HU0301201A3 - Methods and compositions utilizing quinazolinones - Google Patents

Methods and compositions utilizing quinazolinones

Info

Publication number
HU0301201A3
HU0301201A3 HU0301201A HU0301201A HU0301201A3 HU 0301201 A3 HU0301201 A3 HU 0301201A3 HU 0301201 A HU0301201 A HU 0301201A HU 0301201 A HU0301201 A HU 0301201A HU 0301201 A3 HU0301201 A3 HU 0301201A3
Authority
HU
Hungary
Prior art keywords
methods
compositions utilizing
utilizing quinazolinones
quinazolinones
compositions
Prior art date
Application number
HU0301201A
Other versions
HU229078B1 (en
HU0301201A2 (en
Original Assignee
Cytokinetics Inc South San Fra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US21310400P priority Critical
Priority to US09/699,047 priority patent/US6545004B1/en
Application filed by Cytokinetics Inc South San Fra filed Critical Cytokinetics Inc South San Fra
Priority to PCT/US2001/013901 priority patent/WO2001098278A1/en
Publication of HU0301201A2 publication Critical patent/HU0301201A2/en
Publication of HU0301201A3 publication Critical patent/HU0301201A3/en
Publication of HU229078B1 publication Critical patent/HU229078B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/90Oxygen atoms with acyclic radicals attached in positions 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in positions 2 or 3
HU0301201A 1999-10-27 2001-04-27 Quinazolinones and pharmaceutical compositions containing them HU229078B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US21310400P true 2000-06-21 2000-06-21
US09/699,047 US6545004B1 (en) 1999-10-27 2000-10-24 Methods and compositions utilizing quinazolinones
PCT/US2001/013901 WO2001098278A1 (en) 2000-06-21 2001-04-27 Methods and compositions utilizing quinazolinones

Publications (3)

Publication Number Publication Date
HU0301201A2 HU0301201A2 (en) 2003-12-29
HU0301201A3 true HU0301201A3 (en) 2004-03-29
HU229078B1 HU229078B1 (en) 2013-07-29

Family

ID=26907773

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301201A HU229078B1 (en) 1999-10-27 2001-04-27 Quinazolinones and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (7) US6545004B1 (en)
EP (2) EP1296959B1 (en)
JP (1) JP4854906B2 (en)
KR (1) KR100847788B1 (en)
CN (1) CN1229353C (en)
AT (1) AT323684T (en)
AU (3) AU2001259270B2 (en)
BR (1) BR0111898A (en)
CA (1) CA2413426C (en)
CZ (1) CZ303007B6 (en)
DE (1) DE60118921T2 (en)
DK (1) DK1296959T3 (en)
ES (1) ES2262649T3 (en)
HK (1) HK1053837A1 (en)
HU (1) HU229078B1 (en)
IL (1) IL153554A (en)
MX (1) MXPA02012627A (en)
NO (1) NO324440B1 (en)
NZ (1) NZ523233A (en)
PL (1) PL204525B1 (en)
PT (1) PT1296959E (en)
SI (1) SI1296959T1 (en)
WO (1) WO2001098278A1 (en)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965825A (en) 1981-11-03 1990-10-23 The Personalized Mass Media Corporation Signal processing apparatus and methods
US7831204B1 (en) 1981-11-03 2010-11-09 Personalized Media Communications, Llc Signal processing apparatus and methods
EP1216232B1 (en) 1999-08-27 2006-10-11 ChemoCentryx, Inc. Heterocyclic compounds and methods for modulating cxcr3 function
US20070021493A1 (en) * 1999-09-16 2007-01-25 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7671200B2 (en) * 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
PL366311A1 (en) 2000-12-11 2005-01-24 Tularik Inc. Cxcr3 antagonists
WO2002057244A1 (en) * 2001-01-19 2002-07-25 Cytokinetics, Inc. Phenothiazine kinesin inhibitors
US6794379B2 (en) 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
EA200301250A1 (en) 2001-06-22 2004-06-24 Пфайзер Продактс Инк. Pharmaceutical compositions containing a poorly soluble and / or acid-sensitive drugs and neutralized acidic polymers
CA2459583A1 (en) * 2001-09-05 2003-03-13 Minerva Biotechnologies Corporation Compositions and methods of treatment of cancer
WO2003039460A2 (en) 2001-11-07 2003-05-15 Merck & Co., Inc. Mitotic kinesin inhibitors
AU2002366103A1 (en) * 2001-11-19 2003-06-10 Iconix Pharmaceuticals, Inc. Modulators of rho c activity
DK1847534T3 (en) * 2001-12-11 2011-08-29 Kyowa Hakko Kirin Co Ltd Thiadiazoline derivatives for the treatment of cancer
WO2003070701A2 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses of quinazolinones
WO2003076418A1 (en) * 2002-03-07 2003-09-18 X-Ceptor Therapeutics, Inc. Quinazolinone modulators of nuclear receptors
KR101052816B1 (en) * 2002-04-17 2011-07-29 스미스 클라인 비참 코포레이션 Compounds, compositions and methods
EP1553931A4 (en) * 2002-05-09 2006-08-30 Cytokinetics Inc Compounds, compositions, and methods
CA2485148A1 (en) * 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
AU2003265242A1 (en) * 2002-05-23 2003-12-22 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003236527A1 (en) * 2002-06-14 2003-12-31 Cytokinetics, Inc. Compounds, compositions, and methods
EP1539727B1 (en) * 2002-07-17 2009-02-18 Cytokinetics, Inc. Compounds, compositions, and methods for treating cellular proliferative diseases
EP1537089A4 (en) * 2002-07-23 2008-04-16 Cytokinetics Inc Compounds compositions and methods
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
WO2004024086A2 (en) * 2002-09-13 2004-03-25 Cytokinetics, Inc. Compounds, compositions and methods
JP2006501306A (en) * 2002-09-30 2006-01-12 サイトキネティクス・インコーポレーテッドCytokinetics Incorporated Compounds, compositions and methods
US7358262B2 (en) 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
SE0300627D0 (en) 2003-03-07 2003-03-07 Astrazeneca Ab Novel fused heterocycles and uses therof
AR050920A1 (en) * 2003-03-07 2006-12-06 Astrazeneca Ab Enantiomers of fused heterocycles selected and uses thereof
US20060270689A1 (en) * 2003-03-07 2006-11-30 Astrazeneca Ab Novel Fused Heterocycles and Uses Thereof
EP1781674A1 (en) * 2004-08-18 2007-05-09 AstraZeneca AB Enantiomers of selected fused pyrimidones and uses in the treatment and prevention of cancer
EP1622883A4 (en) * 2003-04-10 2008-04-02 Cytokinetics Inc Compounds, compositions, and methods
WO2004092123A2 (en) * 2003-04-10 2004-10-28 Microbia, Inc. Inhibitors of fungal invasion
ES2377498T3 (en) 2003-04-18 2012-03-28 Fujifilm Corporation Kinesin inhibitor stage M
JP2007500213A (en) * 2003-05-07 2007-01-11 サイトキネティクス・インコーポレーテッドCytokinetics Incorporated Compounds, compositions and methods
JP2007500746A (en) * 2003-05-15 2007-01-18 サイトキネティクス・インコーポレーテッドCytokinetics Incorporated Compounds, compositions and methods
US7345046B2 (en) * 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
AU2004247551A1 (en) * 2003-06-10 2004-12-23 Fuji Photo Film Co., Ltd. Thiadiazoline derivative
JP2007520435A (en) * 2003-06-20 2007-07-26 カイロン コーポレイション Pyridino as anticancer agents [1,2-a] pyrimidin-4-one compounds
CA2534729A1 (en) * 2003-08-15 2005-02-24 Merck & Co., Inc. Mitotic kinesin inhibitors
WO2005042697A2 (en) * 2003-10-06 2005-05-12 Cytokinetics, Inc. Compounds, compositions and methods
EP1671957A4 (en) * 2003-10-10 2007-03-14 Thiadiazoline derivatives
JP2007510652A (en) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッドCytokinetics Incorporated Pyrimidin-4-one compounds, compositions, and methods
EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc Compounds, compositions, and methods
EP1689724B1 (en) * 2003-11-25 2011-12-21 Novartis AG Quinazolinone compounds as anticancer agents
US7439254B2 (en) 2003-12-08 2008-10-21 Cytokinetics, Inc. Compounds, compositions, and methods
US7662581B1 (en) 2003-12-18 2010-02-16 Novartis Vaccines And Diagnostics, Inc. Eg5 co-crystals
WO2005061518A1 (en) * 2003-12-19 2005-07-07 Merck & Co., Inc. Mitotic kinesin inhibitors
EP1697331A4 (en) * 2003-12-19 2010-08-04 Merck Sharp & Dohme Mitotic kinesin inhibitors
