HRP20150433T1 - Modulatori estrogenskog receptora i njihova upotreba - Google Patents
Modulatori estrogenskog receptora i njihova upotreba Download PDFInfo
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- HRP20150433T1 HRP20150433T1 HRP20150433TT HRP20150433T HRP20150433T1 HR P20150433 T1 HRP20150433 T1 HR P20150433T1 HR P20150433T T HRP20150433T T HR P20150433TT HR P20150433 T HRP20150433 T HR P20150433T HR P20150433 T1 HRP20150433 T1 HR P20150433T1
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- HR
- Croatia
- Prior art keywords
- phenyl
- indazol
- acrylic acid
- chloro
- fluoro
- Prior art date
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- 239000002834 estrogen receptor modulator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 16
- 150000001204 N-oxides Chemical class 0.000 claims 15
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 11
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- -1 C 1 -C 4 alkoxy Chemical group 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 238000001647 drug administration Methods 0.000 claims 2
- 201000010260 leiomyoma Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- TUMMXIVJPZXKBO-TUJULSABSA-N (e)-3-[2-chloro-4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C(Cl)=C1 TUMMXIVJPZXKBO-TUJULSABSA-N 0.000 claims 1
- XKBONISHLKAPOX-TUJULSABSA-N (e)-3-[2-fluoro-4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C(F)=C1 XKBONISHLKAPOX-TUJULSABSA-N 0.000 claims 1
- HOAPRJAOYTZQCB-JSLWQCDDSA-N (e)-3-[3-fluoro-4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(/C=1C=C2C=NNC2=CC=1)C1=CC=C(\C=C\C(O)=O)C=C1F HOAPRJAOYTZQCB-JSLWQCDDSA-N 0.000 claims 1
- DVCGFGFMOUUALV-FDTZCEHLSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(2-methoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(OC)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 DVCGFGFMOUUALV-FDTZCEHLSA-N 0.000 claims 1
- BDTDWAOALQTEAC-DZVGZYAASA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(2-methyl-5-methylsulfonylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C(S(C)(=O)=O)=CC=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 BDTDWAOALQTEAC-DZVGZYAASA-N 0.000 claims 1
- OWILQQLRRDHHNQ-USWLQZPQSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(2-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 OWILQQLRRDHHNQ-USWLQZPQSA-N 0.000 claims 1
- JOXWDTFEGLTGOU-FDTZCEHLSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(2-methylsulfonylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(S(C)(=O)=O)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 JOXWDTFEGLTGOU-FDTZCEHLSA-N 0.000 claims 1
- BVPKYELDOZEBDH-ZGCBMYLXSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(3-methoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(OC)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 BVPKYELDOZEBDH-ZGCBMYLXSA-N 0.000 claims 1
- UMSUUPBNKRTMTJ-ZGCBMYLXSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(3-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(C)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 UMSUUPBNKRTMTJ-ZGCBMYLXSA-N 0.000 claims 1
- WCLZCRRVBJRXFV-ZGCBMYLXSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(3-methylsulfonylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(S(C)(=O)=O)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WCLZCRRVBJRXFV-ZGCBMYLXSA-N 0.000 claims 1
- JXLNKPJHDGWEKE-NELRVNDQSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(3-pentoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound CCCCCOC1=CC=CC(C(\CC)=C(/C=2C=CC(\C=C\C(O)=O)=CC=2)C=2C=C3C=NNC3=CC=2)=C1 JXLNKPJHDGWEKE-NELRVNDQSA-N 0.000 claims 1
- RVYPZRNHFSCZEI-HLFSCZJQSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(4-methoxy-2-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OC)C=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 RVYPZRNHFSCZEI-HLFSCZJQSA-N 0.000 claims 1
- UFUSGJQEDZTQBO-FPYWSAHRSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(4-methoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OC)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 UFUSGJQEDZTQBO-FPYWSAHRSA-N 0.000 claims 1
- WKSFDHJTQLNTKL-JGDCARROSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(4-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(C)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WKSFDHJTQLNTKL-JGDCARROSA-N 0.000 claims 1
- FXZWSRPBSIVUET-JXYKICOVSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-(4-pentoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(OCCCCC)=CC=C1C(\CC)=C(C=1C=C2C=NNC2=CC=1)/C1=CC=C(\C=C\C(O)=O)C=C1 FXZWSRPBSIVUET-JXYKICOVSA-N 0.000 claims 1
- RZHZLTZXGKSTHL-QARSQNMTSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-[2-(trifluoromethyl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(C(F)(F)F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 RZHZLTZXGKSTHL-QARSQNMTSA-N 0.000 claims 1
- IJOHCLDJKCAOPL-MSIMQYHBSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-[3-(2-methoxyethoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(OCCOC)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 IJOHCLDJKCAOPL-MSIMQYHBSA-N 0.000 claims 1
- VGKFBNHJAXDCHW-YGIOWPMDSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-[3-(3-methoxypropoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(OCCCOC)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 VGKFBNHJAXDCHW-YGIOWPMDSA-N 0.000 claims 1
- WJEYHMGZXYEZGX-LDPXRHKHSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-[3-(trifluoromethoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(OC(F)(F)F)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WJEYHMGZXYEZGX-LDPXRHKHSA-N 0.000 claims 1
- LCRKTNQOHPQXCA-ZQDHGUJHSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-[4-(2-methoxyethoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OCCOC)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 LCRKTNQOHPQXCA-ZQDHGUJHSA-N 0.000 claims 1
- JIGCKBZPEYMBAF-YZWLJOCZSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-[4-(3-methoxypropoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OCCCOC)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 JIGCKBZPEYMBAF-YZWLJOCZSA-N 0.000 claims 1
- GPQSZOTUHGICPT-RBBFJMDNSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]-2-methylphenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C(C)=C1 GPQSZOTUHGICPT-RBBFJMDNSA-N 0.000 claims 1
- LYWHXGFLZJQQMP-OUWXVUHSSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]-2-methylprop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C(/C)C(O)=O)C=C1 LYWHXGFLZJQQMP-OUWXVUHSSA-N 0.000 claims 1
- PAAUSJRJCJHNJT-LVMHYTKUSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 PAAUSJRJCJHNJT-LVMHYTKUSA-N 0.000 claims 1
- YSZJTABEYJPUJH-UBQCLMHDSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-phenylhex-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CCCC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 YSZJTABEYJPUJH-UBQCLMHDSA-N 0.000 claims 1
- OSGYMPYUAXZAJU-GSDWXQOLSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-phenylpent-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CCC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 OSGYMPYUAXZAJU-GSDWXQOLSA-N 0.000 claims 1
- SABQJNWQZSPKQX-KMOWNNSLSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-2-phenylprop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/C)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 SABQJNWQZSPKQX-KMOWNNSLSA-N 0.000 claims 1
- DZKGJLVINAXXDR-AUMJCACJSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-3-methyl-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1/C(C(C)C)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 DZKGJLVINAXXDR-AUMJCACJSA-N 0.000 claims 1
- AXEAZDVBFMLOLG-ZGCBMYLXSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-4-methoxy-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CCOC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 AXEAZDVBFMLOLG-ZGCBMYLXSA-N 0.000 claims 1
- MXUNPWHNQHVJAA-FVBYSXICSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-4-methyl-2-phenylpent-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC(C)C)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 MXUNPWHNQHVJAA-FVBYSXICSA-N 0.000 claims 1
- IPICIPSXQKXOGD-QSEXUEPCSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-5-methoxy-2-phenylpent-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CCCOC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 IPICIPSXQKXOGD-QSEXUEPCSA-N 0.000 claims 1
- AFSOYKHAPNJNDV-QNRQJRPTSA-N (e)-3-[4-[(e)-1-(1h-indazol-5-yl)-6-methoxy-2-phenylhex-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CCCCOC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 AFSOYKHAPNJNDV-QNRQJRPTSA-N 0.000 claims 1
- NNQKLLSZBAAXTB-UXNQVWTBSA-N (e)-3-[4-[(e)-1-(1h-indol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=CNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 NNQKLLSZBAAXTB-UXNQVWTBSA-N 0.000 claims 1
- KSNHDGRBAZTHRZ-PUMILQKDSA-N (e)-3-[4-[(e)-1-(2h-benzotriazol-5-yl)-2-(2-chloro-4-fluorophenyl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1C(/CC)=C(C=1C=C2N=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 KSNHDGRBAZTHRZ-PUMILQKDSA-N 0.000 claims 1
- SQYGGLLVAPIAIF-YNWFTHOWSA-N (e)-3-[4-[(e)-1-(2h-benzotriazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2N=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 SQYGGLLVAPIAIF-YNWFTHOWSA-N 0.000 claims 1
- JQLXGEQOVVDQMU-YNWFTHOWSA-N (e)-3-[4-[(e)-1-(3-chloro-2h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C(Cl)=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 JQLXGEQOVVDQMU-YNWFTHOWSA-N 0.000 claims 1
- NNOSFXILAIFGCS-YNWFTHOWSA-N (e)-3-[4-[(e)-1-(3-fluoro-2h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C(F)=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 NNOSFXILAIFGCS-YNWFTHOWSA-N 0.000 claims 1
- WOTGOXCBRHPKOH-TZZSVADHSA-N (e)-3-[4-[(e)-1-(3-methyl-2h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C(C)=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WOTGOXCBRHPKOH-TZZSVADHSA-N 0.000 claims 1
- KUIJCZWHBYMGOS-YJFMDEFYSA-N (e)-3-[4-[(e)-1-(3h-benzimidazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2N=CNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 KUIJCZWHBYMGOS-YJFMDEFYSA-N 0.000 claims 1
- HMRPAKZNRVAKLG-BJTNWVBWSA-N (e)-3-[4-[(e)-1-(4-fluoro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C(=C2C=NNC2=CC=1)F)\C1=CC=C(\C=C\C(O)=O)C=C1 HMRPAKZNRVAKLG-BJTNWVBWSA-N 0.000 claims 1
- FYBQRWJSNFMOJZ-FCOVXDGGSA-N (e)-3-[4-[(e)-1-(4-methyl-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C(=C2C=NNC2=CC=1)C)\C1=CC=C(\C=C\C(O)=O)C=C1 FYBQRWJSNFMOJZ-FCOVXDGGSA-N 0.000 claims 1
- WCWAIVPTMUKHHI-OICJBESASA-N (e)-3-[4-[(e)-1-(6-chloro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C(=CC=2NN=CC=2C=1)Cl)\C1=CC=C(\C=C\C(O)=O)C=C1 WCWAIVPTMUKHHI-OICJBESASA-N 0.000 claims 1
- IQGJLBMADSVPQY-OICJBESASA-N (e)-3-[4-[(e)-1-(6-fluoro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C(=CC=2NN=CC=2C=1)F)\C1=CC=C(\C=C\C(O)=O)C=C1 IQGJLBMADSVPQY-OICJBESASA-N 0.000 claims 1
- ZFIGEFACRMPUIG-USDPSEJKSA-N (e)-3-[4-[(e)-1-(6-methyl-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C(=CC=2NN=CC=2C=1)C)\C1=CC=C(\C=C\C(O)=O)C=C1 ZFIGEFACRMPUIG-USDPSEJKSA-N 0.000 claims 1
- QHMMCGARWOBKCO-CHPAAOTMSA-N (e)-3-[4-[(e)-1-(7-chloro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=C(Cl)C=1)\C1=CC=C(\C=C\C(O)=O)C=C1 QHMMCGARWOBKCO-CHPAAOTMSA-N 0.000 claims 1
- UHUJSXRAADEZGF-CHPAAOTMSA-N (e)-3-[4-[(e)-1-(7-fluoro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=C(F)C=1)\C1=CC=C(\C=C\C(O)=O)C=C1 UHUJSXRAADEZGF-CHPAAOTMSA-N 0.000 claims 1
- PUGUFCMUACUOSA-WPSLJESESA-N (e)-3-[4-[(e)-1-(7-fluoro-1h-indol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=CNC2=C(F)C=1)\C1=CC=C(\C=C\C(O)=O)C=C1 PUGUFCMUACUOSA-WPSLJESESA-N 0.000 claims 1
- NLSOBACAJNFWFZ-RKAYHTRNSA-N (e)-3-[4-[(e)-1-(7-methyl-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=C(C)C=1)\C1=CC=C(\C=C\C(O)=O)C=C1 NLSOBACAJNFWFZ-RKAYHTRNSA-N 0.000 claims 1
- WSDBFYFUSISNEU-BNLNVERLSA-N (e)-3-[4-[(e)-2-(2,3-difluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(F)=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WSDBFYFUSISNEU-BNLNVERLSA-N 0.000 claims 1
- OJSGCLBRJPCHGI-KJGLQBJMSA-N (e)-3-[4-[(e)-2-(2,4-dichlorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 OJSGCLBRJPCHGI-KJGLQBJMSA-N 0.000 claims 1
- SGAWUCFIHCYVOE-YGEAOWTPSA-N (e)-3-[4-[(e)-2-(2,4-dichlorophenyl)-1-(4-fluoro-1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(/CC)=C(C=1C(=C2C=NNC2=CC=1)F)\C1=CC=C(\C=C\C(O)=O)C=C1 SGAWUCFIHCYVOE-YGEAOWTPSA-N 0.000 claims 1
- HHBQCWWOGRMDNS-XELCXUBQSA-N (e)-3-[4-[(e)-2-(2,4-dichlorophenyl)-1-(7-fluoro-1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=C(F)C=1)\C1=CC=C(\C=C\C(O)=O)C=C1 HHBQCWWOGRMDNS-XELCXUBQSA-N 0.000 claims 1
- NCNWWAIUKNBBHR-DFXJZTCFSA-N (e)-3-[4-[(e)-2-(2,4-dichlorophenyl)-1-(7-fluoro-1h-indol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=CNC2=C(F)C=1)\C1=CC=C(\C=C\C(O)=O)C=C1 NCNWWAIUKNBBHR-DFXJZTCFSA-N 0.000 claims 1
- DFPJANHGZMAQJR-HBACUYKESA-N (e)-3-[4-[(e)-2-(2,4-dichlorophenyl)-4-fluoro-1-(4-fluoro-1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C(=C2C=NNC2=CC=1)F)=C(\CCF)C1=CC=C(Cl)C=C1Cl DFPJANHGZMAQJR-HBACUYKESA-N 0.000 claims 1
- SDTGDKAKBYALSL-KJGLQBJMSA-N (e)-3-[4-[(e)-2-(2,4-difluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 SDTGDKAKBYALSL-KJGLQBJMSA-N 0.000 claims 1
- YCUVMBGXVZJVSY-KJGLQBJMSA-N (e)-3-[4-[(e)-2-(2,5-difluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C(F)=CC=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 YCUVMBGXVZJVSY-KJGLQBJMSA-N 0.000 claims 1
- JPASJZBSQRCKGO-BNLNVERLSA-N (e)-3-[4-[(e)-2-(2,6-dichlorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound ClC=1C=CC=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 JPASJZBSQRCKGO-BNLNVERLSA-N 0.000 claims 1
- UQUVVQOZNGXWDP-BNLNVERLSA-N (e)-3-[4-[(e)-2-(2,6-difluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound FC=1C=CC=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 UQUVVQOZNGXWDP-BNLNVERLSA-N 0.000 claims 1
- ABNRIGHTJXRAFU-BNLNVERLSA-N (e)-3-[4-[(e)-2-(2-chloro-3-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(F)=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 ABNRIGHTJXRAFU-BNLNVERLSA-N 0.000 claims 1
- KIESNUNGVMHCMO-QARSQNMTSA-N (e)-3-[4-[(e)-2-(2-chloro-3-methoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(OC)=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 KIESNUNGVMHCMO-QARSQNMTSA-N 0.000 claims 1
- VEOABZQSUJRZEG-KDPSZLDMSA-N (e)-3-[4-[(e)-2-(2-chloro-4-cyanophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(C#N)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 VEOABZQSUJRZEG-KDPSZLDMSA-N 0.000 claims 1
- GLVGUGJKNCWSNA-XNMQOOQSSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)-3-methylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1/C(C(C)C)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 GLVGUGJKNCWSNA-XNMQOOQSSA-N 0.000 claims 1
- SEHVFHLSNJBWAA-GCKDJBEWSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)-4-methylpent-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1C(/CC(C)C)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 SEHVFHLSNJBWAA-GCKDJBEWSA-N 0.000 claims 1
- BURHGPHDEVGCEZ-KJGLQBJMSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 BURHGPHDEVGCEZ-KJGLQBJMSA-N 0.000 claims 1
- ATBQANQGSCAUNI-KJGLQBJMSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-1-[1-(difluoromethyl)indazol-5-yl]but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=NN(C2=CC=1)C(F)F)\C1=CC=C(\C=C\C(O)=O)C=C1 ATBQANQGSCAUNI-KJGLQBJMSA-N 0.000 claims 1
- DGXJMSJTWAKGLL-GWYNGDBJSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-2-cyclobutyl-1-(1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C(=CC(F)=CC=1)Cl)\C1CCC1 DGXJMSJTWAKGLL-GWYNGDBJSA-N 0.000 claims 1
- BBVZRIZIRTYQJJ-YELFRASBSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-2-cyclobutyl-1-(3-fluoro-2h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C(F)=NNC2=CC=1)=C(C=1C(=CC(F)=CC=1)Cl)\C1CCC1 BBVZRIZIRTYQJJ-YELFRASBSA-N 0.000 claims 1
- KHAIVUVDUMXYNX-FAXREOPTSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-2-cyclopropyl-1-(1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C(=CC(F)=CC=1)Cl)\C1CC1 KHAIVUVDUMXYNX-FAXREOPTSA-N 0.000 claims 1
- WZDRTKOOEIPUJO-HZXYQDOXSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-2-cyclopropyl-1-(4-fluoro-1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C(=C2C=NNC2=CC=1)F)=C(C=1C(=CC(F)=CC=1)Cl)\C1CC1 WZDRTKOOEIPUJO-HZXYQDOXSA-N 0.000 claims 1
- BURHGPHDEVGCEZ-MAYQKEIGSA-N (e)-3-[4-[(e)-2-(2-chloro-4-fluorophenyl)-3,3,4,4,4-pentadeuterio-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1/C(C([2H])([2H])C([2H])([2H])[2H])=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 BURHGPHDEVGCEZ-MAYQKEIGSA-N 0.000 claims 1
- GHGOQVWUWPIZAU-LPOJXSLPSA-N (e)-3-[4-[(e)-2-(2-chloro-4-methoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OC)C=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 GHGOQVWUWPIZAU-LPOJXSLPSA-N 0.000 claims 1
