HU0002680A3 - Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4 - Google Patents

Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4

Info

Publication number
HU0002680A3
HU0002680A3 HU0002680A HU0002680A HU0002680A3 HU 0002680 A3 HU0002680 A3 HU 0002680A3 HU 0002680 A HU0002680 A HU 0002680A HU 0002680 A HU0002680 A HU 0002680A HU 0002680 A3 HU0002680 A3 HU 0002680A3
Authority
HU
Hungary
Prior art keywords
vla
leukocyte adhesion
benzyl compounds
adhesion mediated
inhibit leukocyte
Prior art date
Application number
HU0002680A
Other versions
HU0002680A2 (en
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US90358597A priority Critical
Application filed by American Home Prod filed Critical American Home Prod
Priority to PCT/US1998/015327 priority patent/WO1999006436A1/en
Publication of HU0002680A2 publication Critical patent/HU0002680A2/en
Publication of HU0002680A3 publication Critical patent/HU0002680A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
HU0002680A 1997-07-31 1998-07-31 Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4 HU0002680A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US90358597A true 1997-07-31 1997-07-31
PCT/US1998/015327 WO1999006436A1 (en) 1997-07-31 1998-07-31 Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
HU0002680A2 HU0002680A2 (en) 2001-07-30
HU0002680A3 true HU0002680A3 (en) 2001-12-28

Family

ID=25417733

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002680A HU0002680A3 (en) 1997-07-31 1998-07-31 Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4

Country Status (12)

Country Link
EP (1) EP1001975A1 (en)
JP (1) JP2001512138A (en)
KR (1) KR20010022413A (en)
CN (1) CN1265675A (en)
AU (1) AU8585198A (en)
BR (1) BR9811573A (en)
CA (1) CA2291473A1 (en)
HU (1) HU0002680A3 (en)
IL (1) IL133635D0 (en)
NO (1) NO20000414L (en)
PL (1) PL338510A1 (en)
WO (1) WO1999006436A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
AU7667498A (en) * 1997-05-30 1998-12-30 Celltech Therapeutics Limited Anti-inflammatory tyrosine derivatives
GB2365338B (en) * 1997-06-14 2002-04-03 Enzacta R & D Ltd Therapeutic systems
JP2001517246A (en) 1997-06-23 2001-10-02 ファルマシア・アンド・アップジョン・カンパニー alpha ▲ lower 4 ▼ beta ▲ under 1 ▼ mediated cell adhesion inhibitor
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
US6197794B1 (en) * 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
WO1999043642A1 (en) 1998-02-26 1999-09-02 Celltech Therapeutics Limited Phenylalanine derivatives as inhibitors of alpha4 integrins
US6521626B1 (en) * 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) * 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9811969D0 (en) * 1998-06-03 1998-07-29 Celltech Therapeutics Ltd Chemical compounds
US6685617B1 (en) 1998-06-23 2004-02-03 Pharmacia & Upjohn Company Inhibitors of α4β1 mediated cell adhesion
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6333340B1 (en) * 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
GB9919776D0 (en) * 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9821222D0 (en) 1998-09-30 1998-11-25 Celltech Therapeutics Ltd Chemical compounds
GB9825652D0 (en) 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6407066B1 (en) 1999-01-26 2002-06-18 Elan Pharmaceuticals, Inc. Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
ES2335643T3 (en) * 1999-12-16 2010-03-31 Biogen Idec Ma Inc. Methods of treating ischemic or hemorrhagic CNS antagonists using anti-alpha4 integrins.
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
CN1413210A (en) 1999-12-28 2003-04-23 辉瑞产品公司 Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
AU4855301A (en) 2000-04-17 2001-10-30 Celltech R And D Ltd Enamine derivatives
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
US6740654B2 (en) 2000-07-07 2004-05-25 Celltech R & D Limited Squaric acid derivatives
CA2417059A1 (en) 2000-08-02 2002-02-07 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
JP2005022976A (en) * 2001-07-18 2005-01-27 Ajinomoto Co Inc Carboxylic acid derivative
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
US20050215605A1 (en) * 2002-03-28 2005-09-29 Page Patrick N Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor
CA2514117A1 (en) * 2003-01-24 2004-08-12 Elan Pharmaceuticals, Inc. Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
MXPA06012143A (en) * 2004-04-20 2007-05-15 Amgen Inc Arylsulfonamides and uses related thereto.
DK1778637T3 (en) * 2004-06-29 2012-06-18 Aventis Pharma Inc FKBP binding compositions and pharmaceutical use thereof
US20100150915A1 (en) 2007-02-20 2010-06-17 Stewart Edward J Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
WO2009126920A2 (en) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
CN102675244B (en) * 2011-03-16 2016-03-30 中国人民解放军军事医学科学院毒物药物研究所 Thiazine derivatives and their use for controlling the drug in the manufacture of a neurodegenerative disease
KR20170052526A (en) 2014-03-13 2017-05-12 프로테나 바이오사이언시즈 리미티드 Combination treatment for multiple sclerosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04154732A (en) * 1990-10-18 1992-05-27 Nippon Kayaku Co Ltd Optical resolution method
WO1995015973A1 (en) * 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors

Also Published As

Publication number Publication date
HU0002680A2 (en) 2001-07-30
NO20000414L (en) 2000-03-28
CN1265675A (en) 2000-09-06
KR20010022413A (en) 2001-03-15
WO1999006436A1 (en) 1999-02-11
IL133635D0 (en) 2001-04-30
EP1001975A1 (en) 2000-05-24
BR9811573A (en) 2000-09-19
JP2001512138A (en) 2001-08-21
AU8585198A (en) 1999-02-22
PL338510A1 (en) 2000-11-06
NO20000414D0 (en) 2000-01-27
CA2291473A1 (en) 1999-02-11

Similar Documents

Publication Publication Date Title
EG24177A (en) Novel compounds
IL144353D0 (en) Novel compounds
ZA9810249B (en) Novel substituted phenylketoenols
IL132238D0 (en) Fungicidal trifluromethylalkylamino - triazolopyrimidines
GR3036714T3 (en) Fungicidal trifluorophenyl-triazolopyrimidines
GB9926302D0 (en) Novel compounds
HRP980439A2 (en) Fungicidal 2-methoxybenzophenones
OA11352A (en) Substituted 4-amino-thiazol-2-yl compounds as CDKsinhibitors.
GB9905124D0 (en) Novel compounds
IL132949D0 (en) Herbicidal compositions
GB9722520D0 (en) Compounds
GB9714102D0 (en) Compounds
PL191094B1 (en) Novel substituted 6-phenylphenatridines
SG77195A1 (en) Fungicidal 2-methoxybenzophenones
EP1156798A4 (en) Felbamate derived compounds
IL134167A (en) Fluoropyrazole biphenylamide fungicides
IL132153D0 (en) Novel compounds
IES81166B2 (en) Novel compound
HU0004529A3 (en) Sulfonilated dipeptide-compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use
PL338510A1 (en) Benzyl compounds inhinbiting the adhesion of leucocytes occurring through the mediation of vla-4
SG97811A1 (en) Fluxing adhesive
HU0004531A3 (en) 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use
HU0002495A3 (en) Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use
CZ20012876A3 (en) SP-C analogs
ZA9805763B (en) Novel substituted imidazole compounds