HRP20040741A2 - Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds - Google Patents

Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds

Info

Publication number
HRP20040741A2
HRP20040741A2 HRP20040741A HRP20040741A2 HR P20040741 A2 HRP20040741 A2 HR P20040741A2 HR P20040741 A HRP20040741 A HR P20040741A HR P20040741 A2 HRP20040741 A2 HR P20040741A2
Authority
HR
Croatia
Prior art keywords
antithrombic
polymorphs
compounds
clopidogrel hydrochloride
clopidogrel
Prior art date
Application number
Other languages
English (en)
Inventor
Puter Kotay Nagy
Jozsef Barkoczy
Gyula Simig
Zsuzsa Szent Kirsllyi
Tamss Gregor
Bula Farkas
Gyoergyi Vereczkeynu Donsth
Kslmsn Nagy
Gylulsnu Koertvulyessy
Original Assignee
Egis Gyogyszergysr Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergysr Rt filed Critical Egis Gyogyszergysr Rt
Publication of HRP20040741A2 publication Critical patent/HRP20040741A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
HRP20040741 2002-02-06 2004-08-17 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds HRP20040741A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
PCT/HU2002/000157 WO2003066637A1 (en) 2002-02-06 2002-12-20 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds

Publications (1)

Publication Number Publication Date
HRP20040741A2 true HRP20040741A2 (en) 2004-12-31

Family

ID=89980128

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040741 HRP20040741A2 (en) 2002-02-06 2004-08-17 Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds

Country Status (15)

Country Link
US (1) US20050113406A1 (EP2818471A1)
EP (1) EP1474427A1 (EP2818471A1)
JP (1) JP2005522441A (EP2818471A1)
KR (1) KR20040079987A (EP2818471A1)
AU (1) AU2002353251A1 (EP2818471A1)
BG (1) BG108868A (EP2818471A1)
CZ (1) CZ2004901A3 (EP2818471A1)
EA (1) EA007119B1 (EP2818471A1)
HR (1) HRP20040741A2 (EP2818471A1)
HU (1) HUP0200438A3 (EP2818471A1)
IS (1) IS7385A (EP2818471A1)
PL (1) PL370038A1 (EP2818471A1)
SK (1) SK3362004A3 (EP2818471A1)
WO (1) WO2003066637A1 (EP2818471A1)
YU (1) YU69604A (EP2818471A1)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
EA008972B1 (ru) * 2004-01-13 2007-10-26 Зентива А.С. Новые кристаллические формы гидробромида клопидогреля и способы их получения
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate
CA2562532C (en) * 2004-04-09 2010-02-16 Hanmi Pharm. Co., Ltd. Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
ZA200608035B (en) * 2004-04-20 2008-07-30 Sanofi Aventis Clopidogrel salt and polymorphic forms thereof
ZA200608569B (en) * 2004-04-20 2007-12-27 Sanofi Aventis Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
WO2005117866A1 (en) * 2004-06-01 2005-12-15 Ivax Pharmaceuticals S.R.O. Amorphous clopidogrel hydrochloride and its antithrombotic use
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
WO2007029096A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Novel polymorphic forms of clopidogrel hydrochloride
WO2007029080A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Preparation of form i of clopidogrel hydrochloride
KR20070066518A (ko) * 2005-12-22 2007-06-27 에스케이케미칼주식회사 고체상 반응을 이용한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR101235117B1 (ko) 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR100742134B1 (ko) * 2006-02-07 2007-07-24 경동제약 주식회사 결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
ES2855700T3 (es) 2007-04-27 2021-09-24 Cydex Pharmaceuticals Inc Formulaciones que contienen clopidogrel y sulfoalquil éter-ciclodextrina y métodos de uso
US7985859B2 (en) * 2007-05-30 2011-07-26 Wockhardt Ltd. Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
EP3100728B1 (en) 2009-05-13 2019-11-20 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Also Published As

Publication number Publication date
PL370038A1 (en) 2005-05-16
SK3362004A3 (sk) 2005-03-04
IS7385A (is) 2004-08-05
AU2002353251A1 (en) 2003-09-02
BG108868A (en) 2005-09-30
HUP0200438A3 (en) 2003-10-28
CZ2004901A3 (cs) 2005-02-16
EP1474427A1 (en) 2004-11-10
US20050113406A1 (en) 2005-05-26
EA007119B1 (ru) 2006-06-30
JP2005522441A (ja) 2005-07-28
HU0200438D0 (en) 2002-04-29
WO2003066637A1 (en) 2003-08-14
HUP0200438A2 (hu) 2003-09-29
EA200401025A1 (ru) 2004-12-30
KR20040079987A (ko) 2004-09-16
YU69604A (sh) 2006-08-17

Similar Documents

Publication Publication Date Title
HRP20040741A2 (en) Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
PL376575A1 (pl) Podstawione związki heterocykliczne oraz sposoby wykorzystania
AU2003217870A8 (en) Pini-modulating compounds and methods of use thereof
GB0325192D0 (en) Method of use
IL181524A0 (en) Heterocyclic compounds and methods of use
AU2003213673A8 (en) Pin1-modulating compounds and methods of use thereof
HK1068874A1 (en) Heterocyclic compounds and methods of use
HK1077762A1 (zh) TFGß[轉化生長因子]的抑制劑
ZA200506790B (en) Arylvinylazacycloalkane compounds and method of preparation and use thereof
IL172004A0 (en) Polymorphic forms of ziprasidone hci and processes for their preparation
EP1625111A4 (en) THYRONAMINE DERIVATIVES AND ANALOGUES AND METHODS OF USE THEREOF
GB0305150D0 (en) Use of therapeutic compounds
EP1678157A4 (en) Heterocyclic compounds and process for their preparation and use
ZA200407609B (en) Use of vitamin d compounds
IL165475A0 (en) Nitrooxyderivatives of eyclooxygenase-2 inhibitors
EP1638565A4 (en) SUBSTITUTED PIPERIDINE COMPOUNDS AND METHOD OF USE THEREOF
PL376604A1 (pl) Polimorfy chlorowodorku bicifadyny
EP1619002A4 (en) STRUCTURE OF AN OBJECT
IL175654A0 (en) Cycloalkyl derivatives of 3-hydroxy -4-pyridinones
EP1545287A4 (en) VASOREGULATORY COMPOUNDS AND METHODS RELATING TO THEIR USE
EP1620101A4 (en) POLYMORPHS OF CABERGOLIN
AU2003262141A8 (en) Preperation of desloratatine
GB0304555D0 (en) Compounds and methods of manufacture
PL1656358T3 (pl) Trwały polimorf mesylanu bifeprunoksu
EP1686990A4 (en) 2-GUANIDINYLIMIDAZOLIDINEDIONE COMPOUNDS: METHODS OF PREPARATION AND USE

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20051201

Year of fee payment: 4

OBST Application withdrawn