IL109602A - Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them - Google Patents

Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL109602A
IL109602A IL10960294A IL10960294A IL109602A IL 109602 A IL109602 A IL 109602A IL 10960294 A IL10960294 A IL 10960294A IL 10960294 A IL10960294 A IL 10960294A IL 109602 A IL109602 A IL 109602A
Authority
IL
Israel
Prior art keywords
urethanes
pharmaceutical compositions
cytokine production
ureas
preparation
Prior art date
Application number
IL10960294A
Other languages
English (en)
Other versions
IL109602A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL109602A0 publication Critical patent/IL109602A0/xx
Publication of IL109602A publication Critical patent/IL109602A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL10960294A 1993-05-12 1994-05-09 Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them IL109602A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/063,174 US5312831A (en) 1993-05-12 1993-05-12 Urethanes and ureas that induce cytokine production

Publications (2)

Publication Number Publication Date
IL109602A0 IL109602A0 (en) 1994-08-26
IL109602A true IL109602A (en) 2000-06-01

Family

ID=22047440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10960294A IL109602A (en) 1993-05-12 1994-05-09 Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (6) US5312831A (ja)
EP (1) EP0652228B1 (ja)
JP (1) JP3583469B2 (ja)
KR (1) KR100296543B1 (ja)
CN (1) CN1094943C (ja)
AT (1) ATE144533T1 (ja)
AU (1) AU669064B2 (ja)
CA (1) CA2123261A1 (ja)
CZ (1) CZ290445B6 (ja)
DE (1) DE69400798T2 (ja)
DK (1) DK0652228T3 (ja)
ES (1) ES2094004T3 (ja)
FI (1) FI942186A (ja)
GR (1) GR3022253T3 (ja)
HU (1) HU219768B (ja)
IL (1) IL109602A (ja)
NO (1) NO311223B1 (ja)
NZ (1) NZ260507A (ja)
PH (1) PH30182A (ja)
PL (1) PL179984B1 (ja)
RU (1) RU2135515C1 (ja)
SG (1) SG43071A1 (ja)
SI (1) SI0652228T1 (ja)
SK (1) SK281120B6 (ja)
TW (1) TW380129B (ja)
ZA (1) ZA943266B (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1007183A3 (fr) * 1993-06-18 1995-04-18 Solvay Ureines derivees d'alpha, omega-diaminoacides et procede pour leur preparation.
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
BR9709952A (pt) * 1996-06-27 1999-08-10 Smithkline Beecham Corp Antagonistas de receptor de il-8
EP0915651A4 (en) 1996-06-27 2001-10-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
WO1998006398A1 (en) * 1996-08-15 1998-02-19 Smithkline Beecham Corporation Il-8 receptor antagonists
EP1072591A4 (en) * 1998-03-26 2005-01-05 Santen Pharmaceutical Co Ltd NEW UREA CONNECTIONS
US7465754B1 (en) 1999-09-15 2008-12-16 Wyeth Method of potentiating chemotherapy and treating solid tumors
US7332158B2 (en) * 2002-05-29 2008-02-19 Demao Yang Compositions and treatments for myelosuppression by ex vivo activated immune cells
US7048922B2 (en) * 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
US20060057121A1 (en) * 2004-09-10 2006-03-16 Demao Yang Compositions and treatments using ex vivo activated cells for myelosuppressed patients
EA014958B1 (ru) * 2006-04-21 2011-04-29 Смитклайн Бичам Корпорейшн Антагонисты рецептора il-8
WO2007124423A2 (en) * 2006-04-21 2007-11-01 Smithkline Beecham Corporation Il-8 receptor antagonists
AR061571A1 (es) * 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
WO2013148965A2 (en) 2012-03-30 2013-10-03 Givaudan S.A. Improvements in or relating to organic compounds
WO2013149025A1 (en) * 2012-03-30 2013-10-03 Givaudan, S., A. N-acyl serine derivatives as food flavouring compounds
SG11201405295WA (en) 2012-03-30 2014-11-27 Givaudan Sa N-acyl-amino acid derivatives for improvement of the flavour profile edible|compositions
KR102045592B1 (ko) 2012-03-30 2019-11-15 지보당 에스아 식품 향미 화합물로서의 n-아실 프롤린 유도체
US10582715B2 (en) 2012-03-30 2020-03-10 Givaudan Sa Powder flavour composition
CN104244734B (zh) 2012-03-30 2018-04-03 奇华顿股份有限公司 作为食品加香化合物的n‑酰化1‑氨基环烷基羧酸
US10913922B2 (en) 2012-03-30 2021-02-09 Givaudan S.A. N-acylated methionine derivatives as food flavoring compounds
SG11201405413SA (en) 2012-03-30 2014-10-30 Givaudan Sa N-acyl derivatives of gamma amino - butyric acid and and beta alanine as food flavouring compounds
CN105636934B (zh) 2013-10-02 2019-03-29 奇华顿股份有限公司 N-酰化的2-氨基异丁酸化合物和包含它们的香味组合物
WO2015050537A1 (en) 2013-10-02 2015-04-09 Givaudan S.A. Organic compounds
EP3057447B1 (en) 2013-10-02 2017-12-06 Givaudan S.A. Organic compounds having taste-modifying properties
GB201317424D0 (en) * 2013-10-02 2013-11-13 Givaudan Sa Improvements in or relating to organic compounds
CN105636459A (zh) 2013-10-02 2016-06-01 奇华顿股份有限公司 有机化合物
WO2015050535A1 (en) 2013-10-02 2015-04-09 Givaudan S.A. Organic compounds
US10834943B2 (en) 2013-10-02 2020-11-17 Givaudan S.A. Organic compounds having taste-modifying properties
CN105592720B (zh) 2013-10-02 2020-07-07 奇华顿股份有限公司 具有味道改进特性的有机化合物
CA3072735A1 (en) 2017-08-21 2019-02-28 Celgene Corporation Processes for the preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate
CN109601739B (zh) * 2019-01-17 2022-10-14 河南湾流生物科技有限公司 一种复合氨基酸饲料添加剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2033906B (en) * 1978-10-19 1982-12-01 Anvar Water-soluble compounds derived from extracts of streptomyces stimulosus process for their production and compositions containing them
US4725582A (en) * 1978-11-14 1988-02-16 Fujisawa Pharmaceutical Company, Ltd. Peptide, process for preparation thereof and use thereof
US4349466A (en) * 1978-11-14 1982-09-14 Fujisawa Pharmaceutical Co Peptide, process for preparation thereof and use thereof
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
AU664210B2 (en) * 1991-09-27 1995-11-09 Board Of Regents, The University Of Texas System Amino acids containing parenteral formulations for the treatment of hypotension and related pathologies

