IE50646B1 - Novel 4-aroylimidazol-2-ones - Google Patents

Novel 4-aroylimidazol-2-ones

Info

Publication number
IE50646B1
IE50646B1 IE1162/80A IE116280A IE50646B1 IE 50646 B1 IE50646 B1 IE 50646B1 IE 1162/80 A IE1162/80 A IE 1162/80A IE 116280 A IE116280 A IE 116280A IE 50646 B1 IE50646 B1 IE 50646B1
Authority
IE
Ireland
Prior art keywords
alkyl
hydrogen
methyl
phenyl
pharmaceutical composition
Prior art date
Application number
IE1162/80A
Other languages
English (en)
Other versions
IE801162L (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE50646(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IE801162L publication Critical patent/IE801162L/xx
Publication of IE50646B1 publication Critical patent/IE50646B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IE1162/80A 1979-06-18 1980-06-05 Novel 4-aroylimidazol-2-ones IE50646B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4980879A 1979-06-18 1979-06-18
US11920780A 1980-02-07 1980-02-07

Publications (2)

Publication Number Publication Date
IE801162L IE801162L (en) 1980-12-18
IE50646B1 true IE50646B1 (en) 1986-06-11

Family

ID=26727558

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1162/80A IE50646B1 (en) 1979-06-18 1980-06-05 Novel 4-aroylimidazol-2-ones

Country Status (20)

Country Link
AT (1) AT375349B (de)
AU (1) AU532783B2 (de)
CA (1) CA1132554A (de)
CH (1) CH646155A5 (de)
DE (1) DE3021792A1 (de)
DK (1) DK160269C (de)
ES (1) ES8105299A1 (de)
FR (1) FR2459233A1 (de)
GB (1) GB2055364B (de)
HK (1) HK61486A (de)
HU (1) HU186736B (de)
IE (1) IE50646B1 (de)
IL (1) IL60243A (de)
IT (1) IT1143922B (de)
MY (1) MY8600709A (de)
NL (2) NL193752C (de)
NO (1) NO152841C (de)
NZ (1) NZ193935A (de)
PH (1) PH18683A (de)
SE (2) SE447107B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
JPS57185266A (en) * 1981-05-04 1982-11-15 Merrell Dow Pharma 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazole- 2-one
US4329470A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2005092332A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
CA2560538A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (de) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylat-cyclase-c-agonisten
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP4424697A2 (de) 2013-06-05 2024-09-04 Bausch Health Ireland Limited Ultrareine agonisten der guanylatcyclase c, verfahren zur herstellung und verwendung davon
EP3492106B1 (de) 2013-08-09 2021-02-17 Ardelyx, Inc. Verbindungen und verfahren zur hemmung eines phosphattransports
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合
CN114539157B (zh) * 2022-03-03 2023-12-22 曲靖师范学院 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Also Published As

Publication number Publication date
AU5911880A (en) 1981-01-08
SE464559B (sv) 1991-05-13
SE8004253L (sv) 1980-12-19
AU532783B2 (en) 1983-10-13
NL300015I2 (nl) 2000-10-02
CH646155A5 (de) 1984-11-15
FR2459233A1 (fr) 1981-01-09
DK160269C (da) 1991-07-22
AT375349B (de) 1984-07-25
GB2055364B (en) 1983-06-08
SE8501452D0 (sv) 1985-03-25
FR2459233B1 (de) 1983-09-23
DK160269B (da) 1991-02-18
NL300015I1 (nl) 2000-11-01
DK259080A (da) 1980-12-19
NO152841C (no) 1985-11-27
DE3021792A1 (de) 1981-01-22
IT1143922B (it) 1986-10-29
IT8048997A0 (it) 1980-06-17
CA1132554A (en) 1982-09-28
MY8600709A (en) 1986-12-31
PH18683A (en) 1985-08-29
NL193752C (nl) 2000-09-04
ES492255A0 (es) 1981-06-01
DE3021792C2 (de) 1989-08-10
ES8105299A1 (es) 1981-06-01
IE801162L (en) 1980-12-18
IL60243A (en) 1987-01-30
SE8501452L (sv) 1985-03-25
NL193752B (nl) 2000-05-01
NO801796L (no) 1980-12-19
ATA314280A (de) 1983-12-15
SE447107B (sv) 1986-10-27
HK61486A (en) 1986-08-29
HU186736B (en) 1985-09-30
IL60243A0 (en) 1980-09-16
NZ193935A (en) 1985-05-31
GB2055364A (en) 1981-03-04
NL8003498A (nl) 1980-12-22
NO152841B (no) 1985-08-19

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Legal Events

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SPCF Request for grant of supplementary protection certificate

Free format text: SPC 52/93:19930623

SPCG Supplementary protection certificate granted

Free format text: SPC 52/93 EXPIRES:20021027

MK9A Patent expired