HU0104129A3 - Use of 2-phenylbenzimidazoles and 2-phenylindoles for producing pharmaceutical compositions having parp enzym effect and new 2-phenylbenzimidazol derivatives - Google Patents

Use of 2-phenylbenzimidazoles and 2-phenylindoles for producing pharmaceutical compositions having parp enzym effect and new 2-phenylbenzimidazol derivatives

Info

Publication number
HU0104129A3
HU0104129A3 HU0104129A HU0104129A HU0104129A3 HU 0104129 A3 HU0104129 A3 HU 0104129A3 HU 0104129 A HU0104129 A HU 0104129A HU 0104129 A HU0104129 A HU 0104129A HU 0104129 A3 HU0104129 A3 HU 0104129A3
Authority
HU
Hungary
Prior art keywords
phenylbenzimidazoles
phenylindoles
phenylbenzimidazol
enzym
parp
Prior art date
Application number
HU0104129A
Other versions
HU0104129A2 (en
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19852816 priority Critical
Application filed by Basf Ag filed Critical Basf Ag
Publication of HU0104129A2 publication Critical patent/HU0104129A2/en
Publication of HU0104129A3 publication Critical patent/HU0104129A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
HU0104129A 1998-11-17 1999-11-05 Use of 2-phenylbenzimidazoles and 2-phenylindoles for producing pharmaceutical compositions having parp enzym effect and new 2-phenylbenzimidazol derivatives HU0104129A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19852816 1998-11-17

Publications (2)

Publication Number Publication Date
HU0104129A2 HU0104129A2 (en) 2002-05-29
HU0104129A3 true HU0104129A3 (en) 2002-09-30

Family

ID=7887971

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104129A HU0104129A3 (en) 1998-11-17 1999-11-05 Use of 2-phenylbenzimidazoles and 2-phenylindoles for producing pharmaceutical compositions having parp enzym effect and new 2-phenylbenzimidazol derivatives

Country Status (27)

Country Link
US (1) US6509365B1 (en)
EP (1) EP1131301B1 (en)
JP (2) JP2002529537A (en)
CN (1) CN1331683A (en)
AR (1) AR021297A1 (en)
AT (1) AT302758T (en)
AU (1) AU755694B2 (en)
BG (1) BG105550A (en)
BR (1) BR9915381A (en)
CA (1) CA2350734C (en)
CO (1) CO5140115A1 (en)
CZ (1) CZ20011724A3 (en)
DE (1) DE59912473D1 (en)
DK (1) DK1131301T3 (en)
ES (1) ES2247867T3 (en)
HR (1) HRP20010451A2 (en)
HU (1) HU0104129A3 (en)
ID (1) ID28846A (en)
IL (1) IL143102D0 (en)
NO (1) NO20012419L (en)
PL (1) PL347684A1 (en)
RU (1) RU2001116581A (en)
SK (1) SK6742001A3 (en)
TR (1) TR200101400T2 (en)
TW (1) TW460466B (en)
WO (1) WO2000029384A1 (en)
ZA (1) ZA200103834B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919366B2 (en) 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6759425B2 (en) 1999-10-21 2004-07-06 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
ES2449713T3 (en) 1998-11-03 2014-03-20 Abbvie Deutschland Gmbh & Co Kg 2-substituted phenylbenzimidazoles and their use as PARP inhibitors
DE19920936A1 (en) * 1999-05-07 2000-11-09 Basf Ag Heterocyclic substituted benzimidazoles, their preparation and application
RU2003127367A (en) 2001-03-12 2005-03-20 Аванир Фармасьютиклз (Us) Benzimidazole compounds for modulating ige and inhibition of cell proliferation
DE10022925A1 (en) * 2000-05-11 2001-11-15 Basf Ag New indole-carboxamide or azepino-indole derivatives and analogs, are poly-ADP ribose polymerase inhibitors useful e.g. for treating neurodegenerative disease, ischemia, epilepsy, tumors, sepsis or diabetes mellitus
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
CA2493364A1 (en) 2002-07-26 2004-02-12 Basf Plant Science Gmbh Inversion of the negative-selective effect of negative marker proteins using selection methods
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003270426A1 (en) * 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
US7179832B2 (en) * 2003-01-23 2007-02-20 Crystalgenomics, Inc. Glycogen synthase kinase 3β inhibitor, composition and process for the preparation thereof
JP2007501618A (en) * 2003-08-08 2007-02-01 アバニール・ファーマシューティカルズ Selective pharmacological inhibition of protein transport and related methods of treating human diseases
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CN100431606C (en) 2004-11-22 2008-11-12 山东蓝金生物工程有限公司;孔庆忠 Anti-cancer medicine composition
EP2045327B8 (en) 2005-03-08 2012-03-14 BASF Plant Science GmbH Expression enhancing intron sequences
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
EP1957477B1 (en) 2005-09-29 2011-12-07 Abbott Laboratories 1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors
CN101309908A (en) * 2005-11-15 2008-11-19 艾博特公司 Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
EP2007733B1 (en) * 2006-04-03 2016-05-25 MSD Italia S.r.l. Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors
ES2385849T3 (en) * 2006-05-02 2012-08-01 Abbott Laboratories The substituted 1H-benzimidazol-4-carboxamides are potent inhibitors of PARP
SI2805945T1 (en) 2007-01-10 2019-09-30 Msd Italia S.R.L. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
US8067613B2 (en) 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
KR101653548B1 (en) 2008-01-08 2016-09-02 머크 샤프 앤드 돔 리미티드 2-4-3--3--2--7- Pharmaceutically acceptable salts of 2-4-3-piperidin-3-ylphenyl-2H-indazole-7-carboxamide
WO2010083199A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
US20120324603A1 (en) 2009-11-27 2012-12-20 BASF Plant Sceience Company GmbH Chimeric Endonucleases and Uses Thereof
AU2010325549B2 (en) 2009-11-27 2017-04-20 Basf Plant Science Company Gmbh Optimized endonucleases and uses thereof
JP5922029B2 (en) 2009-11-27 2016-05-24 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー Chimeric endonuclease and use thereof
US20110218103A1 (en) * 2010-03-04 2011-09-08 Bayer Cropscience Ag Fluoroalkyl-substituted 2-amidobenzimidazoles
EP2561759A1 (en) 2011-08-26 2013-02-27 Bayer Cropscience AG Fluoroalkyl-substituted 2-amidobenzimidazoles and their effect on plant growth
CN103242273B (en) * 2012-02-09 2015-06-03 中国科学院上海药物研究所 2-arylbenzofuran-7-methanamide compound, preparation method and application thereof
CN102627620B (en) * 2012-04-10 2015-12-16 江苏先声药物研究有限公司 A class of benzofuran derivatives and pharmaceutically Applications
JP2015532650A (en) * 2012-09-05 2015-11-12 バイエル・クロップサイエンス・アクチェンゲゼルシャフト Use of substituted 2-amidobenzimidazoles, 2-amidobenzoxazoles and 2-amidobenzothiazoles or their salts as active substances against abiotic plant stress
CN104230896A (en) * 2013-06-17 2014-12-24 上海汇伦生命科技有限公司 Benzimidazole-2-piperazine heterocycle ramification and medicine composition as well as preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522230A1 (en) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K New 2-arylimidazoles, medicaments containing these compounds and methods for their production
DE4304455A1 (en) * 1993-02-15 1994-08-18 Bayer Ag Heterocyclic substituted phenyl-cyclohexane-carboxylic acid derivatives
EP0841924B1 (en) * 1995-08-02 2002-10-02 Newcastle University Ventures Limited Benzimidazole compounds
WO1998006703A1 (en) * 1996-08-14 1998-02-19 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists

Also Published As

Publication number Publication date
NO20012419D0 (en) 2001-05-16
HRP20010451A2 (en) 2003-04-30
AU755694B2 (en) 2002-12-19
JP2009120609A (en) 2009-06-04
CO5140115A1 (en) 2002-03-22
AT302758T (en) 2005-09-15
ZA200103834B (en) 2002-05-13
SK6742001A3 (en) 2001-12-03
TW460466B (en) 2001-10-21
DE59912473D1 (en) 2005-09-29
AU1379800A (en) 2000-06-05
TR200101400T2 (en) 2001-11-21
ID28846A (en) 2001-07-05
JP2002529537A (en) 2002-09-10
EP1131301A1 (en) 2001-09-12
DK1131301T3 (en) 2006-01-09
CA2350734A1 (en) 2000-05-25
CZ20011724A3 (en) 2001-08-15
US6509365B1 (en) 2003-01-21
IL143102D0 (en) 2002-04-21
CA2350734C (en) 2006-10-10
BG105550A (en) 2001-12-31
CN1331683A (en) 2002-01-16
PL347684A1 (en) 2002-04-22
NO20012419L (en) 2001-07-12
HU0104129A2 (en) 2002-05-29
BR9915381A (en) 2001-08-14
RU2001116581A (en) 2004-02-20
ES2247867T3 (en) 2006-03-01
AR021297A1 (en) 2002-07-03
WO2000029384A1 (en) 2000-05-25
EP1131301B1 (en) 2005-08-24

Similar Documents

Publication Publication Date Title
DE59903917D1 (en) Coat and binder for oral or derivative medicinal products
TW575435B (en) Pharmaceutical formulation of omeprazole
AP1709A (en) Ethanolate of zithromycin process for manufacture and pharmaceutical compositions thereof
DE60025604D1 (en) Benzimidazole derivatives and pharmaceutical compositions containing them
PL365789A1 (en) Compositions and methods for the therapy and diagnosis of her-2/neu-associated malignancies
HU0202263A3 (en) Benzimidazole, indole and imidazo-pyridine derivatives and pharmaceutical compositions containing them
PL348817A1 (en) Compositions and methods for the treatment of anorectal disorders
IL135258D0 (en) Bioadhesive compositions and methods for topical administration of active agents
IL148384A (en) Glucopyranosyloxypyrazole derivatives and medicinal compositions containing the same
PL338950A1 (en) Parp inhibitors as well as methods of and pharmacological compositions for healing a damaged nervous and cardiovasculat tissue
IL126203A (en) Pharmaceutical synergistic analgesic compositions comprising olanzapine and another analgesic compound
PL339342A1 (en) Synergetically acting analgesic combination of an opioidic antaligic drug and an inhibitor of cyclo-oxygenase-2
IL132388D0 (en) Kappa-opioid agonist compounds pharmaceutical compositions and method of prevention and treatment of pruritus therewith
EP1045636A4 (en) Pharmaceutical compositions and methods for the treatment of failing myocardial tissue
PT1105123E (en) Pharmaceutical compositions containing lipase and quitosane inhibitors
HU0103341A3 (en) Azetidine derivatives, preparation and pharmaceutical compositions thereof
HU0201214A3 (en) Inhibitors of impdh enzyme, pharmaceutical compositions containing them and their use
AU6918700A (en) Pharmaceutical compositions and methods for reducing the appearance of cellulite
PL352163A1 (en) Derivatives of 5-cyano-2-aminopyrimidine
HK1038556A1 (en) Benzamide derivatives and their use as cytokine inhibitors
HU0300880A3 (en) Hydroxamate derivatives useful as deacetylase inhibitors and pharmaceutical compositions containing them
PT929530E (en) Quinazoline derivatives and pharmaceutical compositions that contain them
AT324872T (en) Oral pharmaceutical composition with delayed active substance release of proton-pump inhibitors
IL140554D0 (en) Oxamyl derivatives and pharmaceutical compositions containing the same
HU0301834A3 (en) Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them