HUE029188T2 - Fenilamino-pirimidin vegyületek és felhasználásuk - Google Patents
Fenilamino-pirimidin vegyületek és felhasználásuk Download PDFInfo
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- HUE029188T2 HUE029188T2 HUE08714386A HUE08714386A HUE029188T2 HU E029188 T2 HUE029188 T2 HU E029188T2 HU E08714386 A HUE08714386 A HU E08714386A HU E08714386 A HUE08714386 A HU E08714386A HU E029188 T2 HUE029188 T2 HU E029188T2
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- pyrimidin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Claims (5)
1. Vggyäfet képiét lb speriM
ahoi Z io van. vÄsziva : InggeíRa# lü^rœt kómák N és CH;: Ri* Id.: vag.· választva iuggel lenül * föverteSk ħk :H,: Mbg&k €Ri, €φ0Κ\ ÇÛM(W%: £%f RÏQR*, KM, K-ofíbílin ímóy>rfeimit boniOzMin-'l, l-dioxid. szabsztinndi: vagy itisáifeí|ais |^ï|>eiisïiíxiI, mmsztlteáit vagy sxabszdmákdsp inpeíszkiii, imídazöüí* »rmbssülnäM: vagy szofebbtitaáistte pkroiídíríl es C^aiksíén, ahol a szénatomok opcionálisan helyedeätve vannak a következőkkel: NR'* és/vagy O sxubsxtiíaáif: omríhlmnal uomoslóknil, üöKxrrMin-L l-dioxid, sznhszumált vagy sxufesKtitmdatlaíí pspen#ni sznhsztitiÄ vagy sc«$^i«Äte piperaxmih imidazolii vagy smibvzntnäh vagy sanfesah aÄbsp pimdidinili R:í sgiésztítpált vagy szsfetituálsiian €(,4¾¾¾¾ RY H vagy sgöhszbiuáb vagy saxtbsztitiiâl utlan C^aikü; R- RXCN; .# iSgabaíSiRált vagy szabsztiíusiatlan Crmikilén ahol iegia|éhb g szsggoiö opcipöáU&aa :h«ip«eshheíp a ko veikégovdl; CÍÖ, MS#, NR ';,: CIOM'1. , BO, '$*% vagy Q; R:: II vagy € szikii nM a axahsziiSöpsek ki van választva: a következőkbe 0è :Gw β, €?,« <ákRslkiis £n, ííikenik, C;3,fi sdkmR «Iküani, :a»| hetsiwiklil». haló, Imíosríl, haioiRReocikiiL hi&öxi, €»* ailkoxs, ar.k>:«. karboxi. araiao, Okaikba«;, aritaem heicTödkibacb. acbmmno. adloxi. Cd^&ikayzslRííii arikaalfead és ekne; vagy annak gnaníiomere, annak. pnA*# vagy ámmk: gyógy^éaaetikg eifh^dkaié^ ahol a prodíggok ktvannak választva,ki van •.árasa;va a következők kozák » vegyiiietek, ami rnnmossv maradék, vagy polipephd láac két vagy több mninosav maradék MvaRíisen kspcsöióátk pepiid kWm P a leplet Ife; szerion vegyiles szabad «mfo* bidroxi vagy karhöxiissíiv csoportsához; ·». vogyäieRk ahol kaths^nàt, ksrbapm. »t&'VM? sM'észter kovalensen köt & képiéi ib széntől vegyhict szabad amino, atnklfx hsdroxi vagy kasbovoxn c esopösdjáboz· .karonon »zea ps ddrag sddalníBeep át; és * vegpkmk, ahol s RépRi ib szgáaii vegypfet szabad hidmxiija feszlbnoxigén Miésen sí kapcsolódik egy vegyidet ípíM sav, sav sója. vagy észter) tésztát sKnbiaaékahíXx.
2. '1, %én$jK>»t érinti: vegyül«*,. ahp| !&* mörlolip·
3 Az I. vagy 2, igénypont .szerisn vegyület, ahol X Clí,
4. Az i . igénypont s«ínti vogyüiet &tsdy ki van válasa®?« « kővefezök feMM: .AHoiaôo8a^âH“(^4"m>rfolM«^iN8àno-)pjriï8ïd.«x-4“8.)b^»üiâi ΑΗ2-οΐ8^θ^8η"2;·ϊΙΗ^2Κ#*^<^0β3®ί«;βί1^ΐη0^«0®ιΜΐ%4“0)^^?!^>: Α^α3»<3«®^8)^2^3“Β8^»Η«&^ί»ίηο)ρ«ΐηίΜΐ»τ440^β0ΐ^Β*^· A' {cói:K>)notiO-4~(2-44-»osi«ixfi)iinieRiía>nit5o} pinnnd«v4-H)b£H2âtBM; /^{ctejn>moíi])-4-42444M&niknn«!o)|miXöíM--4í4Rííonzaptd; ^Kcsns>xneüî)-#4^''C2 ii;kxt!orÍ0Ítnfenlkíini;ío);0ÍTini3dln-4-4i)fcnü}mct;ta!ii5o:llbíian'iil; Aí4í':í4iPi>®^^feía4toÍ--2<íS;0«t|Íj4'4á~^-5B<>rfc4nt^iíla#!iió)pn4íniáÍt5~4-ü)feöKXsm!d; ^C^^^^^)^^42^^<4-bM3soi»S!^|>^tál^4-iÍ->í^^aíni:í^||pí[plsfí|t<|áiíL-4--tl^í»Ési*»at»á<^. Λ?-(θ5ηηο.τΐκ··ί1}- 4-(2-(4 '(4-85etilpipe:?&m--l -iOftioilaininojpirjníiűtn-A-iijböassmtd; #φ^Ι^#:<^ΗΚ2^443-Μ^ΐ^^%βι^»*^5Ϊ>Ι^ΐ8®ϊ^>)··5··Η}«ΐΠί>ΐίί||§.^8-44ϊ|ΐ>.β«28βϊ{4; 4- (244--( I -îx-îî^v ipipt?ridm--4~ïi:i>sïïfBa:îïlasîm««)pirimï5d:iîÎ -*- iï f-.V 44(;lrfA^4»ac<n(lpiperazf&-i-sS}-fotÂ^ Am^2-(4-mot 0>hntoiaâ»îtM))pÂJ»!ii^43^|!!i^P^'^4g4^|^tâaS'»uî^ip!Îd.tedMi; 2v·(2·(4·{4·-hiάr-c^>;ipi|κyiάm--^·i4}KM5i4s:{niixo^,1·-r(Ki(sipiriît)íd^n-4-·í1)ben;¾m·y; 3i-(ds£toxaeül >-4 -(2 5- '(4-(4-(ciíiix:<KietHksndátiiOÍ()íénil) pírtelá ns-l-s (anMîio>-M#<iit»ettl^-S^sorMiïàsônxnaàâ; ÂdaM»4i"4K4-{4-|daáí» ρΙπηΜ<1·ο241οη!ί5φ2^ iV--Çoi®BOïnettî )-4-( 2-( 3-iluorri ^mitS^afiÂm^pm^âiiBr^^jbetwairàib: A^*Ba^8)-4-^!|ÍÉ^oE8~3^fia«s®^á|feHÜ*ml8o)girtmi#a-4-fl^eá^ö0Éd;' i«orfo(«à>en^8ïiâ; i()SnxlI)íö«tdsS®tií&á3niítk 4-(2--(3'(;il(iosjmeti^-4-xiXi?lb(ínfömlasnno^jdmidin-4-5Í}-i\Hciáneinstt()fcsn3:smlci; #4:4innoindi!>-442-.(4--0:-etiipp^^ #~(4~i2--i>-ejäiay448öi4bHsfanaiOmö}pjXK5iiäm^ i^isæo-iV-<4-42-'^iii(ÂfisiêAi*k8t%irimkâsa4-H)ifëàlbàse«»mid; p4feidäxt--4--il|(508däj«:!ik #-|exanosîsÉH-IM:!4"ICi> 1 ^»xo*^^^omor&fe44Í)m#!jitea|^jbó)^j%íáiá-4-.djbeaeaníki; ci a îiOK îSiï i I} -4 eiï^2 î'fi^ 1¾ «üàsm s^> jmrimMiïï~4 - Iljberiasmicí. es suiîîàk: gj%vsiæ»6sKetiîs?g elfogadható sí>í.: S. Aæ f.; igésjpxot sssdbij vegyalea «$£}$%
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5. Igényperé sxemil vegyidet as«ely: tkövetksed veggtólet sósavas sója
%. Äz Í4igésyposi saerahi vegyidet amelyik
vagy anrtökayógysaejxkíiseáicgvllbgadíurló sója. k. M I-7. ígényfoatok: htósieiyfke: szerjso vegyidet, ek>l a végyxileí: Maáz irMítum #v ΛI. igéayptïpl: SKériíítí 'VöigyuM, ahoi, ss kksaa ftÄ jtó&* m&íbiíör, Í4 Iljáíss fe !, mm** **&Α képlet lh wMtiti vegyidet eiMlföásfe, amely mieêmzm a képiéi: I szerinti vegyálei.k;ipcse]ssásak lépését
ahol ftó! ahogy ax í. igénypontba« \>m ds&nálva és X -áa^ily:-^m&ai víkí: alakosa jeooa a. képlei: Ili és IV vegyaleíekkeí kapceslédsseiöu
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ahol 2, !RS és $f ahogy: az L igényponton vanak definiálva; és Μ B vágy fém. 11:,. Gyógwerészeíi Kompo/jckk amdy tartahnazza m 1-#, igésayponíek bátmdyike szeeipi vegyiiietet és gyóg\ sgerészc'· ik-g elfogadható tKnxkizoanyagot, K, jfopiant&u'.ß, amely t&rtaltnazza a* 1*9. jg^jKts« hérmdyixt szerinti vegykiérét 13, A* 1 -9. igénypontok bármdyrke szerittti vegyüld vagy a 1G %#>* sz«í; gyögysgprésseíí lomnozieio felhasználásra djarasbaa kttunatai társított betegség kezelésére, áttol az d:j;kás tsrtdmazzá a vegvlMet vagy a gyógykkPrészeP keíSpozició Itatásos metsnyasegének adagelasa? sKetnetynek, akinen asta. szüksége van. 14, à. O, Igénypont szerbié vegyüld vagy gyógyszerészeti kompozíció Mbasznitlásfa, aboi a ksnàzzd iátxiíoít: betegség: Immunológiát vagy gyállssfásos betegség; btptaprobiètatsv betegség,; vsrasos betegség; anyagcsere: betegség; vágy vítscnláris betegség, 15, A 14. igénypont szerinti vegyiket vagy gyógyszerészeti kompozíció felhasználásra. ahol a» ümramolögiai vagy gyulladásos betegség szervtranszpiaréáeió. . ló, A 14. igénypont szerűm vegyüiet vagy gyógyszerészeti kompozíció felhasználásra, ahol. hlpeemolifbrahv betegség; tál vagy KiyeioproJifeativ íxírépég. Γ?. A ló. igénvporst szerinti vegymlct vagy gyógyszerészeti kompozíció felhasználásra, ahoi a Inperproliierativ betegség; egy reyeSopiXtirératt v betegség, amely ki van választva a kővetkezőkből Ilié csoportból: poíicstévnia vem (TV), printer ntydobbov.!*, thtombocirétnia, esszenciális tbtostibociténya (Fi), agnogen myeloid oxbaptázia (ΛΜΜ), Miópatkiés rnyekníbrózls (IMF), krónikus myelogén leukémia (CMF), szisztémás masdocitózis (SM), krónikus oeutrofii leulétnia |€NU, ntydodiszpfeszbteís szindróma (MOS) és szisztémás Mzöréjt betegség (SMCD). }.R, Â 17. igénypont szerinti vegyüld vagy gyógyszerészeti kompozíció felhasználásra, ahol & myeloprobföfatxy betegség ki van választva a következükből álló csoportból: polyemimia vem (PY), prstner mydoltbrózis, forombodîêtïtta, és esszenciális îinonilxx'kémiâ (FT).
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Families Citing this family (215)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2702650C (en) | 2007-03-12 | 2017-01-03 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine compounds and uses thereof |
CA2698511C (en) * | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
PL2265607T3 (pl) | 2008-02-15 | 2017-07-31 | Rigel Pharmaceuticals, Inc. | Związki pirymidyno-2-aminowe i ich zastosowanie jako inhibitory kinaz JAK |
CA2713716A1 (en) * | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
NZ599826A (en) * | 2009-10-12 | 2014-08-29 | Myrexis Inc | Amino-pyrimidine compounds as inhibitors of ikk epsilon and/or tbk1 |
GB201012105D0 (en) | 2010-07-19 | 2010-09-01 | Domainex Ltd | Novel pyrimidine compounds |
CN103298794A (zh) | 2010-11-09 | 2013-09-11 | 塞尔卓姆有限公司 | 作为tyk2抑制剂的吡啶化合物及其氮杂类似物 |
KR20130137011A (ko) * | 2010-12-03 | 2013-12-13 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | Jak-2 매개 병태의 치료 방법 |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
CA2826459C (en) | 2011-03-02 | 2019-09-17 | Lead Discovery Center Gmbh | Pharmaceutically active disubstituted pyridine derivatives |
CA2833288A1 (en) | 2011-04-19 | 2012-10-26 | Bayer Intellectual Property Gmbh | Substituted 4-aryl-n-phenyl-1,3,5-triazin-2-amines |
PE20140750A1 (es) * | 2011-05-02 | 2014-07-06 | Ym Biosciences Australia Pty | Tratamiento del mieloma multiple |
TWI555737B (zh) | 2011-05-24 | 2016-11-01 | 拜耳知識產權公司 | 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺 |
DE102011112978A1 (de) | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
CA2848616A1 (en) | 2011-09-16 | 2013-03-21 | Bayer Intellectual Property Gmbh | Disubstituted 5-fluoro-pyrimidines |
JP5976814B2 (ja) | 2011-09-16 | 2016-08-24 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | スルホキシイミン基を含有する二置換5−フルオロピリミジン誘導体 |
CN103102359B (zh) * | 2011-11-15 | 2016-11-09 | 江苏先声药业有限公司 | 嘧啶类化合物及其应用 |
DK2861595T5 (en) | 2012-06-13 | 2018-01-15 | Incyte Holdings Corp | Substituted tricyclic compounds as FGFR inhibitors |
US8809359B2 (en) * | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
ES2595222T3 (es) | 2012-10-18 | 2016-12-28 | Bayer Pharma Aktiengesellschaft | Derivados de 5-fluoro-N-(piridin-2-il)piridin-2-amina que contienen un grupo sulfona |
JP2015536311A (ja) | 2012-10-18 | 2015-12-21 | バイエル ファーマ アクチエンゲゼルシャフト | スルホン基を含有する4−(オルト)−フルオロフェニル−5−フルオロピリミジン−2−イルアミン |
TW201418243A (zh) | 2012-11-15 | 2014-05-16 | Bayer Pharma AG | 含有磺醯亞胺基團之n-(吡啶-2-基)嘧啶-4-胺衍生物 |
WO2014075318A1 (zh) * | 2012-11-19 | 2014-05-22 | 江苏先声药业有限公司 | 嘧啶类化合物及其应用 |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
WO2014110189A1 (en) | 2013-01-09 | 2014-07-17 | Concert Pharmaceuticals Inc. | Deuterated momelotinib |
CN103965114B (zh) | 2013-01-28 | 2016-01-06 | 苏州泽璟生物制药有限公司 | 氘代的苯基氨基嘧啶化合物以及包含该化合物的药物组合物 |
MX367878B (es) | 2013-04-19 | 2019-09-10 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
TWI527811B (zh) | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
CN105612154A (zh) * | 2013-08-07 | 2016-05-25 | 卡迪拉保健有限公司 | 作为詹纳斯激酶的抑制剂的n-氰基甲基酰胺 |
CA2931615A1 (en) | 2013-11-26 | 2015-06-04 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
HRP20230086T1 (hr) * | 2013-12-11 | 2023-03-31 | Celgene Quanticel Research, Inc. | Inhibitori lizin specifične demetilaze-1 |
WO2015109286A1 (en) | 2014-01-20 | 2015-07-23 | Gilead Sciences, Inc. | Therapies for treating cancers |
EP3110820B1 (en) | 2014-02-28 | 2022-04-06 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
TW202134236A (zh) | 2014-06-12 | 2021-09-16 | 美商西爾拉癌症醫學公司 | N-(氰基甲基)-4-(2-(4-𠰌啉基苯基胺基)嘧啶-4-基)苯甲醯胺 |
KR20170012560A (ko) | 2014-06-13 | 2017-02-02 | 길리애드 사이언시즈, 인코포레이티드 | 포스파티딜이노시톨 3-키나제 억제제 |
MX2016016517A (es) | 2014-06-13 | 2017-05-01 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-cinasa. |
WO2016024230A1 (en) | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor |
RS63364B1 (sr) | 2014-08-11 | 2022-07-29 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora, pd-1 inhibitora i/ili pd-l1 inhibitora |
TW201618773A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Btk抑制劑、pi3k抑制劑、jak-2抑制劑、及/或cdk4/6抑制劑的治療組合物 |
CN117164657A (zh) | 2014-08-12 | 2023-12-05 | 莫纳什大学 | 定向淋巴的前药 |
CN104262263B (zh) * | 2014-08-29 | 2017-01-11 | 西安交通大学 | 一种N,6二苯基嘧啶-4-胺类Bcr-Abl抑制剂及其制备方法和应用 |
WO2016049211A1 (en) | 2014-09-26 | 2016-03-31 | Gilead Sciences, Inc. | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
ES2720525T3 (es) | 2014-10-16 | 2019-07-22 | Bayer Pharma AG | Derivados fluorados de benzofuranil-pirimidina que contienen un grupo sulfona |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
EP3259269B9 (en) | 2015-02-20 | 2020-03-04 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
EP3262049B1 (en) | 2015-02-27 | 2022-07-20 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
WO2016150903A1 (en) | 2015-03-24 | 2016-09-29 | Bayer Pharma Aktiengesellschaft | Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating lymphomas |
JP2018509439A (ja) | 2015-03-24 | 2018-04-05 | バイエル ファーマ アクチエンゲゼルシャフト | 多発性骨髄腫を治療するための4−(4−フルオロ−2−メトキシフェニル)−n−{3−[(s−メチルスルホンイミドイル)メチル]フェニル}−1,3,5−トリアジン−2−アミンの使用 |
WO2016150902A1 (en) | 2015-03-24 | 2016-09-29 | Bayer Pharma Aktiengesellschaft | Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating gastric cancers |
CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
CN106316963B (zh) * | 2015-06-26 | 2021-06-08 | 苏州泽璟生物制药股份有限公司 | 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物 |
WO2017004134A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
EP3344624B8 (en) | 2015-09-02 | 2023-11-29 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
CN108137482B (zh) | 2015-09-08 | 2024-03-15 | 莫纳什大学 | 定向淋巴的前药 |
US10683308B2 (en) | 2015-09-11 | 2020-06-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
ES2786552T3 (es) | 2015-09-29 | 2020-10-13 | Bayer Pharma AG | Compuestos de sulfondiimina macrocíclicos nuevos |
EP3359544B1 (en) | 2015-10-08 | 2020-08-12 | Bayer Pharma Aktiengesellschaft | Novel modified macrocyclic compounds |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
PL3364958T3 (pl) | 2015-10-23 | 2023-05-02 | Navitor Pharmaceuticals, Inc. | Modulatory interakcji sestryna-gator2 i ich zastosowania |
US11370792B2 (en) | 2015-12-14 | 2022-06-28 | Raze Therapeutics, Inc. | Caffeine inhibitors of MTHFD2 and uses thereof |
CA3008289C (en) | 2015-12-16 | 2023-10-31 | The Walter And Eliza Hall Institute Of Medical Research | Inhibition of cytokine-induced sh2 protein in nk cells |
US11014882B2 (en) * | 2016-03-09 | 2021-05-25 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
EP3426243B1 (en) | 2016-03-09 | 2021-05-19 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
CN105837515B (zh) * | 2016-04-06 | 2018-08-03 | 中国药科大学 | 一种JAK抑制剂Momelotinib的制备方法 |
WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
CA3027498A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
WO2017223229A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
EP3472129A4 (en) | 2016-06-21 | 2019-12-04 | X4 Pharmaceuticals, Inc. | CXCR4 INHIBITORS AND USES THEREOF |
WO2018031579A1 (en) | 2016-08-10 | 2018-02-15 | Gilead Sciences, Inc. | Momelotinib for treating of acvr1 -mediated diseases |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
CA3039202A1 (en) | 2016-10-14 | 2018-04-19 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
AU2017345736B2 (en) | 2016-10-21 | 2022-04-07 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
EP3538091A4 (en) | 2016-11-08 | 2020-06-10 | Navitor Pharmaceuticals, Inc. | PHENYL AMINO PIPERIDINE MTORC INHIBITORS AND USES THEREOF |
CN110177544A (zh) | 2016-11-29 | 2019-08-27 | 普尔泰克健康有限公司 | 用于递送治疗剂的外泌体 |
WO2018106636A1 (en) | 2016-12-05 | 2018-06-14 | Raze Therapeutics, Inc. | Shmt inhibitors and uses thereof |
WO2018115203A1 (en) | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
US10624968B2 (en) | 2017-01-06 | 2020-04-21 | Bicyclerd Limited | Compounds for treating cancer |
TWI783978B (zh) | 2017-03-08 | 2022-11-21 | 美商林伯士拉克許米公司 | Tyk2抑制劑、其用途及生產方法 |
EP3375784A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
EP3375778A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidine derivatives |
ES2900199T3 (es) | 2017-03-28 | 2022-03-16 | Bayer Ag | Novedosos compuestos macrocíclicos inhibidores de PTEFB |
EP3601236A1 (en) | 2017-03-28 | 2020-02-05 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
US11339144B2 (en) | 2017-04-10 | 2022-05-24 | Navitor Pharmaceuticals, Inc. | Heteroaryl Rheb inhibitors and uses thereof |
JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
TWI776886B (zh) | 2017-04-26 | 2022-09-11 | 美商奈維特製藥公司 | Sestrin-gator2交互作用之調節劑及其用途 |
US10857196B2 (en) | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
US10899798B2 (en) | 2017-06-26 | 2021-01-26 | Bicyclerd Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
WO2019023468A1 (en) | 2017-07-28 | 2019-01-31 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
EP3661948B1 (en) | 2017-08-04 | 2022-06-01 | BicycleTx Limited | Bicyclic peptide ligands specific for cd137 |
US20200283482A1 (en) | 2017-08-14 | 2020-09-10 | Bicyclerd Limited | Bicyclic peptide ligand prr-a conjugates and uses thereof |
US20200291096A1 (en) | 2017-08-14 | 2020-09-17 | Bicyclerd Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
AU2018324037A1 (en) | 2017-08-29 | 2020-04-16 | Monash University | Lymphatic system-directing lipid prodrugs |
IL295603B2 (en) | 2017-09-22 | 2024-03-01 | Kymera Therapeutics Inc | Protein compounds and their uses |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
WO2019076817A1 (en) | 2017-10-19 | 2019-04-25 | Bayer Animal Health Gmbh | USE OF FUSED HETEROAROMATIC PYRROLIDONES FOR THE TREATMENT AND PREVENTION OF DISEASES IN ANIMALS |
WO2019126378A1 (en) | 2017-12-19 | 2019-06-27 | Ariya Therapeutics, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
CA3086763A1 (en) | 2017-12-26 | 2019-07-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
TWI816742B (zh) | 2018-01-29 | 2023-10-01 | 美商維泰克斯製藥公司 | Gcn2抑制劑及其用途 |
IL312674A (en) | 2018-01-29 | 2024-07-01 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
UA126458C2 (uk) | 2018-02-13 | 2022-10-05 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
MX2020008447A (es) | 2018-02-13 | 2020-09-28 | Bayer Ag | Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b. |
CN112189009B (zh) | 2018-02-27 | 2023-09-29 | 阿塔克斯生物制药有限公司 | 作为tcr-nck相互作用的抑制剂的色烯衍生物 |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
IL278142B2 (en) | 2018-04-24 | 2023-11-01 | Merck Patent Gmbh | Antiproliferative compounds and their uses |
IL278122B2 (en) | 2018-04-24 | 2024-01-01 | Vertex Pharma | Petridinon compounds and their uses |
JP2021523118A (ja) | 2018-05-04 | 2021-09-02 | インサイト・コーポレイションIncyte Corporation | Fgfr阻害剤の塩 |
BR112020022392A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | formas sólidas de um inibidor de fgfr e processos para preparação das mesmas |
US10703733B2 (en) | 2018-05-14 | 2020-07-07 | Gilead Sciences, Inc. | MCL-1 inhibitors |
EP3801476A4 (en) * | 2018-05-25 | 2022-07-06 | Kartos Therapeutics, Inc. | METHODS OF TREATMENT OF MYELOPROLIFERATIVE NEOPLASMA |
AU2019286524A1 (en) | 2018-06-15 | 2021-01-07 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
CN108707119A (zh) * | 2018-06-25 | 2018-10-26 | 抚顺大恒化工有限公司 | 一种Momelotinib的制备方法 |
US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
SI3820572T1 (sl) | 2018-07-13 | 2023-12-29 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
TW202021590A (zh) | 2018-08-21 | 2020-06-16 | 美商西爾拉癌症醫學公司 | 血小板計數-治療骨髓纖維化之不可知方法 |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
US12030875B2 (en) | 2018-09-07 | 2024-07-09 | PIC Therapeutics, Inc. | EIF4E inhibitors and uses thereof |
WO2020081508A1 (en) | 2018-10-15 | 2020-04-23 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
JP2022512779A (ja) | 2018-10-23 | 2022-02-07 | バイスクルテクス・リミテッド | 二環式ペプチドリガンドおよびその使用 |
WO2020086816A1 (en) | 2018-10-24 | 2020-04-30 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
CA3115830C (en) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
US20220119383A1 (en) | 2018-10-30 | 2022-04-21 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
JP7530360B2 (ja) | 2018-11-30 | 2024-08-07 | 武田薬品工業株式会社 | Tyk2阻害剤およびその使用 |
WO2020113233A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
EP3670659A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Biomarkers, and uses in treatment of viral infections, inflammations, or cancer |
JP2022518505A (ja) | 2019-01-23 | 2022-03-15 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
WO2020165600A1 (en) | 2019-02-14 | 2020-08-20 | Bicycletx Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2020182159A1 (zh) | 2019-03-14 | 2020-09-17 | 上海华汇拓医药科技有限公司 | Jak激酶抑制剂及其制备方法和在医药领域的应用 |
EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
EP3946462A1 (en) | 2019-04-02 | 2022-02-09 | BicycleTX Limited | Bicycle toxin conjugates and uses thereof |
MA55565A (fr) | 2019-04-05 | 2022-02-09 | Kymera Therapeutics Inc | Agents de dégradation de stat et leurs utilisations |
SG11202113154YA (en) | 2019-05-31 | 2021-12-30 | Ikena Oncology Inc | Tead inhibitors and uses thereof |
WO2021091535A1 (en) | 2019-11-05 | 2021-05-14 | Constellation Pharmaceuticals, Inc. | Treating myeloproliferative disorders with cpi-0610 and a jak inhibitor |
WO2020257644A1 (en) | 2019-06-21 | 2020-12-24 | Constellation Pharmaceuticals, Inc. | Methods of treating myeloproliferative disorders |
WO2020256739A1 (en) | 2019-06-21 | 2020-12-24 | Constellation Pharmaceuticals, Inc. | Methods of treating myeloproliferative disorders |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CN110330484B (zh) * | 2019-07-18 | 2022-08-26 | 中国药科大学 | 取代类苯基嘧啶衍生物作为jak激酶抑制剂或其可药用的盐、制备方法及用途 |
TW202110485A (zh) | 2019-07-30 | 2021-03-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
AU2020345962A1 (en) | 2019-09-11 | 2022-03-31 | Vincere Biosciences, Inc. | USP30 inhibitors and uses thereof |
KR20220105631A (ko) | 2019-09-13 | 2022-07-27 | 님버스 새턴 인코포레이티드 | Hpk1 길항제 및 이의 용도 |
BR112022007163A2 (pt) | 2019-10-14 | 2022-08-23 | Incyte Corp | Heterociclos bicíclicos como inibidores de fgfr |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
BR112022008287A2 (pt) | 2019-11-01 | 2022-07-26 | Navitor Pharm Inc | Métodos de tratamento usando um modulador de mtorc1 |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
IL293001A (en) | 2019-12-04 | 2022-07-01 | Incyte Corp | Derivatives of fgfr repressors |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
