HU0203704A3 - L-pantolactone-hydrolase and a method for producing d-pantolactone - Google Patents

L-pantolactone-hydrolase and a method for producing d-pantolactone

Info

Publication number
HU0203704A3
HU0203704A3 HU0203704A HU0203704A HU0203704A3 HU 0203704 A3 HU0203704 A3 HU 0203704A3 HU 0203704 A HU0203704 A HU 0203704A HU 0203704 A HU0203704 A HU 0203704A HU 0203704 A3 HU0203704 A3 HU 0203704A3
Authority
HU
Hungary
Prior art keywords
pantolactone
hydrolase
producing
method
Prior art date
Application number
HU0203704A
Other versions
HU0203704A2 (en
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19952501A priority Critical patent/DE19952501A1/en
Priority to DE10029194A priority patent/DE10029194A1/en
Application filed by Basf Ag filed Critical Basf Ag
Priority to PCT/EP2000/010320 priority patent/WO2001032890A1/en
Publication of HU0203704A2 publication Critical patent/HU0203704A2/en
Publication of HU0203704A3 publication Critical patent/HU0203704A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
HU0203704A 1999-10-29 2000-10-20 L-pantolactone-hydrolase and a method for producing d-pantolactone HU0203704A3 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19952501A DE19952501A1 (en) 1999-10-29 1999-10-29 New nucleic acid encoding L-pantolactone hydrolase, useful for producing pure D-pantolactone, an intermediate for vitamins, from its racemate
DE10029194A DE10029194A1 (en) 2000-06-19 2000-06-19 New isolated nucleic acid encoding L-pantolactone hydrolase, useful for production of optically pure D-pantolactone from its racemate
PCT/EP2000/010320 WO2001032890A1 (en) 1999-10-29 2000-10-20 L-pantolactone-hydrolase and a method for producing d-pantolactone

Publications (2)

Publication Number Publication Date
HU0203704A2 HU0203704A2 (en) 2003-03-28
HU0203704A3 true HU0203704A3 (en) 2006-03-28

Family

ID=26006072

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203704A HU0203704A3 (en) 1999-10-29 2000-10-20 L-pantolactone-hydrolase and a method for producing d-pantolactone

Country Status (16)

