HK1169396A1 - Improved process for the preparation of ambrisentan and novel intermediates thereof - Google Patents
Improved process for the preparation of ambrisentan and novel intermediates thereofInfo
- Publication number
- HK1169396A1 HK1169396A1 HK12110072.6A HK12110072A HK1169396A1 HK 1169396 A1 HK1169396 A1 HK 1169396A1 HK 12110072 A HK12110072 A HK 12110072A HK 1169396 A1 HK1169396 A1 HK 1169396A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ambrisentan
- preparation
- improved process
- novel intermediates
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1626MU2009 | 2009-07-10 | ||
IN2233MU2009 | 2009-09-25 | ||
IN462MU2010 | 2010-02-19 | ||
PCT/IN2010/000464 WO2011004402A2 (en) | 2009-07-10 | 2010-07-12 | Improved process for the preparation of ambrisentan and novel intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1169396A1 true HK1169396A1 (en) | 2013-01-25 |
Family
ID=43297159
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12110072.6A HK1169396A1 (en) | 2009-07-10 | 2012-10-11 | Improved process for the preparation of ambrisentan and novel intermediates thereof |
HK14105259.9A HK1192880A1 (zh) | 2009-07-10 | 2012-10-11 | 安貝生坦製備的改進過程 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14105259.9A HK1192880A1 (zh) | 2009-07-10 | 2012-10-11 | 安貝生坦製備的改進過程 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8962832B2 (es) |
EP (2) | EP2451786B1 (es) |
JP (1) | JP5531097B2 (es) |
ES (2) | ES2462065T3 (es) |
HK (2) | HK1169396A1 (es) |
WO (1) | WO2011004402A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2309996A2 (de) * | 2008-08-11 | 2011-04-20 | Ratiopharm GmbH | Amorphes ambrisentan |
CN102219748B (zh) * | 2011-05-04 | 2014-05-07 | 天津市医药集团技术发展有限公司 | 无定型安贝生坦及其制备方法 |
CN102276536B (zh) | 2011-06-10 | 2015-04-29 | 中国科学院化学研究所 | 一种光学纯的(+)-安倍生坦和光学纯的(+)-达芦生坦的制备方法 |
CN102887861B (zh) * | 2011-07-18 | 2015-04-15 | 天津市医药集团技术发展有限公司 | 一种安贝生坦新晶型及其制备方法 |
JP2015502916A (ja) * | 2011-10-19 | 2015-01-29 | シプラ・リミテッド | エンドセリン受容体拮抗薬の調製法 |
CN103420811B (zh) * | 2012-05-18 | 2015-04-15 | 上海医药工业研究院 | 用于制备安立生坦的中间体化合物及其制备方法、以及安立生坦的制备 |
DK2867214T3 (en) | 2012-06-29 | 2016-11-28 | Kern Pharma S L | A process for preparing carboxylic acid derivatives and intermediates thereof |
CN103524425A (zh) * | 2012-07-04 | 2014-01-22 | 天津药物研究院 | 一种安立生坦的晶型v及其制备方法和应用 |
WO2014139087A1 (zh) * | 2013-03-12 | 2014-09-18 | 江苏康缘药业股份有限公司 | 一种手性2-[(4,6-二甲基嘧啶-2-基)氧基]-3-甲氧基-3,3-二苯基丙酸的消旋化方法 |
CN104515816B (zh) * | 2013-09-29 | 2016-04-20 | 天津药物研究院 | 一种安立生坦原料及制剂有关物质的检测方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4313412A1 (de) | 1993-04-23 | 1994-10-27 | Basf Ag | 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung |
DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
KR20010023615A (ko) * | 1997-09-04 | 2001-03-26 | 스타르크, 카르크 | 신규 카르복실산 유도체, 그 제조 및 혼합 eta/etb엔도텔린 수용체 길항제로서의 용도 |
DE19850301A1 (de) | 1998-10-30 | 2000-05-04 | Basf Ag | Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren |
DE19858779A1 (de) * | 1998-12-18 | 2000-06-21 | Basf Ag | Neue ß-Amido und ß-Sulfonamidocarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
DE19933164A1 (de) * | 1999-07-20 | 2001-01-25 | Basf Ag | Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
US20080262006A1 (en) * | 2007-02-02 | 2008-10-23 | Harbeson Scott L | Selective endothelin type-a antagonists |
EP2309996A2 (de) | 2008-08-11 | 2011-04-20 | Ratiopharm GmbH | Amorphes ambrisentan |
WO2010070658A2 (en) * | 2008-11-05 | 2010-06-24 | Msn Laboratories Limited | Improved process for the preparation of endothelin receptor antagonists |
WO2010091877A2 (en) | 2009-02-13 | 2010-08-19 | Ratiopharm Gmbh | Process for producing ambrisentan |
-
2010
- 2010-07-12 EP EP10779052.9A patent/EP2451786B1/en active Active
- 2010-07-12 ES ES10779052.9T patent/ES2462065T3/es active Active
- 2010-07-12 EP EP13199182.0A patent/EP2712865B1/en not_active Not-in-force
- 2010-07-12 WO PCT/IN2010/000464 patent/WO2011004402A2/en active Application Filing
- 2010-07-12 US US13/382,988 patent/US8962832B2/en not_active Expired - Fee Related
- 2010-07-12 ES ES13199182.0T patent/ES2575000T3/es active Active
- 2010-07-12 JP JP2012519124A patent/JP5531097B2/ja not_active Expired - Fee Related
-
2012
- 2012-10-11 HK HK12110072.6A patent/HK1169396A1/xx not_active IP Right Cessation
- 2012-10-11 HK HK14105259.9A patent/HK1192880A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1192880A1 (zh) | 2014-09-05 |
JP5531097B2 (ja) | 2014-06-25 |
ES2575000T3 (es) | 2016-06-23 |
US20120184573A1 (en) | 2012-07-19 |
ES2462065T3 (es) | 2014-05-22 |
WO2011004402A3 (en) | 2011-03-10 |
WO2011004402A2 (en) | 2011-01-13 |
EP2712865B1 (en) | 2016-03-16 |
US8962832B2 (en) | 2015-02-24 |
EP2451786B1 (en) | 2014-01-22 |
EP2451786A2 (en) | 2012-05-16 |
EP2712865A1 (en) | 2014-04-02 |
JP2012532863A (ja) | 2012-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180712 |