HK1143161A1 - 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的鹽 - Google Patents

激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的鹽

Info

Publication number
HK1143161A1
HK1143161A1 HK10109728.8A HK10109728A HK1143161A1 HK 1143161 A1 HK1143161 A1 HK 1143161A1 HK 10109728 A HK10109728 A HK 10109728A HK 1143161 A1 HK1143161 A1 HK 1143161A1
Authority
HK
Hong Kong
Prior art keywords
janus
cyclopentylpropanenitrile
pyrrolo
pyrazol
pyrimidin
Prior art date
Application number
HK10109728.8A
Other languages
English (en)
Inventor
Hui-Yin Li
James D Rodgers
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1143161(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of HK1143161A1 publication Critical patent/HK1143161A1/zh

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
HK10109728.8A 2007-06-13 2010-10-14 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的鹽 HK1143161A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94370507P 2007-06-13 2007-06-13
PCT/US2008/066662 WO2008157208A2 (en) 2007-06-13 2008-06-12 Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Publications (1)

Publication Number Publication Date
HK1143161A1 true HK1143161A1 (zh) 2010-12-24

Family

ID=40029273

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10109728.8A HK1143161A1 (zh) 2007-06-13 2010-10-14 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的鹽
HK14112206.9A HK1198652A1 (zh) 2007-06-13 2014-12-03 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的結晶鹽

Family Applications After (1)

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HK14112206.9A HK1198652A1 (zh) 2007-06-13 2014-12-03 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的結晶鹽

Country Status (42)

Country Link
US (10) US20080312259A1 (zh)
EP (5) EP2173752B2 (zh)
JP (1) JP5475653B2 (zh)
KR (2) KR20150036210A (zh)
CN (2) CN101932582B (zh)
AU (1) AU2008266183B2 (zh)
BR (1) BRPI0814254B8 (zh)
CA (1) CA2689663C (zh)
CO (1) CO6251256A2 (zh)
CR (1) CR11151A (zh)
CU (2) CU24179B1 (zh)
CY (3) CY1115145T1 (zh)
DK (3) DK2740731T3 (zh)
DO (1) DOP2009000280A (zh)
EA (1) EA019784B1 (zh)
EC (1) ECSP099802A (zh)
ES (4) ES2903444T3 (zh)
GE (1) GEP20125533B (zh)
GT (1) GT200900314A (zh)
HK (2) HK1143161A1 (zh)
HR (3) HRP20140541T4 (zh)
HU (2) HUE043732T2 (zh)
IL (5) IL202524A (zh)
LT (1) LT3070090T (zh)
MA (1) MA31517B1 (zh)
ME (1) ME00960B (zh)
MX (2) MX342814B (zh)
MY (1) MY154969A (zh)
NI (1) NI200900216A (zh)
NO (1) NO2019025I1 (zh)
NZ (1) NZ581803A (zh)
PL (3) PL3070090T3 (zh)
PT (2) PT2173752E (zh)
RS (3) RS54878B1 (zh)
SG (3) SG182198A1 (zh)
SI (3) SI2740731T1 (zh)
SM (1) SMP201000002B (zh)
TN (1) TN2009000514A1 (zh)
TR (1) TR201903488T4 (zh)
UA (1) UA99467C2 (zh)
WO (1) WO2008157208A2 (zh)
ZA (1) ZA200908826B (zh)

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SI2401267T1 (sl) 2009-02-27 2014-05-30 Ambit Biosciences Corporation Derivati kinazolina, ki modulirajo JAK-kinazo, in njihova uporaba v postopkih
EA025520B1 (ru) 2009-05-22 2017-01-30 Инсайт Холдингс Корпорейшн N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
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KR101836538B1 (ko) 2010-02-18 2018-03-08 인사이트 홀딩스 코포레이션 야누스 키나아제 억제제로서의 사이클로부탄 및 메틸사이클로부탄 유도체
MX364636B (es) 2010-03-10 2019-05-03 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
KR102040479B1 (ko) * 2010-05-21 2019-11-06 인사이트 홀딩스 코포레이션 Ｊａｋ 저해제에 대한 국소 제형
MX2013002384A (es) 2010-09-01 2013-07-05 Ambit Biosciences Corp Compuestos quinazolina y metodos para utilizarlos.
SI2635299T1 (sl) * 2010-11-02 2020-02-28 The Trustees Of Columbia University In The City Of New York Postopki za zdravljenje motenj izgube las
CA2816957A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
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BR112013032720A2 (pt) 2011-06-20 2016-09-13 Incyte Corp "derivados de azetidinil fenil, piridil ou pirazinil carboxamida como inibidores de jak, composição e uso dos referidos derivados"
CN102921007B (zh) * 2011-08-09 2014-12-10 中国科学院上海生命科学研究院 防治胰岛素抵抗和糖尿病的方法和试剂
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