HRP970441B1 - New thrombin inhibitors - Google Patents

New thrombin inhibitors

Info

Publication number
HRP970441B1
HRP970441B1 HR970441A HRP970441A HRP970441B1 HR P970441 B1 HRP970441 B1 HR P970441B1 HR 970441 A HR970441 A HR 970441A HR P970441 A HRP970441 A HR P970441A HR P970441 B1 HRP970441 B1 HR P970441B1
Authority
HR
Croatia
Prior art keywords
thrombin inhibitors
new thrombin
new
inhibitors
thrombin
Prior art date
Application number
HR970441A
Other languages
English (en)
Inventor
Baucke Dorit
Lange Udo
Mack Helmut
Seitz Werner
Zierke Thomas
Wolfgang Hoeffken Hans
Hornberger Wilfried
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HRP970441A2 publication Critical patent/HRP970441A2/hr
Publication of HRP970441B1 publication Critical patent/HRP970441B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HR970441A 1996-08-14 1997-08-11 New thrombin inhibitors HRP970441B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632773A DE19632773A1 (de) 1996-08-14 1996-08-14 Neue Thrombininhibitoren

Publications (2)

Publication Number Publication Date
HRP970441A2 HRP970441A2 (en) 1998-06-30
HRP970441B1 true HRP970441B1 (en) 2005-04-30

Family

ID=7802624

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970441A HRP970441B1 (en) 1996-08-14 1997-08-11 New thrombin inhibitors

Country Status (30)

Country Link
US (1) US6114358A (sk)
EP (1) EP0956294B1 (sk)
JP (1) JP4089981B2 (sk)
KR (1) KR20000030002A (sk)
CN (1) CN1228783A (sk)
AR (1) AR009070A1 (sk)
AT (1) ATE268781T1 (sk)
AU (1) AU735364B2 (sk)
BG (1) BG103096A (sk)
BR (1) BR9711191A (sk)
CA (1) CA2263220A1 (sk)
CO (1) CO4900030A1 (sk)
CZ (1) CZ299634B6 (sk)
DE (2) DE19632773A1 (sk)
DK (1) DK0956294T3 (sk)
ES (1) ES2221062T3 (sk)
HR (1) HRP970441B1 (sk)
HU (1) HUP0001826A3 (sk)
ID (1) ID17873A (sk)
IL (1) IL127751A0 (sk)
MY (1) MY132820A (sk)
NO (1) NO990662L (sk)
NZ (1) NZ333679A (sk)
PL (1) PL188411B1 (sk)
PT (1) PT956294E (sk)
RU (1) RU2175328C2 (sk)
SK (1) SK284915B6 (sk)
TR (1) TR199900310T2 (sk)
WO (1) WO1998006741A1 (sk)
ZA (1) ZA977239B (sk)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
WO1999037611A1 (de) * 1998-01-26 1999-07-29 Basf Aktiengesellschaft Heterocyclische amidine als kallikrein protease inhibitoren
WO1999037668A1 (de) * 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombininhibitoren
ATE223408T1 (de) * 1998-02-09 2002-09-15 Dimensional Pharm Inc Heteroaryl-amidinen,-methylamidinen und - guanidinen als protease inhibitoren, insbesondere als urokinase inhibitoren
KR20010098982A (ko) * 1999-02-09 2001-11-08 3-디멘져널 파마슈티칼즈 인코오포레이티드 프로테아제 억제제로서의 헤테로아릴 아미딘, 메틸아미딘및 구아니딘
WO2000061608A2 (de) 1999-04-09 2000-10-19 Basf Aktiengesellschaft Niedermolekulare inhibitoren von komplementproteasen
AU3559000A (en) * 1999-04-09 2000-11-14 Basf Aktiengesellschaft Method for producing amidines
US7144902B1 (en) * 1999-04-09 2006-12-05 Abbott Gmbh & Co. Kg Prodrugs of thrombin inhibitors
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) * 1999-06-18 2001-01-15 성재갑 아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de) 1999-07-23 2001-01-25 Basf Ag Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi) 2006-12-04 2012-03-30 Dieffenbacher Panelboard Oy Laitteisto kuitujen, kuten lastujen sirottelemiseksi
KR102113960B1 (ko) 2010-03-30 2020-05-21 베르선 코포레이션 트롬빈 억제제로서의 다중치환된 방향족 화합물
KR20150132148A (ko) * 2013-03-15 2015-11-25 베르선 코포레이션 세린 프로타아제 억제제로서의 다중 치환된 방향족 화합물
CN110423221A (zh) 2013-03-15 2019-11-08 维颂公司 作为凝血酶抑制剂的卤代吡唑
CN103520160B (zh) * 2013-10-17 2015-04-22 广东药学院 三棱中肽类化合物的应用
CA2960790A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
AU2016224974B2 (en) 2015-02-27 2019-09-26 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SI9620037A (sl) * 1995-02-17 1998-02-28 Basf Aktiengesellschaft Novi trombinski inhibitorji
DE19632772A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren

Also Published As

Publication number Publication date
TR199900310T2 (xx) 1999-04-21
AU735364B2 (en) 2001-07-05
WO1998006741A1 (de) 1998-02-19
CA2263220A1 (en) 1998-02-19
ES2221062T3 (es) 2004-12-16
SK899A3 (en) 1999-06-11
SK284915B6 (sk) 2006-02-02
PL188411B1 (pl) 2005-01-31
CZ299634B6 (cs) 2008-10-01
US6114358A (en) 2000-09-05
CZ48699A3 (cs) 1999-05-12
ZA977239B (en) 1999-02-15
PL331540A1 (en) 1999-07-19
AU3941797A (en) 1998-03-06
EP0956294A1 (de) 1999-11-17
BR9711191A (pt) 1999-08-17
BG103096A (en) 1999-09-30
ID17873A (id) 1998-02-05
RU2175328C2 (ru) 2001-10-27
NZ333679A (en) 1999-09-29
CN1228783A (zh) 1999-09-15
NO990662D0 (no) 1999-02-12
AR009070A1 (es) 2000-03-08
CO4900030A1 (es) 2000-03-27
DK0956294T3 (da) 2004-10-11
KR20000030002A (ko) 2000-05-25
HUP0001826A2 (hu) 2000-09-28
DE59711714D1 (de) 2004-07-15
EP0956294B1 (de) 2004-06-09
JP2000516598A (ja) 2000-12-12
DE19632773A1 (de) 1998-02-19
JP4089981B2 (ja) 2008-05-28
NO990662L (no) 1999-02-12
IL127751A0 (en) 1999-10-28
PT956294E (pt) 2004-10-29
HUP0001826A3 (en) 2002-01-28
MY132820A (en) 2007-10-31
ATE268781T1 (de) 2004-06-15
HRP970441A2 (en) 1998-06-30

Similar Documents

Publication Publication Date Title
EP0927035A4 (en) THROMBIN INHIBITORS
EP0969840A4 (en) THROMBIN INHIBITORS
HRP960075B1 (en) New thrombin inhibitors
EP0820453A4 (en) THROMBIN INHIBITORS
EP0923372A4 (en) PYRIDINONE THROMBINE INHIBITORS
PL331338A1 (en) Thiosulphonamidic metaloprotease inhibitors
HRP970441B1 (en) New thrombin inhibitors
EP1124822A4 (en) THROMBIN INHIBITORS
EP0971891A4 (en) THROMBIN INHIBITORS
PL328307A1 (en) Serinic protease inhibitors
IL128665A0 (en) Bidenatate metalloprotease inhibitors
PL328875A1 (en) Serinic protease inhibitors
EP1117660A4 (en) THROMBIN INHIBITORS
PL328223A1 (en) Aspartil protease inhibitors
IL136139A0 (en) Thrombin inhibitors
AU3396697A (en) Thrombin inhibitor
GB9613718D0 (en) Thrombin inhibitors
IL121474A0 (en) Thrombin inhibitors
ZA974779B (en) Thrombin inhibitors.
EP1017383A4 (en) THROMBIN INHIBITORS
EP1039907A4 (en) THROMBIN INHIBITORS
EP1027333A4 (en) THROMBIN INHIBITORS
GB9605163D0 (en) Thrombin inhibitors
GB9624278D0 (en) Thrombin inhibitors
GB9624292D0 (en) Thrombin inhibitors

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20080731

Year of fee payment: 12

PBON Lapse due to non-payment of renewal fee

Effective date: 20090812