IL103319D0 - Novel 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines - Google Patents

Novel 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Info

Publication number
IL103319D0
IL103319D0 IL103319A IL10331992A IL103319D0 IL 103319 D0 IL103319 D0 IL 103319D0 IL 103319 A IL103319 A IL 103319A IL 10331992 A IL10331992 A IL 10331992A IL 103319 D0 IL103319 D0 IL 103319D0
Authority
IL
Israel
Prior art keywords
deoxytetracyclines
demethyl
amino
substituted
novel
Prior art date
Application number
IL103319A
Other versions
IL103319A (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/771,697 priority Critical patent/US5281628A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL103319D0 publication Critical patent/IL103319D0/en
Publication of IL103319A publication Critical patent/IL103319A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/461,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
IL10331992A 1991-10-04 1992-10-01 9-Amino-7-(substituted amino)-6-demethyl-6- deoxytetracyclines intermediates thereof their production and pharmaceutical compositions containing them IL103319A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (2)

Publication Number Publication Date
IL103319D0 true IL103319D0 (en) 1993-03-15
IL103319A IL103319A (en) 1996-07-23

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10331992A IL103319A (en) 1991-10-04 1992-10-01 9-Amino-7-(substituted amino)-6-demethyl-6- deoxytetracyclines intermediates thereof their production and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (3) US5281628A (en)
EP (1) EP0535346B1 (en)
JP (1) JP3183729B2 (en)
KR (1) KR100261528B1 (en)
CN (1) CN1053182C (en)
AT (1) AT129697T (en)
AU (1) AU651734B2 (en)
CA (1) CA2079703C (en)
CZ (1) CZ285015B6 (en)
DE (2) DE69205792D1 (en)
DK (1) DK0535346T3 (en)
ES (1) ES2081005T3 (en)
FI (1) FI111716B (en)
GR (1) GR3017978T3 (en)
HK (1) HK1000319A1 (en)
HU (2) HU211214B (en)
IL (1) IL103319A (en)
MX (1) MX9205573A (en)
NO (1) NO300129B1 (en)
NZ (1) NZ244556A (en)
PH (1) PH30343A (en)
PL (2) PL170933B1 (en)
SK (1) SK281113B6 (en)
TW (1) TW222616B (en)
ZA (1) ZA9207608B (en)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DK0643775T3 (en) * 1992-05-28 2004-09-06 Ct For Molecular Biology And M Quinone derivatives to improve cellular bioenergy
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
CA2183565A1 (en) * 1994-02-17 1995-08-24 Wei-Guo Su 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
IL137445D0 (en) * 1998-01-23 2001-07-24 Tufts College Pharmaceutically active compounds and methods of use thereof
HU0202798A3 (en) * 1999-09-14 2003-11-28 Trustees Of Tufts College Medf Methods of preparing substituted tetracyclines with transition metal-based reactions
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
AU6847501A (en) * 2000-06-16 2002-01-02 Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
BR0112265A (en) * 2000-07-07 2003-06-24 Tufts College Compounds Substituted tetracycline, and 7-substituted sancycline, the method for treating a tetracycline responsive state in the individual, and pharmaceutical composition
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1301467B1 (en) 2000-07-07 2006-08-16 Trustees Of Tufts College 9-substituted minocycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
EP2301913A1 (en) * 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2332549A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Novel tetracyclines and their use in medicine
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN101307017A (en) * 2002-03-08 2008-11-19 帕拉特克药品公司 Amino-methyl substituted tetracycline compounds
CN1653037A (en) 2002-03-21 2005-08-10 帕拉特克药品公司 Substituted tetracycline compounds
EP1534300A4 (en) 2002-07-12 2008-04-23 Paratek Pharm Innc 3, 10, and 12a substituted tetracycline compounds
WO2004060425A2 (en) * 2002-12-27 2004-07-22 Angiotech International Ag Compositions and methods of using collagen and mmpi
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
AU2004259659B2 (en) 2003-07-09 2011-11-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP5010284B2 (en) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド Aromatic A-ring derivatives of tetracycline compounds
EP2284155A3 (en) 2004-10-25 2011-10-12 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057033A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp Methods for preparing tigecycline and 9-nitrominociclina
AR057324A1 (en) * 2005-05-27 2007-11-28 Wyeth Corp Methods for preparing tigecycline and 9-aminominociclina
AR057034A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp Methods for purifying tigecycline
AR057032A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp Tigecycline and methods of preparation
WO2007014154A2 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
RU2008120672A (en) * 2005-12-22 2010-01-27 Вайет (Us) Compositions for oral administration containing taigetsiklin
CA2631632A1 (en) * 2005-12-22 2007-07-05 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
EP2007713A2 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
WO2007127292A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Tigeycline crystalline forms and processes for preparation thereof
CA2649660A1 (en) * 2006-05-10 2007-11-22 Teva Pharmaceutical Industries Ltd. Methods for reducing 7/9-nitrotetracycline derivatives
EP2029749A2 (en) 2006-05-15 2009-03-04 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2008066935A2 (en) 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (en) * 2006-11-30 2011-03-29 Teva Pharma processes for preparing 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
PT2225253E (en) 2007-11-29 2012-09-19 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
US20120059190A1 (en) * 2009-03-12 2012-03-08 Wyeth Llc Novel nitration of tetracyclines
SI2327676T1 (en) * 2009-11-26 2014-07-31 Sandoz Ag Reaction of organic compounds with low amounts of hydrogen

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US2482055A (en) * 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3007965A (en) * 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (en) * 1960-05-23 1966-05-25
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) * 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3397230A (en) * 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3373198A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 5a, 11a-dehydro-6-epitetracyclines
US3360561A (en) * 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
CA999855A (en) * 1972-09-18 1976-11-16 Societa' Farmaceutici Italia S.P.A. Process for the preparation of tetracyclines derivatives in the 7 position
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
JPH04295458A (en) * 1991-03-22 1992-10-20 Fuji Photo Film Co Ltd Compound to produce acid by irradiation with light
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5258398A (en) * 1991-12-16 1993-11-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic diaminoalkanoic acid derivatives

Also Published As

Publication number Publication date
NZ244556A (en) 1994-06-27
HU211214B (en) 1995-11-28
US5281628A (en) 1994-01-25
EP0535346B1 (en) 1995-11-02
IL103319A (en) 1996-07-23
TW222616B (en) 1994-04-21
AU2618292A (en) 1993-04-08
CN1053182C (en) 2000-06-07
JP3183729B2 (en) 2001-07-09
CN1071415A (en) 1993-04-28
PL170939B1 (en) 1997-02-28
DK0535346T3 (en) 1995-12-04
FI924453A0 (en) 1992-10-02
AT129697T (en) 1995-11-15
SK281113B6 (en) 2000-12-11
PH30343A (en) 1997-04-02
PL170933B1 (en) 1997-02-28
US5326759A (en) 1994-07-05
US5401863A (en) 1995-03-28
HUT64298A (en) 1993-12-28
ZA9207608B (en) 1993-04-13
DE69205792D1 (en) 1995-12-07
JPH05239006A (en) 1993-09-17
EP0535346A1 (en) 1993-04-07
DE69205792T2 (en) 1996-06-20
NO300129B1 (en) 1997-04-14
SK297292A3 (en) 1994-12-07
HU211922A9 (en) 1996-01-29
ES2081005T3 (en) 1996-02-16
HK1000319A1 (en) 1998-02-27
CZ285015B6 (en) 1999-05-12
MX9205573A (en) 1993-05-01
FI924453D0 (en)
PL296140A1 (en) 1993-11-02
KR100261528B1 (en) 2000-07-15
FI111716B1 (en)
NO923856D0 (en) 1992-10-02
NO923856L (en) 1993-04-05
CA2079703C (en) 2004-07-20
FI111716B (en) 2003-09-15
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
KR930007895A (en) 1993-05-20
FI924453A (en) 1993-04-05
CZ297292A3 (en) 1993-04-14
HU9203143D0 (en) 1992-12-28
GR3017978T3 (en) 1996-02-29

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees