HRP20020513B1 - Substituted bisindolylmaleimides for the inhibition of cell proliferation - Google Patents
Substituted bisindolylmaleimides for the inhibition of cell proliferationInfo
- Publication number
- HRP20020513B1 HRP20020513B1 HR20020513A HRP20020513A HRP20020513B1 HR P20020513 B1 HRP20020513 B1 HR P20020513B1 HR 20020513 A HR20020513 A HR 20020513A HR P20020513 A HRP20020513 A HR P20020513A HR P20020513 B1 HRP20020513 B1 HR P20020513B1
- Authority
- HR
- Croatia
- Prior art keywords
- inhibition
- cell proliferation
- bisindolylmaleimides
- substituted
- substituted bisindolylmaleimides
- Prior art date
Links
- 150000003924 bisindolylmaleimides Chemical class 0.000 title 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17105199P | 1999-12-16 | 1999-12-16 | |
| PCT/EP2000/012559 WO2001044234A1 (fr) | 1999-12-16 | 2000-12-12 | Bisindolylmaleimides substitues destines a inhiber la proliferation cellulaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20020513A2 HRP20020513A2 (en) | 2004-08-31 |
| HRP20020513B1 true HRP20020513B1 (en) | 2006-10-31 |
Family
ID=22622296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020513A HRP20020513B1 (en) | 1999-12-16 | 2002-06-12 | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6313143B1 (fr) |
| EP (1) | EP1242408B1 (fr) |
| JP (2) | JP2003516986A (fr) |
| KR (1) | KR100507422B1 (fr) |
| CN (1) | CN1229374C (fr) |
| AR (1) | AR029415A1 (fr) |
| AT (1) | ATE306484T1 (fr) |
| AU (1) | AU783616B2 (fr) |
| BR (1) | BRPI0016329B8 (fr) |
| CA (1) | CA2392902C (fr) |
| CO (1) | CO5050293A1 (fr) |
| CZ (1) | CZ304130B6 (fr) |
| DE (1) | DE60023182T2 (fr) |
| ES (1) | ES2249314T3 (fr) |
| GC (1) | GC0000265A (fr) |
| HK (1) | HK1054385B (fr) |
| HR (1) | HRP20020513B1 (fr) |
| HU (1) | HU230003B1 (fr) |
| IL (2) | IL150128A0 (fr) |
| JO (1) | JO2296B1 (fr) |
| MA (1) | MA26856A1 (fr) |
| MX (1) | MXPA02005560A (fr) |
| MY (1) | MY126998A (fr) |
| NO (1) | NO322240B1 (fr) |
| NZ (1) | NZ519173A (fr) |
| PE (1) | PE20011034A1 (fr) |
| PL (1) | PL200243B1 (fr) |
| RS (1) | RS50449B (fr) |
| RU (1) | RU2264398C2 (fr) |
| TW (1) | TWI274752B (fr) |
| UY (1) | UY26485A1 (fr) |
| WO (1) | WO2001044234A1 (fr) |
| ZA (1) | ZA200204258B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102373A1 (fr) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Procede d'administration d'un agent destine a la therapie du cancer |
| WO2003037384A2 (fr) * | 2001-10-29 | 2003-05-08 | Nektar Therapeutics Al, Corporation | Conjugues polymeres d'inhibiteurs de proteine kinease c |
| JP6106437B2 (ja) * | 2010-01-07 | 2017-03-29 | アルカーメス ファーマ アイルランド リミテッド | 複素芳香族化合物のプロドラッグ |
| EP2474541A1 (fr) * | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Composés conjugués de 3-(indolyl)- et 3-(azaindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| GB9416467D0 (en) * | 1994-08-13 | 1994-10-05 | Wellcome Found | Compounds for use in medicine |
| WO1997033552A1 (fr) * | 1996-03-12 | 1997-09-18 | Pg-Txl Company, L.P. | Bioprecurseurs de paclitaxel solubles dans l'eau |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
| PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| JP2002500184A (ja) * | 1998-01-09 | 2002-01-08 | アリゾナ ボード オブ リーゼンツ | フェンスタチンとそのプロドラッグの合成 |
| KR100659411B1 (ko) | 1998-03-17 | 2006-12-18 | 에프. 호프만-라 로슈 아게 | 세포 증식 억제를 위한 치환된 비스인돌리말레이미드 |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| MXPA02003667A (es) * | 1999-10-12 | 2002-08-30 | Hoffmann La Roche | Pirroles sustituidos como agentes antiproliferativos para tratamiento del cancer. |
-
2000
- 2000-11-07 US US09/707,678 patent/US6313143B1/en not_active Expired - Lifetime
- 2000-12-11 JO JO2000198A patent/JO2296B1/en active
- 2000-12-12 MX MXPA02005560A patent/MXPA02005560A/es active IP Right Grant
- 2000-12-12 AT AT00983288T patent/ATE306484T1/de active
- 2000-12-12 RU RU2002119209/04A patent/RU2264398C2/ru active
- 2000-12-12 WO PCT/EP2000/012559 patent/WO2001044234A1/fr active IP Right Grant
- 2000-12-12 CZ CZ20022447A patent/CZ304130B6/cs not_active IP Right Cessation
- 2000-12-12 RS YUP-433/02A patent/RS50449B/sr unknown
- 2000-12-12 HU HU0203696A patent/HU230003B1/hu unknown
- 2000-12-12 JP JP2001544724A patent/JP2003516986A/ja not_active Withdrawn
- 2000-12-12 KR KR10-2002-7007517A patent/KR100507422B1/ko active IP Right Grant
- 2000-12-12 CN CNB008170665A patent/CN1229374C/zh not_active Expired - Lifetime
- 2000-12-12 PL PL355856A patent/PL200243B1/pl unknown
- 2000-12-12 NZ NZ519173A patent/NZ519173A/en not_active IP Right Cessation
- 2000-12-12 DE DE60023182T patent/DE60023182T2/de not_active Expired - Lifetime
- 2000-12-12 BR BRPI0016329A patent/BRPI0016329B8/pt not_active IP Right Cessation
- 2000-12-12 ES ES00983288T patent/ES2249314T3/es not_active Expired - Lifetime
- 2000-12-12 AU AU20082/01A patent/AU783616B2/en not_active Expired
- 2000-12-12 EP EP00983288A patent/EP1242408B1/fr not_active Expired - Lifetime
- 2000-12-12 IL IL15012800A patent/IL150128A0/xx active IP Right Grant
- 2000-12-12 CA CA002392902A patent/CA2392902C/fr not_active Expired - Lifetime
- 2000-12-13 CO CO00094815A patent/CO5050293A1/es unknown
- 2000-12-14 AR ARP000106636A patent/AR029415A1/es active IP Right Grant
- 2000-12-14 PE PE2000001346A patent/PE20011034A1/es not_active IP Right Cessation
- 2000-12-14 MY MYPI20005871A patent/MY126998A/en unknown
- 2000-12-15 UY UY26485A patent/UY26485A1/es not_active Application Discontinuation
- 2000-12-16 TW TW089126995A patent/TWI274752B/zh not_active IP Right Cessation
- 2000-12-16 GC GCP20001101 patent/GC0000265A/en active
-
2002
- 2002-05-28 ZA ZA200204258A patent/ZA200204258B/en unknown
- 2002-06-10 IL IL150128A patent/IL150128A/en unknown
- 2002-06-11 NO NO20022776A patent/NO322240B1/no not_active IP Right Cessation
- 2002-06-12 HR HR20020513A patent/HRP20020513B1/xx not_active IP Right Cessation
- 2002-06-14 MA MA26691A patent/MA26856A1/fr unknown
-
2003
- 2003-09-16 HK HK03106629.3A patent/HK1054385B/zh not_active IP Right Cessation
-
2007
- 2007-01-22 JP JP2007011821A patent/JP4763623B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20181204 Year of fee payment: 19 |
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| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20191203 Year of fee payment: 20 |
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| PB20 | Patent expired after termination of 20 years |
Effective date: 20201212 |