IE37596B1 - 21-substituted 3alpha-hydroxy pregnanes - Google Patents
21-substituted 3alpha-hydroxy pregnanesInfo
- Publication number
- IE37596B1 IE37596B1 IE709/73A IE70973A IE37596B1 IE 37596 B1 IE37596 B1 IE 37596B1 IE 709/73 A IE709/73 A IE 709/73A IE 70973 A IE70973 A IE 70973A IE 37596 B1 IE37596 B1 IE 37596B1
- Authority
- IE
- Ireland
- Prior art keywords
- alpha
- substituted
- 3alpha
- hydroxy
- additionally
- Prior art date
Links
- -1 azide ions Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2114272A GB1430942A (en) | 1972-05-05 | 1972-05-05 | 21-substituted 3alpha-hydroxy pregnanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37596L IE37596L (en) | 1973-11-05 |
| IE37596B1 true IE37596B1 (en) | 1977-08-31 |
Family
ID=10157915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE709/73A IE37596B1 (en) | 1972-05-05 | 1973-05-04 | 21-substituted 3alpha-hydroxy pregnanes |
Country Status (16)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5939545A (en) * | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
| BR9506779A (pt) * | 1994-02-14 | 1997-10-14 | Cocensys Inc | Composto composição farmacéutica método para modular o complexo ionóforo receptor gaba-cloreto em um paciente animal pela ligação ao sitio neuroesteróide no dito complexo método para tratar ou evitar estresse ou ansiedade em um paciente animal método para aliviar ou evitar isônia pms ou pnd em um paciente animal método para tratar ou evitar perturbacões na disposicão de ánimo em um paciente animal e método para induzir anestesia em um paciente animal |
| GR1003861B (el) * | 2000-12-29 | 2002-04-11 | Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa. | |
| JP4915427B2 (ja) * | 2009-03-30 | 2012-04-11 | ブラザー工業株式会社 | 液体供給ジョイント、これを使用した液体吐出ヘッド及び記録装置 |
| CA3152410A1 (en) | 2011-10-14 | 2013-04-18 | Sage Therapeutics, Inc. | 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders |
| WO2013112605A2 (en) | 2012-01-23 | 2013-08-01 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
| BR112015003747A2 (pt) | 2012-08-21 | 2017-07-04 | Sage Therapeutics Inc | métodos de tratamento de epilepsia ou estado de mal epiléptico |
| JP6239091B2 (ja) | 2013-04-17 | 2017-11-29 | セージ セラピューティクス， インコーポレイテッド | １９−ノル神経刺激性ステロイドおよびその使用方法 |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| IL310348A (en) | 2013-04-17 | 2024-03-01 | Sage Therapeutics Inc | 19- NOR C3, 3- dimomer C21- N- pyrazole Steroids and methods of using them |
| HRP20210610T1 (hr) | 2013-07-19 | 2021-05-28 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihove uporabe |
| CN105579043B (zh) | 2013-08-23 | 2021-09-14 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物和其用途 |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| CN118344423A (zh) | 2014-10-16 | 2024-07-16 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| AU2015331597B2 (en) | 2014-10-16 | 2020-04-30 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| ES2793237T3 (es) | 2014-11-27 | 2020-11-13 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| EP3250210B1 (en) | 2015-01-26 | 2020-12-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| DK3258939T3 (da) | 2015-02-20 | 2022-12-12 | Sage Therapeutics Inc | Neuroaktive steroider, sammensætninger og anvendelser heraf |
| CA3017172C (en) | 2016-03-08 | 2023-03-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| US20190233465A1 (en) | 2016-07-11 | 2019-08-01 | Sage Therapeutics, Inc. | C7, c12, and c16 substituted neuroactive steroids and their methods of use |
| US11396525B2 (en) | 2016-07-11 | 2022-07-26 | Sage Therapeutics, Inc. | C17, C20, and C21 substituted neuroactive steroids and their methods of use |
| AU2020284110A1 (en) | 2019-05-31 | 2021-11-25 | Sage Therapeutics, Inc. | Neuroactive steroids and compositions thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1346292A (fr) * | 1962-09-14 | 1963-12-20 | Roussel Uclaf | Nouveau procédé de préparation des 21-amino stéroïdes |
| US3144446A (en) * | 1963-12-20 | 1964-08-11 | Upjohn Co | Mono and bis nu-(3alpha, 17alpha-dihydroxy-11, 20-dioxo-5beta-pregnan-21-yl) quaternary ammonium salts of triethylenediamine |
-
1972
- 1972-05-05 GB GB2114272A patent/GB1430942A/en not_active Expired
-
1973
- 1973-05-04 ES ES0414411A patent/ES414411A1/es not_active Expired
- 1973-05-04 ZA ZA733035A patent/ZA733035B/xx unknown
- 1973-05-04 IL IL42196A patent/IL42196A/xx unknown
- 1973-05-04 DE DE2322532A patent/DE2322532A1/de not_active Ceased
- 1973-05-04 JP JP48050183A patent/JPS4961150A/ja active Pending
- 1973-05-04 LU LU67546A patent/LU67546A1/xx unknown
- 1973-05-04 CA CA170,482A patent/CA1013341A/en not_active Expired
- 1973-05-04 IE IE709/73A patent/IE37596B1/xx unknown
- 1973-05-04 SE SE7306330A patent/SE400771B/xx unknown
- 1973-05-04 CH CH636073A patent/CH617710A5/de not_active IP Right Cessation
- 1973-05-04 BE BE130749A patent/BE799102A/xx unknown
- 1973-05-04 AU AU55284/73A patent/AU475168B2/en not_active Expired
- 1973-05-04 NL NL7306234A patent/NL7306234A/xx not_active Application Discontinuation
- 1973-05-04 AT AT395173A patent/AT355232B/de not_active IP Right Cessation
- 1973-05-04 FR FR7316108A patent/FR2183792B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES414411A1 (es) | 1976-02-01 |
| JPS4961150A (enrdf_load_stackoverflow) | 1974-06-13 |
| SE400771B (sv) | 1978-04-10 |
| CA1013341A (en) | 1977-07-05 |
| FR2183792B1 (enrdf_load_stackoverflow) | 1977-07-15 |
| LU67546A1 (enrdf_load_stackoverflow) | 1973-07-13 |
| AT355232B (de) | 1980-02-25 |
| CH617710A5 (en) | 1980-06-13 |
| NL7306234A (enrdf_load_stackoverflow) | 1973-11-07 |
| ATA395173A (de) | 1979-07-15 |
| FR2183792A1 (enrdf_load_stackoverflow) | 1973-12-21 |
| BE799102A (fr) | 1973-11-05 |
| GB1430942A (en) | 1976-04-07 |
| IE37596L (en) | 1973-11-05 |
| DE2322532A1 (de) | 1973-11-22 |
| IL42196A (en) | 1978-10-31 |
| AU5528473A (en) | 1974-11-07 |
| IL42196A0 (en) | 1973-07-30 |
| ZA733035B (en) | 1974-04-24 |
| AU475168B2 (en) | 1976-08-12 |
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