- ACMFLSSHHVCGTC-KJGLQBJMSA-N (e)-3-[4-[(e)-2-(2-chloro-5-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C(F)=CC=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 ACMFLSSHHVCGTC-KJGLQBJMSA-N 0.000 claims 1
- QQEOPSGOJJEEMK-LPOJXSLPSA-N (e)-3-[4-[(e)-2-(2-chloro-5-methoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C(OC)=CC=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 QQEOPSGOJJEEMK-LPOJXSLPSA-N 0.000 claims 1
- IWEHZFCBKMSKSB-KNUXPBIZSA-N (e)-3-[4-[(e)-2-(2-chloro-6-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound CC=1C=CC=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 IWEHZFCBKMSKSB-KNUXPBIZSA-N 0.000 claims 1
- JTDKFGGWADHEPW-FDTZCEHLSA-N (e)-3-[4-[(e)-2-(2-chlorophenyl)-1-(1-methylindazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(Cl)C=1C(/CC)=C(C=1C=C2C=NN(C)C2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 JTDKFGGWADHEPW-FDTZCEHLSA-N 0.000 claims 1
- LZVNCFNDQVAKET-QARSQNMTSA-N (e)-3-[4-[(e)-2-(2-chlorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(Cl)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 LZVNCFNDQVAKET-QARSQNMTSA-N 0.000 claims 1
- PAWQXSKMQLPAQC-FUGMXNRTSA-N (e)-3-[4-[(e)-2-(2-chlorophenyl)-2-cyclopropyl-1-(1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C(=CC=CC=1)Cl)\C1CC1 PAWQXSKMQLPAQC-FUGMXNRTSA-N 0.000 claims 1
- GWNSEPJAUQMQBM-BMMXBHDXSA-N (e)-3-[4-[(e)-2-(2-cyano-4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(C#N)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 GWNSEPJAUQMQBM-BMMXBHDXSA-N 0.000 claims 1
- GMLSHAFHBVCTIM-ZKQQSUMPSA-N (e)-3-[4-[(e)-2-(2-cyano-4-methoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OC)C=C(C#N)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 GMLSHAFHBVCTIM-ZKQQSUMPSA-N 0.000 claims 1
- REVXGMJBPXMJCS-MVIRSQBCSA-N (e)-3-[4-[(e)-2-(2-cyanophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(C#N)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 REVXGMJBPXMJCS-MVIRSQBCSA-N 0.000 claims 1
- AIRLYZAYNKJCBJ-WWECBPANSA-N (e)-3-[4-[(e)-2-(2-ethylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(CC)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 AIRLYZAYNKJCBJ-WWECBPANSA-N 0.000 claims 1
- BGQVEMPWNIWCSU-LPOJXSLPSA-N (e)-3-[4-[(e)-2-(2-fluoro-4-methoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OC)C=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 BGQVEMPWNIWCSU-LPOJXSLPSA-N 0.000 claims 1
- GFEQSJHJPJSRHS-LPOJXSLPSA-N (e)-3-[4-[(e)-2-(2-fluoro-4-methylsulfonylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(S(C)(=O)=O)C=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 GFEQSJHJPJSRHS-LPOJXSLPSA-N 0.000 claims 1
- WQUCDESRQHEUJT-LMNVZGDYSA-N (e)-3-[4-[(e)-2-(2-fluorophenyl)-1-(1h-indazol-4-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(F)C=1C(/CC)=C(C=1C=2C=NNC=2C=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WQUCDESRQHEUJT-LMNVZGDYSA-N 0.000 claims 1
- FWSLXARFNOXOIU-QARSQNMTSA-N (e)-3-[4-[(e)-2-(2-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 FWSLXARFNOXOIU-QARSQNMTSA-N 0.000 claims 1
- BRNNCBGOHGSMJP-QARSQNMTSA-N (e)-3-[4-[(e)-2-(2-hydroxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(O)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 BRNNCBGOHGSMJP-QARSQNMTSA-N 0.000 claims 1
- UMWYZUZCAXKTFP-XVFKSGQCSA-N (e)-3-[4-[(e)-2-(3-butoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound CCCCOC1=CC=CC(C(\CC)=C(/C=2C=CC(\C=C\C(O)=O)=CC=2)C=2C=C3C=NNC3=CC=2)=C1 UMWYZUZCAXKTFP-XVFKSGQCSA-N 0.000 claims 1
- FNPBSZAJZKLOLM-LDPXRHKHSA-N (e)-3-[4-[(e)-2-(3-chlorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(Cl)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 FNPBSZAJZKLOLM-LDPXRHKHSA-N 0.000 claims 1
- YZJRUJRONPLBAO-GUSHTPMWSA-N (e)-3-[4-[(e)-2-(3-cyano-2-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(C#N)=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 YZJRUJRONPLBAO-GUSHTPMWSA-N 0.000 claims 1
- IWXJZZOYVNLIOY-YRLLLCFKSA-N (e)-3-[4-[(e)-2-(3-cyanophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(C#N)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 IWXJZZOYVNLIOY-YRLLLCFKSA-N 0.000 claims 1
- LSGVKKAUSWQZLE-XDQQEAPGSA-N (e)-3-[4-[(e)-2-(3-cyclohexyloxyphenyl)-1-(4-fluoro-1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(OC2CCCCC2)=CC=1C(/CC)=C(C=1C(=C2C=NNC2=CC=1)F)\C1=CC=C(\C=C\C(O)=O)C=C1 LSGVKKAUSWQZLE-XDQQEAPGSA-N 0.000 claims 1
- GWAKSCZWXHCIGQ-LDPXRHKHSA-N (e)-3-[4-[(e)-2-(3-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(F)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 GWAKSCZWXHCIGQ-LDPXRHKHSA-N 0.000 claims 1
- MRYAYJSNOFKAJU-AHGPHAKWSA-N (e)-3-[4-[(e)-2-(3-hexoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound CCCCCCOC1=CC=CC(C(\CC)=C(/C=2C=CC(\C=C\C(O)=O)=CC=2)C=2C=C3C=NNC3=CC=2)=C1 MRYAYJSNOFKAJU-AHGPHAKWSA-N 0.000 claims 1
- YLYPFXNQBZFOBP-LDPXRHKHSA-N (e)-3-[4-[(e)-2-(3-hydroxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(O)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 YLYPFXNQBZFOBP-LDPXRHKHSA-N 0.000 claims 1
- VBJSNQLMBNHMCZ-LNIUFMFBSA-N (e)-3-[4-[(e)-2-(4-butoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(OCCCC)=CC=C1C(\CC)=C(C=1C=C2C=NNC2=CC=1)/C1=CC=C(\C=C\C(O)=O)C=C1 VBJSNQLMBNHMCZ-LNIUFMFBSA-N 0.000 claims 1
- MASFUGHSPXARQV-BMMXBHDXSA-N (e)-3-[4-[(e)-2-(4-chloro-2-cyanophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(C#N)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 MASFUGHSPXARQV-BMMXBHDXSA-N 0.000 claims 1
- IRMRJQVTYUVQMK-DKXRTFGMSA-N (e)-3-[4-[(e)-2-(4-chloro-2-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 IRMRJQVTYUVQMK-DKXRTFGMSA-N 0.000 claims 1
- ZAHGMGPWRINUDV-XXMGVWMESA-N (e)-3-[4-[(e)-2-(4-chloro-2-methylphenyl)-2-cyclopropyl-1-(1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound CC1=CC(Cl)=CC=C1\C(C1CC1)=C(C=1C=C2C=NNC2=CC=1)/C1=CC=C(\C=C\C(O)=O)C=C1 ZAHGMGPWRINUDV-XXMGVWMESA-N 0.000 claims 1
