HU0401195A3 - Compositions to prevent abuse of opioids containing aversive agent and process of their preparation - Google Patents

Compositions to prevent abuse of opioids containing aversive agent and process of their preparation

Info

Publication number
HU0401195A3
HU0401195A3 HU0401195A HU0401195A HU0401195A3 HU 0401195 A3 HU0401195 A3 HU 0401195A3 HU 0401195 A HU0401195 A HU 0401195A HU 0401195 A HU0401195 A HU 0401195A HU 0401195 A3 HU0401195 A3 HU 0401195A3
Authority
HU
Hungary
Prior art keywords
compositions
preparation
process
aversive agent
prevent abuse
Prior art date
Application number
HU0401195A
Other versions
HU0401195A2 (en
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US31053701P priority Critical
Priority to US31051601P priority
Priority to US31051501P priority
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Priority to PCT/US2002/024934 priority patent/WO2003013479A1/en
Publication of HU0401195A2 publication Critical patent/HU0401195A2/en
Publication of HU0401195A3 publication Critical patent/HU0401195A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
HU0401195A 2001-08-06 2002-08-06 Compositions to prevent abuse of opioids containing aversive agent and process of their preparation HU0401195A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US31053701P true 2001-08-06 2001-08-06
US31051601P true 2001-08-06 2001-08-06
US31051501P true 2001-08-06 2001-08-06
PCT/US2002/024934 WO2003013479A1 (en) 2001-08-06 2002-08-06 Compositions and methods to prevent abuse of opioids

Publications (2)

Publication Number Publication Date
HU0401195A2 HU0401195A2 (en) 2004-10-28
HU0401195A3 true HU0401195A3 (en) 2006-11-28

Family

ID=27405462

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401195A HU0401195A3 (en) 2001-08-06 2002-08-06 Compositions to prevent abuse of opioids containing aversive agent and process of their preparation

Country Status (10)

Country Link
EP (1) EP1414418A1 (en)
JP (1) JP2005501067A (en)
KR (1) KR20040060917A (en)
AU (1) AU2002319774B2 (en)
BR (1) BR0212019A (en)
CA (1) CA2456322A1 (en)
DE (1) DE20220910U1 (en)
HU (1) HU0401195A3 (en)
MX (1) MXPA04001208A (en)
WO (1) WO2003013479A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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PT1041987E (en) 1997-12-22 2006-07-31 Euro Celtique Sa Pharmaceutical form of oral dosage, understanding a combination of an agronist of opioide and naltrexone
CA2446550C (en) 2001-05-11 2012-03-06 Endo Pharmaceuticals, Inc. Abuse-resistant controlled-release opioid dosage form
DK1416842T3 (en) * 2001-07-18 2009-03-16 Euro Celtique Sa Pharmaceutical combinations of oxycodone and naloxone
AU2002337686B2 (en) * 2001-09-26 2008-05-15 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
BRPI0309544B1 (en) 2002-04-05 2018-04-03 Euro-Celtique S.A. Oral pharmaceutical preparation storage storage understanding oxycodone and naloxone
JP4732696B2 (en) 2002-04-09 2011-07-27 フラメル・テクノロジーFlamel Technologies Oral pharmaceutical formulation in the form of an aqueous suspension of microcapsules for modified release of the active ingredient
DE10250083A1 (en) * 2002-06-17 2003-12-24 Gruenenthal Gmbh Abuse-proofed dosage form
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
SI1542658T1 (en) * 2002-08-15 2011-04-29 Euro Celtique Sa Pharmaceutical compositions comprising an opioid analgesic
DE10250088A1 (en) * 2002-10-25 2004-05-06 Grünenthal GmbH Abuse-proofed dosage form
DE10250084A1 (en) * 2002-10-25 2004-05-06 Grünenthal GmbH Abuse-proofed dosage form
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
MXPA05011071A (en) * 2003-04-21 2005-12-12 Euro Celtique Sa Tamper resistant dosage form comprising co-extruded, adverse agent particles and process of making same.
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US20060165790A1 (en) * 2003-06-27 2006-07-27 Malcolm Walden Multiparticulates
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
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MXPA06011122A (en) 2004-03-30 2007-03-21 Euro Celtique Sa Tamper resistant dosage form comprising an adsorbent and an adverse agent.
DE102004019916A1 (en) * 2004-04-21 2005-11-17 Grünenthal GmbH Anti-abuse drug-containing patch
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
GB0501638D0 (en) * 2005-01-28 2005-03-02 Euro Celtique Sa Particulates
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
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WO2006133733A1 (en) 2005-06-13 2006-12-21 Flamel Technologies Oral dosage form comprising an antimisuse system
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
EP2292220A3 (en) 2005-11-22 2012-01-04 Orexigen Therapeutics, Inc. Composition and methods for increasing insulin sensitivity
EP1810714A1 (en) * 2006-01-19 2007-07-25 Holger Lars Hermann Use of a combination of heroin and naloxon for drug substitution
WO2007145863A2 (en) * 2006-06-05 2007-12-21 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
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DE102007011485A1 (en) 2007-03-07 2008-09-11 Grünenthal GmbH Dosage form with more difficult abuse
US8420700B1 (en) * 2008-06-04 2013-04-16 James M. Bausch Tamper resistant lipid-based oral dosage form for sympathomimetic amines
US8273798B2 (en) * 2007-06-04 2012-09-25 Shear Kershman Laboratories Tamper resistant lipid-based oral dosage form for opioid agonists
CA2696341C (en) 2007-08-13 2016-05-17 Abuse Deterrent Pharmaceutical Llc Abuse resistant drugs, method of use and method of making
WO2009076764A1 (en) 2007-12-17 2009-06-25 Labopharm Inc. Misuse preventative, controlled release formulation
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AU2009327312A1 (en) 2008-12-16 2011-08-04 Labopharm Europe Limited Misuse preventative, controlled release formulation
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US10080721B2 (en) 2009-07-22 2018-09-25 Gruenenthal Gmbh Hot-melt extruded pharmaceutical dosage form
WO2011009603A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive oploids
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RS57913B1 (en) 2012-04-18 2019-01-31 Gruenenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
ES2436344B1 (en) * 2012-05-29 2014-08-07 Onedose Pharma, S.L. Pharmaceutical composition of diacetylmorphine and naloxone for oral administration
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6375957B1 (en) * 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations

Also Published As

Publication number Publication date
CA2456322A1 (en) 2003-02-20
KR20040060917A (en) 2004-07-06
JP2005501067A (en) 2005-01-13
BR0212019A (en) 2005-08-09
DE20220910U1 (en) 2004-08-05
EP1414418A1 (en) 2004-05-06
MXPA04001208A (en) 2004-07-08
AU2002319774B2 (en) 2005-04-21
WO2003013479A1 (en) 2003-02-20
HU0401195A2 (en) 2004-10-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees