HUP0600868A2 - 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation - Google Patents

5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation

Info

Publication number
HUP0600868A2
HUP0600868A2 HU0600868A HUP0600868A HUP0600868A2 HU P0600868 A2 HUP0600868 A2 HU P0600868A2 HU 0600868 A HU0600868 A HU 0600868A HU P0600868 A HUP0600868 A HU P0600868A HU P0600868 A2 HUP0600868 A2 HU P0600868A2
Authority
HU
Hungary
Prior art keywords
polimorphs
benzisothiazol
indol
piperazinyl
dihydro
Prior art date
Application number
HU0600868A
Other languages
English (en)
Inventor
Jozsef Neu
Adam Dr Demeter
Zoltan Varga
Balazs Dr Havasi
Sandor Garadnay
Bela Dr Hegedues
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU0600868A priority Critical patent/HUP0600868A3/hu
Publication of HU0600868D0 publication Critical patent/HU0600868D0/hu
Priority to US12/516,094 priority patent/US20100081668A1/en
Priority to EP07848771A priority patent/EP2084156A1/en
Priority to PCT/HU2007/000112 priority patent/WO2008062244A1/en
Priority to EA200900725A priority patent/EA200900725A1/ru
Publication of HUP0600868A2 publication Critical patent/HUP0600868A2/hu
Publication of HUP0600868A3 publication Critical patent/HUP0600868A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0600868A 2006-11-24 2006-11-24 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation HUP0600868A3 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
HU0600868A HUP0600868A3 (en) 2006-11-24 2006-11-24 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation
US12/516,094 US20100081668A1 (en) 2006-11-24 2007-11-23 Polymorphs of 5--6-chloro-1,3-dihydro-2h-indol-2-one hydrobromide and processes for preparation thereof
EP07848771A EP2084156A1 (en) 2006-11-24 2007-11-23 Polymorphs of 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrobromide and processes for preparation thereof
PCT/HU2007/000112 WO2008062244A1 (en) 2006-11-24 2007-11-23 Polymorphs of 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrobromide and processes for preparation thereof
EA200900725A EA200900725A1 (ru) 2006-11-24 2007-11-23 Полиморфы гидробромида 5-{2-[4-(1,2-бензоизотиазол-3-ил)-1-пиперазинил]этил}-6-хлор-1,3-дигидро-2н-индол-2-она и способы их получения

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0600868A HUP0600868A3 (en) 2006-11-24 2006-11-24 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation

Publications (3)

Publication Number Publication Date
HU0600868D0 HU0600868D0 (en) 2007-01-29
HUP0600868A2 true HUP0600868A2 (en) 2008-09-29
HUP0600868A3 HUP0600868A3 (en) 2009-03-30

Family

ID=89987153

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0600868A HUP0600868A3 (en) 2006-11-24 2006-11-24 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation

Country Status (5)

Country Link
US (1) US20100081668A1 (hu)
EP (1) EP2084156A1 (hu)
EA (1) EA200900725A1 (hu)
HU (1) HUP0600868A3 (hu)
WO (1) WO2008062244A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
AU2011374217A1 (en) 2011-08-03 2014-01-16 Diverse Barrel Solutions Pty Ltd System and method for the reconditioning of barrels including a robotic arm with a removable laser module

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
US20050197347A1 (en) * 2003-12-18 2005-09-08 Judith Aronhime Polymorphic form B2 of ziprasidone base
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.

Also Published As

Publication number Publication date
EP2084156A1 (en) 2009-08-05
EA200900725A1 (ru) 2009-10-30
WO2008062244A8 (en) 2009-06-11
HUP0600868A3 (en) 2009-03-30
US20100081668A1 (en) 2010-04-01
WO2008062244A1 (en) 2008-05-29
HU0600868D0 (en) 2007-01-29

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Legal Events

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished