HK1216651A1 - 工程化肝組織、其陣列及其製備方法 - Google Patents
工程化肝組織、其陣列及其製備方法Info
- Publication number
- HK1216651A1 HK1216651A1 HK16104477.6A HK16104477A HK1216651A1 HK 1216651 A1 HK1216651 A1 HK 1216651A1 HK 16104477 A HK16104477 A HK 16104477A HK 1216651 A1 HK1216651 A1 HK 1216651A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- arrays
- making
- methods
- same
- liver tissues
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2535/00—Supports or coatings for cell culture characterised by topography
- C12N2535/10—Patterned coating
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/841,430 US9442105B2 (en) | 2013-03-15 | 2013-03-15 | Engineered liver tissues, arrays thereof, and methods of making the same |
PCT/US2014/026679 WO2014151921A1 (en) | 2013-03-15 | 2014-03-13 | Engineered liver tissues, arrays thereof, and methods of making the same |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1216651A1 true HK1216651A1 (zh) | 2016-11-25 |
Family
ID=51529845
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16104477.6A HK1216651A1 (zh) | 2013-03-15 | 2016-04-19 | 工程化肝組織、其陣列及其製備方法 |
HK16108356.3A HK1220480A1 (zh) | 2013-03-15 | 2016-07-15 | 工程化肝組織、其陣列及其製備方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16108356.3A HK1220480A1 (zh) | 2013-03-15 | 2016-07-15 | 工程化肝組織、其陣列及其製備方法 |
Country Status (14)
Country | Link |
---|---|
US (5) | US9442105B2 (zh) |
EP (1) | EP2970896B1 (zh) |
JP (5) | JP2016514968A (zh) |
KR (4) | KR20150122260A (zh) |
CN (1) | CN105209605B (zh) |
AU (4) | AU2014236780C9 (zh) |
BR (1) | BR112015023515A8 (zh) |
CA (1) | CA2903844C (zh) |
DK (1) | DK2970896T3 (zh) |
HK (2) | HK1216651A1 (zh) |
IL (1) | IL241055A (zh) |
RU (1) | RU2625016C2 (zh) |
SG (1) | SG11201507202YA (zh) |
WO (1) | WO2014151921A1 (zh) |
Families Citing this family (75)
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US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
EP2310847B1 (en) | 2008-06-24 | 2016-05-04 | The Curators Of The University Of Missouri | Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same |
US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
RU2560393C2 (ru) | 2010-10-21 | 2015-08-20 | Органово, Инк. | Устройства, системы и способы изготовления ткани |
RU2014113641A (ru) * | 2011-09-12 | 2015-10-20 | Органово, Инк. | Сконструированные ткани для применения в исследованиях in vitro, их массивы и способы их изготовления |
US9499779B2 (en) | 2012-04-20 | 2016-11-22 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking |
KR102258565B1 (ko) | 2012-11-15 | 2021-05-28 | 알로소스 | 세절 연골 시스템 및 방법 |
CA2894750C (en) | 2013-02-22 | 2021-12-14 | Allosource | Cartilage mosaic compositions and methods |
AU2014236705B2 (en) | 2013-03-15 | 2018-04-12 | Allosource | Perforated osteochondral allograft compositions |
US9442105B2 (en) | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
SG11201600770RA (en) | 2013-07-31 | 2016-02-26 | Organovo Inc | Automated devices, systems, and methods for the fabrication of tissue |
CN106536720B (zh) | 2014-04-04 | 2021-04-30 | 奥加诺沃公司 | 工程化的三维乳腺组织,脂肪组织和肿瘤疾病模型 |
CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
SG11201702795QA (en) | 2014-10-06 | 2017-05-30 | Organovo Inc | Engineered renal tissues, arrays thereof, and methods of making the same |
AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
WO2016073782A1 (en) | 2014-11-05 | 2016-05-12 | Organovo, Inc. | Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same |
TWI741980B (zh) | 2015-04-07 | 2021-10-11 | 大陸商四川藍光英諾生物科技股份有限公司 | 一種生物磚及其用途 |
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JP7026040B2 (ja) | 2015-06-16 | 2022-02-25 | アスペクト バイオシステムズ リミティド | 連続的にバイオプリントされた多層組織構造体 |
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EP3362076B1 (en) * | 2015-10-15 | 2024-07-03 | Wake Forest University Health Sciences | Methods of producing in vitro liver constructs and uses thereof |
JP7007267B2 (ja) | 2015-11-09 | 2022-01-24 | オルガノボ インコーポレイテッド | 組織製造のための改善された方法 |
CN106916781A (zh) * | 2015-12-25 | 2017-07-04 | 清华大学 | 一种体外三维人体肝组织的构建方法及其应用 |
WO2017123722A1 (en) | 2016-01-12 | 2017-07-20 | Cleveland State University | 3d-printed miniature biological constructs |
CN105561389A (zh) * | 2016-01-18 | 2016-05-11 | 西北工业大学 | 一种蛋白质自组装人工肝支架制备方法 |
WO2017139455A1 (en) * | 2016-02-10 | 2017-08-17 | Wake Forest University Health Sciences | Model system of liver fibrosis and method of making and using the same |
CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
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KR102558606B1 (ko) | 2016-12-05 | 2023-07-26 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
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WO2018151223A1 (ja) * | 2017-02-16 | 2018-08-23 | 国立大学法人京都大学 | 細胞評価方法、細胞評価装置、及び細胞評価プログラム |
US20200115682A1 (en) * | 2017-04-03 | 2020-04-16 | Deborah Lynn GREENE NGUYEN | Use of Engineered Liver Tissue Constructs for Modeling Liver Disorders |
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KR102062465B1 (ko) | 2017-09-25 | 2020-01-03 | 아주대학교산학협력단 | 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법 |
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KR20200092948A (ko) | 2017-10-20 | 2020-08-04 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 | 돼지 세포의 3d 무 지지체 바이오프린팅 |
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