CA2549641A1 (en) * 2003-12-19 2005-07-21 Merck & Co., Inc. Mitotic kinesin inhibitors
WO2005095360A1 (en) 2004-04-02 2005-10-13 Prana Biotechnology Limited Neurologically-active compounds
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
US7795448B2 (en) * 2004-05-06 2010-09-14 Cytokinetics, Incorporated Imidazoyl-benzamide anti-cancer agents
US7504413B2 (en) * 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
DK1753723T3 (en) * 2004-05-21 2008-10-20 Novartis Vaccines & Diagnostic Substituted quinoline derivatives mitotic kinesininhibitorer
US20050282834A1 (en) * 2004-06-09 2005-12-22 Fady Malik Compositions, devices and methods for treating cardiovascular disease
AU2005258135B2 (en) 2004-06-18 2011-09-22 Novartis Vaccines And Diagnostics Inc. N- (1- (1-benzyl -4-phenyl-1H-imidazol-2-YL) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (KSP) inhibitors for the treatment of cancer
US7375102B2 (en) 2004-06-28 2008-05-20 Amgen Sf, Llc Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
US7939538B2 (en) 2004-06-28 2011-05-10 Amgen Inc. Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
US7271271B2 (en) 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
BRPI0513513A (en) * 2004-07-22 2008-05-06 Astrazeneca Ab compound or a pharmaceutically acceptable salt thereof, process for preparing the same, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, and methods to produce an inhibitory effect of Eg5 and anticancer effect in a warm-blooded animal and for treating cancers in a warm-blooded animal
US20060041128A1 (en) * 2004-08-18 2006-02-23 Astrazeneca Ab Selected fused heterocyclics and uses thereof
EP1786265A4 (en) * 2004-08-30 2009-08-19 Smithkline Beecham Corp Novel compositions and methods of treatment
WO2007053135A1 (en) * 2004-09-14 2007-05-10 Minerva Biotechnologies Corporation Methods for diagnosis and treatment of cancer
US7449486B2 (en) * 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
BRPI0517314A (en) * 2004-10-19 2008-10-07 Novartis Vaccines & Diagnostic indole derivatives and benzimidazole
WO2006060737A2 (en) * 2004-12-03 2006-06-08 Takeda San Diego, Inc. Mitotic kinesin inhibitors
US20070161644A1 (en) * 2005-01-25 2007-07-12 Stockwell Brent R Erastin analogs and uses thereof
US7615554B2 (en) * 2005-01-25 2009-11-10 Prolexys Pharmaceuticals, Inc. Erastin and erastin binding proteins, and uses thereof
TW200714593A (en) * 2005-03-22 2007-04-16 Kyowa Hakko Kogyo Kk Agent for treatment of solid tumor
CA2602559A1 (en) * 2005-03-22 2006-09-28 Kyowa Hakko Kogyo Co., Ltd. Agent for treatment of hematopoietic tumor
DE102005024017A1 (en) * 2005-05-25 2006-11-30 Merck Patent Gmbh quinazolinones
EP1908755A4 (en) * 2005-06-24 2009-06-24 Kyowa Hakko Kirin Co Ltd Therapeutic agent for restenosis
MY147188A (en) * 2005-08-09 2012-11-14 Novartis Ag Substituted imidazole compounds as ksp inhibitors
JP2009509969A (en) * 2005-09-26 2009-03-12 メルク エンド カムパニー インコーポレーテッドMerck & Company Incoporated Androgen receptor modulators as the n-(4-oxo-3,4-dihydroquinazolin-2-yl) butanamide
DE102006002065B4 (en) * 2006-01-16 2007-11-29 Infineon Technologies Austria Ag Compensation component with a reduced on-resistance and adjustable
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US8535897B2 (en) * 2006-06-19 2013-09-17 The Trustees Of Columbia University In The City Of New York Assays for non-apoptotic cell death and uses thereof
WO2008014373A2 (en) * 2006-07-27 2008-01-31 Smithkline Beecham Corporation Hspa1a as a marker for sensitivity to ksp inhibitors
US8173629B2 (en) 2006-09-22 2012-05-08 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
MX2009003673A (en) * 2006-10-04 2009-04-22 Pfizer Prod Inc Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists.
