HK148195A - Fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase - Google Patents

Fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase

Info

Publication number
HK148195A
HK148195A HK148195A HK148195A HK148195A HK 148195 A HK148195 A HK 148195A HK 148195 A HK148195 A HK 148195A HK 148195 A HK148195 A HK 148195A HK 148195 A HK148195 A HK 148195A
Authority
HK
Hong Kong
Prior art keywords
coa
acyl
inhibitors
fatty acid
acid amides
Prior art date
Application number
HK148195A
Other languages
English (en)
Inventor
Milton Louis Hoefle
Ann Holmes
Bruce David Roth
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HK148195A publication Critical patent/HK148195A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
HK148195A 1987-02-24 1995-09-14 Fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase HK148195A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/017,960 US4716175A (en) 1987-02-24 1987-02-24 Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase

Publications (1)

Publication Number Publication Date
HK148195A true HK148195A (en) 1995-09-22

Family

ID=21785503

Family Applications (1)

Application Number Title Priority Date Filing Date
HK148195A HK148195A (en) 1987-02-24 1995-09-14 Fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase

Country Status (17)

Country Link
US (1) US4716175A (de)
EP (1) EP0283742B1 (de)
JP (1) JPH07121895B2 (de)
KR (1) KR880009933A (de)
AT (1) ATE89814T1 (de)
CA (1) CA1336913C (de)
DE (1) DE3881249T2 (de)
DK (1) DK165406C (de)
ES (1) ES2056843T3 (de)
FI (1) FI89593C (de)
HK (1) HK148195A (de)
IE (1) IE59998B1 (de)
MX (1) MX9203139A (de)
NO (1) NO174043C (de)
NZ (1) NZ223410A (de)
PT (1) PT86811B (de)
ZA (1) ZA88604B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827152D0 (en) * 1988-11-21 1988-12-29 Wellcome Found Anti-atherosclerotic diaryl compounds
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
AU6659090A (en) * 1989-11-16 1991-06-13 Warner-Lambert Company Acat inhibitors
WO1991015464A1 (en) * 1990-04-11 1991-10-17 Warner-Lambert Company Amide ester acat inhibitors
US5149709A (en) * 1990-07-03 1992-09-22 Schering Corporation Inhibitors of acyl-coenzyme A: cholesterol acyl transferase
WO1992001681A1 (fr) * 1990-07-25 1992-02-06 Teijin Limited Derive de benzopyrane, sa production, et composition pharmaceutique le contenant
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
ATE137744T1 (de) * 1990-11-26 1996-05-15 Taisho Pharmaceutical Co Ltd Anilidderivat
FR2673625B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
EP0619312A4 (de) * 1991-12-25 1995-07-19 Taisho Pharmaceutical Co Ltd Anilid-derivate.
SK142694A3 (en) * 1992-05-28 1995-06-07 Pfizer N-aryl and n-heteroarylurea derivatives as inhibitors of acylcoenzyme a:cholesterol-acyltransferase, pharmaceutical preparations contains these compounds and use
HUT67475A (en) * 1992-07-20 1995-04-28 Eisai Co Ltd Benzene derivatives and pharmaceutical compositions containing them as active components
US5321031A (en) * 1992-09-23 1994-06-14 Schering Corporation 1,2-disubstituted ethyl amides as inhibitors of ACAT
CA2107196A1 (en) * 1992-09-29 1994-03-30 Mitsubishi Chemical Corporation Carboxamide derivatives
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
AU672699B2 (en) * 1993-06-30 1996-10-10 Sankyo Company Limited Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5596001A (en) * 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
IT1265209B1 (it) * 1993-11-22 1996-10-31 Pierrel Spa Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro
US6133326A (en) * 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
KR960031425A (ko) * 1995-02-08 1996-09-17 시미주 마사미 다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그의 용도
GEP20043286B (en) * 2000-02-02 2004-07-26 Warner Lambert Co Dual Inhibitors of Cholesteryl Ester and Wax Ester Synthesis for Sebaceous Gland Disorders
CA2373411A1 (en) * 2000-03-16 2001-09-20 Taeyoung Yoon 5-substituted arylpyrimidines
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
EP1281399A3 (de) * 2001-08-01 2004-02-11 Warner-Lambert Company Hemmer mit doppelter Wirkung auf Wachsester- und Cholesterylestersynthese zur Hemmung der Sebumproduktion
DK1725234T4 (en) 2004-03-05 2016-05-09 Univ Pennsylvania METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
RU2010128543A (ru) 2007-12-11 2012-01-20 Сайтопатфайндер, Инк. (Jp) Карбоксамидные соединения и их применение в качестве агонистов хемокиновых рецепторов
WO2010039801A2 (en) 2008-10-02 2010-04-08 The J. David Gladstone Institutes Methods of treating hepatitis c virus infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL120013C (de) * 1958-04-14
BE620639A (de) * 1961-07-25
SE353319B (de) * 1964-08-15 1973-01-29 Sumitomo Chemical Co
DE1618959C3 (de) * 1967-10-04 1978-12-14 Sumitomo Chemical Co., Ltd., Osaka (Japan) Fettsäureamide und Verfahren zu ihrer Herstellung
DE2830351A1 (de) * 1978-07-11 1980-01-24 Consortium Elektrochem Ind Acylanilide
GR69292B (de) * 1979-06-25 1982-05-13 May & Baker Ltd
BR8106184A (pt) * 1980-01-25 1981-11-24 Reanal Finomvegyszergyar Processo para preparacao de derivados de n-aril-n'-(mono-ou dissubstituido)-ureia
NZ216253A (en) * 1985-05-27 1989-07-27 Mitsui Toatsu Chemicals N-(3-chloro-4-isopropylphenyl)-carboxamide derivatives and herbicidal compositions
MA20552A1 (fr) * 1985-10-11 1986-07-01 Pan Medica Sa Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations

Also Published As

Publication number Publication date
AU610558B2 (en) 1991-05-23
US4716175A (en) 1987-12-29
PT86811A (pt) 1988-03-01
EP0283742B1 (de) 1993-05-26
FI89593C (fi) 1993-10-25
JPH07121895B2 (ja) 1995-12-25
DE3881249D1 (en) 1993-07-01
DK94188A (da) 1988-08-25
NZ223410A (en) 1989-11-28
US4716175B1 (de) 1993-06-22
ES2056843T3 (es) 1994-10-16
ATE89814T1 (de) 1993-06-15
NO174043C (no) 1994-03-09
DK165406B (da) 1992-11-23
KR880009933A (ko) 1988-10-05
DE3881249T2 (de) 1993-09-16
PT86811B (pt) 1992-05-29
FI880796A0 (fi) 1988-02-19
IE59998B1 (en) 1994-05-18
EP0283742A3 (en) 1989-07-26
NO174043B (no) 1993-11-29
EP0283742A2 (de) 1988-09-28
IE880204L (en) 1988-08-24
MX9203139A (es) 1992-07-01
NO880774L (no) 1988-08-25
DK165406C (da) 1993-04-13
JPS63253060A (ja) 1988-10-20
DK94188D0 (da) 1988-02-23
NO880774D0 (no) 1988-02-23
AU1135488A (en) 1988-08-25
FI89593B (fi) 1993-07-15
FI880796A (fi) 1988-08-25
CA1336913C (en) 1995-09-05
ZA88604B (en) 1989-09-27

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)