107B (sv) 1995-07-21
AU676729B2 (en) 1997-03-20
SG52147A1 (en) 1998-09-28
EP0641793A1 (en) 1995-03-08
IL110060A0 (en) 1994-10-07
UA39859C2 (uk) 2001-07-16
CA2126118A1 (en) 1995-02-28
NZ260851A (en) 1996-03-26
HU9401954D0 (en) 1994-09-28
CZ286524B6 (cs) 2000-05-17
NO942309D0 (no) 1994-06-17
PL175870B1 (pl) 1999-02-26
KR950005823A (ko) 1995-03-20
JP2673937B2 (ja) 1997-11-05
CZ157494A3 (en) 1995-10-18
PL304063A1 (en) 1995-03-06
CN1048242C (zh) 2000-01-12
ES2096413T3 (es) 1997-03-01
US5547962A (en) 1996-08-20
ATE144508T1 (de) 1996-11-15
GR3021715T3 (en) 1997-02-28
DE69400791D1 (de) 1996-11-28
NO942309L (no) 1995-02-28
CN1117491A (zh) 1996-02-28
JPH07309864A (ja) 1995-11-28
HUT67259A (en) 1995-03-28
AU6487094A (en) 1995-03-09
HU221952B1 (hu) 2003-03-28
DK0641793T3 (da) 1996-11-25
KR100218807B1 (ko) 1999-09-01
MY111702A (en) 2000-11-30
EP0641793B1 (en) 1996-10-23
NO305515B1 (no) 1999-06-14
FI942976A (sv) 1995-02-28
FI113174B (sv) 2004-03-15
DE69400791T2 (de) 1997-03-06
FI942976A0 (sv) 1994-06-21
CA2126118C (en) 2001-02-06

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