HU0003328A2 - Feeder Structure dose counter - Google Patents

Feeder Structure dose counter Download PDF

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Publication number
HU0003328A2
HU0003328A2 HU0003328A HU0003328A HU0003328A2 HU 0003328 A2 HU0003328 A2 HU 0003328A2 HU 0003328 A HU0003328 A HU 0003328A HU 0003328 A HU0003328 A HU 0003328A HU 0003328 A2 HU0003328 A2 HU 0003328A2
Authority
HU
Hungary
Prior art keywords
container
housing
element
characterized
device according
Prior art date
Application number
HU0003328A
Other languages
Hungarian (hu)
Other versions
HU228280B1 (en
HU0003328A3 (en
Inventor
Stanley George Bonney
Peter John Brand
James William Godfrey
Paul Kenneth Rand
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB9711889.7A priority Critical patent/GB9711889D0/en
Priority to GBGB9721875.4A priority patent/GB9721875D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Priority to PCT/EP1998/003377 priority patent/WO1998056444A1/en
Publication of HU0003328A2 publication Critical patent/HU0003328A2/en
Publication of HU0003328A3 publication Critical patent/HU0003328A3/en
Publication of HU228280B1 publication Critical patent/HU228280B1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007Mechanical counters
    • A61M15/0071Mechanical counters having a display or indicator
    • A61M15/0076Mechanical counters having a display or indicator on a drum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008Electronic counters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081Locking means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered

Abstract

The present invention relates to a dispensing device for dispensing a medicament comprising a housing (1) having a support structure (5); a container disposed in a housing (1) and having an outlet element having a single outlet (3), the container is movable relative to the housing (1), and the healing agent can be discharged therefrom, and the outlet member has a retaining structure (5) for the container. is prevented from being displaced in a housing (1); and includes a single action indicator located in the housing (1). The essence of the dispensing device according to the invention is that the container and the operating unit are removably and removably disposed in the housing (1). HE

Description

COPIES

DOSE STRUCTURE WITH ADAG CALCULATION

EXTRACT

The present invention relates to a dispensing device for dispensing a medicament comprising a housing (1) having a support structure (5);

a container disposed in the housing (1) and having an outlet element having an outlet (3), the container being movable relative to the housing (1) and the medicament dispensed therefrom and the outlet member with the support structure (5) ) the displacement of the container in the housing (1) is prevented relative to one another; and includes an operating indicator disposed in the housing (1).

The essence of the dispenser according to the invention is that the container and the operating indicator are removably and removably disposed in the housing (1) as a single unit.

Figure 41) C ö M · M · · · · · · · · · · · ·

DOSE STRUCTURE WITH ADAG CALCULATION

The present invention relates to a dispensing device having an actuating element which is essentially a measuring element indicating the number of actuation of the dispenser. More particularly, the invention relates to a metered dose inhaler device for delivering drugs in an aerosol container to a patient.

It is well known that various patients are treated with drugs that are in an aerosol, such as those used for bronchodilation. It is also known that in this method of treatment, medicaments, which are in an aerosol, are delivered to the patient by means of inhalers for the treatment of the patient, which inhaler comprises a cylindrical tubular casing or a vaginal element in which the aerosol container is disposed, and there is an outlet tube which is projecting out of this tubular housing. The aerosol containers used in such inhalers are designed to deliver a predetermined amount of medication during each operating phase and are implemented with an outlet valve, one end of which can be operated by pushing the pump element and the container in a stationary position. or the container is pushed forward and the pump element is in the upright position. When using these devices, the aerosol container is housed in a cylindrical housing provided with an outlet valve member connected to the outlet tube through a suitable support structure, for example, the outlet tube may be a nose fitting or mouth piece. When the drug is administered, for example, in the case of bronchodilating treatment, the housing portion is held more or less upright by the patient, and the mouth piece or tube connector, which belongs to the inhaler device 91140-5194 KK / Tz • · ·· · · ·· * · · · · · · • ·· · · · · ·· • ···· · · · the • · · · ··· " ·· ··

- 2 is located in the patient's mouth or nose. The aerosol container must be suppressed in the direction of a suitable support structure to deliver a dose of medicament from the container which is then inhaled by the patient.

The disadvantage of such devices is that the patient cannot accurately determine the amount of drug at a given time in the container. In extreme cases, this can lead to a patient suffering from severe bronchospasm and a certain amount of medication, for example, and will find that the container will not deliver a full dose to him, since the medicine in the container has been inhaled before. there is no medicine in the container. U.S. Pat. No. 4,817,822 discloses an aerosol dispenser of this type which has a control and monitoring device for dispensing, one embodiment of which is removably removable to the end of a protruding portion of the aerosol container. The metering counter actuator mechanism is located in a separate housing extending from the end of the aerosol container to the outer surface of the tubular housing. It is important to note that for inhalers containing a medicament, the aerosol container will be clearly labeled to ensure that the patient knows exactly what the drug is in the container at all times. The positioning of the dispensing device in this manner has the disadvantage that this device obscures at least a portion of the aerosol container and thus requires reading difficulties.

A further disadvantage of the above-described device is that the dose indicating, sorting can be removably attached to the aerosol container, and thus it is also possible for the metering device to detach from the aerosol container, thereby preventing the aerosol dispenser from being used together. the dosing indicator or the actuating mechanism of the signaling device will not be suitable, resulting in a false reading when the deactivated dosing indicator is returned to the container. Patients using different inhalers may also find that this indicator is returned to the wrong dispenser.

A second embodiment of the solution described in U.S. Pat. No. 4,817,822 is configured so that the actuating mechanism of the dispensing device is disposed in a compartment of the housing and the actuating member connected to the aerosol container. In this embodiment, if the dosing tank is already in the housing, it cannot be removed. This, in turn, makes it difficult to clean the house. Even if the container is removable, the dosing indicator actuator mechanism may be severely damaged when the container is washed with water, soap, disinfectant or antiseptic solution. This is of great importance because aerosol formulations that are used in these structures and devices always leave some residue on the container, which then absorbs the powder or particles. Of these, there are media that promote the development of undesirable microorganisms. If the growth of the microorganisms cannot be controlled, they may be a source of infection for the patient and, if they enter the patient's airway, may cause various lesions.

WO 96/16686 discloses an aerosol dispenser wherein the actuating mechanism of the dose indicating device is electronic, and the actuator comprises a microswitch located on the wall of the housing. The electronic counter mechanism and the microswitch are housed in a hermetically sealed housing. Although this type of electrical arrangement is relatively expensive compared to the arrangement of mechanisms, it is typically five or six times more expensive depending on the amount of product produced. These costs are ultimately borne by the user, and this may be a disadvantage in this way.

US 5482030 discloses an aerosol dispenser having a mechanical dose indicating device disposed within the housing, attached to the aerosol container outlet tube. The mechanical configuration of this arrangement makes it relatively difficult to form a seal against moisture, and the difficulty with this dispenser is that the actuator mechanism of the dosing indicator can be kept clean without damage.

Many different pharmaceutical products are marketed by aerosol containers. as mentioned above, and require containers and / or valves of different sizes depending on the specifications required. Therefore, it can be considered normal that the dimensions of different aerosol containers may vary greatly. Where appropriate, there may be differences in size due to manufacturing standardization for the same product. There is a problem that occurs with all dispensing indicating devices as described above, namely the signaling mechanism that can be operated by a switch which then indicates the relative displacement between the body of the container and the housing, and this switch is not capable of compensating for changes in size between aerosol containers of different sizes. This also means that the signaling devices described above must always be dimensioned for the product in question, which is why they are used, i.e. they cannot be used with other products, i.e. they are not interchangeable. In order for these dosing markers to function properly, the indicator, the aerosol container and the housing have to be dimensioned with high accuracy.

It is an object of the present invention to provide a dispenser whose operating indication eliminates the above-mentioned drawbacks. It also aims at a

- Developing a dispenser for 5 inventions which, taking into account the patient's aspects, is more favorable in terms of appearance and function than the currently available dispensers.

The present invention therefore relates to a dispensing device for dispensing a medicament comprising a housing having a support structure, a container disposed in the housing, and an outlet member having an outlet, the container movable relative to the housing and the medicament dispensed therefrom, and the medicament is dispensed therefrom, and the outlet is dispensed therefrom the element with the support structure is arranged to prevent the movement of the container in the housing relative to one another; and includes an operating indicator disposed in the housing.

The essence of the dispenser is that the container and the operating indicator are removably and removably mounted in the housing as a single unit.

The invention is advantageous if the operating indicator is connected to the container near the outlet and when the operating indicator is connected to the output element.

The invention is advantageous if the operating indicator is provided with a gripping element which is connected to the neck portion of the container, and if the neck portion (12) is adjacent to or positioned on the output element.

The invention is preferred if the container is an aerosol container.

It is further preferred that the housing is provided with an outlet, preferably a mouthpiece.

The invention is also preferred if it comprises a passage on which the dispensing portion is discharged from the container to the outlet.

The invention is preferred when the container contains metered doses.

The invention is also preferred if the operating indicator or the discharged doses

or the number of doses remaining in the container.

It is preferred that the invention comprises a signaling mechanism operated by a predetermined movement of the container in the housing.

It is further preferred that the signaling mechanism is provided as a motion coupling mechanism to allow the container to move relative to the housing and compensate for excess motion.

By attaching the last displacement, it is possible to provide an actuator with one dimension to fit the valves, and the actuating elements can be produced with a relatively wide manufacturing span and even in this case fits to the dispensers of different sizes.

The invention is preferred if the signaling mechanism is formed by a predetermined rotational movement of the first element, the first element being displaced relative to the second element during the operation of the dispenser.

The invention is further preferred if the second element is in a stationary position relative to the housing during the operation of the dispenser.

The invention is advantageous if the first element is a toothed shaft with a drive shaft connected to a drive movement and the second element is a rack.

The invention is preferred if the first element is a support structure coupled to the second element by means of a dead-end element.

The invention is also advantageous if the engagement element allowing the dead motion comprises a friction drive mechanism.

It is further preferred that the invention is provided by a user actuated by inhaled air.

The invention is advantageous if the aerosol dispenser comprises a housing in which a container is removably mounted, the housing has an outlet element and there is a support structure disposed in the housing and provided with an outlet member of the container. the support structure has a passage through which the container is connected to the outlet, the output is secured in the support structure, and the body of the container is displaceable relative to the outlet, the housing itself is designed to transmit metered portions and is provided with a dose indicating device having there is a dose indicator that is configured to measure the number of doses dispensed from the container or the number of doses remaining in the container, the metering device is connected in series to the container near the outlet member so that the container and the metering device are removably removable from the housing as a unit.

The present invention further relates to an operating means for a dispenser comprising a housing, a container and a housing disposed in the housing, the housing having an outlet element and the engaging means for securing its engagement with the container.

The invention is advantageous if the element for connection to the housing is a clamping element connected to a neck portion formed around the container.

The invention is also preferred if the neck portion is disposed between the container and the outlet and is connected to the container.

Finally, the invention is further advantageous if the operating means has an operating indicator which is designed to indicate the number of doses remaining in the container or the number of discharged doses from the container, and the operating means comprises an adapter element adjacent to the container outlet element. the serial alignment is deformed.

By attaching the operating display device to the container near the outlet element, it is possible for conventional containers to

- The physical dimensions of the 8 clamp retaining rings are used to create a suitable snap fit between the data indicator device and the aerosol container, which makes it easy to assemble the arrangement, but if it is already assembled, it cannot be easily separated. This ensures that the operating indicator gives accurate information about the tank to which the operating indicator is fitted.

Preferably, according to the invention, a dispenser is provided which is a metered dose inhaler having a housing in which the aerosol container is removably disposed, has an outlet which leads out of the housing, a housing in the housing which is the container outlet. and has a passage through which the contents of the container can be transmitted to the outlet, and its output element is gripped on the housing support structure, while the body of the container can be displaced relative to the outlet and the housing is capable of dispensing the measured doses and a window is created through which the dose display can be viewed.

Placing the dose display near the outlet element of the container for inhalation devices delivering the metered dose has the advantage that the device according to the invention, both externally and for operation, is very similar to a metered dose inhaler available on the market for which there is no dose indicating device, thus, when the metering device is coupled to the metered dose inhaler device, the patient only detects a very small change over the conventional dispensers, thus affecting only minimally patient handling and use of the device.

The dispensing device according to the invention will now be described in more detail with reference to the accompanying drawings, by way of example.

Figure 1 shows a standard inhaler comprising an aerosol dispenser;

9 shows a section taken through the dose indicating device when connected to the aerosol dispenser in the inhaler; Fig. 3 is a partial sectional view of the metering device illustrating the counter mechanism used in the dose indicator of the device shown in Fig. 2 in a spatial drawing, FIGS. 4a, 4b, 4c. and 4d. Fig. 5a shows the steps of operation of the counting mechanism shown in Fig. 3 in FIG. and 5b. Fig. 6 shows a sectional view of the second embodiment of the metering device in a lateral and longitudinal section when connected to the housing of the inhaler; Fig. 7 shows a further disassembled drawing of the dose indicating device shown in Fig. 6 with the aerosol container and housing; Fig. 8 schematically shows an inhaler comprising the dose indicator device shown in Fig. 6 at rest; while Fig. 9 shows the inhaler shown in Fig. 8 in its actuated position.

Thus, Figure 1 shows a standard metered dose delivery inhaler comprising a cylindrical housing 1 in which an aerosol container 2 can be placed. One end of the housing 1 is open, which is further considered as the upper part of the device and the other part closed. From the housing 1, at the closed end, an outlet 3 is laterally outward. As an example! In an embodiment, the outlet 3 is a mouthpiece that can be placed in the mouth of the patient, but optionally, if desired, a tube, for example, placed in the patient's nasal passage.

At one end of the aerosol container 2 there is an outlet valve stem 4 • · «• · · · · · · · 1 · ** · · · * ·> · · · ·

- 10 placed. This valve member can be depressed and, when pressed, passes a predetermined dose from the aerosol container 2, but optionally the valve stem 4 may be fixed, in which case the housing of the aerosol container 2 is moved relative to the valve member to provide dose.

As can be clearly seen in Figure 1, the aerosol container 2 is housed in the housing 1 so that one end is positioned so that one end extends beyond its open top. The spacer ribs not shown in the figure may optionally be placed inside the housing 1, which grips the outer surface of the aerosol container 2 from the inner surface of the housing 1 at a given distance. At the lower end of the housing 1, a support structure 5 is provided, the carrier 5 having a passageway 6 in which the valve stem 4 of the aerosol container 2 can be placed and held. A second second passage 7 is provided in the support structure 5, and this second passage 7 is directed towards the interior of the outlet 3. Thus, when the parts are in the position shown in Figure 1, the end of the aerosol container 2 extending beyond the housing 1 can be depressed, and the aerosol container 2 moves relative to the fixed stem 4, opens the valve, and a given dose of medication. - available in the form of an aerosol - empties through route 7 and outlet 3, and is then inhaled by the patient. If the particular drug is emptied from the aerosol container 2, it is completely depressed.

Figure 2 is a bottom view of a device similar to the device shown in Figure 1, but includes a dose indicator device according to the invention. The metering device comprises an element 8 connected to the aerosol container 2 by means of a cylindrical portion 9, provided with a flange 10 of a cylindrical portion 9. The cylindrical portion 9 fits tightly to the circumference of the valve clamping ring 11, while the flange 10 is connected to the neck portion of the valve clamp ring 11 and is then formed

when the valve clamp 11 is pressed into the aerosol container 2. This cylindrical portion 9 and the flange 10 provide an appropriate tight connection to the aerosol container 2, which, after assembly of the arrangement, can no longer be easily disassembled by the cylindrical portion 9 over the clamping ring 11.

