HU0105011A3 - Synthesis method of nitroxymethylphenyl esters of aspirin derivatives - Google Patents

Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Info

Publication number
HU0105011A3
HU0105011A3 HU0105011A HU0105011A HU0105011A3 HU 0105011 A3 HU0105011 A3 HU 0105011A3 HU 0105011 A HU0105011 A HU 0105011A HU 0105011 A HU0105011 A HU 0105011A HU 0105011 A3 HU0105011 A3 HU 0105011A3
Authority
HU
Hungary
Prior art keywords
synthesis method
aspirin derivatives
nitroxymethylphenyl
esters
nitroxymethylphenyl esters
Prior art date
Application number
HU0105011A
Other versions
HU0105011A2 (en
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999MI000134A priority Critical patent/IT1307928B1/en
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to PCT/EP2000/000353 priority patent/WO2000044705A1/en
Publication of HU0105011A2 publication Critical patent/HU0105011A2/en
Publication of HU0105011A3 publication Critical patent/HU0105011A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02Preparation of esters of nitric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Abstract

The invention describes a method for the synthesis of nitroxymethylphenyl esters of aspirin derivatives.
HU0105011A 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives HU0105011A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT1999MI000134A IT1307928B1 (en) 1999-01-26 1999-01-26 A method for synthesizing esters derivatidell'aspirina nitroxymethylphenyl.
PCT/EP2000/000353 WO2000044705A1 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Publications (2)

Publication Number Publication Date
HU0105011A2 HU0105011A2 (en) 2002-04-29
HU0105011A3 true HU0105011A3 (en) 2002-12-28

Family

ID=11381613

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105011A HU0105011A3 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Country Status (18)

Country Link
US (1) US6512137B1 (en)
EP (1) EP1147074B1 (en)
JP (1) JP2002535380A (en)
KR (1) KR100732147B1 (en)
CN (2) CN1191228C (en)
AT (1) AT291567T (en)
AU (1) AU766497B2 (en)
BR (1) BR0007643A (en)
CA (1) CA2361454A1 (en)
DE (1) DE60018902T2 (en)
ES (1) ES2239588T3 (en)
HU (1) HU0105011A3 (en)
IL (1) IL144234D0 (en)
IT (1) IT1307928B1 (en)
PT (1) PT1147074E (en)
RU (1) RU2232747C2 (en)
WO (1) WO2000044705A1 (en)
ZA (1) ZA200105705B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1312115B1 (en) 1999-06-24 2002-04-04 Nicox Sa amorphous compounds and their pharmaceutical compositions
ITMI991517A1 (en) * 1999-07-09 2001-01-09 Nicox Sa A process for obtaining external nitroxymethyl phenyl salicylic acid derivatives
EP1246621A4 (en) 1999-12-23 2004-11-24 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1319202B1 (en) * 2000-10-12 2003-09-26 Nicox Sa Drugs for diseases with inflammatory base.
WO2002060378A2 (en) 2000-12-21 2002-08-08 Nitromed, Inc. Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20011308A1 (en) * 2001-06-21 2002-12-23 Nicox Sa Drugs for chronic pain
ITMI20011307A1 (en) * 2001-06-21 2002-12-23 Nicox Sa Drugs for epilepsy
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1539729A4 (en) * 2002-07-03 2008-02-20 Nitromed Inc Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) * 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
CA2546807A1 (en) * 2003-11-20 2005-06-16 Nicox S.A. New process for the preparation of nitrooxyderivatives of paracetamol
WO2005065361A2 (en) 2003-12-31 2005-07-21 Khosrow Kashfi Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
EP2075011A3 (en) 2004-08-26 2012-02-29 Piramal Life Sciences Limited Prodrugs containing bio-cleavable disulfide linkers
JP2007275193A (en) * 2006-04-04 2007-10-25 Fujifilm Corp Optical probe and optical tomographic imaging equipment
US8236820B2 (en) 2007-08-10 2012-08-07 Basil Rigas Anti-inflammatory compounds and uses thereof
ES2362894B1 (en) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Preparation procedure for �? cido 4-nitro-oxi-metil-benzoico.
CA2885740A1 (en) * 2012-09-21 2014-03-27 Basil Rigas Compounds and compositions for use in the prevention and treatment of inflammation-related disorders, pain and fever, skin disorders, cancer and precancerous conditions thereof
WO2014052889A1 (en) * 2012-09-27 2014-04-03 The Board Of Trustees Of The University Of Illinois Anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (en) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivatives substituted benzoic acids to attivita 'cardiovascular
IT1276071B1 (en) * 1995-10-31 1997-10-24 Nicox Ltd Composites activities to 'anti-inflammatory
SV1997000108A (en) * 1997-12-18 1999-11-24 Manufacturas Humberto Bukele E Synthesis of acetylsalicylic acid in the presence of calcium oxide

Also Published As

Publication number Publication date
US6512137B1 (en) 2003-01-28
EP1147074A1 (en) 2001-10-24
IL144234D0 (en) 2002-05-23
EP1147074B1 (en) 2005-03-23
AT291567T (en) 2005-04-15
AU766497B2 (en) 2003-10-16
CN1191228C (en) 2005-03-02
KR100732147B1 (en) 2007-06-25
DE60018902T2 (en) 2006-03-30
WO2000044705A1 (en) 2000-08-03
CN1572787A (en) 2005-02-02
CA2361454A1 (en) 2000-08-03
RU2232747C2 (en) 2004-07-20
ITMI990134A1 (en) 2000-07-26
AU2664500A (en) 2000-08-18
PT1147074E (en) 2005-07-29
KR20010101653A (en) 2001-11-14
JP2002535380A (en) 2002-10-22
HU0105011A2 (en) 2002-04-29
CN1344244A (en) 2002-04-10
ES2239588T3 (en) 2005-10-01
BR0007643A (en) 2001-10-16
IT1307928B1 (en) 2001-11-29
DE60018902D1 (en) 2005-04-28
ZA200105705B (en) 2002-10-11

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: NICOX S.A., FR

Free format text: FORMER OWNER(S): NICOX S.A., FR