Also Published As

Publication number Publication date
CA2123261A1 (en) 1994-11-13
FI942186A (fi) 1994-11-13
RU2135515C1 (ru) 1999-08-27
SI0652228T1 (en) 1997-10-31
ES2094004T3 (es) 1997-01-01
US5545662A (en) 1996-08-13
CN1100413A (zh) 1995-03-22
US5633280A (en) 1997-05-27
KR100296543B1 (ko) 2001-11-22
GR3022253T3 (en) 1997-04-30
CZ290445B6 (cs) 2002-07-17
HU219768B (hu) 2001-07-30
CZ98194A3 (en) 1994-12-15
NZ260507A (en) 1996-02-27
FI942186A0 (fi) 1994-05-11
US5602275A (en) 1997-02-11
DE69400798D1 (de) 1996-11-28
AU669064B2 (en) 1996-05-23
US5312831A (en) 1994-05-17
TW380129B (en) 2000-01-21
US5658945A (en) 1997-08-19
PH30182A (en) 1997-01-21
US5616612A (en) 1997-04-01
AU6304394A (en) 1994-11-17
HU9401444D0 (en) 1994-08-29
PL179984B1 (pl) 2000-11-30
CN1094943C (zh) 2002-11-27
EP0652228A1 (en) 1995-05-10
SK281120B6 (sk) 2000-12-11
SG43071A1 (en) 1997-10-17
JP3583469B2 (ja) 2004-11-04
EP0652228B1 (en) 1996-10-23
NO941786L (no) 1994-11-14
NO311223B1 (no) 2001-10-29
ATE144533T1 (de) 1996-11-15
DE69400798T2 (de) 1997-03-13
HUT67038A (en) 1995-01-30
ZA943266B (en) 1995-01-12
DK0652228T3 (da) 1996-11-25
SK49194A3 (en) 1995-02-08
JPH07179414A (ja) 1995-07-18
NO941786D0 (no) 1994-05-11
IL109602A0 (en) 1994-08-26

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees