HRP950033A2 - Tricyclic compounds capable of inhibiting tryosine kinases of the epidermal growth factor receptor family - Google Patents
Tricyclic compounds capable of inhibiting tryosine kinases of the epidermal growth factor receptor family Download PDFInfo
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- HRP950033A2 HRP950033A2 HR08/358,352A HRP950033A HRP950033A2 HR P950033 A2 HRP950033 A2 HR P950033A2 HR P950033 A HRP950033 A HR P950033A HR P950033 A2 HRP950033 A2 HR P950033A2
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- carbon atoms
- nitrogen
- represent
- carbon
- lower alkyl
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- 150000001875 compounds Chemical class 0.000 title claims description 66
- 102000001301 EGF receptor Human genes 0.000 title claims description 23
- 108060006698 EGF receptor Proteins 0.000 title claims description 21
- 230000002401 inhibitory effect Effects 0.000 title claims description 4
- 108091000080 Phosphotransferase Proteins 0.000 title description 3
- 102000020233 phosphotransferase Human genes 0.000 title description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 494
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 455
- 229910052757 nitrogen Inorganic materials 0.000 claims description 273
- 125000000217 alkyl group Chemical group 0.000 claims description 188
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 173
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- 239000001257 hydrogen Substances 0.000 claims description 159
- 229910052739 hydrogen Inorganic materials 0.000 claims description 159
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 129
- 229910052717 sulfur Inorganic materials 0.000 claims description 114
- 238000000034 method Methods 0.000 claims description 111
- 229910052760 oxygen Inorganic materials 0.000 claims description 109
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 102
- -1 -O-C(O)-R) Chemical group 0.000 claims description 97
- 235000001508 sulfur Nutrition 0.000 claims description 92
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 91
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 90
- 239000011593 sulfur Substances 0.000 claims description 88
- 239000000203 mixture Substances 0.000 claims description 81
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 76
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- 125000004663 dialkyl amino group Chemical group 0.000 claims description 44
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- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims description 39
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 36
- 125000001424 substituent group Chemical group 0.000 claims description 36
- 229940116977 epidermal growth factor Drugs 0.000 claims description 34
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 33
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
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- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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AU (1) | AU686339B2 (no) |
BG (1) | BG63432B1 (no) |
CZ (1) | CZ197196A3 (no) |
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GE (1) | GEP20002330B (no) |
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PL (1) | PL315632A1 (no) |
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- 1995-01-23 PL PL95315632A patent/PL315632A1/xx unknown
- 1995-01-23 HU HU9602016A patent/HU222572B1/hu not_active IP Right Cessation
- 1995-01-24 HR HR08/358,352A patent/HRP950033A2/hr not_active Application Discontinuation
-
1996
- 1996-05-20 BG BG100615A patent/BG63432B1/bg unknown
- 1996-07-15 FI FI962855A patent/FI114098B/fi active
- 1996-07-24 NO NO963093A patent/NO307182B1/no unknown
-
1997
- 1997-03-06 US US08/811,803 patent/US6596726B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1833495A (en) | 1995-08-08 |
JPH09508126A (ja) | 1997-08-19 |
CZ197196A3 (en) | 1997-07-16 |
PL315632A1 (en) | 1996-11-25 |
EP0741711A1 (en) | 1996-11-13 |
IL112248A0 (en) | 1995-03-30 |
MD960211A (en) | 1998-04-30 |
FI962855A (fi) | 1996-09-13 |
NO307182B1 (no) | 2000-02-21 |
CN1139430A (zh) | 1997-01-01 |
MX9602109A (es) | 1997-05-31 |
SK89596A3 (en) | 1997-08-06 |
US6596726B1 (en) | 2003-07-22 |
CN1137100C (zh) | 2004-02-04 |
HU222572B1 (hu) | 2003-08-28 |
MD1616G2 (ro) | 2001-11-30 |
FI114098B (fi) | 2004-08-13 |
JP3965439B2 (ja) | 2007-08-29 |
FI962855A0 (fi) | 1996-07-15 |
HU9602016D0 (en) | 1996-09-30 |
WO1995019970A1 (en) | 1995-07-27 |
AU686339B2 (en) | 1998-02-05 |
GEP20002330B (en) | 2000-12-25 |
BG100615A (bg) | 1997-02-28 |
NZ281404A (en) | 1999-05-28 |
MD1616F2 (en) | 2001-02-28 |
HUT74590A (en) | 1997-01-28 |
NO963093D0 (no) | 1996-07-24 |
NO963093L (no) | 1996-07-24 |
BG63432B1 (bg) | 2002-01-31 |
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