HRP20161639T1 - Granule za farmaceutske pripravke, metode i uređaj za njihovu proizvodnju - Google Patents
Granule za farmaceutske pripravke, metode i uređaj za njihovu proizvodnju Download PDFInfo
- Publication number
- HRP20161639T1 HRP20161639T1 HRP20161639TT HRP20161639T HRP20161639T1 HR P20161639 T1 HRP20161639 T1 HR P20161639T1 HR P20161639T T HRP20161639T T HR P20161639TT HR P20161639 T HRP20161639 T HR P20161639T HR P20161639 T1 HRP20161639 T1 HR P20161639T1
- Authority
- HR
- Croatia
- Prior art keywords
- granules
- predetermined
- spherical
- granule
- production
- Prior art date
Links
- 239000008187 granular material Substances 0.000 title claims 30
- 238000000034 method Methods 0.000 title claims 13
- 239000000825 pharmaceutical preparation Substances 0.000 title claims 7
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 239000008186 active pharmaceutical agent Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical group NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 1
- 229960004963 mesalazine Drugs 0.000 claims 1
- 239000008016 pharmaceutical coating Substances 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/609—Amides, e.g. salicylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (17)
1. Farmaceutski pripravak sadrži nesferizirane granule od kojih svaka ima jedan aktivni farmaceutski sastojak i od kojih svaka ima predodređenu os i isti predodređeni profil poprečnog presjeka, pri čemu najmanje 80% od broja tih granula ima medijan omjera dimenzija iznad 1.1 i ispod 1.7, omjer dimenzija je definiran kao duljina granule duž predodređene osi podijeljena s najmanjom dimenzijom poprečnog presjeka.
2. Farmaceutski pripravak iz patentnog zahtjeva 1, pri čemu te granule imaju raspon omjera dimenzija manji od 0.9.
3. Farmaceutski pripravak iz patentnog zahtjeva 1 ili patentnog zahtjeva 2, pri čemu je najmanja dimenzija poprečnog presjeka između 0.25 mm i 2.5 mm.
4. Farmaceutski pripravak iz bilo kojeg od prethodnih patentnih zahtjeva, pri čemu je barem neka količina granula obložena.
5. Farmaceutski pripravak iz patentnog zahtjeva 4, pri čemu obloga kontrolira otpuštanje aktivnog farmaceutskog sastojka.
6. Farmaceutski pripravak iz bilo kojeg od prethodnih patentnih zahtjeva, pri čemu aktivni farmaceutski sastojak sadrži protuupalni sastojak.
7. Farmaceutski pripravak iz bilo kojeg od prethodnih patentnih zahtjeva, pri čemu je aktivni farmaceutski sastojak 5-aminosalicilna kiselina.
8. Metoda za proizvodnju farmaceutskog pripravka obuhvaća sljedeće korake: proizvodnju nesferiziranih granula koje imaju predodređeni profil poprečnog presjeka i predodređenu os; razvrstavanje nesferiziranih granula u najmanje jednu frakciju prema njihovom omjeru dimenzija; i odabir za daljnju obradu onih nesferiziranih granula u danoj frakciji ili danim frakcijama, gdje je korak razvrstavanja nesferiziranih granula pod utjecajem prolaska nesferiziranih granula kroz svjetlosni separator, pri čemu granule ostaju bez svojstava koja su rezultat postupka sferiziranja, prije podvrgavanja granula koraku razvrstavanja, pri čemu svjetlosni separator sadrži površinu s oblikovanim šupljinama, površina je uređena tako da slijedi predodređenu putanju tako da će granule na površini, koje imaju predodređeni odnos između dimenzija zadane šupljine i duljine granule, upasti i biti razvrstane u određenu frakciju.
9. Metoda iz patentnog zahtjeva 8, pri čemu su granule pripravljene: prolaskom homogenizirane mokre mase kroz prozor za ekstruziju koji ima otvore ondje oblikovanih predodređenih dimenzija ; i usitnjavanje ekstrudirane mase zbog oblikovanja granula.
10. Metoda iz patentnog zahtjeva 8 ili patentnog zahtjeva 9, pri čemu je površina cilindar, predodređena putanja se rotira oko osi cilindra, a spremnik za skupljanje granula koje će biti razvrstane u određene frakcije smješten je dalje od osi cilindra.
11. Metoda iz bilo kojeg od patentnih zahtjeva 8 do 10 pri čemu je svaka od šupljina na površini pogodna za pojedinu granulu predodređenih dimenzija.
