HUE028777T2 - Deuterált katekolamin-származékok és ezeket a vegyületeket tartalmazó gyógyszerek - Google Patents
Deuterált katekolamin-származékok és ezeket a vegyületeket tartalmazó gyógyszerek Download PDFInfo
- Publication number
- HUE028777T2 HUE028777T2 HUE07703542A HUE07703542A HUE028777T2 HU E028777 T2 HUE028777 T2 HU E028777T2 HU E07703542 A HUE07703542 A HU E07703542A HU E07703542 A HUE07703542 A HU E07703542A HU E028777 T2 HUE028777 T2 HU E028777T2
- Authority
- HU
- Hungary
- Prior art keywords
- trihydroxybenzyl
- acid
- hydrazide
- amino
- drug
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (2)
- i, saervoiaonsafjd, «samlomsfjelvsgÿ dias:defOömmd optikailag hada donnában. továbbá árok fidöldgl&ii&g d fogadható sói gyógyszerként történő a.ikdmsxásm, 2v LP~Ámmppddjdsm®n>~M;M'dshld?os:ifdtÍ! kpmpionsav ês sssoreoiaomérmh «naotidnkiyd vagy tSasascmemerjct optikailag stsasa-formában* ievtófei m>* fsxblógtaifag oliógadhsto sol Parklosoïs-kôn nyogtalan láb sdodroma és tcnddlsnos i^ímÉösgs;k^«lóssb«íiy proíaktifi szekréció kiksxrsáfás slimuiai&aahaa. kr#ikns mangámndrgexáaskbcsg amkarőfiáa imsaáls;rklófódsfs>8 éstölidss^di'ös saisídéfbas strófához kapcsoló# »etológia; sjtim|»*-ómák kæaefettbCR törté# alkalmadra. 3 Vegyiket alkalmazásra a 2. Igénypoíd ssérint, kombinádéba® akőksíkAsö csopedbéi válasz# emumgàtlôv&f vagy néhány enanngátiéval: DtL^dHn-2'(2>3í44fíhklr<)Síhsh^|)4h<:lfassd {be8Si;em£ídí4 í-)'L-'a-bádradnodd{fihidrtixi-.x-mehlhidrocümamiöäav (karbkiopith L-ézeHií'-S^jSí^írfhlároX'lfe^i^l^lékazH $ßäxs*2* (2Jsf4dbidn>dbe«ssl)4ddrsi:id és L^ifodnddhk'MrihidiOKdíendlj^dtndd. sntgkaporg kabergolhg sgelsgbh® tookfobemkh traailjeígrorom, kalc.ian#*b#Jkplk0Élnát és ksickon'5'pentikpildlMh ioyslha azok íksötö^kllág olíbpdbsíóséi,
- 4. Oyógyszerésacii készítmény, amely tanaimat i^S-andno^jHiídooisíO'O-p^-dihidmsifónilkpfopiimsavai: és stsercoaomerjeit, enantîotnfçeâ vagy d>asz?«»t:<»z»m«tjelt «3^i.kÄg::Ö5d:Ä»ib8»» ixníábl^sd feioiógssílag elfogadható sóit gyógysíwrósxettUtg ellógadható adjuvánsokfcai éa sgyéh #gédanykjpldcsl «gvdft 5. A 4. igénypont saannti gyógyszerészeti késdtméayj antély a ka$gi$t&g3fe Alköíía hsopodbdl vólssdod enddtpil-Ä vagy néltáoy «riximgádót8l)>L^KsrisPd2:>3d-tnhKÍröídhsnkil^hidásdd: ffeen§zera?ld), {-ivl.-ixdndraadKs-:3v4d.}lBdrôxj-dr?«etilksd?<ïeàmâmlnsâvr{ksdsdopa|,l.yszaî'i»d?K2,3;,4'' trihi#>Kib®«aii}-hid{aaisk glscín-S'i^.a.éArihidrsíkihonzdphidi'aasd ás Lsndsznvdkd.Oíd-Sfíhiíh'úXíhóí'sallJ-'htdraa’.íö, eniakajss'.. katx:rg<)iin, Sírdogiiin, oKiklobonnC irsnikopromlxg kskdpfnP-kidd'pikodnai és karéimn'd'psjnsí'· pikolinât, továbbá azok íiaiologsailag elfogadható sói.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006008316 | 2006-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE028777T2 true HUE028777T2 (hu) | 2017-01-30 |
Family
ID=38236462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE07703542A HUE028777T2 (hu) | 2006-02-17 | 2007-02-16 | Deuterált katekolamin-származékok és ezeket a vegyületeket tartalmazó gyógyszerek |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | USRE46555E1 (hu) |
| EP (2) | EP3101001B1 (hu) |
| JP (1) | JP5248331B2 (hu) |
| KR (1) | KR101411422B1 (hu) |
| CN (1) | CN101384545B (hu) |
| AU (1) | AU2007214622B2 (hu) |
| BR (1) | BRPI0708071A8 (hu) |
| CA (1) | CA2642593C (hu) |
| CY (1) | CY1117995T1 (hu) |
| DK (1) | DK1991522T3 (hu) |
| EA (1) | EA017983B1 (hu) |
| ES (1) | ES2587368T3 (hu) |
| HR (1) | HRP20161039T1 (hu) |
| HU (1) | HUE028777T2 (hu) |
| IL (1) | IL193102A (hu) |
| LT (1) | LT1991522T (hu) |
| ME (1) | ME02508B (hu) |
| PL (1) | PL1991522T3 (hu) |
| PT (1) | PT1991522T (hu) |
| RS (1) | RS55142B1 (hu) |
| SI (1) | SI1991522T1 (hu) |
| UA (1) | UA97795C2 (hu) |
| WO (1) | WO2007093450A2 (hu) |
| ZA (1) | ZA200806568B (hu) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| CA2726833C (en) | 2008-06-06 | 2016-03-22 | Pharma Two B Ltd. | Pharmaceutical compositions for treatment of parkinson's disease |
| MX2011000637A (es) | 2008-07-15 | 2011-05-02 | Theracos Inc | Derivados deuretados de bencilbenceno y metodos de uso. |
| WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| BR112015005894B1 (pt) | 2012-09-18 | 2022-03-29 | Auspex Pharmaceuticals, Inc | Composto, composição farmacêutica, método para tratar um distúrbio mediado por vmat2 e formulação farmacêutica de liberação prolongada |
| US9763904B2 (en) | 2013-02-05 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds |
| BR112015016889A8 (pt) | 2013-02-05 | 2018-01-23 | Imphar Ag | derivados de catecolamina enriquecidos com deutério em posição específica |
| WO2014174425A2 (en) * | 2013-04-24 | 2014-10-30 | Mahesh Kandula | Compositions and methods for the treatment of orthostasis and neurological diseases |
| EA201600093A1 (ru) * | 2013-07-08 | 2016-08-31 | Ауспекс Фармасьютикалс, Инк. | Дигидроксифенильные нейромедиаторные соединения, композиции и способы |
| MX2016006622A (es) * | 2013-11-22 | 2016-12-09 | Auspex Pharmaceuticals Inc | Metodos para tratar actividad muscular anormal. |
| NZ720301A (en) | 2013-12-03 | 2022-01-28 | Auspex Pharmaceuticals Inc | Deuterated tetrabenazine compounds |
| EP3102190A4 (en) | 2014-02-07 | 2017-09-06 | Auspex Pharmaceuticals, Inc. | Novel pharmaceutical formulations |
| EP2918266A1 (en) | 2014-03-11 | 2015-09-16 | CDRD Berolina AB | Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease |
| GB201420341D0 (en) * | 2014-11-17 | 2014-12-31 | Evolution Valves Ltd | Valve arrangement |
| CA3236214A1 (en) | 2015-03-06 | 2016-09-15 | Auspex Pharmaceuticals, Inc. | Methods for the treatment of abnormal involuntary movement disorders |
| CN106343013A (zh) * | 2015-07-19 | 2017-01-25 | 中国科学院上海有机化学研究所 | 一种粮食储存方法 |
| CN105360267B (zh) * | 2015-10-09 | 2017-11-10 | 青岛振坤食品机械有限公司 | 一种全自动穿串机 |
| WO2017060870A1 (en) | 2015-10-09 | 2017-04-13 | Hermann Russ | Combination of deuterated levodopa with carbidopa and opicapone for the treatment of parkinson`s disease |
| CN105862897B (zh) * | 2016-04-11 | 2018-01-16 | 江苏省华建建设股份有限公司 | 砂质泥岩地基浅基础原槽浇筑施工工法 |
| CN113383391A (zh) * | 2018-12-06 | 2021-09-10 | 先达生物科技公司 | 季铵盐作为三甲胺产生的抑制剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3699158A (en) | 1969-08-25 | 1972-10-17 | Merck & Co Inc | Selective deuteration of tyrosine, aspartic and glutamic acids |
| DE2049807A1 (en) | 1970-10-10 | 1972-04-13 | Hartmeyer H | Conversion of closed cell plastics foam to - open cell structure |
| DE2049115C3 (de) | 1970-10-06 | 1981-07-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa) |
| EP0252290B1 (en) * | 1986-06-10 | 1992-06-03 | CHIESI FARMACEUTICI S.p.A. | Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof |
| IT1226902B (it) | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi del levodopa |
| US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| DE10261807A1 (de) * | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
| DE10261808A1 (de) | 2002-12-19 | 2004-07-08 | Turicum Drug Development Ag | Verwendung von L-DOPA, seiner Derivate und diese Verbindungen enthaltender Arzneimittel zur Prophylaxe psychotischer Erkrankungen |
-
2007
- 2007-02-16 EP EP16170031.5A patent/EP3101001B1/en active Active
- 2007-02-16 US US14/464,568 patent/USRE46555E1/en not_active Expired - Fee Related
- 2007-02-16 US US12/224,120 patent/US8247603B2/en not_active Ceased
- 2007-02-16 JP JP2008554702A patent/JP5248331B2/ja not_active Expired - Fee Related
- 2007-02-16 EA EA200801826A patent/EA017983B1/ru not_active IP Right Cessation
- 2007-02-16 ES ES07703542.6T patent/ES2587368T3/es active Active
- 2007-02-16 AU AU2007214622A patent/AU2007214622B2/en not_active Ceased
- 2007-02-16 CN CN200780005912.6A patent/CN101384545B/zh not_active Expired - Fee Related
- 2007-02-16 RS RS20160674A patent/RS55142B1/sr unknown
- 2007-02-16 BR BRPI0708071A patent/BRPI0708071A8/pt not_active Application Discontinuation
- 2007-02-16 UA UAA200811184A patent/UA97795C2/uk unknown
- 2007-02-16 HU HUE07703542A patent/HUE028777T2/hu unknown
- 2007-02-16 PT PT77035426T patent/PT1991522T/pt unknown
- 2007-02-16 DK DK07703542.6T patent/DK1991522T3/en active
- 2007-02-16 SI SI200731819A patent/SI1991522T1/sl unknown
- 2007-02-16 CA CA2642593A patent/CA2642593C/en active Active
- 2007-02-16 KR KR1020087022011A patent/KR101411422B1/ko active IP Right Grant
- 2007-02-16 PL PL07703542T patent/PL1991522T3/pl unknown
- 2007-02-16 WO PCT/EP2007/001555 patent/WO2007093450A2/en active Application Filing
- 2007-02-16 LT LTEP07703542.6T patent/LT1991522T/lt unknown
- 2007-02-16 EP EP07703542.6A patent/EP1991522B1/en active Active
- 2007-02-16 ME MEP-2016-167A patent/ME02508B/me unknown
-
2008
- 2008-07-28 ZA ZA200806568A patent/ZA200806568B/xx unknown
- 2008-07-29 IL IL193102A patent/IL193102A/en active IP Right Grant
-
2016
- 2016-08-17 HR HRP20161039TT patent/HRP20161039T1/hr unknown
- 2016-08-17 CY CY20161100808T patent/CY1117995T1/el unknown
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