HU0003760A3 - Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation, process for production thereof and their use - Google Patents

Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation, process for production thereof and their use

Info

Publication number
HU0003760A3
HU0003760A3 HU0003760A HU0003760A HU0003760A3 HU 0003760 A3 HU0003760 A3 HU 0003760A3 HU 0003760 A HU0003760 A HU 0003760A HU 0003760 A HU0003760 A HU 0003760A HU 0003760 A3 HU0003760 A3 HU 0003760A3
Authority
HU
Hungary
Prior art keywords
metalloproteinases
liberation
tnf
thio
inhibitors
Prior art date
Application number
HU0003760A
Other versions
HU0003760A2 (en
Original Assignee
Darwin Discovery Ltd Cambridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB9520354.3A priority Critical patent/GB9520354D0/en
Priority to GBGB9607126.1A priority patent/GB9607126D0/en
Application filed by Darwin Discovery Ltd Cambridge filed Critical Darwin Discovery Ltd Cambridge
Priority to PCT/GB1996/002438 priority patent/WO1997012902A1/en
Publication of HU0003760A2 publication Critical patent/HU0003760A2/en
Publication of HU0003760A3 publication Critical patent/HU0003760A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043Leu-amino acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
HU0003760A 1995-10-05 1996-10-04 Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation, process for production thereof and their use HU0003760A3 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB9520354.3A GB9520354D0 (en) 1995-10-05 1995-10-05 Compounds
GBGB9607126.1A GB9607126D0 (en) 1996-04-04 1996-04-04 Compounds
PCT/GB1996/002438 WO1997012902A1 (en) 1995-10-05 1996-10-04 Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation

Publications (2)

Publication Number Publication Date
HU0003760A2 HU0003760A2 (en) 2001-04-28
HU0003760A3 true HU0003760A3 (en) 2001-05-28

Family

ID=26307887

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003760A HU0003760A3 (en) 1995-10-05 1996-10-04 Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation, process for production thereof and their use

Country Status (20)

Country Link
US (1) US5981490A (en)
EP (1) EP0859784B1 (en)
JP (1) JPH11512733A (en)
KR (1) KR100472752B1 (en)
CN (1) CN1145637C (en)
AT (1) AT229972T (en)
AU (1) AU710072B2 (en)
BR (1) BR9610922A (en)
CA (1) CA2229434A1 (en)
CZ (1) CZ289711B6 (en)
DE (2) DE69625506T2 (en)
DK (1) DK0859784T3 (en)
ES (1) ES2186803T3 (en)
HU (1) HU0003760A3 (en)
IL (1) IL123430A (en)
MX (1) MX9802680A (en)
NO (1) NO981520D0 (en)
NZ (1) NZ319222A (en)
PL (1) PL185312B1 (en)
WO (1) WO1997012902A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9607120D0 (en) * 1996-04-04 1996-06-12 Chiroscience Ltd Compounds
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
WO1998039024A1 (en) * 1997-03-03 1998-09-11 Darwin Discovery Limited Selective mmp inhibitors having reduced side-effects
EP1123308A1 (en) 1998-10-23 2001-08-16 Darwin Discovery Limited Single morphic forms of known peptide metalloproteinase inhibitors
NL1013404C2 (en) * 1999-10-27 2001-05-01 Dsm Nv A process for the preparation of a dipeptide, and intermediate in such a method.
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
AU778368B2 (en) 2000-05-15 2004-12-02 Darwin Discovery Limited Hydroxamic acid derivatives
JP2004518688A (en) * 2001-01-30 2004-06-24 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Sulfonamide lactam Factor Xa inhibitor and method
MXPA03009689A (en) * 2001-04-26 2004-02-12 Squibb Bristol Myers Co A pharmaceutical tablet having a high api content.
NZ616594A (en) 2001-06-26 2015-06-26 Amgen Inc Antibodies to opgl
AU2002356979A1 (en) * 2001-11-30 2003-06-17 Bristol-Myers Squibb Company Method of producing n-((2s)-sulfanyl-4-(1,5,5-trimethylhydantoinyl)butanoyl)-l-leucyl-l-tert-leucine n-methylamide and intermediate thereof
US20060167334A1 (en) * 2003-06-26 2006-07-27 Anstadt Mark P Method and apparatus for direct mechanical ventricular actuation with favorable conditioning and minimal heart stress
WO2005004861A1 (en) * 2003-07-15 2005-01-20 Korea Research Institute Of Bioscience And Biotechnology A use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
CN103254291B (en) * 2013-05-30 2014-06-25 常州亚当生物技术有限公司 Tumor necrosis factor-alpha polypeptide inhibitors and application thereof
CN103285373A (en) * 2013-05-30 2013-09-11 苏州普罗达生物科技有限公司 Preparation method and application of tumor necrosis factor (TNF)-alpha polypeptide inhibitor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
DE3889726D1 (en) * 1987-03-17 1994-06-30 Res Corp Technologies Inc Synthetic inhibitors of mammalian collagenase.
DE4311021A1 (en) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunctional chelating agents, the technetium and rhenium complexes, processes for their preparation and these compounds radiopharmaceutical agents
AU687436B2 (en) * 1993-08-23 1998-02-26 Immunex Corporation Inhibitors of TNF-alpha secretion
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds
CA2201639A1 (en) * 1994-10-05 1996-04-18 John Montana Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases
DE69627483T2 (en) * 1995-05-10 2004-04-01 Darwin Discovery Ltd., Slough The peptide-type materials that metalloproteinases and inhibit TNF release, and their therapeutic use
AU706064B2 (en) * 1995-05-10 1999-06-10 Darwin Discovery Limited Peptide compounds which inhibit metalloproteinase and TNF liberation, and their therapeutic use

Also Published As

Publication number Publication date
EP0859784B1 (en) 2002-12-18
PL325824A1 (en) 1998-08-03
AT229972T (en) 2003-01-15
NZ319222A (en) 1999-09-29
BR9610922A (en) 1999-12-21
NO981520D0 (en) 1998-04-03
WO1997012902A1 (en) 1997-04-10
EP0859784A1 (en) 1998-08-26
US5981490A (en) 1999-11-09
CZ101798A3 (en) 1998-08-12
MX9802680A (en) 1998-11-30
CN1145637C (en) 2004-04-14
ES2186803T3 (en) 2003-05-16
JPH11512733A (en) 1999-11-02
PL185312B1 (en) 2003-04-30
CA2229434A1 (en) 1997-04-10
HU0003760A2 (en) 2001-04-28
AU7139896A (en) 1997-04-28
CZ289711B6 (en) 2002-03-13
DE69625506D1 (en) 2003-01-30
DK0859784T3 (en) 2003-04-22
DE69625506T2 (en) 2003-07-24
DK859784T3 (en)
AU710072B2 (en) 1999-09-16
IL123430D0 (en) 1998-09-24
NO981520L (en) 1998-04-03
IL123430A (en) 2001-04-30
CN1198747A (en) 1998-11-11
KR19990063996A (en) 1999-07-26
KR100472752B1 (en) 2006-01-27

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees