HUP0100731A2 - Új oxazolidin-, tiazolidin-, pirrolidin- és piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyászati készítmények - Google Patents
Új oxazolidin-, tiazolidin-, pirrolidin- és piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0100731A2 HUP0100731A2 HU0100731A HUP0100731A HUP0100731A2 HU P0100731 A2 HUP0100731 A2 HU P0100731A2 HU 0100731 A HU0100731 A HU 0100731A HU P0100731 A HUP0100731 A HU P0100731A HU P0100731 A2 HUP0100731 A2 HU P0100731A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- thiazolidine
- pyrrolidine
- preparation
- pharmaceutical compositions
- Prior art date
Links
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title 1
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- AXIPBRXJGSXLHF-UHFFFAOYSA-N piperidine;pyrrolidine Chemical class C1CCNC1.C1CCNCC1 AXIPBRXJGSXLHF-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- -1 amino- Chemical class 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány (I) általános képletű vegyületekre, azok gyógyászatilagalkalmazható sóira és szolvátjaira a vegyületek előállítási eljárásáraés ezeket tartalmazó gyógyszerkészítményekre vonatkozik - a képletbenX oxigénatomot, kénatomot vagy -NH-, -CH2-, -CH2CH2- vagy -OCH2-csoportot jelent, Y -CH2- vagy -CO- csoportot jelent, R1piridilcsoportot (előnyösen 3- vagy 4-piridilcsoportot) vagypirimidinilcsoportot jelent, és R2 fenil-, piridil- vagypirimidinilcsoportot jelent, amelyek bármelyikéhez adott esetben egyvagy több, azonos vagy eltérő szubsztituens, éspedig halogénatom,amino-, ciano-, hidroxil-, nitro-, 1-6 szénatomos alkil-, halogénezett1-6 szénatomos alkil-, 1-6 szénatomos alkoxi-, (1-6 szénatomos alkil)-tio-, (di)-(1-6 szénatomos alkil)-amino-, (1-6 szénatomos alkil)-karbonil-, (1-6 szénatomos alkoxi)-karbonil-, (1-6 szénatomos alkil)-szulfinil- vagy (1-6 szénatomos alkil)-szulfonilcsoport vagy -NR3SO2R4, -SO2NR5R6 vagy -Z-(CH2)p-Z-(CH2)q-H általános képletűcsoport kapcsolódhat. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704546A SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100731A2 true HUP0100731A2 (hu) | 2002-05-29 |
| HUP0100731A3 HUP0100731A3 (en) | 2002-08-28 |
Family
ID=20409283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100731A HUP0100731A3 (en) | 1997-12-05 | 1998-12-01 | New oxazolidine-, thiazolidine-, pyrrolidine-and piperidin derivatives process for their preparation and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1037889A1 (hu) |
| JP (1) | JP2001525406A (hu) |
| KR (1) | KR20010032800A (hu) |
| CN (1) | CN1284074A (hu) |
| AU (1) | AU1791599A (hu) |
| BR (1) | BR9813378A (hu) |
| CA (1) | CA2312357A1 (hu) |
| EE (1) | EE200000321A (hu) |
| HU (1) | HUP0100731A3 (hu) |
| IL (1) | IL136368A0 (hu) |
| NO (1) | NO20002787L (hu) |
| PL (1) | PL340837A1 (hu) |
| SE (1) | SE9704546D0 (hu) |
| SK (1) | SK8442000A3 (hu) |
| TR (1) | TR200001544T2 (hu) |
| WO (1) | WO1999029686A1 (hu) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9901875D0 (sv) | 1999-05-25 | 1999-05-25 | Astra Pharma Prod | Novel compounds |
| SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
| SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
| TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
| JP2002330787A (ja) * | 2000-10-21 | 2002-11-19 | Astrazeneca Ab | 化学物質 |
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| ATE355273T1 (de) | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
| GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
| BRPI0512781A (pt) | 2004-06-29 | 2008-04-08 | Pfizer Prod Inc | método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila |
| US8546579B2 (en) | 2006-03-16 | 2013-10-01 | Evotec (Us) Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| DK1937643T3 (en) | 2006-03-16 | 2016-10-10 | Second Genome Inc | Bicycloheteroarylforbindelser som p2x7-modulatorer og anvendelser deraf |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| TW200813018A (en) | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| GB0613473D0 (en) * | 2006-07-06 | 2006-08-16 | Glaxo Group Ltd | Novel compounds |
| MX2009000117A (es) | 2006-07-06 | 2009-01-23 | Glaxo Group Ltd | N-fenilmetil-5-oxo-prolin-2-amidas sustituidas como antagonistas de receptores p2x7 y sus metodos de uso. |
| ES2576643T3 (es) | 2007-03-09 | 2016-07-08 | Second Genome, Inc. | Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos |
| US20100168171A1 (en) * | 2007-03-28 | 2010-07-01 | Paul John Beswick | Piperidinone Carboxamide Derivatives as P2X7 Modulators |
| WO2008119685A2 (en) * | 2007-03-29 | 2008-10-09 | Glaxo Group Limited | Oxazolidine and morpholine carboxamide derivatives as p2x7 modulators |
| CN101679291A (zh) * | 2007-04-03 | 2010-03-24 | 葛兰素集团有限公司 | 作为p2x7调节剂的咪唑烷甲酰胺衍生物 |
| US8119661B2 (en) | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| GB0803729D0 (en) * | 2008-02-29 | 2008-04-09 | Ge Healthcare Ltd | Imaging the central nervous system |
| DK2105164T3 (da) | 2008-03-25 | 2011-03-21 | Affectis Pharmaceuticals Ag | Nye P2X7R-antagonister og deres anvendelse |
| BRPI1014902A2 (pt) | 2009-04-14 | 2016-04-19 | Affectis Pharmaceuticals Ag | composto antagonista de p2x7r, sua composição e seus usos |
| EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
| SG185400A1 (en) | 2010-05-14 | 2012-12-28 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of p2x7r antagonists |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| JP7337083B2 (ja) | 2017-11-21 | 2023-09-01 | スリーエム イノベイティブ プロパティズ カンパニー | 口腔用植物系水中油型エマルジョン及び使用方法 |
| JP7308835B2 (ja) | 2017-12-20 | 2023-07-14 | スリーエム イノベイティブ プロパティズ カンパニー | 口腔用組成物及び使用方法 |
| WO2019123171A1 (en) | 2017-12-20 | 2019-06-27 | 3M Innovative Properties Company | Oral compositions and methods of use |
-
1997
- 1997-12-05 SE SE9704546A patent/SE9704546D0/xx unknown
-
1998
- 1998-12-01 CN CN98813490A patent/CN1284074A/zh active Pending
- 1998-12-01 EE EEP200000321A patent/EE200000321A/xx unknown
- 1998-12-01 WO PCT/SE1998/002190 patent/WO1999029686A1/en not_active Application Discontinuation
- 1998-12-01 EP EP98962753A patent/EP1037889A1/en not_active Withdrawn
- 1998-12-01 TR TR2000/01544T patent/TR200001544T2/xx unknown
- 1998-12-01 JP JP2000524280A patent/JP2001525406A/ja not_active Withdrawn
- 1998-12-01 IL IL13636898A patent/IL136368A0/xx unknown
- 1998-12-01 KR KR1020007006117A patent/KR20010032800A/ko not_active Application Discontinuation
- 1998-12-01 SK SK844-2000A patent/SK8442000A3/sk unknown
- 1998-12-01 CA CA002312357A patent/CA2312357A1/en not_active Abandoned
- 1998-12-01 PL PL98340837A patent/PL340837A1/xx unknown
- 1998-12-01 AU AU17915/99A patent/AU1791599A/en not_active Abandoned
- 1998-12-01 HU HU0100731A patent/HUP0100731A3/hu unknown
- 1998-12-01 BR BR9813378-0A patent/BR9813378A/pt not_active Application Discontinuation
-
2000
- 2000-05-31 NO NO20002787A patent/NO20002787L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20002787D0 (no) | 2000-05-31 |
| KR20010032800A (ko) | 2001-04-25 |
| IL136368A0 (en) | 2001-06-14 |
| TR200001544T2 (tr) | 2000-11-21 |
| BR9813378A (pt) | 2000-10-10 |
| CN1284074A (zh) | 2001-02-14 |
| SK8442000A3 (en) | 2001-01-18 |
| SE9704546D0 (sv) | 1997-12-05 |
| EE200000321A (et) | 2001-08-15 |
| EP1037889A1 (en) | 2000-09-27 |
| HUP0100731A3 (en) | 2002-08-28 |
| WO1999029686A1 (en) | 1999-06-17 |
| JP2001525406A (ja) | 2001-12-11 |
| PL340837A1 (en) | 2001-02-26 |
| CA2312357A1 (en) | 1999-06-17 |
| AU1791599A (en) | 1999-06-28 |
| NO20002787L (no) | 2000-08-01 |
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