HRP20231280T1 - Anti-her2 biparatopski antitijelo-konjugati lijeka i načini uporabe - Google Patents
Anti-her2 biparatopski antitijelo-konjugati lijeka i načini uporabe Download PDFInfo
- Publication number
- HRP20231280T1 HRP20231280T1 HRP20231280TT HRP20231280T HRP20231280T1 HR P20231280 T1 HRP20231280 T1 HR P20231280T1 HR P20231280T T HRP20231280T T HR P20231280TT HR P20231280 T HRP20231280 T HR P20231280T HR P20231280 T1 HRP20231280 T1 HR P20231280T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- her2
- drug conjugate
- antigen
- conjugate according
- Prior art date
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- 239000000611 antibody drug conjugate Substances 0.000 title claims 25
- 229940049595 antibody-drug conjugate Drugs 0.000 title claims 25
- 229920001184 polypeptide Polymers 0.000 claims 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 14
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 13
- 238000012986 modification Methods 0.000 claims 12
- 230000004048 modification Effects 0.000 claims 12
- 108010044540 auristatin Proteins 0.000 claims 6
- 239000000562 conjugate Substances 0.000 claims 5
- 101100330727 Arabidopsis thaliana DAR6 gene Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 229960002087 pertuzumab Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (5)
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US201862642483P | 2018-03-13 | 2018-03-13 | |
US201862658477P | 2018-04-16 | 2018-04-16 | |
US201862743884P | 2018-10-10 | 2018-10-10 | |
EP19766478.2A EP3765525B1 (en) | 2018-03-13 | 2019-03-12 | Anti-her2 biparatopic antibody-drug conjugates and methods of use |
PCT/CA2019/050303 WO2019173911A1 (en) | 2018-03-13 | 2019-03-12 | Anti-her2 biparatopic antibody-drug conjugates and methods of use |
Publications (1)
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HRP20231280T1 true HRP20231280T1 (hr) | 2024-02-02 |
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HRP20231280TT HRP20231280T1 (hr) | 2018-03-13 | 2019-03-12 | Anti-her2 biparatopski antitijelo-konjugati lijeka i načini uporabe |
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EP (2) | EP3765525B1 (hu) |
KR (1) | KR20200131840A (hu) |
CN (1) | CN112020519A (hu) |
AU (1) | AU2019235634A1 (hu) |
BR (1) | BR112020018618A2 (hu) |
CA (1) | CA3093477A1 (hu) |
DK (1) | DK3765525T5 (hu) |
ES (1) | ES2958933T3 (hu) |
FI (1) | FI3765525T3 (hu) |
HR (1) | HRP20231280T1 (hu) |
HU (1) | HUE063489T2 (hu) |
IL (1) | IL277049B2 (hu) |
MX (1) | MX2020009469A (hu) |
PL (1) | PL3765525T3 (hu) |
PT (1) | PT3765525T (hu) |
RS (1) | RS64690B1 (hu) |
SG (1) | SG11202008770QA (hu) |
TW (1) | TWI822740B (hu) |
WO (1) | WO2019173911A1 (hu) |
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CA2968258A1 (en) * | 2014-11-27 | 2016-06-02 | Zymeworks Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
WO2022228422A1 (zh) * | 2021-04-26 | 2022-11-03 | 轩竹生物科技股份有限公司 | 一种双特异抗体偶联物 |
WO2023141714A1 (en) * | 2022-01-26 | 2023-08-03 | Zymeworks Bc Inc. | Methods of using anti-her2 biparatopic antibody-drug conjugates in the treatment of cancer |
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US11000598B2 (en) | 2021-05-11 |
TWI822740B (zh) | 2023-11-21 |
DK3765525T5 (da) | 2024-08-26 |
PL3765525T3 (pl) | 2023-12-27 |
IL277049A (en) | 2020-10-29 |
WO2019173911A1 (en) | 2019-09-19 |
IL277049B2 (en) | 2024-02-01 |
US20210260210A1 (en) | 2021-08-26 |
KR20200131840A (ko) | 2020-11-24 |
TW202003585A (zh) | 2020-01-16 |
JP2021515793A (ja) | 2021-06-24 |
EP3765525A4 (en) | 2022-03-02 |
AU2019235634A1 (en) | 2020-10-22 |
FI3765525T3 (fi) | 2023-10-16 |
IL277049B1 (en) | 2023-10-01 |
CA3093477A1 (en) | 2019-09-19 |
EP3765525A1 (en) | 2021-01-20 |
RS64690B1 (sr) | 2023-11-30 |
PT3765525T (pt) | 2023-10-03 |
ES2958933T3 (es) | 2024-02-16 |
CN112020519A (zh) | 2020-12-01 |
EP4253421A2 (en) | 2023-10-04 |
US20200108152A1 (en) | 2020-04-09 |
US20210346508A1 (en) | 2021-11-11 |
DK3765525T3 (da) | 2023-10-16 |
BR112020018618A2 (pt) | 2020-12-29 |
HUE063489T2 (hu) | 2024-01-28 |
MX2020009469A (es) | 2021-01-29 |
RU2020132555A (ru) | 2022-04-13 |
SG11202008770QA (en) | 2020-10-29 |
EP3765525B1 (en) | 2023-07-19 |
EP4253421A3 (en) | 2024-01-03 |
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