WO2021113665A1 (en) | 2019-12-05 | 2021-06-10 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
BR112022011857A2 (pt) * | 2019-12-16 | 2022-09-06 | Oncobix Co Ltd | Derivado de pirimidina substituído por deutério e composição farmacêutica compreendendo o mesmo |
EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
CA3161878A1 (en) | 2019-12-17 | 2021-06-24 | Matthew M. Weiss | Irak degraders and uses thereof |
AU2020412780A1 (en) | 2019-12-23 | 2022-07-21 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
KR20220149534A (ko) | 2020-02-05 | 2022-11-08 | 퓨어테크 엘와이티, 아이엔씨. | 신경스테로이드의 지질 전구약물 |
CN115515685A (zh) | 2020-03-03 | 2022-12-23 | 皮克医疗公司 | Eif4e抑制剂及其用途 |
BR112022018678A2 (pt) | 2020-03-19 | 2022-11-01 | Kymera Therapeutics Inc | Degradadores de mdm2 e usos dos mesmos |
EP4143189A1 (en) | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
CN113583020B (zh) * | 2020-04-30 | 2022-04-22 | 百极弘烨(广东)医药科技有限公司 | 一种jak2抑制剂及应用 |
TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
WO2022038158A1 (en) | 2020-08-17 | 2022-02-24 | Bicycletx Limited | Bicycle conjugates specific for nectin-4 and uses thereof |
CN112142675B (zh) * | 2020-10-09 | 2021-11-30 | 嘉兴特科罗生物科技有限公司 | 一种作为jak激酶抑制剂的小分子化合物及其用途 |
CA3200814A1 (en) | 2020-12-02 | 2022-06-09 | Alfredo C. Castro | Tead inhibitors and uses thereof |
WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
TWI838670B (zh) | 2020-12-22 | 2024-04-11 | 美商基利科學股份有限公司 | 經取代之吲哚化合物 |
WO2022140390A1 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
JP2024505571A (ja) | 2021-02-02 | 2024-02-06 | リミナル・バイオサイエンシーズ・リミテッド | Gpr84アンタゴニストおよびその使用 |
BR112023015584A2 (pt) | 2021-02-02 | 2023-10-24 | Liminal Biosciences Ltd | Antagonistas de gpr84 e usos dos mesmos |
WO2022166916A1 (zh) * | 2021-02-05 | 2022-08-11 | 深圳市塔吉瑞生物医药有限公司 | 取代的杂芳基衍生物及其组合物及用途 |
TW202246283A (zh) | 2021-02-09 | 2022-12-01 | 美商基利科學股份有限公司 | 噻吩并吡咯化合物 |
CN116867494A (zh) | 2021-02-15 | 2023-10-10 | 凯麦拉医疗公司 | Irak4降解剂和其用途 |
US11926625B2 (en) | 2021-03-05 | 2024-03-12 | Nimbus Saturn, Inc. | HPK1 antagonists and uses thereof |
US12071442B2 (en) | 2021-03-29 | 2024-08-27 | Nimbus Saturn, Inc. | Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists |
EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
CA3215081A1 (en) | 2021-04-16 | 2022-10-20 | Alfredo C. Castro | Mek inhibitors and uses thereof |
CR20230478A (es) | 2021-04-16 | 2023-11-30 | Gilead Sciences Inc | Compuestos de tienopirrol. |
JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Fgfr阻害剤としての三環式ヘテロ環 |
WO2023019095A2 (en) | 2021-08-10 | 2023-02-16 | Sierra Oncology, Inc. | Momelotinib combination therapy |
WO2023023473A1 (en) | 2021-08-16 | 2023-02-23 | Sierra Oncology, Inc. | Methods of using momelotinib to treat chronic kidney disease |
CN118019739A (zh) | 2021-08-25 | 2024-05-10 | 皮克医疗公司 | Eif4e抑制剂及其用途 |
IL310924A (en) | 2021-08-25 | 2024-04-01 | Pic Therapeutics Inc | EIF4E inhibitors and their uses |
EP4398989A1 (en) | 2021-09-10 | 2024-07-17 | Gilead Sciences, Inc. | Thienopyrrole compounds |
WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
WO2023152773A1 (en) * | 2022-02-14 | 2023-08-17 | Dr. Reddy's Institute Of Life Sciences | Solid forms of momelotinib salts and improved processes for the preparation of momelotinib |
WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023211889A1 (en) | 2022-04-25 | 2023-11-02 | Ikena Oncology, Inc. | Polymorphic compounds and uses thereof |
WO2023230205A1 (en) | 2022-05-25 | 2023-11-30 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
CN117304179A (zh) * | 2022-06-21 | 2023-12-29 | 苏州泽璟生物制药股份有限公司 | 杰克替尼二盐酸盐一水合物的制备工艺 |
WO2024028365A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Substituted pyridone gpr84 antagonists and uses thereof |
WO2024028363A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Heteroaryl carboxamide and related gpr84 antagonists and uses thereof |
TW202415650A (zh) | 2022-08-02 | 2024-04-16 | 英商利米那生物科技有限公司 | 芳基-三唑基及相關gpr84拮抗劑及其用途 |
WO2024035771A2 (en) * | 2022-08-09 | 2024-02-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Ulk3 inhibitors and uses thereof |
CN115677676A (zh) * | 2022-10-19 | 2023-02-03 | 黑龙江中医药大学 | 一种治疗银屑病的药物及其制备方法 |
WO2024112894A1 (en) | 2022-11-22 | 2024-05-30 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
WO2024134481A1 (en) | 2022-12-21 | 2024-06-27 | Glaxosmithkline Llc | Combination therapy comprising jaktinib |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3481932A (en) * | 1967-09-01 | 1969-12-02 | Searle & Co | 2-anilino-5-methyl-6-phenylpyrimidines and congeners |
GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
SK2142002A3 (en) * | 1999-08-13 | 2002-07-02 | Scripps Research Inst | Methods and compositions useful for modulation of angiogenesis using protein kinase raf and ras |
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
EP1363702A4 (en) | 2001-01-30 | 2007-08-22 | Cytopia Pty Ltd | PROCESS FOR INHIBITING KINASES |
MXPA03008888A (es) | 2001-03-29 | 2005-03-07 | Vertex Pharma | Inhibidores de n-terminal c-jun cinasas (jnk) y otras proteinas cinasas. |
US6433018B1 (en) | 2001-08-31 | 2002-08-13 | The Research Foundation Of State University Of New York | Method for reducing hypertrophy and ischemia |
EP1427391B1 (en) | 2001-09-12 | 2008-07-09 | ViRexx Medical Corporation | Solid-phase agent for vascular occlusion with immobilised platelet binding agent |
IL165264A0 (en) | 2002-05-23 | 2005-12-18 | Cytopia Pty Ltd | Protein kinase inhibitors |
KR20050042478A (ko) | 2002-08-14 | 2005-05-09 | 버텍스 파마슈티칼스 인코포레이티드 | 프로테인 키나아제 억제제 및 이의 용도 |
AU2003286876A1 (en) * | 2002-11-01 | 2004-06-07 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
WO2004041814A1 (en) | 2002-11-04 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Heteroaryl-pyramidine derivatives as jak inhibitors |
WO2004041810A1 (en) * | 2002-11-05 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of jak and other protein kinases |
GB0317841D0 (en) * | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
JP2007500179A (ja) * | 2003-07-30 | 2007-01-11 | サイクラセル・リミテッド | キナーゼ阻害剤としての2−アミノフェニル−4−フェニルピリミジン |
CA2580913A1 (en) * | 2004-10-13 | 2006-04-27 | Wyeth | N-benzenesulfonyl substituted anilino-pyrimidine analogs |
US7593820B2 (en) | 2005-05-12 | 2009-09-22 | Cytopia Research Pty Ltd | Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof |
CA2611720A1 (en) * | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
EP1979329A2 (en) | 2006-01-30 | 2008-10-15 | Exelixis, Inc. | 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and methods of use |
WO2007101232A2 (en) | 2006-02-28 | 2007-09-07 | Cytopia Research Pty, Ltd. | Inhibition of jak2 as a treatment of pulmonary arterial hypertension |
FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
CA2702650C (en) | 2007-03-12 | 2017-01-03 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine compounds and uses thereof |
CA2698511C (en) * | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
WO2009029998A1 (en) | 2007-09-06 | 2009-03-12 | Cytopia Research Pty Ltd | Retrometabolic compounds |
WO2009073575A2 (en) | 2007-11-30 | 2009-06-11 | Oregon Health & Science University | Methods for treating induced cellular proliferative disorders |
AU2009279825A1 (en) | 2008-08-05 | 2010-02-11 | Targegen, Inc. | Methods of treating thalassemia |
KR20130137011A (ko) | 2010-12-03 | 2013-12-13 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | Jak-2 매개 병태의 치료 방법 |
PE20140750A1 (es) | 2011-05-02 | 2014-07-06 | Ym Biosciences Australia Pty | Tratamiento del mieloma multiple |
US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
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