- XUUATUROCNAHMZ-XHOOSORXSA-N (e)-3-[4-[(e)-2-(4-chloro-2-methylphenyl)-2-cyclopropyl-1-(4-fluoro-1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound CC1=CC(Cl)=CC=C1\C(C1CC1)=C(C=1C(=C2C=NNC2=CC=1)F)/C1=CC=C(\C=C\C(O)=O)C=C1 XUUATUROCNAHMZ-XHOOSORXSA-N 0.000 claims 1
- FKFFBCYANWWUGF-OCCQGNCUSA-N (e)-3-[4-[(e)-2-(4-chlorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 FKFFBCYANWWUGF-OCCQGNCUSA-N 0.000 claims 1
- CVCIYXIXOTZBEE-REBLKOJRSA-N (e)-3-[4-[(e)-2-(4-cyano-2-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(C#N)C=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 CVCIYXIXOTZBEE-REBLKOJRSA-N 0.000 claims 1
- ZRSQCVVTBIYEHE-HMVHHGGDSA-N (e)-3-[4-[(e)-2-(4-cyanophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(C#N)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 ZRSQCVVTBIYEHE-HMVHHGGDSA-N 0.000 claims 1
- SRJSMUBSEVISSQ-DKXRTFGMSA-N (e)-3-[4-[(e)-2-(4-fluoro-2-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 SRJSMUBSEVISSQ-DKXRTFGMSA-N 0.000 claims 1
- NAZJXNRRWPRGRS-DKXRTFGMSA-N (e)-3-[4-[(e)-2-(4-fluoro-3-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 NAZJXNRRWPRGRS-DKXRTFGMSA-N 0.000 claims 1
- LQWPVEQSBQGIPF-OCCQGNCUSA-N (e)-3-[4-[(e)-2-(4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 LQWPVEQSBQGIPF-OCCQGNCUSA-N 0.000 claims 1
- XCYBQHCFSIVPLL-HKEZKNCHSA-N (e)-3-[4-[(e)-2-(4-hexoxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(OCCCCCC)=CC=C1C(\CC)=C(C=1C=C2C=NNC2=CC=1)/C1=CC=C(\C=C\C(O)=O)C=C1 XCYBQHCFSIVPLL-HKEZKNCHSA-N 0.000 claims 1
- SYJFHFAYTHIOAZ-OCCQGNCUSA-N (e)-3-[4-[(e)-2-(4-hydroxyphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 SYJFHFAYTHIOAZ-OCCQGNCUSA-N 0.000 claims 1
- KSGLVLFHSVTIGQ-BCQJMHHZSA-N (e)-3-[4-[(e)-2-(5-cyano-2-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C(C#N)=CC=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 KSGLVLFHSVTIGQ-BCQJMHHZSA-N 0.000 claims 1
- QUUMNHARARIGRU-KYWDJWAXSA-N (e)-3-[4-[(e)-2-(5-fluoro-2-methylphenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C(F)=CC=C(C)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 QUUMNHARARIGRU-KYWDJWAXSA-N 0.000 claims 1
- QMXRCSOTZFMALY-MVIRSQBCSA-N (e)-3-[4-[(e)-2-[2-(hydroxymethyl)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=C(CO)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 QMXRCSOTZFMALY-MVIRSQBCSA-N 0.000 claims 1
- PBKWBBJBGQMKTC-BMMXBHDXSA-N (e)-3-[4-[(e)-2-[2-cyano-4-(trifluoromethyl)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(C(F)(F)F)C=C(C#N)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 PBKWBBJBGQMKTC-BMMXBHDXSA-N 0.000 claims 1
- ZJBSNCUWRDAFGQ-YRLLLCFKSA-N (e)-3-[4-[(e)-2-[3-(hydroxymethyl)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC(CO)=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 ZJBSNCUWRDAFGQ-YRLLLCFKSA-N 0.000 claims 1
- FYNOITALLWWASN-PFNGHRNSSA-N (e)-3-[4-[(e)-2-[4-(2-hydroxyethoxy)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(OCCO)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 FYNOITALLWWASN-PFNGHRNSSA-N 0.000 claims 1
- WSEDFNORQFHHCJ-HMVHHGGDSA-N (e)-3-[4-[(e)-2-[4-(hydroxymethyl)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(CO)C=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 WSEDFNORQFHHCJ-HMVHHGGDSA-N 0.000 claims 1
- XQDSROUBCBIJKW-KJGLQBJMSA-N (e)-3-[4-[(e)-2-[4-chloro-2-(trifluoromethyl)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(C(F)(F)F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 XQDSROUBCBIJKW-KJGLQBJMSA-N 0.000 claims 1
- HSOJLUABCNPNAO-YGEAOWTPSA-N (e)-3-[4-[(e)-2-[4-chloro-2-(trifluoromethyl)phenyl]-1-(4-fluoro-1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(C(F)(F)F)C=1C(/CC)=C(C=1C(=C2C=NNC2=CC=1)F)\C1=CC=C(\C=C\C(O)=O)C=C1 HSOJLUABCNPNAO-YGEAOWTPSA-N 0.000 claims 1
- LUTBDBRSAUMDGF-KJGLQBJMSA-N (e)-3-[4-[(e)-2-[4-fluoro-2-(trifluoromethyl)phenyl]-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(C(F)(F)F)C=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 LUTBDBRSAUMDGF-KJGLQBJMSA-N 0.000 claims 1
- XFZASVJDUHMULE-QPKSJOODSA-N (e)-3-[4-[(e)-2-cyclobutyl-1-(1-methylindazol-5-yl)-2-phenylethenyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C2N(C)N=CC2=CC=1C(\C=1C=CC(\C=C\C(O)=O)=CC=1)=C(C=1C=CC=CC=1)/C1CCC1 XFZASVJDUHMULE-QPKSJOODSA-N 0.000 claims 1
- HCMDSAHYPNHQTM-WKVUNKNDSA-N (e)-3-[4-[(e)-2-cyclobutyl-1-(1h-indazol-5-yl)-2-phenylethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C=CC=CC=1)\C1CCC1 HCMDSAHYPNHQTM-WKVUNKNDSA-N 0.000 claims 1
- KSXYWATXKVMYKL-OMXZRZKWSA-N (e)-3-[4-[(e)-2-cyclobutyl-1-(3-fluoro-2h-indazol-5-yl)-2-phenylethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C(F)=NNC2=CC=1)=C(C=1C=CC=CC=1)\C1CCC1 KSXYWATXKVMYKL-OMXZRZKWSA-N 0.000 claims 1
- UVAMEMLWOGXLFI-QBMVERNNSA-N (e)-3-[4-[(e)-2-cyclohexyl-1-(1h-indazol-5-yl)-2-phenylethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C=CC=CC=1)\C1CCCCC1 UVAMEMLWOGXLFI-QBMVERNNSA-N 0.000 claims 1
- PJDVFPIUHUIHIO-KEZKVWRLSA-N (e)-3-[4-[(e)-2-cyclopropyl-1-(1h-indazol-5-yl)-2-phenylethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C=CC=CC=1)\C1CC1 PJDVFPIUHUIHIO-KEZKVWRLSA-N 0.000 claims 1
- MMCQPJMYUIMNSF-XHOOSORXSA-N (e)-3-[4-[(e)-2-cyclopropyl-1-(4-fluoro-1h-indazol-5-yl)-2-(4-fluoro-2-methylphenyl)ethenyl]phenyl]prop-2-enoic acid Chemical compound CC1=CC(F)=CC=C1\C(C1CC1)=C(C=1C(=C2C=NNC2=CC=1)F)/C1=CC=C(\C=C\C(O)=O)C=C1 MMCQPJMYUIMNSF-XHOOSORXSA-N 0.000 claims 1
- OCCUGCINNISUKU-ISKKVCMFSA-N (e)-3-[4-[(e)-2-cyclopropyl-1-(4-fluoro-1h-indazol-5-yl)-2-phenylethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C(=C2C=NNC2=CC=1)F)=C(C=1C=CC=CC=1)\C1CC1 OCCUGCINNISUKU-ISKKVCMFSA-N 0.000 claims 1
- HXUQDNWJDFQXBL-FAXREOPTSA-N (e)-3-[4-[(e)-2-cyclopropyl-2-(2,4-dichlorophenyl)-1-(1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C(=CC(Cl)=CC=1)Cl)\C1CC1 HXUQDNWJDFQXBL-FAXREOPTSA-N 0.000 claims 1
- VMSJARQVFHNKOH-HZXYQDOXSA-N (e)-3-[4-[(e)-2-cyclopropyl-2-(2,4-dichlorophenyl)-1-(4-fluoro-1h-indazol-5-yl)ethenyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C(=C2C=NNC2=CC=1)F)=C(C=1C(=CC(Cl)=CC=1)Cl)\C1CC1 VMSJARQVFHNKOH-HZXYQDOXSA-N 0.000 claims 1
- OJSGCLBRJPCHGI-MAYQKEIGSA-N (e)-3-[4-[(e)-3,3,4,4,4-pentadeuterio-2-(2,4-dichlorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(Cl)C=C(Cl)C=1/C(C([2H])([2H])C([2H])([2H])[2H])=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 OJSGCLBRJPCHGI-MAYQKEIGSA-N 0.000 claims 1
- HZTYRQHYSIVMFR-VWAYBGSASA-N (e)-3-[4-[(e)-3-cyclopentyl-1-(1h-indazol-5-yl)-2-phenylprop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C=CC=CC=1)\CC1CCCC1 HZTYRQHYSIVMFR-VWAYBGSASA-N 0.000 claims 1
- PDXPQPVQNHTMQU-FVBYSXICSA-N (e)-3-[4-[(e)-3-cyclopropyl-1-(1h-indazol-5-yl)-2-phenylprop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C=1C=CC=CC=1)\CC1CC1 PDXPQPVQNHTMQU-FVBYSXICSA-N 0.000 claims 1
- PAAUSJRJCJHNJT-SZJKYGBKSA-N (e)-3-[4-[(e)-4,4,4-trideuterio-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC([2H])([2H])[2H])=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 PAAUSJRJCJHNJT-SZJKYGBKSA-N 0.000 claims 1
- VICKXNPAPNGWTI-LDPXRHKHSA-N (e)-3-[4-[(e)-4-chloro-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(\CCCl)C1=CC=CC=C1 VICKXNPAPNGWTI-LDPXRHKHSA-N 0.000 claims 1
- NZHZZBWOSYFTKX-BNLNVERLSA-N (e)-3-[4-[(e)-4-chloro-1-(4-fluoro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C(=C2C=NNC2=CC=1)F)=C(\CCCl)C1=CC=CC=C1 NZHZZBWOSYFTKX-BNLNVERLSA-N 0.000 claims 1
- BXUTVAITDFOFDR-LDPXRHKHSA-N (e)-3-[4-[(e)-4-fluoro-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(\CCF)C1=CC=CC=C1 BXUTVAITDFOFDR-LDPXRHKHSA-N 0.000 claims 1
- VXKGIMBXQSHJNA-BNLNVERLSA-N (e)-3-[4-[(e)-4-fluoro-1-(4-fluoro-1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C(=C2C=NNC2=CC=1)F)=C(\CCF)C1=CC=CC=C1 VXKGIMBXQSHJNA-BNLNVERLSA-N 0.000 claims 1
- QPQZHLQUPPUFAC-SAFSSSODSA-N (e)-3-[4-[(e)-4-fluoro-2-(4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(\CCF)C1=CC=C(F)C=C1 QPQZHLQUPPUFAC-SAFSSSODSA-N 0.000 claims 1
- RQMGXFBLPIATQC-LDPXRHKHSA-N (e)-3-[4-[(e)-4-hydroxy-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CCO)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 RQMGXFBLPIATQC-LDPXRHKHSA-N 0.000 claims 1
- CLRXMOXGNFMZIL-TUJULSABSA-N (e)-3-[4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]-2-(trifluoromethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C(C(F)(F)F)=C1 CLRXMOXGNFMZIL-TUJULSABSA-N 0.000 claims 1
- WHDLKJNDYWFBIX-UAWLBYJDSA-N (e)-3-[4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]-2-methoxyphenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C(OC)=C1 WHDLKJNDYWFBIX-UAWLBYJDSA-N 0.000 claims 1
- LMANLGXMQRKGKV-HWRWZSNVSA-N (e)-3-[4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]-3-methoxyphenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(/C=1C=C2C=NNC2=CC=1)C1=CC=C(\C=C\C(O)=O)C=C1OC LMANLGXMQRKGKV-HWRWZSNVSA-N 0.000 claims 1
- NDBFRQKSLQCMOI-RDNHBOATSA-N (e)-3-[4-[(z)-1-(1h-indazol-5-yl)-2-phenylbut-1-enyl]-3-methylphenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/CC)=C(/C=1C=C2C=NNC2=CC=1)C1=CC=C(\C=C\C(O)=O)C=C1C NDBFRQKSLQCMOI-RDNHBOATSA-N 0.000 claims 1
- FFWPTFBKOVWYNP-YITNKKICSA-N (e)-3-[4-[(z)-1-(1h-indazol-5-yl)-3-methoxy-2-phenylprop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(/COC)=C(C=1C=C2C=NNC2=CC=1)\C1=CC=C(\C=C\C(O)=O)C=C1 FFWPTFBKOVWYNP-YITNKKICSA-N 0.000 claims 1
- ZYNYHSHUCBJABP-VMLAWAEDSA-N (e)-3-[4-[(z)-2-(2-chloro-4-fluorophenyl)-3,3-difluoro-1-(1h-indazol-5-yl)prop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(\C(F)F)C1=CC=C(F)C=C1Cl ZYNYHSHUCBJABP-VMLAWAEDSA-N 0.000 claims 1
- UTHAVGDZOQAAKT-QQEJTYDVSA-N (e)-3-[4-[(z)-3,3,3-trifluoro-1-(1h-indazol-5-yl)-2-phenylprop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(C(F)(F)F)/C1=CC=CC=C1 UTHAVGDZOQAAKT-QQEJTYDVSA-N 0.000 claims 1
- QXJXGYLHKGOHQO-QQEJTYDVSA-N (e)-3-[4-[(z)-3,3-difluoro-1-(1h-indazol-5-yl)-2-phenylprop-1-enyl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C(\C=1C=C2C=NNC2=CC=1)=C(\C(F)F)C1=CC=CC=C1 QXJXGYLHKGOHQO-QQEJTYDVSA-N 0.000 claims 1
- DKKGCQGIFQMOGR-LFYBBSHMSA-N (e)-3-[4-[1-(4-fluoro-1h-indazol-5-yl)-2-[4-fluoro-2-(trifluoromethyl)phenyl]butyl]phenyl]prop-2-enoic acid Chemical compound C=1C=C(F)C=C(C(F)(F)F)C=1C(CC)C(C=1C(=C2C=NNC2=CC=1)F)C1=CC=C(\C=C\C(O)=O)C=C1 DKKGCQGIFQMOGR-LFYBBSHMSA-N 0.000 claims 1
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Classifications
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Claims (18)
1. Spoj koji ima strukturu prema Formuli (XII):
[image]
naznačeno time da
X1 je CH, CR3 ili N;
X2 je N, CH, ili CR3;
Z je -OH ili –OR10;
R2 je C1-C4alkil, C1-C4fluoroalkil, C1-C4deuteroalkil, C3-C6cikloalkil, ili -C1-C4alkilen-W;
W je hidroksi, halogen, CN, C1-C4alkil, C1-C4haloalkil, C1-C4alkoksi, C1-C4haloalkoksi, i C3-C6cikloalkil;
svaki R3 je nezavisno halogen, C1-C4alkil, ili C1-C4fluoroalkil;
svaki R4 je nezavisno halogen, -CN, -OR9, -S(=O)2R10, C1-C4alkil, C1-C4fluoroalkil, ili C1-C4heteroalkil;
svaki R5 je nezavisno halogen, -CN, -OR9, -S(=O)2R10, C1-C4alkil, C1-C4fluoroalkil, ili C1-C4heteroalkil;
R6 je H, C1-C4alkil, ili halogen;
R7 je H, C1-C4alkil, ili halogen;
R9 je H, C1-C6alkil, C1-C6fluoroalkil, ili C3-C6cikloalkil;
R10 je C1-C6alkil;
m je 0, 1, ili 2;
n je 0, 1, 2, 3, ili 4; i
p je 0, 1, ili 2;
ili njihova farmaceutski prihvatljiva sol ili N-oksid.
2. Spoj prema zahtjevu 1, ili farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da
Z je -OH;
svaki R3 je nezavisno halogen, C1-C4alkil, ili C1-C4fluoroalkil;
svaki R4 je nezavisno halogen, -CN, -OR9, -S(=O)2R10, C1-C4alkil, C1-C4fluoroalkil, ili C1-C4heteroalkil;
svaki R5 je nezavisno halogen, C1-C4alkil, ili C1-C4fluoroalkil;
R6 je H, -CH3, F, ili Cl;
R7 jeste H, -CH3, F, ili Cl;
m je 0, 1, ili 1;
n je 0, 1, ili 2; i
p je 0 ili 1.
3. Spoj prema zahtjevu 2, ili farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da
Z je -OH;
R2 je C1-C4alkil, C1-C4fluoroalkil, C1-C4deuteroalkil, C3-C6cikloalkil, ili -C1-C4alkilen-W;
W je hidroksi, halogen, CN, C1-C4alkoksi, ili C3-C6cikloalkil;
R6 je H;
R7 je H;
m je 0 ili 1;
n je 0, 1, ili 2; i
p je 0.
4. Spoj prema zahtjevu 3, ili njegova farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da spoj prema Formuli (XII) ima strukturu prema formuli (XIII):
[image]
5. Spoj prema zahtjevu 3, ili farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da spoj prema Formuli (XII) ima strukturu Formule (XIV) ili Formule (XV):
[image]
[image]
6. Spoj prema jednom od zahtjeva 1 do 5, ili farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da
svaki R3 je nezavisno F, Cl, ili -CH3;
svaki R4 je nezavisno halogen, -CN, -OH, -S(=O)2CH3, -S(=O)2CH2CH3, -CH3, -CH2CH3, -CF3, - CH2OH,
-OCF3, -OCH3, ili -OCH2CH3;
svaki R5 je nezavisno F, Cl, ili -CH3;
m je 0 ili 1;
n je 0, 1, ili 2; i
p je 0 ili 1.
7. Spoj prema zahtjevu 6, ili farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da
R2je -CH3, -CH2CH3, -CH2CH2CH3, -CH(CH3)2, -CH2CH2CH2CH3, -CH2CH(CH3)2, -CH2F, -CHF2, -CF3, -CH2CF3, -CD3, -CH2CD3, -CD2CD3, ciklopropil, ciklobutil, ciklopentil, cikloheksil, - CH2-W, ili -CH2CH2-W;
W je hidroksi, F, Cl, -CN, -OCH3, -OCH2CH3, -OCH2CH2CH3, -OCH(CH3)2, ciklopropil, ciklobutil, ciklopentil, ili cikloheksil.
8. Spoj prema zahtjevu 7, ili farmaceutski prihvatljiva sol, ili njegov N-oksid, naznačeno time da
R2 je-CH2CH3 ili ciklobutil;
svaki R4 je nezavisno F, Cl, -CN, -OH, -CH3, -CH2CH3, -CF3, -CH2OH, -OCF3, -OCH3, ili - OCH2CH3;
m je 0 ili 1;
n je 0, 1, ili 2; i
p je 0.
9. Spoj prema zahtjevu 1, naznačeno time da je spoj:
(E)-etil 3-(4-((E)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilat;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-benzo[d][1,2,3]triazol-5-il)-2-fenilbut-1-en-1-il)fenil) akrilna kiselina;
(E)-3-(4-((E)-2-(4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hlorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(3-metoksifenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-(hidroksimetil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-(hidroksimetil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-(hidroksimetil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(o-tolil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(m-tolil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(p-tolil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(2-metoksifenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(4-metoksifenil)but-1-en-1-il)fenil)akrilna kiselina;
((E)-3-(4-((E)-2-(2-hlorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-hlorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-etilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(2-(trifluorometil)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-hloro-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-fluorofenil)-1-(1H-indazol-4-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-cijanofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,4-difluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-3-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklopropil-1-(1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-fluoro-2-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,6-difluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,6-dihlorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4,4,4-trideutero-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-fluoro-3-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(5-fluoro-2-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,3-difluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,5-difluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-5-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-6-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(7-hloro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(4-metil-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(7-metil-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(6-metil-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(3-metil-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(3-hloro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilprop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilpent-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-cijanofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-cijanofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-hidroksi-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-4-metoksi-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-3-metoksi-2-fenilprop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(4-fluoro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(6-hloro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-4-metil-2-fenilpent-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-benzo[d][1,2,3]triazol-5-il)-2-(2-hloro-4-fluorofenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(4-hloro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina
(E)-3-(4-((E)-2-ciklopentil-1-(1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-cikloheksil-1-(1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-3-metil-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-3-ciklopropil-1-(1H-indazol-5-il)-2-fenilprop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hlorofenil)-2-ciklopropil-1-(1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(6-fluoro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-benzo[d]imidazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilheks-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-3-ciklopentil-1-(1H-indazol-5-il)-2-fenilprop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(7-fluoro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(7-fluoro-1H-indol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(1H-indazol-5-il)-4-metilpent-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((Z)-3,3-difluoro-1-(1H-indazol-5-il)-2-fenilprop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(7-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-fluoro-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-hloro-2-(2-hloro-4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((Z)-3,3,3-trifluoro-1-(1H-indazol-5-il)-2-fenilprop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(4-fluoro-1H-indazol-5-il)-2-(4-fluoro-2-metilfenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-metilfenil)-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklopropil-1-(4-fluoro-1H-indazol-5-il)-2-(4-fluoro-2-metilfenil)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-metilfenil)-2-ciklopropil-1-(4-fluoro-1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(4-hloro-1H-indazol-5-il)-2-(2-hloro-4-fluorofenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((Z)-2-(2-hloro-4-fluorofenil)-3,3-difluoro-1-(1H-indazol-5-il)prop-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklopropil-1-(4-fluoro-1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-hloro-1-(4-fluoro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-hloro-2-(2-hloro-4-fluorofenil)-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-fluoro-2-(4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-4-fluoro-1-(4-fluoro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-5-metoksi-2-fenilpent-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-6-metoksi-2-fenilheks-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(1H-indazol-5-il)-3-metilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(3-(trifluorometoksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklobutil-1-(1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-2-ciklobutil-1-(1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(3-fluoro-1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklobutil-1-(3-fluoro-1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(3-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-2-ciklobutil-1-(3-fluoro-1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-etil 3-(4-((E)-2-(4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilat;
(E)-etil 3-(4-((E)-1-(1H-indazol-5-il)-2-(2-metoksifenil)but-1-en-1-il)fenil)akrilat;
(E)-etil 3-(4-((E)-1-(1H-indazol-5-il)-2-(4-metoksifenil)but-1-en-1-il)fenil)akrilat;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)-2-metilakrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-3-metilfenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-2-metilfenil)akrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-2-hlorofenil)akrilna kiselina;
(Z)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)-2-fluoroakrilna kiselina;
(Z)-3-(4-((E)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)-2-hloroakrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-3-fluorofenil)akrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-2-fluorofenil)akrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-2-(trifluorometil)fenil)akrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-3-metoksifenil)akrilna kiselina;
(E)-3-(4-((Z)-1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)-2-metoksifenil)akrilna kiselina;
(E)-etil 3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilat hidroklorid;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-etil 3-(4-((E)-2-(2,4-dihlorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilat;
(E)-3-(4-((E)-2-(2,4-dihlorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-(trifluorometil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-2-ciklopropil-1-(1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-fluoro-2-(trifluorometil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-(1-(4-fluoro-1H-indazol-5-il)-2-(4-fluoro-2-(trifluorometil) fenil)butil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,4-dihlorofenil)-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-(trifluorometil)fenil)-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-4-fluoro-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-metoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,4-dihlorofenil)-4-fluoro-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklopropil-2-(2,4-dihlorofenil)-1-(4-fluoro-1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-2-ciklopropil-1-(4-fluoro-1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklopropil-2-(2,4-dihlorofenil)-1-(1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-metilfenil)-2-ciklopropil-1-(1H-indazol-5-il)vinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(2-metil-5-(metilsulfonil)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(4-metoksi-2-metilfenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-fluoro-4-metoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-5-metoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-fluoro-4-(metilsulfonil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,4-dihlorofenil)-3,3,4,4,4-pentadeutero-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(3-(metilsulfonil)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,4-dihlorofenil)-1-(7-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-3-metoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2,4-dihlorofenil)-1-(7-fluoro-1H-indol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(7-fluoro-1H-indol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-3,3,4,4,4-pentadeutero-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hloro-2-cijanofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-cijano-4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-cijano-4-(trifluorometil)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-cijanofenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-cijano-2-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-cijano-2-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(5-cijano-2-metilfenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-cijano-4-metoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-hidroksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hidroksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-hidroksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-(1-(1H-indazol-5-il)-2-fenilbut-1-en-1-il)fenil)propionska kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(4-(2-metoksietoksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(4-(3-metoksipropoksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(3-(2-metoksietoksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(3-(3-metoksipropoksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-(cikloheksiloksi)fenil)-1-(4-fluoro-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-butoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(3-(pentiloksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(3-(heksiloksi)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-butoksifenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(4-(pentiloksi)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-(heksiloksi)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(4-(2-hidroksietoksi)fenil)-1-(1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-1-(1H-indazol-5-il)-2-(2-(metilsulfonil)fenil)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hlorofenil)-1-(1-metil-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-ciklobutil-1-(1-metil-1H-indazol-5-il)-2-fenilvinil)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(1-metil-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
(E)-3-(4-((E)-2-(2-hloro-4-fluorofenil)-1-(1-(difluorometil)-1H-indazol-5-il)but-1-en-1-il)fenil)akrilna kiselina;
ili njihova farmaceutski prihvatljiva sol ili N-oksid.
10. Spoj prema patentnom zahtjevu 1, naznačeno time da je spoj predstavljen jednom od slijedećih formula:
[image]
[image]
[image]
[image]
ili
[image]
ili njegova farmaceutski prihvatljiva sol ili N-oksid.
11. Farmaceutski prihvatljiva sol spoja prema jednom od zahtjeva 1 do 10.
12. Farmaceutski pripravak koji sadrži spoj prema jednom od patentnih zahtjeva 1 do 10, ili njegovu farmaceutski prihvatljivu sol ili N-oksid i najmanje jedan farmaceutski prihvatljiv neaktivan sastojak.
13. Farmaceutski pripravak prema zahtjevu 12, naznačeno time da je farmaceutski pripravak formuliran za intravensko ubrizgavanje, potkožno ubrizgavanje, oralno davanje lijeka, ili topikalno davanje lijeka.
14. Farmaceutski pripravak prema zahtjevu 15, naznačeno time da je farmaceutski pripravak tableta, pilula, kapsula, tekućina, suspenzija, gel, disperzija, otopina, emulzija, mast ili losion.
15. Spoj prema jednom od zahtjeva 1 do 10, ili njegova farmaceutski prihvatljiva sol, ili njegov N-oksid, za upotrebu u medicini.
16. Spoj prema jednom od zahtjeva 1 do 10, ili njegova farmaceutski prihvatljiva sol, ili njegov N-oksid, za upotrebu za liječenje raka kod sisavaca.
17. Spoj prema zahtjevu 16, ili njegova farmaceutski prihvatljiva sol, ili njegov N-oksid, za upotrebu za liječenje raka dojke, raka jajnika, raka endometrija, raka prostate, ili raka materice kod sisavaca.
18. Spoj prema jednom od zahtjeva 1 do 10, ili njegova farmaceutski prihvatljiva sol, ili njegov N-oksid, za upotrebu za liječenje raka kostiju, raka dojke, kolorektalnog raka, raka endometrija, raka prostate, raka jajnika, raka materice, raka grlića materice, raka pluća, leomioma, leomioma materice, alkoholizme, migrene, aneurizme aorte, podložnosti infarktu miokarda, skleroze zaliska aorte, kardiovaskularne bolesti, bolesti srčanih arterija, hipertenzija, tromboza duboke vene, Gravesove bolesti, artritisa, multipla skleroze, ciroze, hepatitisa B, kronične bolesti jetre, gustoće kostiju, holestaze, hipospadijaze, gojaznosti, osteoartritisa, osteopenije, osteoporoze, Alzheimerove bolesti, Parkinsonove bolesti, migrene, vertiga, anoreksije nervoze, poremećaja hiperaktivnosti i deficita pažnje (ADHD), demencije, teškog depresivnog stanja, psihoze, doba menstruacije, endometrioze, ili neplodnosti kod sisavaca.
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