Under the cylindrical portion 9, the element 8 forms a support member 22 on which the counter mechanism 13 and a toothed drive shaft 14 can be placed. The toothed drive shaft 14 is frictionally positioned on the drive shaft 15 of the counter mechanism. The toothed drive shaft 14 is provided with teeth 21, which may be any non-fully tooth-shaped protrusions associated with recesses or grooves formed on a rod 17. This is essentially a rack that is molded into the interior of the housing 1 and extends parallel to the stem 4 of the base of the housing.

Thus, in the embodiment shown in Figure 2, the rod 17 is a molded part of the housing 1, but of course this rod 17 may be otherwise formed and may form part of the dose indicator device itself. A 2a. 1 shows a simplified drawing of the dose indicating device in which the head portion of the rod 17 is connected to the recesses formed in the element 8 of the device. The teeth formed in the rod 17 are connected to the corresponding tooth of the toothed drive shaft 14. The figure also shows a spring 28 which pushes the rod 17 out of the recess. The rod 17 has an outwardly extending flange 24 lying on a stop 26 so as to hold at least a portion of the rod 17 properly secured in the cutout.

3 and 4, the drive shaft 15 is coupled to a support structure 16 which is part of the counter mechanism 13. The bracket 16 has two latches 18a and 18b which are configured as a latch and are located on two opposing sides of a star wheel 19 such that the support 16 is shifted around the axis of the drive shaft 15, in accordance with FIG. 1 a, in which the latch 18a is connected to one side of the star wheel 19, and a latch 4d. 2, in which the latch 18b engages with the other side of the star wheel 19, can be tilted. The star wheel 19 is connected via a mechanism to a three-digit number wheel system 33, for example, according to EP 0280104, 1-3. Figs. There are printed numbers along the circumference of the 33 number wheels, as will be shown later. When the counter mechanism 13 is inserted into the housing 1, it is configured to be small enough to be positioned adjacent to the side of the support structure 5 and so that it does not interfere with the aerosol stream when it blows the aerosol on the second flight 7. .

The aerosol container 2 can be disposed and used by the patient so that the dose indicator device is originally connected to it. Another possibility is that the housing 1 is positioned relative to the patient that the dose indicating device is in the position shown in Figure 2 and the aerosol 2 is present. separately. In this case, the patient should be provided with appropriate instructions to insert the aerosol container 2 into the housing 1 by first placing the valve stem 4 properly. When the aerosol container 2 is first placed in the housing 1, the cylindrical portion 9 and the flange 10, which are the elements of the dose indicating device, lie along the rim of the clamping ring 11 of the valve 11 of the aerosol container 2 until the flange 10 snaps into the neck portion 12. The dose indicator device is then fitted to the aerosol container 2.

The alignment of the metering device to the aerosol container 2 can also be accomplished by, for example, using an adhesive joint or by welding a sintered sleeve, the fitting being accomplished by thermoforming, extrusion, ultrasonic welding, or the use of an elastic O-ring on the container which can be clamped with teeth to the dose indicating device. If applicable, chin ·

- 13 • · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · • · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

To actuate the device, the protruding portion of the aerosol container 2, as shown in Figure 1, is depressed. As the aerosol container 2 moves downwardly in the housing 1, it also carries the mechanism of the dose indicator device, drives the toothed drive shaft 14, it starts to rotate, and as it is properly connected to the rod 17, rotates the drive shaft 15 of the support 16. When the latch 16 tilts the latch 18a when the drive shaft 15 rotates, it contacts the 4a. 1, the star wheel 19 and the latch 18a cause rotation of the star wheel 19 in the counter-clockwise direction, and the latch 18a cannot move further in this direction; Fig. 19 shows the two tooth of the star wheel 19. At this point, the drive shaft 15 cannot rotate further and any further displacement of the aerosol container 2 in the housing 1 results in the toothed drive shaft 14 continuing to rotate due to its engagement with the rod 17, the toothed drive shaft 14 and the drive shaft 15. friction between the two.

When the valve stem 4 has reached its fully depressed state and the dispensed drug is emptied from the aerosol container 2, the aerosol container 2 can return to its initial position.

When the aerosol container 2 and the metering device 2 return to their initial position, the toothed drive shaft 14, together with the drive shaft 15 and the support structure 16, will move in the opposite direction. Then, the support 16 tilts to a position that the latch 18a extends from its contact with the star wheel 19, while the latch 18b engages as shown in FIG. 4c. Figure 18b, and this increases the counterclockwise increment of the latch 18b by half as long as the latch 18b cannot move further in this direction; Fig. 18b is shown when the latch 18b is the star wheel 19

- It fits between two teeth. There is a repeated case that the drive shaft 15 cannot turn further at this point, and any further movement of the aerosol container 2 out of the housing outward through the connection of the toothed drive shaft 14 with the rod 17 between the toothed drive shaft 14 and the drive shaft 15 spins. Thus, it can be seen that the friction coupling acts as a motion movement movement that allows the dose indicator device to be used with the aerosol container so that the valve stem 4 connected to the aerosol container 2 can be of different lengths during operation.

Each time the aerosol dispenser is operated, the star wheel 19 performs, in the above manner, a rotational movement in two incremental, i.e. consecutive, clockwise directions. These movements are transformed by the counting mechanism into proper movements that rotate the number wheels 33, where the number wheels 33 always belong to one order of magnitude. During the rotation of the counting mechanism, a number is displayed along the circumference of the number wheels 33 through the window 20 at the rear of the housing. This indicates that an additional dose of medicine has been dispensed. If three 33 wheel wheels are used, hundreds of doses can be counted with the dose counter. Of course, the aerosol container 2 may contain a much smaller number of doses, and the dose counter may optionally contain less than 33 booms. In a further embodiment, wherein the aerosol dispenser contains more than one thousand or more, the additional exemplary embodiment of an additional 33 wheel gauge is added to the exemplary embodiment shown.

In order to move the aerosol container 2 from the housing 1 for cleaning, the aerosol container 2 is withdrawn in a manner known per se, i.e. is withdrawn from the housing. When the aerosol container 2 is retracted, the frictional connection between the pinion drive shaft 14 and the drive shaft 15 allows * · · · · · · · ·

- the further movement required for the toothed shaft 14 to protrude from its connection with the rod 17 and to achieve this without having to operate the counter mechanism. When the aerosol container 2 is removed, the housing 1 can be cleaned without the risk that the dose indicator device will be damaged in some way as it remains attached to the aerosol container 2.

When the housing 1 is clean, the aerosol container 2 can be reintroduced into the housing 1 by the dose indicator device. During insertion, the toothed drive shaft 14 is again engaged with the rod 17 and starts to rotate until the aerosol container 2 reaches its normal position when the valve stem 4 is correctly positioned in the support structure 5. When the toothed drive shaft 14 is rotating, the frictional linkage operates as a motion mechanism allowing for dead motion, as already described above, and allows the movement of the aerosol container 2 until the first connection between the toothed drive shaft 14 and the rod 7, and that the spreader 4 is moved. the stem is located in the support structure 5. In this way, this friction engagement automatically operates and compensates for the difference in the length of the valve stem protruding from the valve clamping ring.

5a. and 5b. Figure 1 shows an embodiment of the motion switch mechanism that can be used with the aerosol dispenser of the present invention. Here's an example! In an embodiment, two elastic levers 30 are used instead of toothed drive shaft and support 16, between which the rod 17 is tightly clamped and gripped. This is shown in Figure 5a. FIG. The rod 17 is provided with ribs on its surface (not shown in the figure), which ultimately results in a relatively coarse surface for the rod 17, thereby providing the desired friction between the arms 30 and the rod 17 such that the arms 30 will only clamp the rod 17 until the load, which is exerted on it, fails to overcome the friction.

··· ·· «·· · · · · ··· ·· · ··· · ··· · · · ·

- 16 During the operation of the structure, the aerosol container and the dose indicator mechanism are displaced, and the frictional connection between the arms 30 and the rod 17 will tilt the support 16 around the drive shaft 15 (not shown in Figure 5) until the latch 18a. as a switching element, it does not engage with the star wheel 19, as described in the first embodiment described above. When the switch 18a latch reaches the end of the street, the drive support 16 cannot move further, and any further movement of the aerosol container 2 in the housing 1 will result in the arms 30 sliding down the rod 17 due to the thickening connection. When it returns to its original position, the support 16 is tilted in the other direction until the latch 18b engages again with the star wheel 19 and cannot move further. Any further displacement of the aerosol container 2 from the housing 1 will result in the arms 30 sliding up the rod 17.

Refer to 6-9. as an example! wherein the inhaler is provided with an electromechanical dose display device. As already indicated in the above-described and mechanically designed dosage displays, the dose display device includes a body 40 fitted with a cylindrical portion 41 for the aerosol container 2, provided with gripping elements not shown in the figure. The cylindrical portion 41 fits snugly along the periphery of the valve clamping ring 11, with its rim lying on the neck portion of the valve clamp ring 11. Thus, the cylindrical element 41 and the flange 41 form a tight connection to the aerosol container 2, which, once fitted with the housing 1, by pushing the cylindrical member 41 towards the valve clamping ring 11, is already in place. you can't take it easily.

Under the cylindrical portion 41, the body 40 is provided with a holding member to which the counter mechanism 43 can be attached and positioned, and a · · · · · · · · · · · · · · · · «· · · · · ···· ·· · *

- 17 are compartment-like compartments into which the slide switch 44 can be located. The slide switch 44 is essentially a cylindrical washer formed of silicone rubber and the diameter of which is selected so that the housing and the dose display device, which is housed in the housing, provide frictional fit on the rod 45, which rod is molded together with the housing. and extends through the cavity into the body 40. The frictional fit of the slide switch 44 on the rod 45 ensures that the slide switch 44 does not move along the rod 45 unless it is pushed separately. The arrangement also includes two contact elements 46 and 47, each comprising a switching contact and a printed circuit contact, one of which further includes a contact to be connected to the battery, and the contact elements 46 and 47 are arranged so that the battery and the battery are connected. circuit contacts are in constant contact with one of the terminals of the battery 48 and a printed circuit board 49. The coupling contacts do not come into contact with each other, but are positioned on both sides of the rod 45 to limit the movement of the slide switch 44 in the given space portion. Thus, when it is in the top position of the slider 44, as shown in FIG. 9, both switches are connected by contacts, thus closing the circuit between the sliding ring of silicone rubber and its corresponding electrical conductivity. Although the example described here! In an embodiment, the slider 44 is made of silicone rubber, but it is also apparent that it may be made of other non-conductive rubber having a insert at its upper edge formed of metal or other electrically conductive material.