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (en) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited Complex drug
EP2091926B1 (en) * 2006-11-13 2015-10-21 Novartis AG Substituted pyrazole and triazole compounds as ksp inhibitors
UA97821C2 (en) * 2007-01-05 2012-03-26 Новартис Аг Cyclized derivatives as eg-5 inhibitors
EP2805945B1 (en) 2007-01-10 2019-04-03 MSD Italia S.r.l. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
JP5330274B2 (en) 2007-03-01 2013-10-30 ノバルティス アーゲー Pim kinase inhibitors and methods of use thereof
EP2152700B1 (en) 2007-05-21 2013-12-11 Novartis AG Csf-1r inhibitors, compositions, and methods of use
US8232285B2 (en) 2007-06-22 2012-07-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
WO2009002553A1 (en) * 2007-06-25 2008-12-31 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
EP3103791B1 (en) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
JP5462862B2 (en) 2008-04-22 2014-04-02 サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィクCentre National De La Recherche Scientifique Using Kif13A inhibitors and AP-1 inhibitors for inhibiting melanogenesis
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
RU2624045C2 (en) 2010-08-17 2017-06-30 Сирна Терапьютикс,Инк RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
US8927559B2 (en) * 2010-10-11 2015-01-06 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as CRTH2 antagonists
EP3327125A1 (en) 2010-10-29 2018-05-30 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
EP2455456A1 (en) 2010-11-22 2012-05-23 Institut Curie Use of kinesin inhibitors in HIV infection treatment and a method for screening them
WO2012145471A1 (en) 2011-04-21 2012-10-26 Merck Sharp & Dohme Corp. Insulin-like growth factor-1 receptor inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3453762A1 (en) 2012-05-02 2019-03-13 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
JP6125663B2 (en) 2012-12-21 2017-05-10 ギリアード カリストガ エルエルシー Substituted pyrimidine aminoalkyl as phosphatidylinositol 3-kinase inhibitor - quinazolone
US9029384B2 (en) 2012-12-21 2015-05-12 Gilead Calistoga, LLC. Phosphatidylinositol 3-kinase inhibitors
CA2915129A1 (en) 2013-06-14 2014-12-18 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
SG11201602445SA (en) 2013-10-04 2016-04-28 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
WO2015051241A1 (en) * 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
JP2017523215A (en) 2014-08-06 2017-08-17 ノバルティス アーゲー Protein kinase c inhibitors and methods of use thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
TW201815787A (en) 2016-09-23 2018-05-01 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
TW201813963A (en) 2016-09-23 2018-04-16 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1053063A (en) 1963-05-18
US3320124A (en) 1964-07-20 1967-05-16 American Cyanamid Co Method for treating coccidiosis with quinazolinones
US3846549A (en) 1966-09-03 1974-11-05 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl -2)-n-phenyl-piperazine
US3723432A (en) 1968-11-12 1973-03-27 Sandoz Ag 1-substituted-4-aryl-2(1h)-quinazolinones and their preparation
US3962244A (en) 1971-01-23 1976-06-08 Hoechst Aktiengesellschaft Benzene sulfonyl ureas
US3740442A (en) 1972-01-14 1973-06-19 Sandoz Ag 2-isopropylaminobenzophenones in treating inflammation
US4011324A (en) * 1976-01-20 1977-03-08 Pfizer Inc. Esters and amides of pyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylic acids as antiulcer agents
EP0009008A3 (en) 1978-09-08 1980-05-14 Ciba-Geigy Ag Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4281127A (en) 1979-07-09 1981-07-28 Hoffmann-La Roche Inc. Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives
EP0278530A3 (en) 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Amino acid derivatives, process for their preparation, agents containing them and their use
AU543928B2 (en) 1981-01-16 1985-05-09 Masayuki Ishikawa 4(311)-quinazolinone derivatives
EP0090068A1 (en) 1982-03-31 1983-10-05 Hans Wenner Automatic vending machine for newspapers, magazines, foodstuffs and other articles
GB8524663D0 (en) 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
DE3609598A1 (en) 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane and their salts, processes for their preparation, compositions containing them and their use
US5187167A (en) 1986-03-27 1993-02-16 Imperial Chemical Industries Plc Pharmaceutical compositions comprising quinazolin-4-one derivatives
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4670560A (en) * 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
US4729996A (en) 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use
DE3721855A1 (en) 1987-03-12 1988-09-22 Merck Patent Gmbh Aminosaeurederivate
GB8707053D0 (en) 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4808590A (en) 1987-07-17 1989-02-28 Harbor Branch Oceanographic Institution, Inc. Antiviral, antitumor and antifungal compositions and their methods of use
US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
JPS6430768A (en) * 1987-07-28 1989-02-01 Toshiba Corp Thermal head
US5756450A (en) 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
US4857530A (en) 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8820129D0 (en) 1988-08-24 1988-09-28 Schering Agrochemicals Ltd Fungicides
GB8827820D0 (en) 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
GB8827988D0 (en) 1988-11-30 1989-01-05 Smith Kline French Lab Chemical compounds
US4970226A (en) 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5264439A (en) 1990-02-13 1993-11-23 Merck & Co., Inc. Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element
ZA9103730B (en) 1990-05-30 1992-02-26 Ici Plc Anti-tumor compounds
FR2665159B1 (en) * 1990-07-24 1992-11-13 Rhone Poulenc Sante New derivatives of pyridine and quinoline, their preparation and pharmaceutical compositions containing them.
EP0481614A1 (en) 1990-10-01 1992-04-22 Merck & Co., Inc. Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists
NL9100023A (en) * 1991-01-09 1992-08-03 Crown Gear Bv Grinding disc for the production of crown wheels, as well as process for manufacturing such a grinding wheel.
GB9105771D0 (en) 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
US5714493A (en) 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5316906A (en) 1991-08-23 1994-05-31 Molecular Probes, Inc. Enzymatic analysis using substrates that yield fluorescent precipitates
US5204354A (en) 1992-02-14 1993-04-20 Merck & Co., Inc. Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders
AT180785T (en) 1992-03-12 1999-06-15 Smithkline Beecham Plc Condensed indole derivatives as 5-HT4 receptor-antagonist
GB9205907D0 (en) 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US5430148A (en) 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
GB9220571D0 (en) 1992-09-30 1992-11-11 Ici Plc Quinazoline derivatives
US5817662A (en) 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5804584A (en) 1992-11-16 1998-09-08 Cell Therapeutics, Inc. Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
AU6087894A (en) 1993-01-14 1994-08-15 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
WO1994016704A1 (en) 1993-01-19 1994-08-04 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5574057A (en) 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
US5401745A (en) 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5837703A (en) 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US5342944A (en) 1993-07-19 1994-08-30 American Cyanamid Company Process for the preparation of 2-alkyl-3,5,6,7- or 8-substituted-4(3H)-quinazolinones
US20020198326A1 (en) 1993-11-12 2002-12-26 Taizo Aoyama Polyolefin resin composition
CA2113229C (en) 1994-01-11 1999-04-20 Mark Pines Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
AU1831395A (en) 1994-01-14 1995-08-01 Cell Therapeutics, Inc. Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf
WO1995022546A1 (en) 1994-02-18 1995-08-24 Cell Therapeutics, Inc. Intracellular signalling mediators
AU2096895A (en) 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US5807861A (en) 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
US5801182A (en) 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5756502A (en) 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
JPH09165385A (en) * 1994-08-26 1997-06-24 Kyowa Hakko Kogyo Co Ltd Quinazoline derivative
US5891879A (en) 1994-08-31 1999-04-06 Hadasit Medical Research Services & Development Co., Inc. Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
IL110831A (en) 1994-08-31 1998-12-27 Hadasit Med Res Service Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis
IL112125A (en) 1994-12-22 1998-02-08 Hadasit Med Res Service Quinazolinone-containing pharmaceutical compositions
US5753664A (en) 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
DE69600978T2 (en) * 1995-03-28 1999-04-15 Tanabe Seiyaku Co A process for the preparation of D-amino acids
US6245768B1 (en) 1995-06-05 2001-06-12 Neurogen Corporation 1-(N′-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands
CN1090621C (en) 1995-08-30 2002-09-11 株式会社大冢制药厂 Process for producing quinazoline-4-one derivatives
WO1997010221A1 (en) 1995-09-15 1997-03-20 Torrey Pines Institute For Molecular Studies Synthesis of quinazolinone libraries
US5783577A (en) 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof
DE19546918A1 (en) 1995-12-15 1997-06-19 Bayer Ag Bicyclic heterocycles
DE19615262A1 (en) 1996-04-18 1997-10-23 Bayer Ag Straight Linked phenylglycinolamides
DK0901487T3 (en) 1996-05-15 2003-08-25 Pfizer 2,3,6-tri-substituted 4 (3H) -quinazolinones
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US6008010A (en) 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
BR9714222A (en) * 1996-12-17 2000-04-18 Du Pont Method for the control of plant diseases
US6028075A (en) 1997-02-11 2000-02-22 Pines; Mark Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies
US5852024A (en) 1997-02-11 1998-12-22 Hadasit Treatment and prevention of adhesions
US5948775A (en) 1997-03-19 1999-09-07 American Home Products Corporation 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones
US6627755B1 (en) 1997-06-09 2003-09-30 Pfizer Inc Quinazolin-4-one AMPA antagonists
EP0884310B1 (en) 1997-06-09 2005-09-07 Pfizer Products Inc. Quinazolin-4-one ampa antagonists
US6060479A (en) 1997-06-09 2000-05-09 Pfizer Inc Quinazoline-4-one AMPA antagonists
US5939421A (en) 1997-07-01 1999-08-17 Signal Pharmaceuticals, Inc. Quinazoline analogs and related compounds and methods for treating inflammatory conditions
EP0903344B1 (en) 1997-08-21 2011-01-26 Shiseido Co., Ltd. Quinazolin-4-one derivatives, their preparation and their use as hair growth promoters or in external compositions for skin
JP2934628B2 (en) * 1997-08-21 1999-08-16 株式会社資生堂 Quinazolinone derivatives and hair tonic, skin external agent
IL125950D0 (en) * 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
EP1049475A4 (en) * 1998-01-08 2003-06-04 Univ California KINESIN MOTOR MODULATORS DERIVED FROM THE MARINE SPONGE $i(ADOCIA)
US6214879B1 (en) 1998-03-24 2001-04-10 Virginia Commonwealth University Allosteric inhibitors of pyruvate kinase
AU5322399A (en) 1998-07-27 2000-02-21 President And Fellows Of Harvard College Method of high-throughput screening of molecules and compounds for their effectson biological and chemical processes
US6596497B1 (en) * 1999-03-17 2003-07-22 New York Blood Center, Inc. Screening of antiviral compounds targeted to the HIV-1 gp41 core structure
EP1216232B1 (en) 1999-08-27 2006-10-11 ChemoCentryx, Inc. Heterocyclic compounds and methods for modulating cxcr3 function
US6156758A (en) 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
EP1516876A1 (en) 1999-09-16 2005-03-23 Curis, Inc. Mediators of hedgehog signalling pathways, compositions and uses related thereto
BR0014311A (en) 1999-09-28 2002-05-21 Merck Patent Gmbh quinazolinones
WO2001023365A1 (en) 1999-09-28 2001-04-05 Merck Patent Gmbh Quinazolinones
US6436919B1 (en) 1999-10-01 2002-08-20 Theravance Inc. Local anesthetic compounds
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
NZ518480A (en) * 1999-10-27 2004-02-27 Cytokinetics Inc Methods and compositions utilizing quinazolinones
US6495561B2 (en) * 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6476041B1 (en) * 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
AR026748A1 (en) 1999-12-08 2003-02-26 Vertex Pharma A compound caspase inhibitor, a pharmaceutical composition comprising the same, a method for synthesis thereof and a compound paradicha intermediate synthesis
DE60032342T2 (en) 2000-01-13 2007-07-12 Koninklijke Philips Electronics N.V. A method of protection of the compressed contents after separation from original source
ES2159488B1 (en) 2000-03-07 2002-04-16 Uriach & Cia Sa J Process for the preparation of pyrimidone derivatives with antifungal activity.
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
AT305786T (en) 2000-03-30 2005-10-15 Curis Inc Small organic molecules as regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
JP4642309B2 (en) 2000-04-25 2011-03-02 イコス・コーポレイションIcos Corporation Human phosphatidyl - inositol 3-kinase delta inhibitor
US20020165221A1 (en) 2000-10-13 2002-11-07 Baxter Anthony David Mediators of hedgehog signaling pathways, compositions and uses related thereto
AUPR201600A0 (en) 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
PL366311A1 (en) 2000-12-11 2005-01-24 Tularik Inc. Cxcr3 antagonists
WO2002081467A1 (en) * 2001-04-09 2002-10-17 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
US7365199B2 (en) * 2001-04-20 2008-04-29 Fujifilm Corporation Dye-forming coupler, silver halide photographic light-sensitive material, and azomethine dye compound
WO2002085909A1 (en) * 2001-04-20 2002-10-31 Vertex Pharmaceuticals Incorporated 9-deazaguanine derivatives as inhibitors of gsk-3
US6794379B2 (en) 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
US6936842B2 (en) * 2001-06-27 2005-08-30 Applied Materials, Inc. Method and apparatus for process monitoring
US6596723B1 (en) * 2001-07-16 2003-07-22 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
US20030220338A1 (en) * 2001-07-16 2003-11-27 Watkins Will J. Fungal efflux pump inhibitors
US20030144350A1 (en) * 2001-07-20 2003-07-31 Adipogenix, Inc. Fat accumulation-modulation compounds
CA2459583A1 (en) * 2001-09-05 2003-03-13 Minerva Biotechnologies Corporation Compositions and methods of treatment of cancer
CA2459584A1 (en) * 2001-09-05 2003-03-13 Cynthia C. Bamdad Compositions and use thereof in the treatment of cancer
AU2002366103A1 (en) * 2001-11-19 2003-06-10 Iconix Pharmaceuticals, Inc. Modulators of rho c activity
WO2003043995A1 (en) 2001-11-20 2003-05-30 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
WO2003070701A2 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses of quinazolinones
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US20030158188A1 (en) * 2002-02-20 2003-08-21 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
AU2003226252A1 (en) * 2002-04-04 2003-10-20 Cv Therapeutics, Inc. Compounds dor increasing abca-1 expression useful for treating coronary artery disease and atherosclerosis
EP1553931A4 (en) 2002-05-09 2006-08-30 Cytokinetics Inc Compounds, compositions, and methods
CA2485148A1 (en) 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
AU2003265242A1 (en) 2002-05-23 2003-12-22 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003236527A1 (en) 2002-06-14 2003-12-31 Cytokinetics, Inc. Compounds, compositions, and methods
EP1537089A4 (en) 2002-07-23 2008-04-16 Cytokinetics Inc Compounds compositions and methods
US20040048853A1 (en) 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
US20040092561A1 (en) * 2002-11-07 2004-05-13 Thomas Ruckle Azolidinone-vinyl fused -benzene derivatives
JP4977837B2 (en) * 2003-09-10 2012-07-18 アイカジェン, インコーポレイテッド Fused heterocycle as potassium channel modulators
EP1689724B1 (en) * 2003-11-25 2011-12-21 Novartis AG Quinazolinone compounds as anticancer agents
US20050152940A1 (en) * 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050282834A1 (en) * 2004-06-09 2005-12-22 Fady Malik Compositions, devices and methods for treating cardiovascular disease

Also Published As

Publication number Publication date
CZ303007B6 (en) 2012-02-22
AU5927001A (en) 2002-01-02
PL358412A1 (en) 2004-08-09
DE60118921T2 (en) 2006-11-23
KR100847788B1 (en) 2008-07-23
AT323684T (en) 2006-05-15
US6562831B1 (en) 2003-05-13
CN1437585A (en) 2003-08-20
JP4854906B2 (en) 2012-01-18
EP1707563A2 (en) 2006-10-04
AU2001259270B2 (en) 2006-08-24
IL153554D0 (en) 2003-07-06
CA2413426C (en) 2011-01-04
US7105668B1 (en) 2006-09-12
HU229078B1 (en) 2013-07-29
HK1053837A1 (en) 2006-06-23
US20040254203A1 (en) 2004-12-16
PT1296959E (en) 2006-07-31
BR0111898A (en) 2003-05-13
HU0301201A2 (en) 2003-12-29
KR20030047903A (en) 2003-06-18
EP1296959B1 (en) 2006-04-19
CN1229353C (en) 2005-11-30
NO20026172D0 (en) 2002-12-20
NZ523233A (en) 2004-10-29
US20040023996A1 (en) 2004-02-05
IL153554A (en) 2009-09-01
ES2262649T3 (en) 2006-12-01
US6630479B1 (en) 2003-10-07
EP1296959A1 (en) 2003-04-02
CZ20024178A3 (en) 2003-05-14
US6831085B1 (en) 2004-12-14
AU2006236024A1 (en) 2006-12-07
NO324440B1 (en) 2007-10-15
JP2004501140A (en) 2004-01-15
MXPA02012627A (en) 2003-09-25
DE60118921D1 (en) 2006-05-24
EP1707563A3 (en) 2007-06-06
SI1296959T1 (en) 2007-02-28
NO20026172L (en) 2003-02-20
DK1296959T3 (en) 2006-07-31
US6545004B1 (en) 2003-04-08
WO2001098278A1 (en) 2001-12-27
CA2413426A1 (en) 2001-12-27
US7294634B2 (en) 2007-11-13
PL204525B1 (en) 2010-01-29

Similar Documents

Publication Publication Date Title
DE60136690D1 (en) Axiales wirbelimplantat
DE60111703D1 (en) Modulare hüftprothese
DE60140693D1 (en) Ankheiten
TW572948B (en) IR-absorbing compositions
GB2368600B (en) Well planning and design
GB2359254B (en) Formulation
DE60234903D1 (en) Staumanagement in computernetzen
DE60115644D1 (en) Thiazinoxazolidinon
DE60112948D1 (en) Polyurethandispersion in alkohol-wasser-system
DE50110048D1 (en) Härtbare wässrige polyurethandispersionen
DE60144026D1 (en) Off-center-tomosynthese
DE60121590D1 (en) Pyrazolderivate
DE60115621D1 (en) Imidazolcarbene
TWI316062B (en) Anti-inflammatory compounds and uses thereof
TWI304324B (en) Pestcide composition and uses thereof
EP1311551A4 (en) Bioactive coating compositions and methods
AU6284701A (en) Language-understanding
AU7192801A (en) Cosmetic compositions
HK1053124A1 (en) Substituted quinazoline derivatives and their use as inhibitors
AU8287701A (en) Cosmetic compositions
GB0129260D0 (en) Pharmaceutical compositions and their uses
AU9381701A (en) 4-amino-quinazolines
AU2778801A (en) Antisense compositions and methods
ZA200309911B (en) Substituted dihydro-3halo-1h-pyrazole-5-carboxylates their preparation and use
DE60123472D1 (en) Holographische multifokallinse

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees