IL106330A - Method and instrument for determining the activity of their plaques in the initial coagulation system - Google Patents
Method and instrument for determining the activity of their plaques in the initial coagulation systemInfo
- Publication number
- IL106330A IL106330A IL106330A IL10633093A IL106330A IL 106330 A IL106330 A IL 106330A IL 106330 A IL106330 A IL 106330A IL 10633093 A IL10633093 A IL 10633093A IL 106330 A IL106330 A IL 106330A
- Authority
- IL
- Israel
- Prior art keywords
- vessel
- aggregation
- blood
- ecm
- platelets
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 230000023597 hemostasis Effects 0.000 title claims abstract description 26
- 210000001772 blood platelet Anatomy 0.000 claims abstract description 62
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims abstract description 44
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims abstract description 44
- 210000002744 extracellular matrix Anatomy 0.000 claims abstract description 44
- 239000008280 blood Substances 0.000 claims abstract description 33
- 230000002776 aggregation Effects 0.000 claims abstract description 25
- 238000004220 aggregation Methods 0.000 claims abstract description 25
- 239000000758 substrate Substances 0.000 claims abstract description 11
- 230000001939 inductive effect Effects 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 8
- 239000003146 anticoagulant agent Substances 0.000 claims description 7
- 229940127219 anticoagulant drug Drugs 0.000 claims description 7
- 102100036537 von Willebrand factor Human genes 0.000 claims description 7
- 239000011159 matrix material Substances 0.000 claims description 5
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 102000016359 Fibronectins Human genes 0.000 claims description 3
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- 210000002469 basement membrane Anatomy 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 229960001134 von willebrand factor Drugs 0.000 claims description 3
- 230000023555 blood coagulation Effects 0.000 claims description 2
- 238000009826 distribution Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 31
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- 208000013607 Glanzmann thrombasthenia Diseases 0.000 description 10
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- 238000012360 testing method Methods 0.000 description 8
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
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- YMHOBZXQZVXHBM-UHFFFAOYSA-N 2,5-dimethoxy-4-bromophenethylamine Chemical compound COC1=CC(CCN)=C(OC)C=C1Br YMHOBZXQZVXHBM-UHFFFAOYSA-N 0.000 description 1
- 206010005133 Bleeding tendencies Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 208000032371 Glanzmann thrombasthenia 1 Diseases 0.000 description 1
- 208000024659 Hemostatic disease Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 102000007625 Hirudins Human genes 0.000 description 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 1
- 229940006607 hirudin Drugs 0.000 description 1
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- 238000003760 magnetic stirring Methods 0.000 description 1
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- 230000036961 partial effect Effects 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
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- 238000010008 shearing Methods 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL106330A IL106330A (en) | 1993-07-14 | 1993-07-14 | Method and instrument for determining the activity of their plaques in the initial coagulation system |
| US08/273,549 US5523238A (en) | 1993-07-14 | 1994-07-11 | Method and apparatus for determining platelet function in primary hemostasis |
| AU67384/94A AU682692B2 (en) | 1993-07-14 | 1994-07-12 | Method and apparatus for determining platelet function in primary hemostasis |
| JP18390694A JP3396705B2 (ja) | 1993-07-14 | 1994-07-13 | 一次止血における血小板の機能を測定する方法および装置 |
| ES94401634T ES2160618T3 (es) | 1993-07-14 | 1994-07-13 | Metodo y aparato para la determinacion de la funcion plaquetaria en la hemostasis primaria. |
| DK94401634T DK0635720T3 (da) | 1993-07-14 | 1994-07-13 | Fremgangsmåde og apparat til bestemmelse af blodpladefunktion i primær hæmostase |
| KR1019940016810A KR100346993B1 (ko) | 1993-07-14 | 1994-07-13 | 일차지혈에있어서혈소판의기능을측정하기위한방법및장치 |
| EP94401634A EP0635720B1 (en) | 1993-07-14 | 1994-07-13 | Method and apparatus for determining platelet function in primary hemostasis |
| CA002127899A CA2127899C (en) | 1993-07-14 | 1994-07-13 | Method and apparatus for determining platelet function in primary hemostasis |
| DE69427560T DE69427560T2 (de) | 1993-07-14 | 1994-07-13 | Verfahren und Vorrichtung zur Feststellung der Plättchenfunktion in primärer Blutstillung |
| AT94401634T ATE202631T1 (de) | 1993-07-14 | 1994-07-13 | Verfahren und vorrichtung zur feststellung der plättchenfunktion in primärer blutstillung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL106330A IL106330A (en) | 1993-07-14 | 1993-07-14 | Method and instrument for determining the activity of their plaques in the initial coagulation system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106330A0 IL106330A0 (en) | 1993-11-15 |
| IL106330A true IL106330A (en) | 1998-01-04 |
Family
ID=11065042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL106330A IL106330A (en) | 1993-07-14 | 1993-07-14 | Method and instrument for determining the activity of their plaques in the initial coagulation system |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5523238A (es) |
| EP (1) | EP0635720B1 (es) |
| JP (1) | JP3396705B2 (es) |
| KR (1) | KR100346993B1 (es) |
| AT (1) | ATE202631T1 (es) |
| AU (1) | AU682692B2 (es) |
| CA (1) | CA2127899C (es) |
| DE (1) | DE69427560T2 (es) |
| DK (1) | DK0635720T3 (es) |
| ES (1) | ES2160618T3 (es) |
| IL (1) | IL106330A (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040247611A1 (en) * | 1994-05-23 | 2004-12-09 | Montana State University | Identification of pathogen-ligand interactions |
| US5763199A (en) * | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
| US5783446A (en) * | 1996-03-04 | 1998-07-21 | Biocircuits Corporation | Particle assay using fluid velocity gradients |
| US6043871A (en) * | 1997-03-03 | 2000-03-28 | Brigham Young University | System and method for measuring blood platelet function |
| US20040219681A1 (en) * | 1997-09-18 | 2004-11-04 | Ridgway Helen Jane | Two-tube method and system for platelet function analysis using platelet count |
| US20040219682A1 (en) * | 1997-09-18 | 2004-11-04 | Ridgway Helen Jane | Single-tube method and system for platelet function analysis |
| US6410337B1 (en) * | 1997-09-18 | 2002-06-25 | Helena Laboratories Corporation | Method of platlet function analysis using platelet count |
| US6251615B1 (en) | 1998-02-20 | 2001-06-26 | Cell Analytics, Inc. | Cell analysis methods |
| AUPP660798A0 (en) * | 1998-10-20 | 1998-11-12 | Monash University | Method for measuring cellular adhesion |
| US8008086B2 (en) * | 1999-02-22 | 2011-08-30 | Cora Healthcare, Inc. | Protocol for monitoring direct thrombin inhibition |
| US7179652B2 (en) * | 1999-02-22 | 2007-02-20 | Haemoscope Corporation | Protocol for monitoring platelet inhibition |
| US7732213B2 (en) * | 1999-02-22 | 2010-06-08 | Coramed Healthcare, Inc. | Method of evaluating patient hemostasis |
| US6225126B1 (en) * | 1999-02-22 | 2001-05-01 | Haemoscope Corporation | Method and apparatus for measuring hemostasis |
| DE19939252A1 (de) * | 1999-08-16 | 2001-04-19 | Volker Goltz | Verfahren und Vorrichtung zur Untersuchung von Blut |
| DE10003093C2 (de) * | 2000-01-25 | 2002-05-16 | Goltz Volker Freiherr Von | Vorrichtung zur Untersuchung von Eigenschaften der globalen Hämostasefunktion in Vollblut oder plättchenreichem Plasma |
| US6989272B1 (en) | 2001-03-06 | 2006-01-24 | David Varon | Apparatus and method for processing and testing a biological specimen |
| US20040171002A1 (en) * | 2001-04-26 | 2004-09-02 | Gert Desmet | Method for acceleration and intensification of target-receptor binding and devices therefor |
| US20040131500A1 (en) * | 2002-01-18 | 2004-07-08 | Chow Herbert S. | Device and method for evaluating platelets |
| US20050202566A1 (en) * | 2002-02-14 | 2005-09-15 | Maurice Frojmovic | Device and method for determining parameters |
| JP2005538383A (ja) * | 2002-09-10 | 2005-12-15 | プラコア・インコーポレーテッド | 血小板機能を監視する方法および装置 |
| JP3746756B2 (ja) * | 2002-10-22 | 2006-02-15 | 株式会社日立製作所 | 溶液攪拌装置、溶液攪拌方法 |
| US7262059B2 (en) * | 2003-05-06 | 2007-08-28 | Thrombodyne, Inc. | Systems and methods for measuring fluid properties |
| US7393690B2 (en) * | 2003-05-06 | 2008-07-01 | Thrombodyne, Inc. | Systems and methods for measuring fluid properties |
| ATE536889T1 (de) * | 2003-07-08 | 2011-12-15 | Accumetrics Inc | Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten |
| US20070243632A1 (en) * | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7524670B2 (en) * | 2003-08-05 | 2009-04-28 | Haemoscope Corporation | Protocol and apparatus for determining heparin-induced thrombocytopenia |
| US20050032200A1 (en) * | 2003-08-08 | 2005-02-10 | Ming-Tsung Sun | Shear stress inducing apparatus and automatic shear stress inducing system |
| DE102004006316A1 (de) | 2004-02-09 | 2005-08-25 | Michael Prof. Dr. Kratzer | Einrichtung zur Messung der Aggregation und/oder der Koagulation und/oder der Viskosität des Blutes |
| US7439069B2 (en) * | 2004-02-27 | 2008-10-21 | Nippoldt Douglas D | Blood coagulation test cartridge, system, and method |
| US7422905B2 (en) * | 2004-02-27 | 2008-09-09 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
| US7399637B2 (en) * | 2004-04-19 | 2008-07-15 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
| US8486337B2 (en) * | 2004-04-21 | 2013-07-16 | Vdg-Von Der Goltz Gmbh | Device for analyzing the coagulation or aggregation behavior of blood |
| US7745223B2 (en) | 2004-08-12 | 2010-06-29 | C A Casyso Ag | Device with novel and improved surface properties |
| US7544514B2 (en) | 2004-12-27 | 2009-06-09 | David Varon | Method and system for determining platelet-mediated clot formation |
| US20060269978A1 (en) * | 2005-04-25 | 2006-11-30 | Haworth William S | Method and device for monitoring platelet function |
| US20100099130A1 (en) * | 2006-10-25 | 2010-04-22 | Placor Inc. | Methods and devices for monitoring platelet function |
| JP4926854B2 (ja) * | 2007-06-27 | 2012-05-09 | シスメックス株式会社 | 血小板凝集測定方法および血小板凝集測定装置 |
| WO2009111615A2 (en) | 2008-03-05 | 2009-09-11 | Thrombovision, Inc. | Systems for measuring properties of a physiological fluid suspension |
| WO2010058412A1 (en) * | 2008-11-19 | 2010-05-27 | Dilip Shrinivas Velaskar | A new rapid thrombochek test kit based on whole blood screening test to detect platelet hyperaggregation at a temparature of 37°c in the clinical laboratory |
| US9546981B2 (en) * | 2012-08-22 | 2017-01-17 | Neotek Biosciences Co. Ltd. | Device and method for performing blood thromboelastographic assays by magnetic sensing |
| US10823743B1 (en) * | 2013-10-28 | 2020-11-03 | Ifirst Medical Technologies, Inc. | Methods of measuring coagulation of a biological sample |
| CN103638856B (zh) * | 2013-12-04 | 2015-11-11 | 西北大学 | 磁子悬浮式磁力搅拌器 |
| CN106438668A (zh) * | 2016-08-30 | 2017-02-22 | 诺泰科生物科技（苏州）有限公司 | 一种连接组件、支架、血栓弹力仪及使用方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5967936A (ja) * | 1982-10-08 | 1984-04-17 | テルモ株式会社 | 採血管 |
| DE3522098A1 (de) * | 1985-06-20 | 1987-01-02 | Jung Friedrich | Vorrichtung zur bestimmung einer der erythrozytenaggregation entsprechenden me?groesse |
| US4880788A (en) * | 1987-10-30 | 1989-11-14 | Baylor College Of Medicine | Method for preventing and treating thrombosis |
| EP0337300B1 (en) * | 1988-04-08 | 1994-11-09 | Toray Industries, Inc. | Apparatus and method for determining functions of cells |
-
1993
- 1993-07-14 IL IL106330A patent/IL106330A/en not_active IP Right Cessation
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1994
- 1994-07-11 US US08/273,549 patent/US5523238A/en not_active Expired - Lifetime
- 1994-07-12 AU AU67384/94A patent/AU682692B2/en not_active Ceased
- 1994-07-13 CA CA002127899A patent/CA2127899C/en not_active Expired - Fee Related
- 1994-07-13 AT AT94401634T patent/ATE202631T1/de not_active IP Right Cessation
- 1994-07-13 DK DK94401634T patent/DK0635720T3/da active
- 1994-07-13 ES ES94401634T patent/ES2160618T3/es not_active Expired - Lifetime
- 1994-07-13 KR KR1019940016810A patent/KR100346993B1/ko not_active IP Right Cessation
- 1994-07-13 DE DE69427560T patent/DE69427560T2/de not_active Expired - Lifetime
- 1994-07-13 EP EP94401634A patent/EP0635720B1/en not_active Expired - Lifetime
- 1994-07-13 JP JP18390694A patent/JP3396705B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU6738494A (en) | 1995-01-27 |
| US5523238A (en) | 1996-06-04 |
| JPH07146291A (ja) | 1995-06-06 |
| KR960014934A (ko) | 1996-05-22 |
| EP0635720B1 (en) | 2001-06-27 |
| JP3396705B2 (ja) | 2003-04-14 |
| DE69427560T2 (de) | 2002-04-18 |
| KR100346993B1 (ko) | 2002-11-29 |
| IL106330A0 (en) | 1993-11-15 |
| ES2160618T3 (es) | 2001-11-16 |
| DE69427560D1 (de) | 2001-08-02 |
| CA2127899C (en) | 2003-12-16 |
| CA2127899A1 (en) | 1995-01-15 |
| EP0635720A3 (en) | 1996-06-12 |
| DK0635720T3 (da) | 2001-08-27 |
| AU682692B2 (en) | 1997-10-16 |
| ATE202631T1 (de) | 2001-07-15 |
| EP0635720A2 (en) | 1995-01-25 |
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