12. Metoda iz bilo kojeg od patentnih zahtjeva 8 do 11 pri čemu odabrane granule imaju svojstva granula iz bilo kojeg od patentnih zahtjeva 1 do 3.
13. Metoda iz bilo kojeg od patentnih zahtjeva 8-12, pri čemu su odabrane granule nadalje obložene farmaceutskom oblogom pogodnom za liječenje upalne bolesti crijeva.
14. Metoda iz bilo kojeg od patentnih zahtjeva 8 do 13 pri čemu se granule koje nisu odabrane za daljnju obradu nadalje ponovo usitnjavaju i slijedom dalje razvrstavaju prema njihovoj veličini.
15. Metoda iz patentnog zahtjeva 14, pri čemu se granule koje nisu odabrane za daljnju obradu nadalje ponovo razvrstavaju istim postupkom kao što je razvrstavanje granula u ranijem koraku razvrstavanja.
16. Uporaba svjetlosnog separatora u metodi za proizvodnju farmaceutskog pripravka, pri čemu je uporaba za vrijeme odabira nesferiziranih granula od kojih svaka ima predodređenu os i isti predodređeni profil poprečnog presjeka i od kojih barem dio ima aktivni farmaceutski sastojak, pri čemu duljina separatora obuhvaća površinu koja ima brojne identične ondje predoblikovane šupljine, svaka šupljina je pogodna za prihvaćanje pojedinačne, nesferizirane granule, površina je uređena tako da slijedi predodređenu putanju, tako da će nesferizirane granule početno zadržane u šupljini ispasti iz šupljine na mjestu duž predodređene putanje, pri čemu to mjesto ovisi o duljini određene nesferizirane granule.
17. Uporaba u skladu s patentnim zahtjevom 16, pri čemu metoda za proizvodnju farmaceutskog pripravka obuhvaća primjenu oblaganja na odabrane nesferizirane granule tako da se aktivni farmaceutski sastojak u uporabi otpušta predodređenom brzinom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179877A EP2340812A1 (en) | 2009-12-18 | 2009-12-18 | Granules for pharmaceutical preparations, methods and apparatus for their production |
| EP10793226.1A EP2512453B1 (en) | 2009-12-18 | 2010-12-15 | Granules for pharmaceutical preparations, methods and apparatus for their production |
| PCT/EP2010/069733 WO2011073245A2 (en) | 2009-12-18 | 2010-12-15 | Granules for pharmaceutical preparations, methods and apparatus for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161639T1 true HRP20161639T1 (hr) | 2017-02-10 |
Family
ID=42110308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161639TT HRP20161639T1 (hr) | 2009-12-18 | 2016-12-05 | Granule za farmaceutske pripravke, metode i uređaj za njihovu proizvodnju |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8765185B2 (hr) |
| EP (2) | EP2340812A1 (hr) |
| JP (1) | JP5593396B2 (hr) |
| KR (1) | KR101882880B1 (hr) |
| CN (2) | CN105769772A (hr) |
| AR (1) | AR079536A1 (hr) |
| AU (1) | AU2010332884B2 (hr) |
| BR (1) | BR112012014935B1 (hr) |
| CA (1) | CA2784235C (hr) |
| DK (1) | DK2512453T3 (hr) |
| ES (1) | ES2612870T3 (hr) |
| HR (1) | HRP20161639T1 (hr) |
| HU (1) | HUE031228T2 (hr) |
| IL (1) | IL220319A (hr) |
| JO (1) | JO3762B1 (hr) |
| LT (1) | LT2512453T (hr) |
| MX (2) | MX351365B (hr) |
| NL (1) | NL1038373C2 (hr) |
| NZ (1) | NZ600582A (hr) |
| PL (1) | PL2512453T3 (hr) |
| PT (1) | PT2512453T (hr) |
| RS (1) | RS55438B1 (hr) |
| RU (1) | RU2584349C2 (hr) |
| SI (1) | SI2512453T1 (hr) |
| TW (1) | TWI511723B (hr) |
| WO (1) | WO2011073245A2 (hr) |
| ZA (1) | ZA201204441B (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2520197A1 (en) | 2003-04-23 | 2004-11-04 | Ferring B.V. | Sachet for a pharmaceutical composition |