Country Link
US (1) US6998258B1 (en)
EP (1) EP1224296A1 (en)
JP (1) JP2003530080A (en)
CN (1) CN1384880A (en)
AU (1) AU782517B2 (en)
BR (1) BR0015114A (en)
CA (1) CA2389064A1 (en)
CZ (1) CZ20021449A3 (en)
EE (1) EE200200225A (en)
HU (1) HU0203704A3 (en)
IL (1) IL148973D0 (en)
MX (1) MXPA02003417A (en)
NO (1) NO20021931L (en)
PL (1) PL355487A1 (en)
RU (1) RU2002114044A (en)
WO (1) WO2001032890A1 (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
EP1570060B1 (en) 2002-12-02 2007-08-01 Basf Aktiengesellschaft L-rhamnose-inducible expression systems
WO2004085651A2 (en) * 2003-03-28 2004-10-07 Dsm Ip Assets B.V. Pantolactone hydrolase
WO2007131750A1 (en) * 2006-05-16 2007-11-22 Dsm Ip Assets B.V. Process for the production of panthenol
WO2008013943A2 (en) * 2006-07-27 2008-01-31 Wyeth High-cell density fed-batch fermentation process for producing recombinant protein
US8378311B2 (en) 2008-05-22 2013-02-19 Vladimir Balakin Synchrotron power cycling apparatus and method of use thereof
US9616252B2 (en) 2008-05-22 2017-04-11 Vladimir Balakin Multi-field cancer therapy apparatus and method of use thereof
US8089054B2 (en) 2008-05-22 2012-01-03 Vladimir Balakin Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system
US10086214B2 (en) 2010-04-16 2018-10-02 Vladimir Balakin Integrated tomography—cancer treatment apparatus and method of use thereof
US10029122B2 (en) 2008-05-22 2018-07-24 Susan L. Michaud Charged particle—patient motion control system apparatus and method of use thereof
US9579525B2 (en) 2008-05-22 2017-02-28 Vladimir Balakin Multi-axis charged particle cancer therapy method and apparatus
US10070831B2 (en) 2008-05-22 2018-09-11 James P. Bennett Integrated cancer therapy—imaging apparatus and method of use thereof
US8288742B2 (en) * 2008-05-22 2012-10-16 Vladimir Balakin Charged particle cancer therapy patient positioning method and apparatus
US8718231B2 (en) 2008-05-22 2014-05-06 Vladimir Balakin X-ray tomography method and apparatus used in conjunction with a charged particle cancer therapy system
US9974978B2 (en) 2008-05-22 2018-05-22 W. Davis Lee Scintillation array apparatus and method of use thereof
US8368038B2 (en) * 2008-05-22 2013-02-05 Vladimir Balakin Method and apparatus for intensity control of a charged particle beam extracted from a synchrotron
US10376717B2 (en) 2010-04-16 2019-08-13 James P. Bennett Intervening object compensating automated radiation treatment plan development apparatus and method of use thereof
US8188688B2 (en) 2008-05-22 2012-05-29 Vladimir Balakin Magnetic field control method and apparatus used in conjunction with a charged particle cancer therapy system
US9498649B2 (en) 2008-05-22 2016-11-22 Vladimir Balakin Charged particle cancer therapy patient constraint apparatus and method of use thereof
US9907981B2 (en) 2016-03-07 2018-03-06 Susan L. Michaud Charged particle translation slide control apparatus and method of use thereof
US8374314B2 (en) 2008-05-22 2013-02-12 Vladimir Balakin Synchronized X-ray / breathing method and apparatus used in conjunction with a charged particle cancer therapy system
US10179250B2 (en) 2010-04-16 2019-01-15 Nick Ruebel Auto-updated and implemented radiation treatment plan apparatus and method of use thereof
US9177751B2 (en) 2008-05-22 2015-11-03 Vladimir Balakin Carbon ion beam injector apparatus and method of use thereof
US9981147B2 (en) 2008-05-22 2018-05-29 W. Davis Lee Ion beam extraction apparatus and method of use thereof
US8598543B2 (en) * 2008-05-22 2013-12-03 Vladimir Balakin Multi-axis/multi-field charged particle cancer therapy method and apparatus
US9095040B2 (en) 2008-05-22 2015-07-28 Vladimir Balakin Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system
US9744380B2 (en) 2008-05-22 2017-08-29 Susan L. Michaud Patient specific beam control assembly of a cancer therapy apparatus and method of use thereof
US10518109B2 (en) 2010-04-16 2019-12-31 Jillian Reno Transformable charged particle beam path cancer therapy apparatus and method of use thereof
US9737731B2 (en) 2010-04-16 2017-08-22 Vladimir Balakin Synchrotron energy control apparatus and method of use thereof
US8969834B2 (en) 2008-05-22 2015-03-03 Vladimir Balakin Charged particle therapy patient constraint apparatus and method of use thereof
US9737733B2 (en) 2008-05-22 2017-08-22 W. Davis Lee Charged particle state determination apparatus and method of use thereof
US9782140B2 (en) 2008-05-22 2017-10-10 Susan L. Michaud Hybrid charged particle / X-ray-imaging / treatment apparatus and method of use thereof
US9937362B2 (en) 2008-05-22 2018-04-10 W. Davis Lee Dynamic energy control of a charged particle imaging/treatment apparatus and method of use thereof
US8569717B2 (en) * 2008-05-22 2013-10-29 Vladimir Balakin Intensity modulated three-dimensional radiation scanning method and apparatus
US8436327B2 (en) * 2008-05-22 2013-05-07 Vladimir Balakin Multi-field charged particle cancer therapy method and apparatus
US8624528B2 (en) * 2008-05-22 2014-01-07 Vladimir Balakin Method and apparatus coordinating synchrotron acceleration periods with patient respiration periods
US10349906B2 (en) 2010-04-16 2019-07-16 James P. Bennett Multiplexed proton tomography imaging apparatus and method of use thereof
US8625739B2 (en) 2008-07-14 2014-01-07 Vladimir Balakin Charged particle cancer therapy x-ray method and apparatus
US9682254B2 (en) 2008-05-22 2017-06-20 Vladimir Balakin Cancer surface searing apparatus and method of use thereof
US9155911B1 (en) 2008-05-22 2015-10-13 Vladimir Balakin Ion source method and apparatus used in conjunction with a charged particle cancer therapy system
US8198607B2 (en) * 2008-05-22 2012-06-12 Vladimir Balakin Tandem accelerator method and apparatus used in conjunction with a charged particle cancer therapy system
US8373143B2 (en) * 2008-05-22 2013-02-12 Vladimir Balakin Patient immobilization and repositioning method and apparatus used in conjunction with charged particle cancer therapy
US8178859B2 (en) * 2008-05-22 2012-05-15 Vladimir Balakin Proton beam positioning verification method and apparatus used in conjunction with a charged particle cancer therapy system
US8710462B2 (en) * 2008-05-22 2014-04-29 Vladimir Balakin Charged particle cancer therapy beam path control method and apparatus
US8975600B2 (en) 2008-05-22 2015-03-10 Vladimir Balakin Treatment delivery control system and method of operation thereof
US8229072B2 (en) * 2008-07-14 2012-07-24 Vladimir Balakin Elongated lifetime X-ray method and apparatus used in conjunction with a charged particle cancer therapy system
US8373146B2 (en) * 2008-05-22 2013-02-12 Vladimir Balakin RF accelerator method and apparatus used in conjunction with a charged particle cancer therapy system
US7939809B2 (en) * 2008-05-22 2011-05-10 Vladimir Balakin Charged particle beam extraction method and apparatus used in conjunction with a charged particle cancer therapy system
US8637833B2 (en) 2008-05-22 2014-01-28 Vladimir Balakin Synchrotron power supply apparatus and method of use thereof
US8642978B2 (en) 2008-05-22 2014-02-04 Vladimir Balakin Charged particle cancer therapy dose distribution method and apparatus
US8378321B2 (en) * 2008-05-22 2013-02-19 Vladimir Balakin Charged particle cancer therapy and patient positioning method and apparatus
US8519365B2 (en) * 2008-05-22 2013-08-27 Vladimir Balakin Charged particle cancer therapy imaging method and apparatus
US10188877B2 (en) 2010-04-16 2019-01-29 W. Davis Lee Fiducial marker/cancer imaging and treatment apparatus and method of use thereof
US9044600B2 (en) * 2008-05-22 2015-06-02 Vladimir Balakin Proton tomography apparatus and method of operation therefor
US8399866B2 (en) 2008-05-22 2013-03-19 Vladimir Balakin Charged particle extraction apparatus and method of use thereof
US20090314960A1 (en) * 2008-05-22 2009-12-24 Vladimir Balakin Patient positioning method and apparatus used in conjunction with a charged particle cancer therapy system
US9737272B2 (en) 2008-05-22 2017-08-22 W. Davis Lee Charged particle cancer therapy beam state determination apparatus and method of use thereof
US9910166B2 (en) 2008-05-22 2018-03-06 Stephen L. Spotts Redundant charged particle state determination apparatus and method of use thereof
US8907309B2 (en) 2009-04-17 2014-12-09 Stephen L. Spotts Treatment delivery control system and method of operation thereof
US9855444B2 (en) 2008-05-22 2018-01-02 Scott Penfold X-ray detector for proton transit detection apparatus and method of use thereof
US8309941B2 (en) * 2008-05-22 2012-11-13 Vladimir Balakin Charged particle cancer therapy and patient breath monitoring method and apparatus
US9737734B2 (en) 2008-05-22 2017-08-22 Susan L. Michaud Charged particle translation slide control apparatus and method of use thereof
US10143854B2 (en) 2008-05-22 2018-12-04 Susan L. Michaud Dual rotation charged particle imaging / treatment apparatus and method of use thereof
US9168392B1 (en) 2008-05-22 2015-10-27 Vladimir Balakin Charged particle cancer therapy system X-ray apparatus and method of use thereof
US10092776B2 (en) 2008-05-22 2018-10-09 Susan L. Michaud Integrated translation/rotation charged particle imaging/treatment apparatus and method of use thereof
US10037863B2 (en) 2016-05-27 2018-07-31 Mark R. Amato Continuous ion beam kinetic energy dissipater apparatus and method of use thereof
US9056199B2 (en) 2008-05-22 2015-06-16 Vladimir Balakin Charged particle treatment, rapid patient positioning apparatus and method of use thereof
US8129699B2 (en) 2008-05-22 2012-03-06 Vladimir Balakin Multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration
US8373145B2 (en) * 2008-05-22 2013-02-12 Vladimir Balakin Charged particle cancer therapy system magnet control method and apparatus
US8627822B2 (en) * 2008-07-14 2014-01-14 Vladimir Balakin Semi-vertical positioning method and apparatus used in conjunction with a charged particle cancer therapy system
ES2703770T3 (en) 2009-06-05 2019-03-12 Basf Se Biocatalytic preparation of ambroxan
US8963112B1 (en) 2011-05-25 2015-02-24 Vladimir Balakin Charged particle cancer therapy patient positioning method and apparatus
US8933651B2 (en) 2012-11-16 2015-01-13 Vladimir Balakin Charged particle accelerator magnet apparatus and method of use thereof
JP2018524317A (en) * 2015-06-19 2018-08-30 ビーエーエスエフ ソシエタス・ヨーロピアBasf Se Production of pantolactone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572182A (en) * 1978-11-28 1980-05-30 Sagami Chem Res Center Optical resolution of pantolactone
JPH0655156B2 (en) * 1986-06-13 1994-07-27 三菱化成株式会社 Dl- optical resolution method of pantolactone
JPH0667320B2 (en) * 1986-06-13 1994-08-31 三菱化成株式会社 Process for the preparation of D- pantolactone
JP2844354B2 (en) 1989-08-03 1999-01-06 富士薬品工業株式会社 Process for the preparation of D- pantolactone
DE4005150A1 (en) 1990-02-17 1991-08-22 Hoechst Ag Process for the enzymatic resolution of racemic pantolactone
JP3011449B2 (en) * 1990-10-05 2000-02-21 富士薬品工業株式会社 D- pantolactone hydrolase and their preparation
AU647603B2 (en) 1991-04-02 1994-03-24 Hoechst Aktiengesellschaft An immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor
DE4126580A1 (en) 1991-08-12 1993-02-18 Degussa D-2,4-dihydroxy-3,3-dimethylbutansaeurenitril, its production and use
EP0626467B1 (en) 1992-10-15 1997-05-21 Kawasaki Steel Corporation Method of continuously carburizing steel strip
RU2218405C2 (en) * 1995-09-13 2003-12-10 Дайити Файн Кемикал Ко., Лтд. Protein eliciting activity of d-pantolactone hydrolase, nucleic acid encoding thereof, vector, strain, method for preparing protein, method for preparing d-pantolactone
AU1909900A (en) 1998-11-10 2000-05-29 Novozymes Biotech, Inc. Polypeptides having lactonohydrolase activity and nucleic acids encoding same
US6395529B1 (en) * 1998-11-10 2002-05-28 Novozymes Biotech, Inc. Polypeptides having lactonohydrolase activity and nucleic acids encoding same

Also Published As

Publication number Publication date
JP2003530080A (en) 2003-10-14
EE200200225A (en) 2003-06-16
MXPA02003417A (en) 2002-08-20
NO20021931D0 (en) 2002-04-24
US6998258B1 (en) 2006-02-14
CN1384880A (en) 2002-12-11
NO20021931L (en) 2002-04-24
EP1224296A1 (en) 2002-07-24
BR0015114A (en) 2002-07-16
RU2002114044A (en) 2004-03-27
CZ20021449A3 (en) 2002-10-16
IL148973D0 (en) 2002-11-10
HU0203704A2 (en) 2003-03-28
WO2001032890A1 (en) 2001-05-10
AU1141601A (en) 2001-05-14
AU782517B2 (en) 2005-08-04
CA2389064A1 (en) 2001-05-10
PL355487A1 (en) 2004-05-04

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