In addition to the slider switch 44 being connected to the contacts 46 and 47 and to the printed circuit board 49, there is also connected to the other terminal of the battery 48 and three-point liquid crystal display 50, this connection being implemented in a manner known per se. The printed circuit board 49 has a dedicated integrated integrated circuit for a given purpose • · «· · · ·« · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

- 18, which also includes a logic circuit, by means of which the dose indicating device is controllable, programmable, and operable to perform, as discussed below. It should be noted how many times the switching circuit is switched on or off. how many times the circuit is closed, the liquid crystal display (LCD) 50 also shows how many doses of the drug remain in the aerosol container. The design and programming of the integrated circuit itself can also be accomplished in a manner known per se.

Instead of a digital display, which is accomplished with the liquid crystal display, the display can be done in an analogous way. When the aerosol container is placed in the housing forming the actuator, the liquid crystal display 50 is visible through the window 20. In the embodiment shown in Figure 7, the liquid crystal display 50 and the window 20 are located at the rear of the housing 1, but can of course also be placed at the front of the housing or at other parts of the housing.

The counter mechanism 43 is small enough to be positioned adjacent to or behind the support structure 5, the support structure being poured out with the housing, and thus does not interfere with the aerosol channel on which the aerosol flows.

To operate the device, the protruding portion of the aerosol container, when properly fitted to the housing 1, must be pressed downwards as described above. When the aerosol container 2, which carries the mechanism of the metering device, is displaced in the housing 1 from its starting position (shown in Figure 8), the chamber cooperating with the slide switch 44 also moves downward until the upper side of the slide switch 44, mounted on the rod 45, engages the contacts 46 and 47, and the switching circuit closes. As a result, the number displayed on the liquid crystal display 50 decreases by one using the integrated circuit. When the aerosol container 2 continues its movement, the measured drug dose is emptied through the valve, • »·» • »*

- 19, while the slider 44 along the rod 45, due to the friction between the friction element and the slider 44 and the rod 45, slides downward on the rod 45 until the valve stem reaches its limit of movement and the aerosol container 2 is no longer can move (shown in Figure 9). Thus, it can be seen that the frictional movement of the slide switch 44 on the rod 45 allows it to pass over the valve stem after the switching circuit is closed, thereby operating an unused motion coupling element. The aerosol container 2 then returns to its original position within the housing 1, and when the chamber cooperating with the slide switch 44 moves upward, it interrupts the switching circuit by removing the contacts 46 and 47 from the slide switch 44. The body 40 then meets the lower surface of the slide switch 44 and pulls the slide switch 44 along the rod 45 until the valve stem returns to its starting position (shown in Figure 8).

Since the dose indicator device is designed and designed to be suitable for a variety of aerosol cans of various sizes and sizes, capable of delivering a number of doses, the integrated circuit arrangement itself is configured to fit the size of the aerosol container, which is integrated into the aerosol container. circuit controlled. Once the metering device is assembled and first switched to the battery, the integrated circuit arrangement enters self-test mode. The programmed mode is then activated when the switch is operated, allowing you to program the number of doses you want to count. This can be for example 200, 120, 80 or 60. This can be done automatically. After programming, the integrated circuit arrangement enters a counter mode when the liquid crystal display 50 reduces the value by closing the switch circuit. When the counter reaches zero, the integrated circuit arrangement is designed to prevent additional numbers * * · · w *

- 20 hits. To prevent incorrect counting, or to prevent due to a switching error, the counter is activated, the integrated circuit arrangement is configured to reduce the number only when the switching circuit has been closed for a predetermined length of time. In the event that the aerosol container 2 is stuck in the given position after operation or the switching circuit is clamped by some mechanical damage or contamination, the circuit arrangement may be designed to shut off the liquid crystal display 50 and give the user a warning that there is a problem with the device.

As with all embodiments of the invention, the aerosol container can be pulled out of the housing in a manner known per se. When the aerosol container is withdrawn, the body 40 moves the slide switch 44 along the rod 45 until the rod 45 is completely released. When the aerosol container 2 is removed, the housing 1 can be cleaned without damaging or influencing the dosage device in any way, as it is always fixed on the aerosol container.

When the aerosol container is reinstalled - which can only occur if the body of the dose indicator device is positioned in the right direction relative to the housing and in the correct shape - the slide switch 44 engages with the rod 45, pushes it upward until the upper surface is in the upward direction. Connects to terminals 46 and 47. Further positioning of the aerosol container causes the slide switch 44 to slide downwardly along the rod 45 until the valve stem fits and is located in the support structure 5.

Obviously, the programming of the integrated circuit arrangement or the dose indicator device can be used for aerosol containers of different capacities. As a result of the switching mechanism, the same data signal device ·

21 can also be used for valves having a different length or different travel parameters for the valve stem.

The present invention has been described primarily with respect to an inhaler for delivering a given dose, which may be operated by the patient himself, but may also employ other than the known actuation mechanisms. It is also possible to provide an inhaler that acts as a result of breathing, and where the operation starts, for example, as a result of inhalation by the patient.

The delivery device according to the invention can be used primarily for the administration of medicaments for the treatment of respiratory diseases. The drugs can be selected from the group consisting of analgesics such as codeine, dihydromorphine, ergotamine, fentanyl or morphine, anginal preparations such as diltzem, anti-allergy preparations such as chromoglycate, ketotifen or neodocromil, anti-infectives such as cephalosporin, penicillins, streptomycin, sulfonamides, tetracyclines and pentamidine, antihistamines such as metapyrilene, anti-inflammatory agents such as beclomethasone dipropionate, fluticasone propionate, flunisolide, budsonide, rofleponide, mometasone furoate or triamcinolone acetonide, antitussives such as noscapine, bronchodilators such as albuterol, salmeterol, ephedrin, adrenaline, phenoterol, formoterol, isoprenaline, metaproterenol, phenylephrine, phenylpropanolamine, pyrbuterol, reproterol, rimeterol, terbutaline, isoetharin, tulobuterol, or (-) - 4-amino-3,5-dichloro - ([[6- [2- [2- (2-Surinyl) ethoxy] hexyl] amino] methyl] benzene methanol, diuretics such as amiloride, a nticolinergics such as ipratropium, tiotropium, atropine or oxitropium; hormones such as cortisone, hydrocortisone or prednisolone; xanthine derivatives such as aminophylline, choline theophyllinate, lysine theophyllinate or theophylline; therapeutic proteins and peptides, such as insulin or glucagon. It will also be appreciated by those skilled in the art that when suitable medications are used in the form of salts, such as the form of alkali metal salts or amines • · · · · · · · · · · · · · · · · · · · ···· · · · · «·· · · * ·· ··

22 or as acid addition salts, or as esters such as low alkyl esters or solvents such as hydrates, may be used to optimize drug activity and / or stability. Also preferred are pharmaceuticals such as albuterol, salmeterol, fluticasone propionate and beclomethasondipropionate, as well as salts or solvates thereof, such as albuterol sulfate or salmeterol xinafoate.

Various drugs may be used in combinations, such as active ingradients such as salbutamol, such as free base or sulphate salt or salmeterol, e.g. .

It is to be emphasized that the exemplary embodiment, as well as the exemplified drugs, may be used in addition to other modifications, and recognition of the invention may be accomplished otherwise.

• ···· · · · · ··· · · «··« · ·

Claims (9)

PATIENT INDIVIDUAL POINTS
1 house 40 test 2 aerosol containers 41 cylindrical part 3 outputs 43 counter mechanism 4 valve stem 44 slider switches 5 support structure 45 bars 6 flights (first) 46, 47 contacts 7 flights (second) 48 colonies 8 items 49 printed circuit boards 9 cylindrical parts 50 liquid crystal displays
flange valve clamping ring neck part counter mechanism serrated drive shaft drive shaft bracket frame frame
18a, 18b latch, latch star wheel window tooth bracket flange retaining battery stop 28 spring 30 arm wheel
í.iétel:
gums • ·· ·
A dispensing device for administering a medicament comprising a housing (1) having a support structure (5);
a container disposed in the housing (1) and having an outlet element having an outlet (3), the container being movable relative to the housing (1) and the medicament dispensed therefrom and the outlet member with the support structure (5) ) the displacement of the container in the housing (1) is prevented relative to one another; and comprising an operating indicator disposed in the housing (1), characterized in that the container and the operating signal are removably and removably disposed in the housing (1) as a single unit.
2/7 / í
FIGURE 2
Ϊ
,) Í
Dispensing device according to claim 1, characterized in that the operating indicator is connected to the container (2) near the outlet (3).
Figure 3
4c. FIGURE
18b
4d. FIGURE
FIGURE 5a
5b. FIGURE
A dispenser according to claim 2, characterized in that the operating indicator is connected to the output element.
4. Referring to 1-3. Dispensing device according to one of Claims 1 to 3, characterized in that the operating indicator is provided with a gripping element which is connected to the neck portion (12) of the container (2).
5. A dispensing device according to claim 4, characterized in that the neck portion (12) is adjacent to or disposed with the outlet element.
FIGURE 6 '20
6. Dispensing device according to one of Claims 1 to 3, characterized in that the container is an aerosol container (2).
7/7
FIGURE 7
7. Dispensing device according to one of Claims 1 to 3, characterized in that the housing (1) is provided with an outlet, preferably a mouthpiece.
FIGURE 8
A dispenser according to claim 7, characterized in that
- 24 includes a passage on which the portion to be dispensed is discharged from the container to the outlet.
9. Dispensing device according to one of Claims 1 to 3, characterized in that the container comprises metered doses.
10. References 1-9. A dispenser according to any one of claims 1 to 4, characterized in that the operating indicator is either an indication of the number of discharged doses or the number of doses remaining in the container.
11. Referring to Figs. Dispensing device according to one of Claims 1 to 3, characterized in that the operating indicator comprises a signaling mechanism operated by a predetermined displacement of the container in the housing (1).
12. A dispensing device according to claim 11, characterized in that the signaling mechanism is formed as a motion coupling mechanism that permits the movement of the container relative to the housing (1) and compensates for its unnecessary movement.
A dispensing device according to claim 11 or 12, characterized in that the signaling mechanism is formed by a predetermined rotational movement of the first element, the first element being displaced relative to the second element during the operation of the dispenser.
A dispenser according to claim 13, characterized in that the second element is in a stationary position relative to the housing (1) during the operation of the dispenser.
A dispensing device according to claim 13 or 14, characterized in that the first element is a toothed shaft (14) connected to a drive shaft (15) in the drive motion and the second element is a rack.
A dispensing device according to claim 13 or 14, characterized in that the first element is a support structure (16) connected to the second element by means of a dead-end element.
17. The 12-16. A dispensing device according to any one of claims 1 to 3, characterized in that the engagement element allowing the dead motion comprises a friction drive mechanism.
18. References 1-17. A dispensing device according to any one of claims 1 to 3, characterized in that it is provided by an actuator which is operated by the user by inhaled air.
19. An aerosol dispenser according to claim 1, characterized in that it comprises a housing in which a container is removably removable, the housing has an output element and there is a support structure disposed in the housing and including an outlet member of the container. formed, the support structure has a passage through which the container is connected to the outlet, the output is secured in the support structure, and the body of the container is displaceable relative to the outlet, the housing itself is configured to transmit metered portions and is provided with a metering device equipped with a dose indicator that is configured to measure the number of doses dispensed from the container or the number of doses remaining in the container, the metering device is connected in series to the container near the outlet member so that the container and the metering device can be removed from the housing as a unit. is trained ve.
20. An operating device for a dispenser comprising a housing, a container, and which is housed in the housing, the housing having an outlet member, and the operating element being provided with connecting elements for securing its attachment to the container.
21. An operating device according to claim 20, characterized in that the element for connecting to the housing is a clamping element connected to a neck portion (12) formed around the container (2).
22. A device according to claim 21, wherein the neck portion (12) is disposed between the container (2) and the outlet (3) and is connected to the container (2).
23. The device according to claim 20, characterized in that the operating device has an operating indicator which is designed to indicate the number of doses remaining in the container or the number of doses discharged from the container, and the operating device comprises an adapter element it is arranged in series to align the container near the battery element.
24. The 20-23. An operating device according to any one of claims 1 to 3, characterized in that it is designed as an electromechanical element.
25. The method of claims 1-18. Use of a dispensing device according to any one of claims 1 to 4 for dispensing a medicament.
tUfc-JL
The proxy:
REFERENCE AMOUNTS:
FIGURE 9
HU0003328A 1997-06-10 1998-06-08 Dispenser with doses counter HU228280B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB9711889.7A GB9711889D0 (en) 1997-06-10 1997-06-10 Aerosol dispenser
GBGB9721875.4A GB9721875D0 (en) 1997-10-16 1997-10-16 Aerosol dispenser
PCT/EP1998/003377 WO1998056444A1 (en) 1997-06-10 1998-06-08 Dispenser with doses' counter

Publications (3)

Publication Number Publication Date
HU0003328A2 true HU0003328A2 (en) 2001-02-28
HU0003328A3 HU0003328A3 (en) 2001-04-28
HU228280B1 HU228280B1 (en) 2013-02-28

Family

ID=26311681

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Application Number Title Priority Date Filing Date
HU0003328A HU228280B1 (en) 1997-06-10 1998-06-08 Dispenser with doses counter

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JP2000513632A (en) 2000-10-17
IN192609B (en) 2004-05-08
BR9809554A (en) 2000-06-20
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MA24562A1 (en) 1998-12-31
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CN1265601A (en) 2000-09-06
EP1475116A2 (en) 2004-11-10
US20020195102A1 (en) 2002-12-26
AT305320T (en) 2005-10-15
JP3487865B2 (en) 2004-01-19
DE69818819D1 (en) 2003-11-13
EP1475116A3 (en) 2010-11-17
US7107986B2 (en) 2006-09-19
CO4830464A1 (en) 1999-08-30
EP0988078A1 (en) 2000-03-29
DE69804609D1 (en) 2002-05-08
US8245704B2 (en) 2012-08-21
IS5282A (en) 1999-11-30
CA2293484A1 (en) 1998-12-17
WO1998056446A1 (en) 1998-12-17
CN1150038C (en) 2004-05-19
PL337316A1 (en) 2000-08-14
BR9809980A (en) 2000-08-01
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EP1163922B1 (en) 2004-09-01
HRP980304B1 (en) 2003-06-30
TR199903066T2 (en) 2000-07-21
AP1126A (en) 2002-12-05
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US6431168B1 (en) 2002-08-13
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ID24128A (en) 2000-07-06
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NO331497B1 (en) 2012-01-16
JP2000513634A (en) 2000-10-17
EA199901017A1 (en) 2000-06-26
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EP0986412B1 (en) 2002-04-03
US6360739B1 (en) 2002-03-26
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AU8213798A (en) 1998-12-30
AR012939A1 (en) 2000-11-22
ES2207841T3 (en) 2004-06-01
EP0988078B1 (en) 2005-09-28
CA2293484C (en) 2010-04-13
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EP0988077A1 (en) 2000-03-29
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MY124574A (en) 2006-06-30
RS49632B (en) 2007-08-03
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DE69826039T2 (en) 2005-09-22

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