HU1500363A2 - Method for increasing the galactose content of recombinant proteins - Google Patents

Method for increasing the galactose content of recombinant proteins

Info

Publication number
HU1500363A2
HU1500363A2 HU1500363A HU1500363A HU1500363A2 HU 1500363 A2 HU1500363 A2 HU 1500363A2 HU 1500363 A HU1500363 A HU 1500363A HU 1500363 A HU1500363 A HU 1500363A HU 1500363 A2 HU1500363 A2 HU 1500363A2
Authority
HU
Hungary
Prior art keywords
increasing
method
recombinant proteins
galactose content
galactose
Prior art date
Application number
HU1500363A
Inventor
Laszlo Parta
Aron Schleicher
Gaspar Nagy
Akos Dr Putics
Denes Zsolt Zalai
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU1500363A priority Critical patent/HU1500363A2/en
Publication of HU1500363A2 publication Critical patent/HU1500363A2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/34Sugars
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/40Nucleotides, nucleosides, bases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
HU1500363A 2015-08-04 2015-08-04 Method for increasing the galactose content of recombinant proteins HU1500363A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU1500363A HU1500363A2 (en) 2015-08-04 2015-08-04 Method for increasing the galactose content of recombinant proteins

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
HU1500363A HU1500363A2 (en) 2015-08-04 2015-08-04 Method for increasing the galactose content of recombinant proteins
US15/749,978 US20180230228A1 (en) 2015-08-04 2016-08-04 Method for increasing the galactose content of recombinant proteins
PCT/EP2016/068651 WO2017021493A1 (en) 2015-08-04 2016-08-04 Method for increasing the galactose content of recombinant proteins
JP2018505597A JP2018521676A (en) 2015-08-04 2016-08-04 Method of increasing the galactose content of recombinant proteins
CA2994611A CA2994611A1 (en) 2015-08-04 2016-08-04 Method for increasing the galactose content of recombinant proteins
EP16750431.5A EP3331911A1 (en) 2015-08-04 2016-08-04 Method for increasing the galactose content of recombinant proteins
CN201680058299.3A CN108350075A (en) 2015-08-04 2016-08-04 Method for increasing the galactose content of recombinant proteins
KR1020187006240A KR20180070553A (en) 2015-08-04 2016-08-04 Method of increasing the galactose content of the recombinant protein

Publications (1)

Publication Number Publication Date
HU1500363A2 true HU1500363A2 (en) 2017-02-28

Family

ID=57942485

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1500363A HU1500363A2 (en) 2015-08-04 2015-08-04 Method for increasing the galactose content of recombinant proteins

Country Status (8)

Country Link
US (1) US20180230228A1 (en)
EP (1) EP3331911A1 (en)
JP (1) JP2018521676A (en)
KR (1) KR20180070553A (en)
CN (1) CN108350075A (en)
CA (1) CA2994611A1 (en)
HU (1) HU1500363A2 (en)
WO (1) WO2017021493A1 (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2736076A1 (en) 1991-03-18 1992-09-19 New York University Monoclonal and chimeric antibodies specific for human tumor necrosis factor
LU91067I2 (en) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab and its variants and derivatives chemical immuno including immotoxines
RU2139731C1 (en) 1992-11-13 1999-10-20 Айдек Фармасьютикалс Корпорейшн (US Methods of treatment, antibodies, hybridoma
CN103275221B (en) 1996-02-09 2016-08-17 艾伯维生物技术有限公司 Human antibody binding to human TNFα of
DE122007000021I1 (en) 1997-04-07 2007-05-24 Genentech Inc Anti-VEFG Antibodies
DK1409016T3 (en) 2001-06-26 2010-06-21 Amgen Fremont Inc Antibodies to OPGL
EP2511293A1 (en) 2011-04-13 2012-10-17 LEK Pharmaceuticals d.d. A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
EP2702077A2 (en) * 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2014170866A2 (en) 2013-04-18 2014-10-23 Dr. Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased galactosylation content

Also Published As

Publication number Publication date
CN108350075A (en) 2018-07-31
EP3331911A1 (en) 2018-06-13
JP2018521676A (en) 2018-08-09
US20180230228A1 (en) 2018-08-16
CA2994611A1 (en) 2017-02-09
KR20180070553A (en) 2018-06-26
WO2017021493A1 (en) 2017-02-09

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