HUP0000889A2 - Acarbose (acb) cluster from actinoplanes sp. se 50/110 - Google Patents
Acarbose (acb) cluster from actinoplanes sp. se 50/110Info
- Publication number
- HUP0000889A2 HUP0000889A2 HU0000889A HUP0000889A HUP0000889A2 HU P0000889 A2 HUP0000889 A2 HU P0000889A2 HU 0000889 A HU0000889 A HU 0000889A HU P0000889 A HUP0000889 A HU P0000889A HU P0000889 A2 HUP0000889 A2 HU P0000889A2
- Authority
- HU
- Hungary
- Prior art keywords
- actinoplanes
- acb
- acarbose
- cluster
- Prior art date
Links
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title 1
- 241000936716 Actinoplanes sp. SE50/110 Species 0.000 title 1
- 229960002632 acarbose Drugs 0.000 title 1
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19708127A DE19708127A1 (de) | 1997-02-28 | 1997-02-28 | Acarbose acb-Cluster: Isolierung von weiteren Genen der Acarbose Biosynthese und des Acarbose-Stoffwechsels aus Actinoplanes sp. SE 50/110 sowie deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0000889A2 true HUP0000889A2 (en) | 2000-07-28 |
Family
ID=7821816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000889A HUP0000889A2 (en) | 1997-02-28 | 1998-02-16 | Acarbose (acb) cluster from actinoplanes sp. se 50/110 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0968294A1 (zh) |
| KR (1) | KR20000075777A (zh) |
| CN (1) | CN1249001A (zh) |
| AU (1) | AU6296898A (zh) |
| BG (1) | BG103672A (zh) |
| BR (1) | BR9807640A (zh) |
| CA (1) | CA2282735A1 (zh) |
| CZ (1) | CZ9903054A3 (zh) |
| DE (1) | DE19708127A1 (zh) |
| HU (1) | HUP0000889A2 (zh) |
| IL (1) | IL131433A0 (zh) |
| NO (1) | NO994164D0 (zh) |
| PL (1) | PL335369A1 (zh) |
| WO (1) | WO1998038313A1 (zh) |
| ZA (1) | ZA981659B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0796915A3 (de) * | 1996-03-22 | 1999-04-14 | Bayer Ag | Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen |
| TW201217533A (en) | 2010-08-04 | 2012-05-01 | Bayer Pharma AG | Genomics of actinoplanes utahensis |
| CN106167814B (zh) * | 2016-08-31 | 2019-08-09 | 河北华荣制药有限公司 | 一种提高阿卡波糖发酵单位的方法 |
| CN106566796B (zh) * | 2016-10-28 | 2020-11-10 | 上海交通大学 | 阿卡波糖生产菌Actinoplanes spp.的遗传操作体系 |
| WO2021073900A1 (en) * | 2019-10-16 | 2021-04-22 | Bayer Aktiengesellschaft | Methods for the improved formation of acarbose |
| CN112592878B (zh) * | 2020-12-25 | 2022-08-26 | 上海交通大学 | 增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法 |
| CN113444670A (zh) * | 2021-07-28 | 2021-09-28 | 山东鲁抗医药股份有限公司 | 一种高活性阿卡波糖产生菌的筛选方法和培养方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19507214A1 (de) * | 1995-03-02 | 1996-10-31 | Bayer Ag | Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung |
| DE19622783A1 (de) * | 1996-06-07 | 1997-12-11 | Hoechst Ag | Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung |
-
1997
- 1997-02-28 DE DE19708127A patent/DE19708127A1/de not_active Withdrawn
-
1998
- 1998-02-16 HU HU0000889A patent/HUP0000889A2/hu unknown
- 1998-02-16 KR KR1019997007849A patent/KR20000075777A/ko not_active Application Discontinuation
- 1998-02-16 AU AU62968/98A patent/AU6296898A/en not_active Abandoned
- 1998-02-16 EP EP98906953A patent/EP0968294A1/de not_active Withdrawn
- 1998-02-16 IL IL13143398A patent/IL131433A0/xx unknown
- 1998-02-16 WO PCT/EP1998/000862 patent/WO1998038313A1/de not_active Application Discontinuation
- 1998-02-16 CN CN98802927A patent/CN1249001A/zh active Pending
- 1998-02-16 CZ CZ993054A patent/CZ9903054A3/cs unknown
- 1998-02-16 CA CA002282735A patent/CA2282735A1/en not_active Abandoned
- 1998-02-16 BR BR9807640A patent/BR9807640A/pt not_active Application Discontinuation
- 1998-02-16 PL PL98335369A patent/PL335369A1/xx unknown
- 1998-02-27 ZA ZA981659A patent/ZA981659B/xx unknown
-
1999
- 1999-08-20 BG BG103672A patent/BG103672A/xx unknown
- 1999-08-27 NO NO994164A patent/NO994164D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1249001A (zh) | 2000-03-29 |
| EP0968294A1 (de) | 2000-01-05 |
| NO994164L (no) | 1999-08-27 |
| BR9807640A (pt) | 2000-03-21 |
| KR20000075777A (ko) | 2000-12-26 |
| CZ9903054A3 (cs) | 1999-11-17 |
| NO994164D0 (no) | 1999-08-27 |
| PL335369A1 (en) | 2000-04-25 |
| ZA981659B (en) | 1998-09-10 |
| CA2282735A1 (en) | 1998-09-03 |
| DE19708127A1 (de) | 1998-09-03 |
| BG103672A (en) | 2000-05-31 |
| IL131433A0 (en) | 2001-01-28 |
| AU6296898A (en) | 1998-09-18 |
| WO1998038313A1 (de) | 1998-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA9610070B (en) | Cyclosporin compositions. | |
| GB2308874B (en) | Actuating arrangement | |
| PL344341A1 (en) | Peptides | |
| IL129519A0 (en) | Heptapeptide oxytocin analogs | |
| ZA975533B (en) | Cyclosporin-containing pharmaceutical composition. | |
| EP0765165A4 (en) | PREVENTED PEPTIDES | |
| ZA964011B (en) | Cyclic peptide antifungal agents. | |
| EP0804469A4 (en) | NEW PEPTIDE | |
| HUP0000889A2 (en) | Acarbose (acb) cluster from actinoplanes sp. se 50/110 | |
| GB9825854D0 (en) | Peptide | |
| GB2300086B (en) | Switching arrangement | |
| GB9812675D0 (en) | Peptides | |
| GB9506372D0 (en) | New peptide compounds | |
| HK1014964A1 (en) | Somatostatin peptides. | |
| GB9700950D0 (en) | Valve arrangements | |
| ZA978475B (en) | Sulphide containing peptides. | |
| GB9807890D0 (en) | Peptides | |
| GB2319757B (en) | Instrument cluster | |
| DE69601161D1 (en) | Thermoplastisches elastomer | |
| GB9521589D0 (en) | Rocker switch assembly | |
| GB9700839D0 (en) | Valve arrangement | |
| ZA983685B (en) | Pregnanes. | |
| ZA983706B (en) | Pregnanes. | |
| TW334000U (en) | Improved deafening partition (2) | |
| GB9505924D0 (en) | Peptide |