| SI3628319T1 (sl) | 2008-10-02 | 2024-04-30 | Salix Pharmaceuticals, Ltd. | Zdravljenje jetrne encefalopatije z rifaksiminom |
| EP2340812A1 (en) | 2009-12-18 | 2011-07-06 | Ferring International Center S.A. | Granules for pharmaceutical preparations, methods and apparatus for their production |
| US20140141075A1 (en) | 2012-11-21 | 2014-05-22 | Warner Chilcott Company, Llc | 5-aminosalicylic acid capsule formulation |
| DE202017102645U1 (de) * | 2017-05-03 | 2018-08-06 | Romaco Kilian Gmbh | Ablaufvorrichtung für Presslinge einer Rundläufer-Tablettenpresse sowie Rundläufer-Tablettenpresse mit Ablaufvorrichtung |
| RU2667637C1 (ru) * | 2017-06-26 | 2018-09-21 | Гермес Арцнаймиттель ГмбХ | Фармацевтическая композиция для перорального применения, содержащая n-ацетилцистеин с маскированным вкусом |
| EP3459529A1 (en) | 2017-09-20 | 2019-03-27 | Tillotts Pharma Ag | Preparation of sustained release solid dosage forms comprising antibodies by spray drying |
| ES2938608T3 (es) | 2017-09-20 | 2023-04-13 | Tillotts Pharma Ag | Método para preparar una forma farmacéutica sólida que comprende anticuerpos mediante granulación en húmedo, extrusión y esferonización |
| ES2938609T3 (es) | 2017-09-20 | 2023-04-13 | Tillotts Pharma Ag | Preparación de formas farmacéuticas sólidas que comprenden anticuerpos mediante estratificación de solución/suspensión |
| KR102161235B1 (ko) * | 2020-07-22 | 2020-09-29 | 주식회사 피티케이 | 이송 일체형 과립 제조 장치 및 방법 |
| CN114472139A (zh) * | 2022-01-04 | 2022-05-13 | 安徽宏信药业发展有限公司 | 一种中药药丸干燥筛选装置 |
| CN115445902B (zh) * | 2022-09-21 | 2023-06-06 | 重庆科技学院 | 一种条形颗粒物三维尺寸分选方法及装置 |
| CN116942532B (zh) * | 2023-09-20 | 2023-12-12 | 北京爱力佳医药科技有限公司 | 一种粉状药物制备装置 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57500432A (hr) | 1980-03-20 | 1982-03-11 | ||
| EP0479343B1 (en) * | 1986-03-10 | 1997-08-13 | Cri International, Inc. | Production of improved catalyst-type particles using density grading |
| US4720473A (en) * | 1986-03-10 | 1988-01-19 | Cri International, Inc. | Production of improved catalyst-type particles using length and density grading |
| JPH0827133B2 (ja) | 1993-07-13 | 1996-03-21 | 不二パウダル株式会社 | 湿潤粉粒体の処理装置 |
| PL186790B1 (pl) | 1995-12-21 | 2004-02-27 | Ferring Farma Lab | Farmaceutyczna kompozycja doustna zawierająca 5-ASA i zastosowanie 5-ASA do jej wytwarzania |
| US6004581A (en) | 1995-12-21 | 1999-12-21 | Farmaceutisk Laboratorium Ferring A/S | Modified release oral pharmaceutical composition and method for the treatment of bowel diseases |
| AUPO637197A0 (en) | 1997-04-23 | 1997-05-15 | F.H. Faulding & Co. Limited | Taste-masked pharmaceutical compositions |
| DE19724181A1 (de) * | 1997-06-09 | 1998-12-10 | Bayer Ag | Multiple-unit-retard-Zubereitungen und Verfahren zu ihrer Herstellung |
| JP2000128774A (ja) | 1998-10-26 | 2000-05-09 | Tanabe Seiyaku Co Ltd | 薬物を含有する球形微粒子の製法 |
| US6146685A (en) | 1998-11-05 | 2000-11-14 | Delsys Pharmaceutical Corporation | Method of deposition a dry powder and dispensing device |
| NZ513037A (en) * | 1999-01-29 | 2003-05-30 | Disphar Internat B | Coated sustained release pharmaceutical composition for the release of an agent in the gastrointestinal tract |
| US6735487B1 (en) | 1999-07-01 | 2004-05-11 | Ods Properties, Inc. | Interactive wagering system with promotions |
| GB0113841D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| AR036797A1 (es) | 2001-10-15 | 2004-10-06 | Ferring Bv | Un metodo para preparar una composicion farmaceutica que comprende acido 5-aminosalicilico para utilizar en el tratamiento de colitis ulcerosa y enfermedades de crohn |
| DE60130270T2 (de) * | 2001-10-15 | 2008-05-29 | Ferring B.V. | Verfahren zur herstellung einer pharmazeutischen zubereitung mit 5-aminosalicylsäure zur verwendung bei der behandlung von colitis ulcerosa und morbus crohn |
| US7445796B2 (en) | 2002-08-19 | 2008-11-04 | L. Perrigo Company | Pharmaceutically active particles of a monomodal particle size distribution and method |
| CA2520197A1 (en) | 2003-04-23 | 2004-11-04 | Ferring B.V. | Sachet for a pharmaceutical composition |
| EP1470819A1 (en) * | 2003-04-23 | 2004-10-27 | Ferring B.V. | High drug load mesalazine sachet |
| EP1547601A1 (en) * | 2003-12-23 | 2005-06-29 | Ferring B.V. | Coating method |
| US7207505B2 (en) | 2004-06-04 | 2007-04-24 | Bender Martin P | Method for producing small granules |
| DE102004028977A1 (de) * | 2004-06-16 | 2006-01-05 | Add Advanced Drug Delivery Technologies Ltd. | Neutralpellets |
| EP1954667B1 (en) | 2005-11-17 | 2017-02-08 | Teva Pharmaceutical Industries Ltd | Methods for isolating propargylated aminoindans |
| EP2340812A1 (en) | 2009-12-18 | 2011-07-06 | Ferring International Center S.A. | Granules for pharmaceutical preparations, methods and apparatus for their production |
-
2009
- 2009-12-18 EP EP09179877A patent/EP2340812A1/en not_active Withdrawn
-
2010
- 2010-11-10 NL NL1038373A patent/NL1038373C2/en not_active IP Right Cessation
- 2010-12-15 CN CN201610133023.9A patent/CN105769772A/zh active Pending
- 2010-12-15 RS RS20161111A patent/RS55438B1/sr unknown
- 2010-12-15 MX MX2014011350A patent/MX351365B/es unknown
- 2010-12-15 RU RU2012124834/15A patent/RU2584349C2/ru active
- 2010-12-15 NZ NZ600582A patent/NZ600582A/en unknown
- 2010-12-15 KR KR1020127018413A patent/KR101882880B1/ko active IP Right Grant
- 2010-12-15 DK DK10793226.1T patent/DK2512453T3/en active
- 2010-12-15 CA CA2784235A patent/CA2784235C/en active Active
- 2010-12-15 US US13/516,145 patent/US8765185B2/en active Active
- 2010-12-15 SI SI201031345A patent/SI2512453T1/sl unknown
- 2010-12-15 PT PT107932261T patent/PT2512453T/pt unknown
- 2010-12-15 AU AU2010332884A patent/AU2010332884B2/en active Active
- 2010-12-15 EP EP10793226.1A patent/EP2512453B1/en active Active
- 2010-12-15 ES ES10793226.1T patent/ES2612870T3/es active Active
- 2010-12-15 JO JOP/2010/0446A patent/JO3762B1/ar active
- 2010-12-15 WO PCT/EP2010/069733 patent/WO2011073245A2/en active Application Filing
- 2010-12-15 PL PL10793226T patent/PL2512453T3/pl unknown
- 2010-12-15 JP JP2012543713A patent/JP5593396B2/ja active Active
- 2010-12-15 HU HUE10793226A patent/HUE031228T2/en unknown
- 2010-12-15 LT LTEP10793226.1T patent/LT2512453T/lt unknown
- 2010-12-15 CN CN201080063456.2A patent/CN102791257B/zh active Active
- 2010-12-15 BR BR112012014935-0A patent/BR112012014935B1/pt active IP Right Grant
- 2010-12-15 MX MX2012006851A patent/MX2012006851A/es active IP Right Grant
- 2010-12-17 TW TW099144475A patent/TWI511723B/zh active
- 2010-12-20 AR ARP100104755A patent/AR079536A1/es not_active Application Discontinuation
-
2012
- 2012-06-12 IL IL220319A patent/IL220319A/en active IP Right Grant
- 2012-06-15 ZA ZA2012/04441A patent/ZA201204441B/en unknown
-
2014
- 2014-05-16 US US14/279,806 patent/US9114083B2/en active Active
-
2016
- 2016-12-05 HR HRP20161639TT patent/HRP20161639T1/hr unknown
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