HRP20131165T1 - Novel milk thistle extract, method for the production, and use - Google Patents

Claims (8)

1. The process for obtaining fruit extract from milk thistle has a silymarin release rate of 80% or more, characterized by a.) this herbal medicine (Silybum marianum) is extracted at 40-80 degrees Celsius with a solvent that has moderate polarity, where the solvent of moderate polarity is chosen from the group of ethyl acetate, ethanol, methanol, acetone, b.) separated, preferably filtered, c.) concentrated, preferably under vacuum with stirring, at a temperature less than 60 degrees Celsius, preferably less than 40 degrees Celsius, and c') optionally washed with warm water, d.) combined with ethanol, preferably ethanol of 96% or more, and then combined with hexane and concentrated, preferably at a pressure of 1-100 mbar, and the resulting ethanol-water phase is removed, e.) dried and optionally cut into leaves, f.) placed in anhydrous alcohol, preferably ethanol, g.) optionally filtered and concentrated, i h.) dried and optionally cut into strips. 2. The procedure for obtaining fruit extract from milk thistle has a silymarin dissolution rate of 80% or more, characterized by the fact that it is extracted in step a.) at 50-70 degrees Celsius. 3. The process for obtaining fruit extract from milk thistle has a dissolution rate of silymarin of 80% or more, according to claim 1, characterized by the fact that in step f.) the anhydrous alcohol is anhydrous C1-C4 alcohol. 4. Fruit extract from milk thistle which can be obtained by the process according to one of the patent claims 1 to 3. 5. The milk thistle fruit extract that can be obtained by the process according to one of patent claims 1 to 3 or the fruit extract from milk thistle according to claim 4, consists of an amorphous modification of crystals, where the crystal content is less than 20%, and especially less than 10%, and preferably less than 7%. 6. Fruit extract from milk thistle which can be obtained by the process according to one of patent claims 1 to 3 or fruit extract from milk thistle according to claim 4 for use in the treatment and prevention of liver and gall bladder dysfunction, especially for toxic liver damage (fatty liver, alcohol), hepatosis such as mushroom poisoning, acute liver failure, liver necrosis, liver dystrophy, liver cirrhosis, hepatic fibrosis, hepatomegaly, and fatty liver degeneration, liver failure, and hepatitis, especially hepatitis C. 7. Fruit extract from milk thistle which can be obtained by the process according to one of patent claims 1 to 3 or fruit extract from milk thistle according to claim 4 for use in the treatment and prevention of liver and gall bladder dysfunction, especially for toxic liver damage (fatty liver, alcohol), hepatosis such as mushroom poisoning, acute liver failure, liver necrosis, liver dystrophy, liver cirrhosis, hepatic fibrosis, hepatomegaly, and fatty liver degeneration, liver failure, and hepatitis, especially hepatitis C. 8. A pharmaceutical preparation containing a fruit extract from milk thistle can be obtained by a process according to one of claims 1 to 3 or a fruit extract from milk thistle according to claim 4.