HU0304101A3 - Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates - Google Patents

Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates

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Publication number
HU0304101A3
HU0304101A3 HU0304101A HU0304101A HU0304101A3 HU 0304101 A3 HU0304101 A3 HU 0304101A3 HU 0304101 A HU0304101 A HU 0304101A HU 0304101 A HU0304101 A HU 0304101A HU 0304101 A3 HU0304101 A3 HU 0304101A3
Authority
HU
Hungary
Prior art keywords
intermediates
producing
process
use
pharmaceutical compositions
Prior art date
Application number
HU0304101A
Other versions
HU0304101A2 (en
HU0304101D0 (en
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Priority to HU0304101A priority Critical patent/HU0304101A3/en
Publication of HU0304101D0 publication Critical patent/HU0304101D0/en
Publication of HU0304101A2 publication Critical patent/HU0304101A2/en
Publication of HU0304101A3 publication Critical patent/HU0304101A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring-systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
HU0304101A 2003-12-22 2003-12-22 Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates HU0304101A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU0304101A HU0304101A3 (en) 2003-12-22 2003-12-22 Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
HU0304101A HU0304101A3 (en) 2003-12-22 2003-12-22 Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
PCT/HU2004/000117 WO2005060959A1 (en) 2003-12-22 2004-12-15 Pyrazole derivatives and use thereof as orexin receptor antagonists
AT04806274T AT438395T (en) 2003-12-22 2004-12-15 Pyrazol derivatives and their use as orexin receptor antagonists
EP20040806274 EP1699454B1 (en) 2003-12-22 2004-12-15 Pyrazole derivatives and use thereof as orexin receptor antagonists
DE200460022458 DE602004022458D1 (en) 2003-12-22 2004-12-15 Pyrazone derivatives and their use as orexine receptor antagonists
JP2006546344A JP4861829B2 (en) 2003-12-22 2004-12-15 Pyrazole derivatives and their use as orexin receptor antagonists
TW93139247A TWI289558B (en) 2003-12-22 2004-12-17 New compounds
ARP040104839 AR046793A1 (en) 2003-12-22 2004-12-22 Pyrazole derivatives, antagonists orexin receptor
US11/425,583 US7659298B2 (en) 2003-12-22 2006-06-21 Pyrazole derivatives and use thereof as orexin receptor antagonists
US12/699,231 US20110059964A1 (en) 2003-12-22 2010-02-03 Pyrazole derivatives and use thereof as orexin receptor antagonists

Publications (3)

Publication Number Publication Date
HU0304101D0 HU0304101D0 (en) 2004-03-29
HU0304101A2 HU0304101A2 (en) 2005-09-28
HU0304101A3 true HU0304101A3 (en) 2008-10-28

Family

ID=32012034

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0304101A HU0304101A3 (en) 2003-12-22 2003-12-22 Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates

Country Status (9)

Country Link
US (2) US7659298B2 (en)
EP (1) EP1699454B1 (en)
JP (1) JP4861829B2 (en)
AR (1) AR046793A1 (en)
AT (1) AT438395T (en)
DE (1) DE602004022458D1 (en)
HU (1) HU0304101A3 (en)
TW (1) TWI289558B (en)
WO (1) WO2005060959A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2527185T3 (en) * 2003-03-07 2015-01-21 Santen Pharmaceutical Co., Ltd New compounds that have a 4-pyridyl alkylthio group as a substituent
HU0304101A3 (en) * 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
AU2005295753A1 (en) * 2004-10-15 2006-04-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
FR2896799B1 (en) * 2006-02-02 2008-03-28 Sanofi Aventis Sa Sulfonamide derivatives, their preparation and their therapeutic application
CA2657623A1 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc Orexin receptor antagonists substituted Diazepam
CL2008000836A1 (en) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd derivatives of thiazolidine compounds, antagonists orexin receptor; pharmaceutical composition which comprises; and their use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's disease, Parkinson's disease, pain, among others.
WO2008143856A1 (en) 2007-05-18 2008-11-27 Merck & Co., Inc. Oxo bridged diazepan orexin receptor antagonists
AT540944T (en) 2007-05-23 2012-01-15 Merck Sharp & Dohme PYRIDYLPIPERIDINOREXIN Receptor Antagonists
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
KR20100017372A (en) * 2007-05-25 2010-02-16 아보트 러보러터리즈 Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2(mglu2 receptor)
JP2011522878A (en) * 2008-06-11 2011-08-04 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd Tetrazole compounds as orexin receptor antagonists
CA2821893A1 (en) * 2010-12-17 2012-06-21 Taisho Pharmaceutical Co., Ltd. Pyrazole derivative
US9303023B2 (en) 2011-02-18 2016-04-05 Actelion Pharmaceuticals Ltd. Pyrazole and imidazole derivatives useful as orexin antagonists
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonists receptor-pyridyloxy 2-4-nitrile orexin
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
CA2863413A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
AR101558A1 (en) 2014-08-13 2016-12-28 Eolas Therapeutics Inc Difluoropirrolidinas as modulators of the orexin
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146721A (en) * 1969-09-12 1979-03-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrazol-4-acetic acid compounds
LU68238A1 (en) * 1973-08-16 1975-05-21
DE3835732A1 (en) * 1988-10-20 1990-04-26 Thomae Gmbh Dr K Heterocyclically substituted 3-hydroxyglutaric acids and their derivatives, process for their preparation and medicaments containing these compounds
GB9708340D0 (en) * 1997-04-25 1997-06-18 Univ Napier Organic blue light emitting materials for use in electroluminescent display devices
US6372757B1 (en) * 1998-05-08 2002-04-16 Smithkline Beecham P.L.C. Phenylurea and phenylthio urea derivatives
PA8535601A1 (en) * 2000-12-21 2002-11-28 Pfizer Benzimidazole derivatives and pyridylimidazole as ligands for GABAA
HU0304101A3 (en) * 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates

Also Published As

Publication number Publication date
AT438395T (en) 2009-08-15
US20110059964A1 (en) 2011-03-10
EP1699454B1 (en) 2009-08-05
HU0304101D0 (en) 2004-03-29
TW200526632A (en) 2005-08-16
US7659298B2 (en) 2010-02-09
HU0304101A2 (en) 2005-09-28
EP1699454A1 (en) 2006-09-13
TWI289558B (en) 2007-11-11
US20070021459A1 (en) 2007-01-25
DE602004022458D1 (en) 2009-09-17
WO2005060959A1 (en) 2005-07-07
JP4861829B2 (en) 2012-01-25
AR046793A1 (en) 2005-12-21
WO2005060959A8 (en) 2006-01-12
JP2007519630A (en) 2007-07-19

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Legal Events

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished