IL108892A - Aza cyclohexapeptide compounds and antimicrobial compositions containing them - Google Patents

Aza cyclohexapeptide compounds and antimicrobial compositions containing them

Info

Publication number
IL108892A
IL108892A IL10889294A IL10889294A IL108892A IL 108892 A IL108892 A IL 108892A IL 10889294 A IL10889294 A IL 10889294A IL 10889294 A IL10889294 A IL 10889294A IL 108892 A IL108892 A IL 108892A
Authority
IL
Israel
Prior art keywords
compositions containing
antimicrobial compositions
aza cyclohexapeptide
cyclohexapeptide compounds
compounds
Prior art date
Application number
IL10889294A
Other languages
English (en)
Other versions
IL108892D0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US08/032,847 priority Critical patent/US5378804A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL108892D0 publication Critical patent/IL108892D0/xx
Publication of IL108892A publication Critical patent/IL108892A/xx
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL108892(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/27Cyclic peptide or cyclic protein
IL10889294A 1993-03-16 1994-03-08 Aza cyclohexapeptide compounds and antimicrobial compositions containing them IL108892A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
IL108892D0 IL108892D0 (en) 1994-06-24
IL108892A true IL108892A (en) 1998-07-15

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10889294A IL108892A (en) 1993-03-16 1994-03-08 Aza cyclohexapeptide compounds and antimicrobial compositions containing them

Country Status (31)

Country Link
US (3) US5378804A (xx)
EP (1) EP0620232B1 (xx)
JP (1) JP2568474B2 (xx)
CN (1) CN1098274C (xx)
AT (1) AT186736T (xx)
AU (1) AU668804B2 (xx)
BG (1) BG63047B1 (xx)
BR (2) BR9406009A (xx)
CA (1) CA2118757C (xx)
CZ (1) CZ286235B6 (xx)
DE (2) DE10299013I2 (xx)
DK (1) DK0620232T3 (xx)
ES (1) ES2139043T3 (xx)
FI (1) FI109542B (xx)
GR (1) GR3031872T3 (xx)
HK (1) HK1008674A1 (xx)
HR (1) HRP940161B1 (xx)
HU (2) HU217614B (xx)
IL (1) IL108892A (xx)
LU (1) LU90875I2 (xx)
LV (1) LV12574B (xx)
NL (1) NL300076I2 (xx)
NO (2) NO318372B1 (xx)
NZ (1) NZ263360A (xx)
PL (1) PL179261B1 (xx)
RO (1) RO113246B1 (xx)
RU (1) RU2122548C1 (xx)
SI (1) SI9420013B (xx)
SK (1) SK282527B6 (xx)
WO (1) WO1994021677A1 (xx)
ZA (1) ZA9401807B (xx)

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US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
WO1996006109A1 (en) * 1994-08-23 1996-02-29 Merck & Co., Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
WO1996008266A1 (en) * 1994-09-16 1996-03-21 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
AT206054T (de) * 1995-01-26 2001-10-15 Merck & Co Inc Neue fungizide cyclohexapeptide
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
WO1997017365A1 (en) * 1995-11-09 1997-05-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
ES2203819T3 (es) * 1996-09-12 2004-04-16 MERCK & CO., INC. Terapia antifungica combinada.
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
WO2001007468A2 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
AT381957T (de) 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
WO2005080423A1 (en) * 2004-02-24 2005-09-01 Commonwealth Scientific And Industrial Research Organisation Antifungal peptides
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
JP5373606B2 (ja) * 2006-07-26 2013-12-18 サンド・アクチエンゲゼルシヤフト カスポファンギン製剤
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
JP5537425B2 (ja) * 2007-06-26 2014-07-02 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 凍結乾燥抗真菌組成物
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2183271A1 (en) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Caspofungin free of caspofungin impurity a
WO2010008493A2 (en) * 2008-06-25 2010-01-21 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TWI374894B (xx) * 2008-12-31 2012-10-21
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
WO2011014990A1 (zh) * 2009-08-06 2011-02-10 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司;上海医药工业研究院 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
JP5914486B2 (ja) 2010-09-20 2016-05-11 クセリア ファーマシューティカルズ エーピーエスXellia Pharmaceuticals ApS カスポファンギン組成物
CN102432674B (zh) * 2010-09-29 2014-01-22 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
JP6000255B2 (ja) * 2010-09-30 2016-09-28 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
US20140005355A1 (en) * 2011-01-03 2014-01-02 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
CN106279369A (zh) 2011-03-03 2017-01-04 奇达拉治疗公司 抗真菌剂及其应用
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
TWI597293B (zh) 2011-04-28 2017-09-01 江蘇盛迪醫藥有限公司 用於合成卡帕芬淨的中間體及其製備方法
JP6117907B2 (ja) 2012-03-19 2017-04-19 シダラ セラピューティクス インコーポレーテッド エキノキャンディン系化合物のための投与レジメン
DK2922530T3 (en) * 2012-11-20 2017-01-09 Fresenius Kabi Usa Llc Caspofunginacetatformuleringer
CN105481952A (zh) * 2014-12-24 2016-04-13 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
WO2017034961A1 (en) 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
EP3399995A4 (en) 2016-01-08 2019-08-21 Cidara Therapeutics Inc Methods for preventing and treating pneumocystis infections
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities

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BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
GB2065130A (en) * 1979-12-13 1981-06-24 Lilly Co Eli Recovery process for a-30912 antibiotics
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc Antifungal antibiotic echinocandin derivative, its production and pharmaceutical compositions containing it
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GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
NZ299314A (en) * 1992-03-19 2001-09-28 Lilly Co Eli Cyclic peptide for inhibiting parasitic and antifungal activity
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
HK1008674A1 (en) 2000-07-07
HU217614B (hu) 2000-03-28
NL300076I1 (nl) 2002-03-01
SK113695A3 (en) 1996-02-07
DE69421639T2 (de) 2000-06-08
CA2118757C (en) 2002-05-14
ES2139043T3 (es) 2000-02-01
BR1100273A (pt) 1999-10-13
PL179261B1 (en) 2000-08-31
US5514650A (en) 1996-05-07
CA2118757A1 (en) 1994-09-17
NO2005020I1 (no) 2005-09-13
NZ263360A (en) 1997-08-22
US5792746A (en) 1998-08-11
US5378804A (en) 1995-01-03
SI9420013B (sl) 2002-12-31
LU90875A9 (xx)
PL310634A1 (en) 1995-12-27
LU90875I2 (en) 2002-03-04
LV12574A (en) 2000-11-20
NO953648L (no) 1995-11-15
KR960701092A (ko) 1996-02-24
HU9502703D0 (en) 1995-11-28
FI954327A0 (fi) 1995-09-14
HUT73496A (en) 1996-08-28
IL108892D0 (en) 1994-06-24
NO2005020I2 (no) 2008-12-01
AU5783294A (en) 1994-09-22
RU2122548C1 (ru) 1998-11-27
DE10299013I2 (de) 2009-11-19
AU668804B2 (en) 1996-05-16
JPH06321986A (ja) 1994-11-22
BR9406009A (pt) 1995-12-26
FI954327A (fi) 1995-09-14
RO113246B1 (ro) 1998-05-29
ZA9401807B (en) 1994-10-13
DK620232T3 (xx)
FI954327D0 (xx)
NO318372B1 (no) 2005-03-14
DK0620232T3 (da) 2000-03-13
DE69421639D1 (de) 1999-12-23
NO953648D0 (no) 1995-09-15
HRP940161A2 (en) 1996-08-31
DE10299013I1 (de) 2003-01-23
SI9420013A (en) 1996-08-31
BG63047B1 (bg) 2001-02-28
WO1994021677A1 (en) 1994-09-29
NL300076I2 (nl) 2002-04-02
FI109542B (fi) 2002-08-30
SK282527B6 (sk) 2002-10-08
HRP940161B1 (en) 2001-04-30
CZ235895A3 (en) 1996-02-14
CZ286235B6 (cs) 2000-02-16
BG99999A (bg) 1996-04-30
EP0620232A1 (en) 1994-10-19
GR3031872T3 (en) 2000-02-29
FI109542B1 (xx)
JP2568474B2 (ja) 1997-01-08
HU211890A9 (en) 1995-12-28
CN1119441A (zh) 1996-03-27
CN1098274C (zh) 2003-01-08
AT186736T (de) 1999-12-15
EP0620232B1 (en) 1999-11-17
LV12574B (en) 2001-04-20

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